[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"burn\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:burn":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,47,80,108,131,163,194,231,258,280,304,329,354,378,403],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100642037","co2-ladd-tac-with-and-without-5-fu-for-hypertrophic-burn-scars-a-triple-blinded-split-scar-rct-100642037",false,"NCT07660120","CO2 LADD TAC With and Without 5-FU for Hypertrophic Burn Scars: A Triple-Blinded, Split Scar RCT","Comparing the Safety and Efficacy of CO2 Laser-Assisted Triamcinolone Delivery With and Without 5-Fluorouracil for Hypertrophic Burn Scars: A Triple-Blinded, Randomized Split Scar Clinical Trial","Inclusion Criteria:\n\n* Patient with hypertrophic scarring secondary to burn injury\n* Ages 18-89\n\nExclusion Criteria:\n\n* Pregnant patients or patients of childbearing age, sexually active, and unwilling to utilize contraception\n* Children\n* Individuals that are cognitively impaired and unable to provide consent\n* Currently breastfeeding\n* Has taken oral retinoids within 6 months of study initiation\n* Prior laser or intralesional TAC\u002F5-FU treatments for their hypertrophic scars\n* Active infection\n* Active malignancy\n* Known hypersensitivity to CO2 laser, TAC, or 5-FU\n* Known dihydropyrimidine dehydrogenase (DPD) deficiency (complete or partial), due to risk of systemic 5-FU toxicity\n* Systemic corticosteroid or immunosuppressive medication use\n* Intolerance to anesthesia\n* Known connective tissue disease","ALL","18 Years","89 Years",{"count":20,"type":21},65,"ESTIMATED","INTERVENTIONAL",[24],"NA","Burn scars can sometimes heal in a way that causes them to become thick, raised, and stiff. These scars may itch, feel uncomfortable, limit movement, and affect how the skin looks. Because of this, many burn survivors look for treatments that can help improve both the appearance and the symptoms of their scars.\n\nOne treatment that has shown promise is fractional CO₂ laser therapy. This laser creates tiny openings in the scar tissue that help soften the scar and stimulate the skin to remodel itself. These openings can also help medications applied to the skin reach deeper into the scar where they may work better.\n\nA steroid medication called triamcinolone is commonly used to treat these scars. Another medication, called 5-fluorouracil (5-FU), has been shown in prior studies to work well when combined with steroids, but it is usually given by injection, which can be painful and sometimes causes side effects.\n\nIn this study, we will look at whether delivering these medications through the laser openings can improve scars more effectively. Each participant's scar will be divided into two halves. One side will receive both medications, and the other side will receive the steroid alone. By comparing the two sides of the same scar, we hope to better understand whether adding 5-FU provides additional benefit.",[27,28,29,30],"Burn","Hypertrophic Scars","Scar Improvement by Laser","CO2 Laser in Scars",[32,33,34,35],"burn scar","hypertrophic scar","CO2 Laser","laser assisted drug delivery","NOT_YET_RECRUITING","2026-06-29",{"date":39,"type":40},"2026-07-01","ACTUAL",{"date":39,"type":21},{"date":43,"type":21},"2028-07-10",{"name":45,"class":46},"University of California, Davis","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":68,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":4},"100644682","burn-asv-trial-adaptive-support-ventilation-in-severe-burn-injury-100644682","NCT07674563","BURN-ASV Trial: Adaptive Support Ventilation in Severe Burn Injury","Adaptive Support Ventilation Versus Conventional Lung-Protective Ventilation in Severe Burn Injury Including Thermobaric and Drone-Related Burns: The BURN-ASV Randomized Controlled Trial","BURN-ASV","Inclusion Criteria:\n\n* Age 18 years or older.\n* Thermal burn injury involving ≥20% total body surface area (TBSA).\n* Requirement for invasive mechanical ventilation expected to exceed 24 hours.\n* Admission to a participating intensive care unit within 48 hours of injury.\n* Burn injury resulting from conventional flame burns, explosion-related burns, drone-related burns, or thermobaric blast burns.\n* Written informed consent provided by the patient or a legally authorized representative.\n\nExclusion Criteria:\n\n* Age younger than 18 years.\n* Pregnancy or breastfeeding.\n* Pre-existing chronic respiratory failure requiring home oxygen therapy or long-term mechanical ventilation.\n* Severe chronic obstructive pulmonary disease (COPD GOLD IV) or other end-stage pulmonary disease.\n* Extracorporeal membrane oxygenation (ECMO) at the time of enrollment.\n* Severe traumatic brain injury requiring controlled hyperventilation.\n* Expected death within 24 hours of ICU admission.\n* Do-not-resuscitate (DNR) order or limitations of life-sustaining treatment.\n* Previous enrollment in the current study.\n* Participation in another interventional trial that may interfere with study outcomes.","50 Years",{"count":57,"type":21},100,[24],"Severe burn injury frequently requires prolonged mechanical ventilation because of inhalation injury, respiratory failure, systemic inflammation, and repeated surgical procedures. Patients with extensive burns are at high risk of ventilator-associated complications, prolonged intensive care unit (ICU) stay, and death.\n\nAdaptive Support Ventilation (ASV) is an automated mode of mechanical ventilation that continuously adjusts breathing support according to the patient's respiratory needs and lung mechanics. Although ASV has shown potential benefits in general ICU populations, its effectiveness in patients with severe burn injuries has not been adequately studied.\n\nThe purpose of this randomized controlled trial is to compare Adaptive Support Ventilation with conventional lung-protective mechanical ventilation in critically ill adult burn patients, including those with inhalation injury, drone-related burns, and thermobaric blast burns. Participants will be randomly assigned to receive either ASV or conventional ventilation. The study will evaluate whether ASV improves ventilator-free days, reduces duration of mechanical ventilation, decreases ventilator-associated complications, and improves clinical outcomes.\n\nThe results of this study may help identify optimal ventilation strategies for patients with severe burn injuries and improve critical care management in both civilian and military burn centers.",[27,61,62,63,64,65,66,67],"Mechanical Ventilation","Mechanical Ventilation Complication","ICU","ICU Hospitalization","Critical Care, Intensive Care","Military Activity","Combat-Related Burn Injury",[69,67,70,71],"burn","adaptive support mechanical ventilation","mechanical ventilation","2026-06-24",{"date":37,"type":40},{"date":75,"type":21},"2026-09-23",{"date":77,"type":21},"2026-11-23",{"name":79,"class":46},"Ukrainian Society of Regional Anesthesia and Pain Therapy",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":91,"conditions":92,"keywords":95,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":4},"100636662","development-and-clinical-study-of-burn-wound-nursing-dressing-based-on-sodium-hyaluronate-carbomer-composite-hydrogel-100636662","NCT07568600","Development and Clinical Study of Burn Wound Nursing Dressing Based on Sodium Hyaluronate Carbomer Composite Hydrogel","Development and Preclinical Study of Nursing Dressing for Ⅰ\u002FShallow Ⅱ Degree Burn Wounds Based on Sodium Hyaluronate Carbomer Composite Hydrogel","Inclusion Criteria:\n\nPartial or full thickness burns requiring split thickness skin grafts Target burn wound size between 10 cm² and 1000 cm² Age ≥ 18 years Ability to read, write, and speak German Provision of voluntary informed consent to participate in the study, following a full explanation of the nature and purpose of the study, by signing the informed consent form approved by the Institutional Ethics Committee (IEC) prior to all evaluations Informed consent will be obtained from the patient or from a legal representative if the patient is not able or competent to consent; in such cases, informed consent will also be obtained from the patient when he\u002Fshe regains competence Women of childbearing potential must test negative on a standard urine pregnancy test and must agree to practice appropriate contraceptive methods for the duration of the study (e.g., oral contraceptive, intrauterine device \\[IUD\\], intramuscular contraceptive, abstinence)\n\nExclusion Criteria:\n\nTarget wound has exposed hyaline cartilage Connective tissue disorder Previous skin graft failure at target wound site Total burn surface area ≥ 70% Infected target wound Immunosuppression therapy Chronic hemodialysis Steroid use Diabetes (Type I) Allergy or sensitivity to any of the ingredients in Prontosan® Wound Gel X Allergy or sensitivity to chlorhexidine Pregnancy Simultaneous participation in another clinical trial","55 Years",{"count":89,"type":21},30,[24],"Development and clinical study of burn wound nursing dressing based on sodium hyaluronate carbomer composite hydrogel",[27,93,94],"Burn Contracture of Skin","Burn Degree Second",[96,97,98],"hydrogel","epidermal growth factor","Benzalkonium chloride","2026-04-28",{"date":101,"type":40},"2026-05-06",{"date":103,"type":21},"2026-08-15",{"date":105,"type":21},"2028-10-20",{"name":107,"class":46},"The First Affiliated Hospital of Xinxiang Medical College",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":115,"targetDuration":4,"studyType":117,"phases":4,"briefSummary":118,"conditions":119,"keywords":4,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":130},"100579758","determining-elements-of-anti-fungal-immunity-in-burn-patients-100579758","NCT06828458","Determining Elements of Anti-Fungal Immunity in BURN Patients","DEFI-BURN","Inclusion Criteria:\n\nBurn patients\n\n* Adult patients ≥ 18 years old\n* Admission \\\u003C 4 days following burn injury\n* Total burn surface Area ≥ 15%\n* Non opposition of the patient or his\u002Fher relatives to the research\n* Affiliation to social security or any health insurance\n\nExclusion Criteria:\n\n* Pregnancy\n* Opposition of the patient or his\u002Fher relatives\n* Decision not to resuscitate or to limit or stop active therapies",{"count":116,"type":21},327,"OBSERVATIONAL","Scientific justification Invasive fungal diseases (IFDs) pose a substantial threat, especially in immunocompromised patients, necessitating urgent research focus and therapeutic advancements. The IFI-BURN study, involving a cohort of patients with severe burn injury (n=276), revealed a significant IFD incidence of 31.6% and underscored their critical impact on morbidity and mortality. While fungi are present everywhere, for moulds within the environment and for yeasts within our microbiota, why certain patients develop IFDs and others do not, remains poorly understood. The answer most likely resides in the impact of the burn injury on the immune response, loss of skin barrier and particular predisposing immune phenotype of patients. The immune system is composed of both cellular and humoral components, but the latter is far less studied in antifungal immunity although they exert multiple antimicrobial mechanisms.",[27],"RECRUITING","2026-04-22",{"date":123,"type":40},"2026-04-23",{"date":125,"type":40},"2025-04-23",{"date":127,"type":21},"2030-10-23",{"name":129,"class":46},"Assistance Publique - Hôpitaux de Paris",1,{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":138,"sex":16,"minAge":139,"maxAge":140,"enrollmentInfo":141,"targetDuration":4,"studyType":22,"phases":143,"briefSummary":144,"conditions":145,"keywords":147,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":162},"100592397","the-effect-of-hologram-application-on-pain-anxiety-and-fear-levels-in-children-during-burn-dressing-100592397","NCT06992895","The Effect of Hologram Application on Pain, Anxiety, and Fear Levels in Children During Burn Dressing","Effect of Hologram Application on Pain, Anxiety and Fear Levels During Burn Dressing in Children: A Randomized Controlled Trial","Inclusion Criteria:\n\n* The subject has indicated their willingness to participate in the study. Physical and mental health.\n* The age range of the subjects included in this study was from 3 to 12 years of age.\n* The subject had never previously engaged in the practice of dressing a burn.\n* The presence of only second degree burns\n* Burn percentage is under 10%\n\nExclusion Criteria:\n\n* The subject is unwilling or unable to provide informed consent or assent (if applicable).\n* The subject has a history of significant physical or mental health disorders that may interfere with participation in the study.\n* The subject is younger than 3 years old or older than 12 years old.\n* The subject has previously engaged in the practice of burn dressing or similar procedures.\n* The presence of burns other than second-degree burns (e.g., first-degree or third-degree burns).\n* The percentage of burn area is greater than 10%.",true,"3 Years","12 Years",{"count":142,"type":21},70,[24],"The process of dressing burn injuries has been shown to cause both physical and psychological difficulties. In children, this process is particularly associated with intense pain and anxiety. Consequently, in addition to pharmacological interventions, non-pharmacological methods such as distraction are employed. In recent years, the utilization of holograms as a method of alleviating pain has emerged as a novel approach. The employment of these visual illusions has been demonstrated to effectively distract children, thereby providing a means of reducing discomfort. The objective of this thesis is to evaluate the effects of hologram application on pain, anxiety, fear, and vital signs during burn dressing in children.",[146,27],"Burn Wounds",[148,149,150,151,152],"Holography","Burns","Pain","Anxiety","Fear","2026-04-07",{"date":155,"type":40},"2026-04-13",{"date":157,"type":40},"2025-10-15",{"date":159,"type":21},"2026-06-20",{"name":161,"class":46},"Ataturk University",2,{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":169,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":171,"targetDuration":4,"studyType":22,"phases":173,"briefSummary":174,"conditions":175,"keywords":179,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":130},"100627845","blue-light-for-donor-site-healing-in-burn-patients-100627845","NCT07453927","Blue Light for Donor Site Healing in Burn Patients","Blue Light in the Treatment of Donor Site in Burn Patient: a Controlled Clinical Trial","CGU01_BL","Inclusion Criteria:\n\n* Patients with intermediate-deep burns with Total Body Surface Area (TBSA) \\> 10% requiring surgical treatment with escharectomy, presenting at least two Donor Site.\n* Patients over 18 years of age;\n* Patients who have signed the informed Consent Form (ICF) and understood the purpose of the study, or, if unable to give consent personally due to their condition, their legal guardian.\n\nExclusion Criteria:\n\n* Intermediate-deep burns TBSA \\\u003C 10% or superficial burns;\n* Patients under the age of 18;\n* Patients who are participating in other clinical trials with drugs or medical devices;\n* Patients with neoplasms or other conditions requiring the use of cytostatic or immunosuppressive drugs;\n* Patients with conditions that induce skin photosensitivity;\n* Pregnant or breastfeeding women;\n* Patients or relatives who are unable to understand the purposes of the trial;",{"count":172,"type":21},25,[24],"The goal of this clinical trial is to learn whether blue light (BL) photobiomodulation can improve the healing of donor site (DS) wounds in patients with burn injuries who are treated surgically. This study will investigate whether adding BL therapy to the usual treatment can improve healing and patient outcomes in adult patients with intermediate and deep burns.\n\nThe main questions it aims to answer are:\n\n* Does the use of BL therapy combined with standard treatment reduce the healing time of DS compared with standard treatment alone?\n* Does BL therapy improve wound conditions, reduce pain, and decrease signs of infection during the healing process?\n* Is BL therapy safe and well tolerated when applied to DS?\n* Does the treatment improve the long-term quality of the scar after healing?\n\nResearchers will compare DS areas treated with standard care alone to DS areas treated with standard care plus BL therapy to see whether BL improves healing outcomes. Each participant will serve as their own comparison: two different DS areas on the same patient will receive the two different treatments.\n\nParticipants will:\n\n* Receive the standard treatment for DS, which includes routine wound care and dressing\n* Receive BL therapy on one DS area in addition to the standard treatment, while another DS area will receive standard treatment alone\n* Attend regular clinical evaluations where clinicians will assess wound healing and the condition of the wound bed\n* Report their pain levels using a simple numeric scale during the healing period\n* Undergo skin swabs to detect possible signs of infection\n* Be monitored for any local side effects, such as redness, burning sensation, warmth, itching, or skin irritation related to the light treatment\n\nAfter the DS have completely healed, participants will return for follow-up visits at 1 month and 3 months. During these visits, researchers will evaluate the quality of the scars and monitor for any late side effects.",[176,27,177,178],"Donor Site Complication","Photobiomodulation Therapy","Blue Light",[180,181,182,183,184],"donor site","burns","photobiomodulation","blue light","healing","2026-03-31",{"date":187,"type":40},"2026-04-06",{"date":189,"type":40},"2025-09-29",{"date":191,"type":21},"2026-09-28",{"name":193,"class":46},"AUSL Romagna Rimini",{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":200,"eligibilityCriteria":201,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":202,"targetDuration":4,"studyType":22,"phases":204,"briefSummary":205,"conditions":206,"keywords":216,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":229,"locationsCount":130},"100617334","vr-pmr-for-post-burn-symptoms-100617334","NCT07317271","VR-PMR for Post-Burn Symptoms","Virtual Reality-Enhanced Progressive Muscle Relaxation for Symptom Management in Burn Survivors","VIBE","Inclusion criteria are:\n\n* ≥18 years old;\n* sustained a burn injury in the last 6 months or longer;\n* Score high on at least one of the following: Insomnia severity index (ISI) score of ≥8, Brief Pain Inventory Short Form (BPI-SF) Pain severity score of ≥3, or PROMIS Itch Severity of ≥55;\n* own a smartphone or computer with reliable internet connection for online visits and survey completion;\n* able to comfortably wear goggles or headsets on face as determined by self-report.\n\nExclusion criteria:\n\n* Cognitive impairment (Mini Mental Status Exam (MMSE) \\\u003C 25);\n* history of motion sickness, photosensitivity, photoinduced seizures, and claustrophobia as determined by self-report;\n* uncorrected visual or hearing impairments as determined by self-report;\n* non-English speaker.",{"count":203,"type":21},34,[24],"The goal of this clinical trial is to learn whether progressive muscle relaxation (PMR), delivered either alone or enhanced with virtual reality (VR), can help treat chronic symptom, such as pain, itch, anxiety, sleep disturbances, and fatigue, in adult burn survivors.\n\nThe main questions it aims to answer are:\n\n* Does VR-enhanced PMR (VR-PMR) reduce chronic pain, anxiety, itch, sleep disturbances, and fatigue more effectively than standard PMR?\n* Is VR-PMR a feasible and acceptable self-administered home-based intervention for burn survivors?\n\nResearchers will compare two self-administered intervention conditions, VR-enhanced PMR and standard PMR, using a randomized to sequence crossover design to see if VR technology enhances the therapeutic effects of PMR on chronic symptom management in burn survivors.\n\nParticipants will:\n\n* Complete home-based sessions of VR-enhanced PMR\n* Complete home-based sessions of standard PMR\n* Report symptoms such as pain, itch, anxiety, sleep disturbances, and fatigue throughout the study\n* Use VR equipment provided for the intervention period (during the VR-PMR arm)",[27,207,208,209,210,151,211,212,213,214,215],"Chronic Pain Following Thermal Burn Injury","Non-Pharmacological Interventions","Virtual Reality","Sleep Disturbance","Depressive Symptoms","Fatigue Symptom","Pruritus","Burn Injury","Progressive Muscle Relaxation",[209,217,215,218,150,219,220,221,149,214],"Burn Survivors","Chronic Symptom Management","Itch","Sleep","Fatigue","2026-03-03",{"date":224,"type":40},"2026-03-05",{"date":226,"type":40},"2026-02-27",{"date":228,"type":21},"2026-12",{"name":230,"class":46},"Johns Hopkins University",{"id":232,"slug":233,"hasResults":11,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":237,"eligibilityCriteria":238,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":239,"targetDuration":4,"studyType":22,"phases":241,"briefSummary":242,"conditions":243,"keywords":245,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":249,"lastUpdatePostDateStruct":250,"startDateStruct":252,"completionDateStruct":254,"leadSponsor":256,"locationsCount":130},"100622684","effect-of-laughie-on-pain-anxiety-and-pain-level-in-second-degree-burn-patients-100622684","NCT07386821","Effect of Laughie on Pain Anxiety and Pain Level in Second-Degree Burn Patients","The Effect of Laughie Exercise on Pain Anxiety and Pain Level in Second-Degree Burn Patients: A Randomised Controlled Trial","LA-PAP","Inclusion Criteria:\n\n* 18 years of age and over\n* Having a second degree burn\n* Arriving for the second dressing change on the unit\n* To agree to participate in the research\n\nExclusion Criteria:\n\n* In multiple burns, a burn degree other than the second degree on any part of the body\n* A maximum of 96 hours have elapsed since the burn injury\n* To have come to the dressing in repetitions other than the second dressing\n* Inability to tolerate the Laughie exercise",{"count":240,"type":21},88,[24],"Burn injuries are traumatic conditions that seriously affect individuals' quality of life, both physically and psychologically. Second-degree burns, in particular, affect the superficial and\u002For deep layers of the dermis, causing intense pain and extensive tissue damage. Pain in burn patients is not only physical; it combines with emotional stress, fear, and uncertainty to increase anxiety levels.\n\nThis study is a parallel group-randomised controlled trial designed to evaluate the effects of the Laughie exercise, administered prior to dressing changes in individuals diagnosed with second-degree burns, on post-dressing pain anxiety levels and pain intensity.",[27,244],"Second Degree Burns",[69,246,247,248],"laughie","pain","pain anxiety","2026-02-03",{"date":251,"type":40},"2026-02-04",{"date":253,"type":21},"2026-02",{"date":255,"type":21},"2028-01",{"name":257,"class":46},"Hacettepe University",{"id":259,"slug":260,"hasResults":11,"nctId":261,"briefTitle":262,"officialTitle":262,"acronym":263,"eligibilityCriteria":264,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":265,"targetDuration":4,"studyType":117,"phases":4,"briefSummary":267,"conditions":268,"keywords":4,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":274,"completionDateStruct":276,"leadSponsor":278,"locationsCount":130},"100610001","the-lateral-anterior-medial-lam-femoral-cutaneous-block-a-case-series-harborview-medical-center-seattle-wa-100610001","NCT07221903","The Lateral, Anterior, Medial (LAM) Femoral Cutaneous Block: A Case Series Harborview Medical Center, Seattle, WA","LAM","Inclusion Criteria:\n\n1. 18 years or older\n2. Scheduled surgery for STSG w\u002F donor site coming from thigh\n3. Care team requests LAM nerve block\n4. Anticipated postop pain in the cutaneous areas of anterior and lateral thigh\n\n   Exclusion Criteria:\n5. Inability to communicate sensation or motor changes in their body\n6. Preexisting sensory or motor deficits in the femoral nerve distribution\n7. Contraindication to the medication used or a peripheral nerve block, such as allergy to amide local anesthetics, severe liver dysfunction, injection site infection etc\n8. Pregnancy\n9. Prisoners\n10. Non-English Speaking\u002Freading\n11. Surgeries with anticipated or actual duration of 6 hours or longer\n12. TBSA 20% or greater\n13. Severe distracting injuries\u002Fpolytrauma (e.g., large or significant bone fractures)",{"count":266,"type":21},10,"Skin donor sites in patients undergoing split-thickness skin grafting surgeries can be very painful postoperatively. This site is most often the anterolateral thigh, the pain at which location can traditionally be covered by a fascia iliaca nerve block, although that comes with the disadvantage of losing motor functions in the femoral nerve distribution. The LAM nerve block, which is relatively new, aims to provide analgesia in the distribution of the lateral and anterior femoral cutaneous nerves. In short, this nerve block would decrease the sensation of the anterolateral thigh area without affecting the motor function of the leg. Investigators aim to study the consistency and coverage size of sensation changes by mapping out the area after the block in each patient.",[269,27,270],"Regional Anesthesia","Skin Grafting","2025-10-31",{"date":273,"type":40},"2025-11-04",{"date":275,"type":40},"2025-10-22",{"date":277,"type":21},"2026-12-31",{"name":279,"class":46},"University of Washington",{"id":281,"slug":282,"hasResults":11,"nctId":283,"briefTitle":284,"officialTitle":284,"acronym":4,"eligibilityCriteria":285,"healthyVolunteers":11,"sex":16,"minAge":286,"maxAge":287,"enrollmentInfo":288,"targetDuration":4,"studyType":22,"phases":290,"briefSummary":291,"conditions":292,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":295,"lastUpdatePostDateStruct":296,"startDateStruct":298,"completionDateStruct":300,"leadSponsor":302,"locationsCount":4},"100588451","effect-of-solutions-used-in-burn-wound-irrigation-on-healing-pain-fear-and-anxiety-randomized-controlled-study-100588451","NCT06941571","Effect of Solutions Used in Burn Wound Irrigation on Healing, Pain, Fear and Anxiety: Randomized Controlled Study","Inclusion Criteria: The child must be between the ages of 5-10, be followed up in the burn clinic of the pediatric surgery service, be conscious, alert, and open to communication, be a child with 10% or 2nd degree superficial and deep burns who are being followed up as an outpatient, have burns on the arms, legs, and torso, have hot water (boiling water, etc.) burns, and the parent and child must agree to participate in the study.\n\nExclusion Criteria: The child must be younger than 5 years old or older than 10 years old, have a general condition disorder due to burns, have a change in consciousness, have genital area and facial burns, have a 10% or more second and third degree burn, have a burn that is an indication for hospitalization, the parent uses topical agents for burn healing at home, and the parent and child do not accept to participate in the study.","5 Years","10 Years",{"count":289,"type":21},69,[24],"Burn, skin and\u002For subcutaneous tissues; It is an acute injury that causes traumatic lesions by exposure to thermal, chemical, mechanical or electrical agents. Among all traumatic injuries, burns are the most common type of injury and affect the entire body system. The World Health Organization reports that approximately 180,00 deaths per year are due to burns, making it the fifth most common type of childhood injury. It is also stated that 80% of burned children have hot water burns. Treatment is in two ways: surgical and non-surgical. The type of burn, its size, depth and the individual characteristics of the child affect the type of treatment.\n\nNon-surgical treatment is always the first choice in burn treatment. The primary method of this method is burn dressings. Before dressing, the burn surface must be cleaned\u002Firrigated with an appropriate antiseptic solution to remove metabolic wastes and tissue exudate. The aim here is to prepare a suitable environment for the burn wound to heal and to accelerate the healing process. In the literature, it is recommended to use various antiseptic solutions such as 0.9% NaCl, 0.5% chlorhexidine and hypochlorous acid for irrigation of burn wounds. Applying these solutions involves physical contact with the wound, and this contact may cause pain in the child. Additionally, the temperature and pH of the solution may cause discomfort. The pain that occurs during the irrigation process can further intensify anxiety and fear. However, it is not known which burn solutions used cause more pain, anxiety and fear. In this project, the effects of irrigation solutions used in the care of pediatric burn wounds on pain, fear, anxiety, infection development and healing will be examined. Child patients aged 5-10 years old with limb burns who present with hot water burns and do not have an indication for hospitalization will be included in the project. Children coming to burn dressing will be divided into three groups by simple randomization method. The burn wound of children in the first group will be irrigated with 0.09% NaCl, the children in the second group will be irrigated with 0.5% chlorhexidine, and the burn wound of children in the third group will be irrigated with hypochlorous acid solution. During irrigation of the burn wound, the child's anxiety, fear and pain status will be evaluated. At the same time, the effectiveness of the irrigation solutions used on the development of infection on the wound and its effectiveness on healing will be examined. For this reason, the burn wound will be monitored every three days. For this reason, children will be called to the burn clinic for dressing every three days. Before each dressing, a wound swab sample will be taken to determine the infection status in the burn wound. The Bates-Jensen wound assessment tool will be used to determine the healing status of the burn wound, and this tool will be evaluated by the burn nurse and two pediatric surgeons. In total, children will be monitored for 12 days. At the end of the project, the effect of the solutions used in burn irrigation on infection and healing will be determined. At the same time, the effects of the solutions on anxiety, fear and pain in children will be evaluated. It is thought that the data obtained as a result of the project will contribute to the development of a burn wound care protocol.",[27,293,294,150,151,152],"Burn Wound","Healing","2025-07-24",{"date":297,"type":40},"2025-07-28",{"date":299,"type":21},"2025-09-30",{"date":301,"type":21},"2026-04-30",{"name":303,"class":46},"Nurdan AKCAY DİDİSEN",{"id":305,"slug":306,"hasResults":11,"nctId":307,"briefTitle":308,"officialTitle":309,"acronym":4,"eligibilityCriteria":310,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":311,"enrollmentInfo":312,"targetDuration":4,"studyType":22,"phases":314,"briefSummary":316,"conditions":317,"keywords":4,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":319,"lastUpdatePostDateStruct":320,"startDateStruct":322,"completionDateStruct":324,"leadSponsor":326,"locationsCount":130},"100594896","phase-2-phase-ii-clinical-trial-of-kj101in-the-treatment-of-deep-ii-degree-burns-100594896","NCT07025408","Phase II Clinical Trial of KJ101in the Treatment of Deep II Degree Burns","A Multicentre, Randomised, Double-blind, Dose-exploratory, Controlled Drug and Placebo-controlled Phase II Clinical Trial Evaluating the Safety, Efficacy, Pharmacokinetic Profile, and Immunogenicity of KJ101 for Wound Debridement in Deep II Degree Burns","Inclusion criteria:\n\n1. Male and female subjects aged 18 to 65 years inclusive, who are neither pregnant nor lactating;\n2. Clinically diagnosed with superficial or deep II degree burns within 72 hours of injury, with a total burn area of ≤30% TBSA. The target burn wound must be isolated or have distinguishable boundaries, with an area between 40 and 200 cm².\n3. Subjects of childbearing age must agree to use effective and safe contraceptive methods during the treatment period and for three months after the final administration.\n\nExclusion criteria:\n\n1. Individuals who are known to be allergic to any component of the test drug or who have a tendency to allergies.\n2. Burns caused by specific factors, such as electrical or chemical burns.\n3. Subjects with shock or inhalation lung injury;\n4. Subjects with target wounds complicated by inflammatory skin diseases (e.g. atopic dermatitis, eczema or psoriasis), or who have undergone enzymatic debridement (e.g. with collagenase, papain, bromelain, chymotrypsin or trypsin).\n5. Subjects who, during screening, are judged by the investigator to have other severe systemic infections requiring systemic treatment;\n6. Abnormal liver or kidney function.","65 Years",{"count":313,"type":21},144,[315],"PHASE2","This multicentre, randomised, double-blind, dose-finding, active- and placebo-controlled Phase II clinical trial will evaluate the safety, efficacy, pharmacokinetic profile, and immunogenicity of KJ101 for the debridement of deep second-degree burns. The trial will provide supporting evidence for subsequent Phase III trials.",[27,318],"Burn Wounds - Partial Thickness (2nd Degree)","2025-06-10",{"date":321,"type":40},"2025-06-17",{"date":323,"type":21},"2025-06-16",{"date":325,"type":21},"2026-08-29",{"name":327,"class":328},"Shanghai Bao Pharmaceuticals Co., Ltd.","INDUSTRY",{"id":330,"slug":331,"hasResults":11,"nctId":332,"briefTitle":333,"officialTitle":334,"acronym":4,"eligibilityCriteria":335,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":336,"targetDuration":4,"studyType":22,"phases":337,"briefSummary":338,"conditions":339,"keywords":342,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":319,"lastUpdatePostDateStruct":346,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":352,"locationsCount":130},"100576560","paraffin-wax-and-exercise-prospective-100576560","NCT06786884","Paraffin Wax and Exercise Prospective","A Pilot, Randomized Controlled Trial Evaluating the Effectiveness of Paraffin Wax On Burn Patient Function, Range of Motion and Scar","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Patients with burn scar that crosses an upper or lower extremity joint (shoulder, elbow, wrist, hand, hip, knee, ankle)\n* Patients that have been prescribed a rehabilitation program where paraffin wax could be used as an adjunct to rehab exercise therapy\n\nExclusion Criteria:\n\n* Adults unable to provide informed consent\n* Injury etiology other than burn (ex: cutaneous trauma, cold injury, etc.)\n* Pregnant women\n* Prisoners",{"count":89,"type":21},[24],"This study is being done to test if paraffin wax can be used to improve the range of motion and function for scars across joints when used in combination with scar rehabilitation therapy sessions. For those randomized to receive it, the paraffin wax will be used alongside the participants' exercise therapy treatments. Currently, treatments that are used in addition to rehabilitation therapy for increasing range of motion across joints in the burn population are limited. By getting more information about how paraffin wax may or may not work, patients in the future that have scars may be able to be helped.",[27,340,341],"Scar","Exercise Therapy",[343,32,344,69,345],"paraffin wax","scar","range of motion",{"date":347,"type":40},"2025-06-13",{"date":349,"type":40},"2025-01-06",{"date":351,"type":21},"2027-02",{"name":353,"class":46},"Medstar Health Research Institute",{"id":355,"slug":356,"hasResults":11,"nctId":357,"briefTitle":358,"officialTitle":359,"acronym":4,"eligibilityCriteria":360,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":361,"targetDuration":4,"studyType":117,"phases":4,"briefSummary":362,"conditions":363,"keywords":364,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":369,"lastUpdatePostDateStruct":370,"startDateStruct":372,"completionDateStruct":374,"leadSponsor":376,"locationsCount":130},"100586902","assessment-of-burn-severity-and-extent-spatial-frequency-domain-imaging-100586902","NCT06921421","Assessment Of Burn Severity and Extent Spatial Frequency Domain Imaging","Assessment Of Burn Severity and Extent Spatial Frequency Domain Imaging (SFDI): An Observational Pilot Study","Inclusion Criteria:\n\n1. Patients 18 years of age or older\n2. Thermal burns of any depth (superficial, deep partial thickness, or full thickness).\n\nExclusion Criteria:\n\n1. Patients less than 18 years of age\n2. Pregnant or breastfeeding women",{"count":5,"type":21},"The goal of this pilot clinical study is to evaluate the feasibility of collecting Spatial Frequency Domain Imaging (SFDI) data in patients with circulatory compromise due to thermal burns using the FDA-cleared Clarifi Imaging System and the next generation handheld m-Clarifi. Accurate assessment of burn depth and assessment at the point of care is an essential input for clinicians to plan proper treatment and management. SFDI has been shown to be a promising method to evaluate burn depth and extent within 24 hours in pre-clinical studies. The two feasibility goals of this study are as follows: 1) Do the values obtained with a commercial SFDI system provide utility in assessing burn depth in a clinical setting? And 2) Do Clarifi and m-Clarifi provide equivalent data when assessing subjects with burn injuries (biomarker imaging values, clinical workflow).",[27,214],[365,366,367,368],"SFDI","Spatial Frequency Domain Imaging","Burn depth","Burn injury assessment","2025-04-08",{"date":371,"type":40},"2025-04-10",{"date":373,"type":21},"2025-04",{"date":375,"type":21},"2025-12",{"name":377,"class":46},"The Metis Foundation",{"id":379,"slug":380,"hasResults":11,"nctId":381,"briefTitle":382,"officialTitle":383,"acronym":4,"eligibilityCriteria":384,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":385,"targetDuration":4,"studyType":22,"phases":387,"briefSummary":388,"conditions":389,"keywords":391,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":394,"lastUpdatePostDateStruct":395,"startDateStruct":397,"completionDateStruct":399,"leadSponsor":401,"locationsCount":130},"100583683","thromboelastography-to-study-burn-coagulopathy-100583683","NCT06879509","Thromboelastography to Study Burn Coagulopathy","The Use of Thromboelastography in Burn Injury to Improve Burn Coagulopathy Evaluation and Intervention","Inclusion Criteria:\n\n* Patients admitted with acute burn injuries\n* Aged 18 years and older\n* Provided consent to participate in the study\n\nExclusion Criteria:\n\n* Patients with a history of venous thromboembolism or hyper\u002Fhypocoagulopathy",{"count":386,"type":21},50,[24],"This pilot study examines the use of thromboelastography (TEG), a specialized blood test, to evaluate clotting abnormalities in burn patients. The study aims to understand how burn injuries impact the body's ability to form and break down blood clots over time. Specifically, the investigators will research whether the percentage of total body surface area burned (%TBSA) is associated with changes in blood clotting, track the evolution of clotting patterns during the first four weeks following a burn injury, and explore whether these changes can predict recovery or complications. By providing new insights into clotting dynamics in burn patients, the study seeks to improve diagnostic methods, enhance monitoring strategies, and guide treatments to optimize patient care and outcomes.",[27,390],"Coagulation, Blood",[69,392,393],"coagulation","Thromboelastography","2025-03-10",{"date":396,"type":40},"2025-03-17",{"date":398,"type":21},"2025-06",{"date":400,"type":21},"2025-08",{"name":402,"class":46},"Francesco Egro",{"id":404,"slug":405,"hasResults":11,"nctId":406,"briefTitle":407,"officialTitle":408,"acronym":409,"eligibilityCriteria":410,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":411,"targetDuration":4,"studyType":22,"phases":413,"briefSummary":415,"conditions":416,"keywords":419,"overallStatus":120,"whyStopped":4,"lastUpdateSubmitDate":423,"lastUpdatePostDateStruct":424,"startDateStruct":426,"completionDateStruct":428,"leadSponsor":429,"locationsCount":130},"100555013","phase-4-low-dose-ketamine-infusion-during-burn-wound-care-100555013","NCT06506565","Low-Dose Ketamine Infusion During Burn Wound Care","A Randomized, Placebo-Controlled, Double-Blind Evaluation of Low-Dose Ketamine Infusion During Burn Wound Care Procedures to Improve Pain Intensity and Reduce Opioid Consumption","IMPROVE","Inclusion Criteria:\n\n* Admitted to burn service with thermal injury\n\nExclusion Criteria:\n\n* unable\u002Funwilling to consent within 72 hours\n* unable to report NRS\n* known contraindication to ketamine\n* \\\u003C than 18 years of age\n* pregnant\n* incarcerated\n* TBSA over 50 %",{"count":412,"type":21},140,[414],"PHASE4","The current standard of care (SOC) (i.e. fentanyl and midazolam) offers limited efficacy for preventing or relieving pain. Ketamine infusions may provide the benefits of analgesia, minimize adverse events, and reduce opioid use. The purpose of this study is to determine if adding a low dose ketamine infusion during wound care will safely provide pain relief for patients with burn injury.",[27,150,417,418],"Dissociation","Opioid",[420,69,421,422],"ketamine","opioid","analgesia","2024-12-09",{"date":425,"type":40},"2024-12-13",{"date":427,"type":40},"2024-07-08",{"date":375,"type":21},{"name":430,"class":46},"University of Tennessee"]