[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"burning-mouth-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:burning-mouth-syndrome":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,71,96],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100631848","mucolock-for-treatment-of-stomatitis-100631848",false,"NCT07506018","MucoLock™ for Treatment of Stomatitis","A Phase II Open-Label Trial of MucoLock™ Oral Rinse for the Treatment of Stomatitis Characterized by Oral Dysesthesia","Inclusion Criteria:\n\n* Age 18 years and older\n* Individuals with oral dysesthesia (worst VAS sensitivity\u002Fburning score ≥ 7 over the last week)\n* Ability to understand and the willingness to sign a written informed consent document\n\nExclusion Criteria:\n\n* Inability to comply with study instructions\n* Uncontrolled intercurrent illness or psychiatric illness\u002Fsocial situations that would limit compliance with study requirements\\*\n* Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the participant or the quality of the data.\n* Advanced kidney disease\n* Patients receiving antineoplastic therapy \\[e.g., tyrosine kinase inhibitors (TKIs), radiation\\] that could increase the risk of oral dysesthesia\n* Known altered mental status, encephalopathy, or cognition impairment\n* Ataxia\n* Known alcohol use disorder\n* Concomitant opioid therapy\n* Diagnosis of oral cancer currently undergoing therapy\n* Already using topical therapy for mouth pain (e.g., lidocaine, Magic mouthwash)\\*\n* Any opioid pain medication\\*\n* Treatment with another investigational drug or other intervention within 2 weeks. Patients will be recommended to stop previous medication for 2 weeks before starting the study treatment.\n\n(asterisk) \\*Modifiable criteria, with a timeframe of 2 weeks for a washout period.","ALL","18 Years",{"count":19,"type":20},25,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this research is to test how well people can tolerate MucoLock™ as a treatment for mouth pain or burning sensation and how well it works to reduce mouth pain or burning sensation. Study participants will be asked to use MucoLock™ topical solution as a \"swish and spit\" solution (similar to mouthwash) three times per day for 5 minutes each time, for 28 days.",[26,27,28,29,30],"Stomatitis","Pain","Burning Mouth","Burning Mouth Syndrome","Oral Dysesthesia","RECRUITING","2026-04-16",{"date":34,"type":35},"2026-04-20","ACTUAL",{"date":37,"type":35},"2026-04-15",{"date":39,"type":20},"2028-05",{"name":41,"class":42},"Baptist Health South Florida","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":51,"targetDuration":53,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":43},"100502241","reducing-patient-memory-recall-in-the-burning-mouth-patient-population-100502241","NCT05819697","Reducing Patient Memory Recall in the Burning Mouth Patient Population","FIRE Trial: Reducing Patient Memory Recall in the Burning Mouth Patient Population","Inclusion Criteria:\n\n1. Individuals aged 18 years and older\n2. Willing and able to provide informed consent\n3. Have been diagnosed with BMS for at least three months by an Oral Medicine or other specialist\n4. Willing to submit a saliva sample\n5. Have continuous access to a smartphone\n\nExclusion criteria:\n\n1. In the opinion of the investigator, is unable or unlikely to comply fully with the study requirements or procedures for any reason (e.g. cognitive or physical impairment)\n2. Prior head and neck radiation and\u002For chemotherapy\n3. Medications that modulate or suppress the inflammatory system",{"count":52,"type":20},10,"12 Weeks","OBSERVATIONAL","The goal of this study is to learn about burning mouth syndrome symptoms in real time in patients with burning mouth syndrome. The main questions it aims to answer are:\n\n(1) To test the ability of a smartphone app to collect repeated observations of individual data to assess fluctuations in BMS symptoms (pain) at multiple points in the day as they happen; (2) To evaluate a panel of salivary biomarkers in patients with burning mouth syndrome (BMS) and to study their relationship with clinical variables. With a collaboration between Penn Dental Medicine and Wharton School of Business, our proposal aims to vastly improve the characterization of burning mouth syndrome through the use of a smartphone app and\u002For text-based notification.\n\nParticipants will attend 2 study visits where they will complete questionnaires and provide saliva samples and will respond to notifications\u002Ftext message prompts on their smart phone 3 times a day for 12 weeks.",[29],[58,59,60,61],"burning mouth syndrome","oral pain","burning mouth","chronic intraoral burning sensation","2026-02-11",{"date":64,"type":35},"2026-02-12",{"date":66,"type":35},"2023-03-14",{"date":68,"type":20},"2026-12-30",{"name":70,"class":42},"University of Pennsylvania",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":78,"minAge":17,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":21,"phases":82,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":92,"leadSponsor":94,"locationsCount":43},"100619460","burning-mouth-syndrome-effects-of-occlusal-splint-therapy-100619460","NCT07344909","Burning Mouth Syndrome: Effects of Occlusal Splint Therapy","The Effects of Essix Splint Therapy on Burning Mouth Syndrome. A Prospective N-of-1 Study.","Inclusion Criteria:\n\n* patients with oral mucosal pain from participants in the previous BMS validation study.\n* greater than 30% pain relief during prior use of an Essix appliance.\n* chronic intraoral pain lasting more than 3 months.\n* age between 18 and 80 years.\n\nExclusion Criteria:\n\n* fibromyalgia\n* ongoing dental treatment","FEMALE","80 Years",{"count":81,"type":20},12,[23],"Burning Mouth Syndrome (BMS) causes chronic oral pain and significantly affects quality of life. Effective treatments are limited and often provide only temporary relief.\n\nThis prospective N-of-1 study evaluates the effect of an intraoral Essix appliance on pain intensity and salivary secretion in patients with BMS.\n\nSaliva samples are collected and analysed for volume and composition.",[29,85,86],"Orofacial Pain","Mouth Dryness","NOT_YET_RECRUITING","2026-01-08",{"date":90,"type":35},"2026-01-15",{"date":90,"type":20},{"date":93,"type":20},"2027-11-01",{"name":95,"class":42},"Malmö University",{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":102,"targetDuration":4,"studyType":21,"phases":104,"briefSummary":106,"conditions":107,"keywords":108,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":115,"leadSponsor":117,"locationsCount":43},"100594216","early-phase-1-burning-mouth-syndrome-symptoms-and-management-100594216","NCT07016555","Burning Mouth Syndrome: Symptoms and Management","Inclusion Criteria:\n\n* Have buring mouth syndrome or experience oral burn\n* Live in the United States\n* At least 18 years old\n* Having been diagnosed or suspected diagnosis of burning mouth syndrome or suffer from chronic oral burn without any identifiable causative lesion\n* No tongue or cheek piercings\n* No history of cancer\n* No recent or scheduled dental treatment\n* No history of gum disease\n* No aversions to mint or hop extracts\n\nExclusion Criteria:\n\n* Have recently undergone dental treatment in the last three months or have plans to undergo dental treatment (e.g., fillings, crowns, root canals, extractions, or other dental procedures) in the coming month.\n* Have started any new treatments for BMS in the last 3 months or have plans to start new treatments in the coming month.",{"count":103,"type":20},50,[105],"EARLY_PHASE1","This research study aims to evaluate how an oral cooling spray, currently a commercial dietary supplement, impacts symptoms associated with burning mouth syndrome (BMS). This study will examine symptoms, frequency, and severity, along with other related side effects of BMS on food intake, enjoyment, and quality of life.",[29],[109,58,110],"Symptom management","oral spray","2025-06-04",{"date":113,"type":35},"2025-06-11",{"date":113,"type":20},{"date":116,"type":20},"2025-12-15",{"name":118,"class":42},"University of Massachusetts, Amherst"]