[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"burst-suppression\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:burst-suppression":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,42,79,102,129],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100635803","relationship-between-induction-burst-suppression-and-bispectral-index-100635803",false,"NCT07557433","Relationship Between Induction Burst Suppression and Bispectral Index","The Relationship Between Burst Suppression Observed During Anesthesia Induction and the Bispectral Index Value During the Maintenance Phase of Anesthesia","Inclusion Criteria:\n\n* Age between 18 and 75 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Scheduled for elective surgery\n* Surgery planned to be performed under total intravenous anesthesia (TIVA)\n\nExclusion Criteria:\n\n* Presence of neurological disease\n* Chronic use of sedative medications or antiepileptic drugs\n* Severe hepatic or renal dysfunction\n* Intraoperative administration of ketamine or dexmedetomidine","ALL","18 Years","75 Years",{"count":20,"type":21},200,"ESTIMATED","1 Day","OBSERVATIONAL","The purpose of this study is to understand whether certain brain activity patterns that can appear at the beginning of anesthesia are related to how deep anesthesia remains during the operation.\n\nThe main question of the study is:\n\nDo patients who show a pattern called burst suppression during the start of anesthesia experience deeper anesthesia during surgery?\n\nPatients who are scheduled for elective surgery under total intravenous anesthesia (TIVA) may take part in this study. During the operation, brain activity will be monitored using a sensor placed on the forehead (Bispectral Index, BIS monitor), which is already commonly used during anesthesia. Information such as BIS values and the doses of anesthesia medications given during the operation will be recorded.\n\nParticipation in this study will not change the type of anesthesia or the routine care that patients receive during surgery. The study only involves recording and analyzing information collected during standard anesthesia monitoring.",[26,27,28],"Bispectral Index Monitoring","Burst Suppression","Total Intravenous Anesthesia","NOT_YET_RECRUITING","2026-04-23",{"date":32,"type":33},"2026-04-29","ACTUAL",{"date":35,"type":21},"2026-06-01",{"date":37,"type":21},"2027-08-01",{"name":39,"class":40},"Amasya University","OTHER",2,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":61,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":41},"100620427","comparison-of-target-controlled-and-manual-total-intravenous-anesthesia-in-supratentorial-surgery-100620427","NCT07357480","Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery","Comparison of Target-Controlled Infusion Using the Eleveld Model and Manual Total Intravenous Anesthesia on Intraoperative Anesthetic Consumption and Postoperative Pain and Delirium in Supratentorial Surgery","Inclusion Criteria:\n\n* Adult patients aged 18 to 60 years\n* Scheduled for elective supratentorial surgery under general anesthesia\n* American Society of Anesthesiologists (ASA) physical status I or II\n* Planned total intravenous anesthesia with propofol and remifentanil\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Refusal or inability to provide written informed consent\n* American Society of Anesthesiologists (ASA) physical status III or higher\n* Pregnancy\n* Emergency surgery\n* Presence of brain herniation\n* Anticipated or documented difficult airway\n* Inability to communicate effectively (e.g., non-Turkish speaking or hearing impairment)\n* Preoperative risk factors for delirium, including substance abuse, use of neuropsychiatric medications, preoperative hemoglobin level \\\u003C 8 g\u002FdL, malnutrition, or electrolyte or thyroid hormone abnormalities\n* Intraoperative deviation from the study protocol, including changes in surgical or anesthetic technique or occurrence of major intraoperative complications\n* Contraindications to propofol or remifentanil","60 Years",{"count":51,"type":21},70,"INTERVENTIONAL",[54],"NA","This study aims to investigate the effect of target-controlled infusion using the Eleveld pharmacokinetic model compared with manually controlled total intravenous anesthesia on the incidence of postoperative delirium in patients undergoing supratentorial surgery. Propofol and remifentanil are administered using either target-controlled or manual infusion techniques according to the study protocol. Secondary objectives include comparisons of intraoperative anesthetic consumption, hemodynamic responses, recovery profiles, postoperative pain, and postoperative nausea and vomiting between the two anesthesia strategies. The study seeks to evaluate whether target-controlled infusion provides improved anesthetic management and postoperative outcomes compared with manual total intravenous anesthesia.",[57,58,59,27,60],"Postoperative Delirium (POD)","Postoperative Pain","PONV","Recovery Period, Anesthesia",[62,28,63,64,65,66,67,68],"Target Controlled Infusion","Eleveld Model","Postoperative Delirium","Supratentorial Surgery","Bispectral Index","Propofol","Remifentanil","RECRUITING","2026-03-24",{"date":72,"type":33},"2026-03-25",{"date":74,"type":33},"2026-01-14",{"date":76,"type":21},"2026-05",{"name":78,"class":40},"Istanbul University - Cerrahpasa",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":49,"enrollmentInfo":86,"targetDuration":4,"studyType":52,"phases":88,"briefSummary":89,"conditions":90,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":41},"100534305","remifentanil-effect-on-burst-suppression-ratio-100534305","NCT06237101","Remifentanil Effect on Burst Suppression Ratio","Influence of Variable Plasma Concentrations of Remifentanil on Burst Suppression (BS) Event Rate in Electroencephalographic (EEG) Recordings of Human Subjects Undergoing Total Intravenous General Anesthesia (TIVA) Under Propofol","Inclusion Criteria:\n\n* American Society of Anesthesiology I or II\n* Elective surgery of low or intermediate risk\n\nExclusion Criteria:\n\n* Neurological disease\n* Psychiatric disease\n* Use of psychoactive drugs or opioids\n* Altered basal state of consciousness\n* Allergy to propofol\n* Body mass index \\> 35 kg\u002Fm2\n* Pre-existing renal, cardiac and\u002For hepatic dysfunction\n* Patient's refusal to participate",{"count":87,"type":21},20,[54],"The goal of this clinical trial is to determine whether remifentanil has a facilitating effect on the generation of burst suppression by propofol in adult patients (18-60 years) candidates for elective surgery who require remifentanil and American Society of Anesthesiology (ASA) classification I or II. The main question it aims to answer are:\n\n• To determine whether remifentanil has a facilitating effect on the generation of burst suppression by propofol.\n\nParticipants will undergo general anesthesia with remifentanil and propofol sequentially. After loss of consciousness, remifentanil will be adjusted to a medium or high concentration randomly and it will be determined at what concentration of propofol the burst suppressions are generated.\n\nThen, the concentrations of propofol that generate burst suppression associated with either a medium or high concentration of remifentanil will be compared.",[91,92,27],"Anesthesia, Intravenous","Electroencephalography","2025-11-17",{"date":95,"type":33},"2025-11-20",{"date":97,"type":33},"2024-03-01",{"date":99,"type":21},"2026-09-30",{"name":101,"class":40},"University of Chile",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":110,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":112,"conditions":113,"keywords":115,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":41},"100595359","incidence-of-slow-delta-eeg-frequencies-01-1-hz-before-burst-suppression-100595359","NCT07031427","Incidence of Slow Delta EEG Frequencies (0.1-1 Hz) Before Burst Suppression","Incidence of Slow Delta EEG Frequencies (0.1-1 Hz) Before Burst Suppression: A Prospective Observational Pilot Study","SLOWWAVE","Inclusion Criteria:\n\n* patients undergoing elective general anaesthesia, and\n* aged 60 or above, and\n* have a good comprehension of German, and\n* require a general anaesthesia length of at least 1 hour (to ensure that we can record enough good quality EEG signal).\n\nExclusion Criteria:\n\n* patients undergoing head or neck surgery or surgery in prone or lateral decubitus position (due to the limited placement space on the forehead required for the two EEG electrode systems, limited access to the forehead during surgery), or\n* patients undergoing emergency surgery, operations only requiring local or regional anaesthesia with sedation, or\n* patients who cannot follow procedures, or have an inability to give consent, or\n* known participation in another human research project (ClinO\u002FHRO) that may affect the objectives of this study.",{"count":111,"type":21},30,"The electroencephalogram (EEG) measures brain waves during general anaesthesia via an electrode placed on the forehead. These brain waves show the different stages of natural sleep as well as the state of the brain when a patient is put under general anaesthesia for an operation. In this research project, the investigators aim to find out if the EEG signal shows slow wave activity (where an EEG wave repeats every 10 to 1 seconds) just before the onset of the burst suppression pattern, where the EEG waveform alternates between very small (suppression) and very large (burst) signals over a period of a few seconds. It is not currently known if and how often this occurs, but if it does, it would be a useful signal to help anaesthetists administer just the right dose of anaesthesia to patients.",[27,114],"Anesthesia",[116,117,27,118,119],"Electroencephalogram (EEG)","General Anesthesia","Delta power","Slowwave power","2025-06-23",{"date":122,"type":33},"2025-06-27",{"date":124,"type":21},"2025-07-01",{"date":126,"type":21},"2025-12",{"name":128,"class":40},"Insel Gruppe AG, University Hospital Bern",{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":16,"minAge":136,"maxAge":4,"enrollmentInfo":137,"targetDuration":4,"studyType":52,"phases":139,"briefSummary":140,"conditions":141,"keywords":143,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":159},"100580974","the-effects-of-anesthesia-depth-monitoring-on-postoperative-recovery-and-cognitive-functions-in-the-geriatric-patient-population-100580974","NCT06844279","The Effects of Anesthesia Depth Monitoring on Postoperative Recovery and Cognitive Functions in the Geriatric Patient Population","Geriatrik Hasta Grubunda Anestezi Derinliği Monitörizasyonlarının Postoperatif Derlenme ve Bilişsel Fonksiyonlara Etkileri","Inclusion Criteria:\n\n* 65 years and older\n* Elective spinal surgeries\n* ASA status I-III\n\nExclusion Criteria:\n\n* Emergent surgeries\n* ASA status IV-V\n* Prediagnosed delirium and or dementia\n* Inability to give consent","65 Years",{"count":138,"type":21},75,[54],"This study will be conducted on patients aged 65 and older scheduled for surgery due to lumbar or cervical disc herniation. General anesthesia is routinely used for these types of surgeries in the hospital. In patients receiving general anesthesia, anesthesia depth monitoring is performed.\n\nAs part of the study, a preoperative anesthesia evaluation will be conducted, which will include age, weight, height, comorbidities, regularly used medications, previous surgical or anesthesia experiences, nutritional habits, mental status, and daily activity levels.\n\nOn the day of surgery, upon arrival in the operating room, the following will be measured and recorded:\n\n* Blood pressure using a non-invasive blood pressure monitor\n* Heart rate and rhythm via electrocardiogram (ECG)\n* Blood oxygen level with a pulse oximeter\n* Anesthesia depth using a forehead-applied sensor\n\nAll monitoring procedures are non-invasive and painless. Following the placement of these monitoring devices and initial measurements, anesthesia induction and surgery will commence. Throughout surgery, blood pressure, heart rate, and brain activity will be continuously recorded. After the surgical procedure, anesthesia emergence and mental status will be assessed. Preoperative evaluation data and intraoperative recordings will be used solely for research purposes, with patient identity information remaining confidential.",[142,57,27],"Geriatric Patient Care Improvement",[144,145,146,147,148,149],"anaesthesia depth monitoring","geriatric","density spectral array","bispectral index","burst supression","postoperative delirium","2025-02-26",{"date":152,"type":33},"2025-02-28",{"date":154,"type":33},"2025-01-10",{"date":156,"type":21},"2025-04",{"name":158,"class":40},"Aslıhan Güleç",1]