[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cad-cam\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cad-cam":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,51,85,107],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100607949","clinical-evaluation-of-additive-and-subtractive-onlay-restorations-100607949",false,"NCT07195201","Clinical Evaluation of Additive and Subtractive Onlay Restorations","Prospective Evaluation of Onlay Restorations Produced by Additive and Subtractive Manufacturing in Vital Posterior Teeth: A Split-Mouth","CIP-ONLAY","Inclusion Criteria:\n\nParticipant-Level Criteria\n\n* Adults aged 18-84 years\n* No active periodontal disease (probing depth ≤ 3 mm, no clinical attachment loss)\n* No parafunctional habits such as bruxism, clenching, or foreign object chewing\n* Willingness to attend regular follow-up visits during the study period\n* Adequate oral hygiene status\n* No history of systemic disease or medically stable condition if present\n* No history of similar restorative procedures involving the target teeth Tooth-Level Criteria\n* Vital posterior teeth (premolars or molars) confirmed by thermal or electric pulp testing; teeth requiring endodontic treatment or with necrosis will be excluded\n* Permanent posterior teeth located in functional occlusion (premolar or molar region)\n* Teeth with moderate structural loss suitable for onlay restorations, including mesio-occlusal (MO), disto-occlusal (DO), or mesio-occluso-distal (MOD) cavities with partial crown loss but sufficient remaining tooth structure not requiring full coverage\n* Periodontally healthy teeth with no mobility, no clinical attachment loss, and probing depth ≤ 3 mm\n* Teeth that can be matched in contralateral quadrants to allow split-mouth design (structurally and clinically comparable teeth)\n* Teeth free from cracks, fractures, or internal resorption; supporting tissues without structural defects that may compromise restoration success\n* Teeth with clearly defined preparation margins located in enamel or sound dentin; subgingival margins extending deep into the sulcus will not be included\n* Teeth without previous extensive prosthetic restorations (crowns, inlays\u002Fonlays, or implant-supported restorations)\n* Opposing natural teeth in stable occlusal contact with the restored tooth\n\nExclusion Criteria:\n\n* Teeth with pulp necrosis or a history of endodontic treatment (previous root canal therapy or non-vital teeth)\n* Teeth with excessive tissue loss requiring full crown coverage and unsuitable for onlay restoration\n* Teeth presenting with cracks, fractures, internal or external resorption, or structural defects compromising prognosis\n* Advanced periodontal disease, including clinical attachment loss, furcation involvement, mobility, or probing depth \\> 3 mm\n* Teeth with subgingival cavity margins extending deep into the gingival sulcus, increasing periodontal risk\n* Teeth with a history of fixed prosthetic restorations (previous crowns, inlays\u002Fonlays, or bridge restorations)\n* Teeth lacking proximal contacts due to adjacent tooth absence, leading to compromised contact stability and occlusal load distribution\n* Teeth in regions with orthodontic appliances or fixed retainers that may interfere with restorative procedures or evaluation\n* Opposing teeth absent or lacking stable occlusal contact with the restoration site\n* Patients with systemic diseases contraindicate elective dental treatment (e.g., uncontrolled diabetes, immunocompromised status)\n* Pregnant or breastfeeding women\n* Patients unable or unwilling to attend scheduled follow-up visits \\[baseline (1 week), 6 months, 12 months, and 18 months\\]","ALL","18 Years","84 Years",{"count":21,"type":22},29,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn whether onlay restorations produced by additive manufacturing \\[three-dimensional (3D) printing\\] and subtractive manufacturing \\[Computer-Aided Design\u002FComputer-Aided Manufacturing (CAD\u002FCAM) milling\\] perform equally well in vital posterior teeth. The main questions it aims to answer are:\n\n* Do 3D printed onlay restorations show similar marginal adaptation and clinical performance compared to CAD\u002FCAM milled onlays?\n* Are there any differences in biological compatibility, surface properties, or postoperative sensitivity between the two techniques over time? Researchers will compare onlay restorations fabricated with 3D printing and CAD\u002FCAM milling using a split-mouth study design.\n\nParticipants will:\n\n* Receive one onlay restoration produced by 3D printing and another produced by CAD\u002FCAM milling, placed on opposite sides of the mouth\n* Have checkups at baseline (1st week), 6 months, 12 months, and 18 months after treatment\n* Be evaluated using the Fédération Dentaire Internationale (FDI) criteria for marginal adaptation, surface quality, anatomical form, and biological compatibility",[28,29,30,31],"CAD-CAM","Prospective Study","3D Printing","Clinical Assessment",[33,34,35,36,37],"onlay restorations","cad-cam","additive manufacturing","3D printing","FDI criteria","NOT_YET_RECRUITING","2025-09-23",{"date":41,"type":42},"2025-09-26","ACTUAL",{"date":44,"type":22},"2025-11-15",{"date":46,"type":22},"2027-08-31",{"name":48,"class":49},"Ayse Tugba Erturk Avunduk","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":23,"phases":62,"briefSummary":63,"conditions":64,"keywords":68,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":84},"100600619","hyaluronic-acid-and-polynucleotides-in-ridge-preservation-100600619","NCT07099846","Hyaluronic Acid and Polynucleotides in Ridge Preservation","The Use of Hyaluronic Acid and Polynucleotides in Ridge Preservation Sites Rehabilitated With a Complete Full Digital Workflow","P-005","Inclusion Criteria:\n\n* ≥25-year-old males and females;\n* good systemic health (self-assessment);\n* presence of an unrestorable\u002Fhopeless tooth with periodontal attachment and buccal bone preserved at least for 2\u002F3rd of the root and not associated with acute periapical pathology;\n* full mouth bleeding and plaque scores ≤ 25%\n\nExclusion Criteria:\n\n* uncontrolled or untreated periodontal disease;\n* history of local (head and neck) radiation therapy in the past 5 years;\n* acute endodontic lesion in the test tooth or in the neighbouring areas to the extraction procedure (sites with presence of an asymptomatic chronic lesion are eligible);\n* medical history that includes uncontrolled diabetes or hepatic or renal disease, or other serious medical conditions that can impact on bone metabolism (e.g. rheumatoid arthritis, osteoporosis) or transmittable diseases (e.g. HIV-related disease);\n* history of alcohol or drug abuse;\n* smokers of ≥10 cigarettes a day;\n* self-reported pregnancy or lactation.","25 Years",{"count":61,"type":22},40,[25],"The aim of this study is to test the use of a bovine-derived bone graft combined with a polynucleotides-rich hyaluronic acid (PNHA) gel for the preservation of the bone after a tooth extraction (alveolar ridge preservation) and to test the performance of a fully-digital workflow to rehabilitate the site with a dental implant. 40 patients in need for a single tooth extraction will be recruited at Centro di Odontoiatria, Università di Parma and they will be randomly assigned to 2 groups: extraction and spontaneous healing or extraction and regeneration of the site with a bovine-derived bone graft combined with a PNHA gel. At 4 months after extraction an implant will be placed in the extraction site, which will be rehabilitated with a fully-digital workflow and patients will be followed up at up to 12 months post rehabilitation. Two 3D x-rays with a small field of view will be performed immediately after extraction and at 4 months post extraction to plan implant placement. These images will also be used to assess changes in the dimension of the post extraction bone (primary outcome). As part of the study different questionnaires will be administered to assess quality of life and perception of the therapy and the wound exudate in the area of the extraction will be collected non invasively with a collagen sponge to assess the expression of different proteins during the early healing days. On the day of implant placement a sample of bone tissue will also be collected as part of the bone drilling and histologically analysed.",[65,66,67,28],"Socket Preservation","Implant-supported Single Crowns","Hyaluronic Acid",[69,70,71,72,28,73],"alveolar ridge preservation","hyaluronic acid","polynucleotides","digital workflow","Implant rehabilitation","RECRUITING","2025-09-01",{"date":77,"type":42},"2025-09-08",{"date":79,"type":42},"2025-06-09",{"date":81,"type":22},"2028-05",{"name":83,"class":49},"University of Parma",2,{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":91,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":92,"targetDuration":4,"studyType":23,"phases":94,"briefSummary":95,"conditions":96,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":50},"100561392","intelligibility-and-acoustic-speech-performance-of-cadcam-milled-titanium-partial-dentures-100561392","NCT06589570","Intelligibility and Acoustic Speech Performance of CAD\u002FCAM Milled Titanium Partial Dentures","Inclusion Criteria:\n\n* Patients with Class IV Kennedy Classification partial edentulism.\n* Sufficient occluso-gingival height of its clinical crown\n* Full opposing arch or restored with acceptable restoration\n* Edentulous ridge covered by healthy firm muco-periosteum\n* The abutment teeth had apparently good periodontal condition\n* Adequate inter-arch space\n* All patients were apparently in good general health\n* Only patients who can be easily motivated to achieve and maintain good oral hygiene were selected\n\nExclusion Criteria:\n\n* without abnormal bony irregularity or sever lingual undercut\n* with no signs of mobility or inflammation with no tissue undercut\n* Patients with shallow floor of the mouth, prominent lingual tori, bony undercuts and lingual inclined teeth were all excluded\n* no tempro-mandibular joint disorders\n* free from systemic diseases as diabetes mellitus",true,{"count":93,"type":22},12,[25],"Partial dentures play a crucial role in restoring oral function and aesthetics for patients with missing teeth. Traditionally, these prostheses have been fabricated using materials such as acrylic resin or cobalt-chromium alloys. However, advancements in digital dentistry have introduced new materials and manufacturing techniques, including computer-aided design and computer-aided manufacturing (CAD\u002FCAM) milled titanium. While titanium offers advantages such as biocompatibility, lightweight properties, and corrosion resistance, its impact on speech performance remains understudied.",[97,98,28],"Speech","Denture, Partial, Removable",{"date":100,"type":42},"2025-09-03",{"date":102,"type":42},"2024-09-09",{"date":104,"type":22},"2025-12-06",{"name":106,"class":49},"Badr University",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":91,"sex":17,"minAge":18,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":23,"phases":116,"briefSummary":117,"conditions":118,"keywords":121,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":50},"100550109","analysis-of-mandibular-proximal-segment-position-using-virtual-orthognathic-surgical-planning-individualized-guides-and-osteosynthesis-plates-100550109","NCT06442787","Analysis of Mandibular Proximal Segment Position Using Virtual Orthognathic Surgical Planning, Individualized Guides, and Osteosynthesis Plates","Inclusion Criteria:\n\n1. Healthy individuals over 18 years of age\n2. Patients with skeletal Class 2 and Class 3 malocclusion requiring bimaxillary orthognathic surgery\n3. Patients who have undergone orthodontic treatment prior to surgery\n\nExclusion Criteria:\n\n1. Patients with cleft lip and palate or craniofacial deformities\n2. Oligodontia\n3. Patients in whom the study protocol could not be continued due to intraoperative complications such as guide mismatch or bad split, or due to reasons such as inability to obtain postoperative CT scans\n4. Patients with pre-existing temporomandibular joint disorders prior to surgery\n5. Patients who have undergone previous orthognathic surgery\n6. Patients with a history of maxillary or mandibular trauma\n7. Patients requiring segmental maxillary surgery\n8. Patients with bone metabolism disorders\n9. Patients allergic to titanium\n10. Pregnant individuals","55 Years",{"count":115,"type":22},60,[25],"Orthognathic surgery is a surgical procedure performed to correct dentofacial deformities. In recent years, with the use of virtual surgical planning, cutting guides, and patient-specific osteosynthesis plates, highly predictable results can be achieved. While there are many positive reports regarding the use of patient-specific plates in maxillary positioning in orthognathic surgery, there is a lack of sufficient studies comparing the results obtained in mandibular positioning. Additionally, numerous designs of proximal segment positioning devices have been published, but comparative studies on their effectiveness have not been conducted. Therefore, a study comparing these approaches has been planned.",[28,119,120],"Patients Specific Manufacturing","Osteotomy, Sagittal Split Ramus",[122,123,124,125],"virtual surgical planning","orthognathic surgery","custom plate","mandibular condyle position","2025-01-26",{"date":128,"type":42},"2025-01-28",{"date":130,"type":42},"2024-10-01",{"date":132,"type":22},"2025-03-01",{"name":134,"class":49},"Bezmialem Vakif University"]