[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"calcification\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:calcification":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,78],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100532795","the-added-value-of-contrast-enhanced-mammography-to-standard-mammography-in-assessing-the-extent-of-dcis-100532795",false,"NCT06217458","The Added Value of Contrast Enhanced Mammography to Standard Mammography in Assessing the Extent of DCIS","The Added Value of Contrast Enhanced Mammography (CEM) to Standard Mammography in Assessing the Extent of Ductal Carcinoma in Situ (DCIS)","CEMinDCIS","Inclusion Criteria:\n\n* Patients with pathohistological diagnosis of ductal in situ carcinoma based on samples obtained by vacuum-assisted breast biopsy (VABB) or ultrasound-guided breast biopsy (CNB)\n* Presented at the meeting of the multidisciplinary breast team of the Clinical Hospital Center in Rijeka\n* Patients who underwent surgery at CHC Rijeka and whose pathohistological diagnosis in the final PH report was pure DCIS or microinvasive breast cancer (DCIS with microinvasion)\n* Patients who agree to participate in the study\n\nExclusion Criteria:\n\n* Patients with contraindications for CEM: renal insufficiency (which is ruled out by presenting creatinine and\u002For eGFR results), iodine allergy, pregnancy\u002Flactation, hyperthyroidism\n* Patients who have undergone a preoperative breast MRI\n* Patients who have both DCIS and invasive carcinoma in the preoperative PH report or the final PH report of the surgical material, with the exception of foci with microinvasion (\\\u003C 1 mm).\n* Patients with ipsilateral DCIS recurrence or with previous ipsilateral breast surgery for invasive cancer.\n* Patients\u002Fsubjects whose CEMs do not correspond to the diagnostic interpretation for technical reasons are excluded from the study: insufficient positioning, contrast agent extravasation, failed subtraction\n* Patients under 18 years of age","FEMALE","18 Years","99 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"NA","The study hypothesis is that the rate of inadequate surgical margins after conservative breast surgery for DICS and the rate of reoperation (re-excision or\u002Fand mastectomy) is lower in the group of patients who underwent standard preoperative mammography and CEM to assess the extent of DICS, compared to the group of patients for whom the preoperative assessment of the extent of in situ breast cancer was not performed using one of the imaging techniques with contrast medium such as contrast mammography or magnetic resonance imaging.",[28,29,30],"DCIS","Breast Carcinoma in Situ","Calcification",[32,33,34,35,36],"Ductal in situ carcinoma","Calcifications","Breast surgery","Screening","Contrast Enhanced Mammography","NOT_YET_RECRUITING","2025-01-03",{"date":40,"type":41},"2025-01-06","ACTUAL",{"date":43,"type":22},"2025-03-01",{"date":45,"type":22},"2027-01-01",{"name":47,"class":48},"Clinical Hospital Center Rijeka","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":57,"minAge":18,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":4},"100567515","intravascular-lithotripsy-for-acute-stent-under-expansion-in-calcified-coronary-lesions-100567515","NCT06669195","Intravascular Lithotripsy for Acute Stent Under-expansion in Calcified Coronary Lesions","Feasibility and Safety of Intravascular Lithotripsy for Acute Stent Under-expansion in Calcified Coronary Lesions","Inclusion Criteria:\n\n* Radiography inclusion criteria\n\n  1. the angiography identified a severely calcified lesion with acute stent under-expansion, i.e., residual stenosis \\>20% after stenting and 16-atm dilatation with a post-dilatation balloon;\n  2. target lesion stenosis must be ≥70% or ≥50% with clear evidence of myocardial ischaemia (visual assessment);\n  3. target lesion vessel diameter is between 2.75mm and 4.0mm, target lesion length must be ≤30 mm (visual assessment);\n\nGeneral inclusion criteria\n\n1. subjects at the age between ≥18 and ≤80 years old;\n2. patients with symptoms or evidence of myocardial ischaemia;\n3. subjects are willing to participate in the study, sign informed consent form, and accept clinical and angiography follow-up after PCI.\n\nExclusion Criteria:\n\n* Radiography exclusion criteria\n\n  1. in-stent lesions;\n  2. For the left main disease and bifurcation lesion (branch vessel diameter shall be ≥ 2.5mm);\n  3. Target lesions were total occlusive lesions (acute or chronic), long lesions (\\>30 mm), lesion vessel reference diameters \\>4.0 mm, and lesion angiomatous dilatation;\n\nGeneral inclusion criteria\n\n1. Patients with severe congestive heart failure (NYHA Level IV severe heart failure) or severe valvular heart disease; or left ventricular ejection fraction of less than 35%;\n2. Patients with stroke, peptic ulcer or gastrointestinal bleeding within the past 6 months; or patients with bleeding tendency or coagulation disorders;\n3. Patients with severe liver failure (ALT and AST are larger than 3 times of the upper limit of normal value), who are judged to be not applicable to angiography by investigators;\n4. Patients with severe renal failure(eGFR\\\u003C30ml\u002Fminute) or such medical history, failure to comply with angiography conditions;\n5. Subjects who are intolerance or allergic to heparin, contrast agent, Biolimus, polyethylene oxide and polylactic acid - glycolic acid polymer;\n6. Patients who plans to accept selective operation within 1 year;\n7. Patients who are participating in the clinical trial of other drug or device without reaching the time limit of primary endpoint;\n8. Subjects who are considered to be not applicable to be enrolled by investigators due to other reasons.","ALL","80 Years",{"count":60,"type":22},40,[25],"Percutaneous coronary intervention (PCI) is the standard treatment for patients with coronary artery disease who have an indication for surgery. Coronary artery calcification not only makes stent delivery and expansion more difficult during PCI, but also increases the risk of vessel perforation. In addition, calcified plaque can lead to incomplete stent expansion, which increases the risk of in-stent restenosis and thrombosis. Although the technology and techniques of interventional devices continue to improve, heavily calcified lesions remain an important risk factor for PCI failure.\n\nThis study is a prospective, multicenter, randomized study. It is planned to select 40 cases of subjects with calcified plaque can lead to incomplete stent expansion who meet the inclusion\u002Fexclusion criteria. They are randomly dividing them into Intravascular lithotripsy treatment group and high-pressure balloon treatment group according to the ratio of 1:1. All subjects accept clinical follow-up after operation, at 30 days, 6 months, and 12 months after operation. Follow-up with angiography and OCT are conducted at 12 months. The primary endpoint was thickness of neointima at 12 months.",[64,30],"Coronary Artery Disease",[66,67,68],"Intravascular lithotripsy","stent under-expansion","calcified coronary lesions","2024-10-31",{"date":71,"type":41},"2024-11-01",{"date":73,"type":22},"2024-12-12",{"date":75,"type":22},"2027-03-13",{"name":77,"class":48},"Xuzhou Third People's Hospital",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":57,"minAge":18,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":86,"phases":4,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":49},"100547944","calcification-on-ctca-of-a-cto-and-pci-outcomes-100547944","NCT06414551","Calcification on CTCA of a CTO and PCI Outcomes","Characteristics of Calcification in a Chronic Total Occlusion on Computed Tomography Coronary Angiogram and Percutaneous Coronary Intervention Outcomes- a Single Centre Observational Study","Inclusion Criteria:\n\n* Patients meeting all the below criteria will be included\n\n  * ≥18 years\n  * Previous CTO PCI attempt in the last 5 years\n  * Undergone CTCA either pre or post CTO PCI\n  * Adequate CTCA images for analysis\n\nExclusion Criteria:\n\n* Patients meeting any of the following criteria will be excluded\n\n  * \\\u003C18 years of age\n  * Did not undergo CTCA\n  * Inadequate\u002Fdegraded CTCA images",{"count":21,"type":22},"OBSERVATIONAL","A chronic total occlusion (CTO) is present in 15-20% of patients who are referred for invasive coronary angiography. CTO Percutaneous Coronary Intervention (PCI) procedure success rates have increased over the years and can be as high as 90% when performed by high-volume CTO operators.Procedurally, excess calcification in the CTO anatomy is one factor which makes it difficult to complete the procedure or obtain ideal stent expansion. Excess calcification is best identified by Computed Tomography Coronary Angiography (CTCA) rather than invasive angiography.\n\nThe investigators plan to retrospectively evaluate CTCA in patients who underwent CTO PCI and correlate calcification characteristics with CTO PCI outcomes and tools utilised for calcium modification.",[89,30,90],"Chronic Total Occlusion of Coronary Artery","Computed Tomography Angiography",[92,93],"CTCA","CTO","RECRUITING","2024-08-28",{"date":97,"type":41},"2024-08-30",{"date":99,"type":41},"2024-07-19",{"date":101,"type":22},"2025-07-01",{"name":103,"class":48},"Sandwell & West Birmingham Hospitals NHS Trust"]