[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"calcium-hydroxide\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:calcium-hydroxide":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,83],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100623442","comparative-evaluation-of-the-effects-of-calcium-hydroxide-and-bio-c-temp-medicaments-on-postoperative-pain-in-patients-undergoing-endodontic-treatment-a-clinical-study-100623442",false,"NCT07396688","Comparative Evaluation of the Effects of Calcium Hydroxide and BIO-C Temp Medicaments on Postoperative Pain in Patients Undergoing Endodontic Treatment: a Clinical Study","Inclusion Criteria:\n\n* • Patients with single-rooted teeth requiring endodontic retreatment.\n\n  * Individuals in good general health, classified as ASA Physical Status I.\n  * Teeth presenting normal anatomical structure and root morphology.\n\nExclusion Criteria:\n\n* • Patients who have used antibiotics or analgesic medications within the last month.\n\n  * Pregnant individuals and patients with systemic diseases (such as chronic illnesses, diabetes mellitus, hypertension).\n  * Teeth with root fractures or perforations.\n  * Teeth with complex root canal anatomy, multirooted teeth, or severely curved roots.\n  * Patients presenting with high baseline pain levels, particularly those with a history of treatment-resistant pain.","ALL","18 Years","65 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","This clinical study is designed to evaluate postoperative pain experienced by patients undergoing multi-visit endodontic retreatment and to investigate whether the choice of intracanal medicament influences pain levels between treatment sessions. Postoperative pain is a common concern following root canal procedures and may negatively affect patient comfort, treatment satisfaction, and overall perception of dental care.\n\nCalcium hydroxide has long been used as a conventional intracanal medicament in endodontic therapy due to its antimicrobial properties. In recent years, bioceramic-based materials such as Bio-C Temp have been introduced as alternative intracanal medicaments, with proposed advantages related to biocompatibility and interaction with dental tissues. However, limited clinical evidence is available regarding their effect on postoperative pain when compared with conventional materials.\n\nIn this study, patients requiring multi-visit endodontic retreatment will receive either calcium hydroxide or Bio-C Temp as an intracanal medicament between treatment sessions. Pain intensity will be evaluated at specific time points following treatment using standardized pain assessment scales. In addition to pain intensity, the use of analgesic medication will also be recorded.\n\nThe primary objective of this study is to compare interappointment postoperative pain levels associated with calcium hydroxide and Bio-C Temp. Secondary objectives include evaluating analgesic consumption. By comparing a conventional intracanal medicament with a newer bioceramic-based alternative, this study aims to contribute to a better understanding of how intracanal medicament selection may influence postoperative pain and patient experience during endodontic retreatment.\n\nThe findings of this study may help clinicians make more informed decisions regarding intracanal medicament selection and improve pain management strategies in endodontic practice.",[26,27,28,29],"Postoperative Pain","Medicaments Substances in Therapeutic Use","Calcium Hydroxide","Root Canal Retreatment",[31,26,32,33,28],"Visual Analog Scale","Bioceramic Intracanal Medicament","Endodontic Retreatment","RECRUITING","2026-03-25",{"date":37,"type":38},"2026-03-27","ACTUAL",{"date":35,"type":20},{"date":41,"type":20},"2026-04-15",{"name":43,"class":44},"Ankara University","OTHER",2,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":15,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":59,"conditions":60,"keywords":66,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100568638","phase-4-comparison-between-egyptian-mta-biodentine-versus-calcium-hydroxide-as-indirect-pulp-capping-materials-in-permanent-teeth-100568638","NCT06683833","Comparison Between Egyptian MTA, Biodentine Versus Calcium Hydroxide as Indirect Pulp Capping Materials In Permanent Teeth","Comparative Analysis of Egyptian MTA, Biodentine, and Calcium Hydroxide as Indirect Pulp Capping Materials in Permanent Teeth. (A 6m Randomized Clinical Trial)","Inclusion Criteria:\n\n* Adult patients aged 22: 45 years old.\n* Males or females.\n* Patients with vital teeth with deep carious lesions.\n* Patients in good general health.\n* Good oral hygiene.\n* Co-operative patients who show interest to participate in the study.\n\nExclusion Criteria:\n\n* Patients with systemic diseases.\n* Patients with known allergic or adverse reaction to the tested materials.\n* Patients with bad oral hygiene.\n* Patient who frequently use analgesic or any drugs that could mask the pain.","22 Years","45 Years",{"count":56,"type":20},35,[58],"PHASE4","Compare the clinical performance and patient satisfaction of Egyptian MTA, Biodentine versus Calcium Hydroxide as indirect pulp capping materials in permanent teeth",[61,62,63,28,64,65],"Deep Caries","Indirect Pulp Capping","Mineral Trioxide Aggregate (MTA)","Biodentine","Patient Reported Outcome Measures",[67,68,69,70,64,71,72],"Deep caries","Indirect pulp capping","Mineral trioxide aggregate (MTA)","Calcium hydroxide","Patient reported outcomes measures (PROMS)","Randomized clinical trial","2026-03-17",{"date":75,"type":38},"2026-03-18",{"date":77,"type":38},"2025-09-03",{"date":79,"type":20},"2026-07-03",{"name":81,"class":44},"Cairo University",1,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":21,"phases":93,"briefSummary":95,"conditions":96,"keywords":101,"overallStatus":106,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":4},"100600710","early-phase-1-effect-of-bio-c-temp-versus-calcium-ydroxide-as-intracanal-dressings-on-postoperative-pain-intensity-and-periapical-mmp-9-level-in-patients-with-necrotic-pulp-100600710","NCT07101029","Effect of Bio-C Temp Versus Calcium Ydroxide as Intracanal Dressings on Postoperative Pain Intensity and Periapical MMP-9 Level in Patients With Necrotic Pulp","Effect of Bio-C Temp Versus Calcium Hydroxide as an Intracanal Dressing on Postoperative Pain Intensity and Periapical MMP-9 Level in Patients With Necrotic Pulp: A Randomized Clinical Trial","Inclusion Criteria:\n\n1. Age between 18-50 years old.\n2. Males and females.\n3. Healthy patients categorized as I or II according to The American Society of Anesthesiologists.\n\n   (ASA I or II), with no underlying allergies.\n4. Single-rooted mandibular premolar teeth, having single root canal:\n\n   * Diagnosed clinically with pulp necrosis.\n   * Absence of spontaneous pulpal pain.\n   * Slight widening in the periodontal membrane space or with periapical radiolucency not exceeding 2\\*2 mm radiographically.\n5. Patients accepting to participate in the trial.\n6. Patients who can understand pain scale and can sign the informed consent\n\nExclusion Criteria:\n\n1. Medically compromised patients having significant systemic disorders (ASA III or IV).\n2. Pregnant females.\n3. If analgesics or antibiotics have been administrated by the patient during the past 24 hours preoperatively as it might alter their pain perception.\n4. Teeth with multiple canals. 9\n5. Teeth that show association with acute periapical abscess, swelling or fistulous tract.\n6. Teeth with vital pulp.\n7. Non-restorable teeth or teeth that could not be adequately isolated with a rubber dam.\n8. Immature teeth.\n9. Teeth with greater than grade I mobility or pocket depth greater than 4 mm.\n10. Teeth showing radiographic evidence of external or internal root resorption, vertical root fracture, perforation or calcification.\n11. Patients with two or more adjacent teeth requiring endodontic treatment.\n12. Patients reporting bruxism, clenching or TMJ problems.\n13. Inability to perceive the given instructions.","50 Years",{"count":92,"type":20},30,[94],"EARLY_PHASE1","To compare the effect of Bio-C Temp Bioceramic intracanal dressing versus calcium hydroxide as intracanal medicaments on:\n\n* Intensity of postoperative pain\n* levels of MMP -9 in Periapical Fluids.",[97,98,28,99,100],"Intracanal Dressing","Apical Periodontitis","Biomarkers","Inflammatory Mediators",[102,28,103,104,99,105],"Bio-C Temp","Intracanal medicament","Matrix Metalloproteinase 9","Post operative pain","NOT_YET_RECRUITING","2025-07-28",{"date":109,"type":38},"2025-08-03",{"date":111,"type":20},"2025-08",{"date":113,"type":20},"2026-07",{"name":81,"class":44}]