[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cancer-related-cognitive-difficulties\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cancer-related-cognitive-difficulties":95},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,55,80,111],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100588219","the-role-of-prolonged-nightly-fasting-to-improve-sleep-and-cognition-in-breast-cancer-survivors-100588219",false,"NCT06938555","The RolE of Prolonged Nightly faSTing to Improve Sleep and cOgnition in bREast Cancer Survivors","The RolE of Prolonged Nightly faSTing to Improve Sleep and cOgnition in bREast Cancer Survivors (RESTORE)","RESTORE","Inclusion Criteria:\n\n1. ≥18 years old\n2. diagnosed with breast cancer (all stages included)\n3. ≥3 months post neoadjuvant or adjuvant chemotherapy (maintenance or palliative systemic therapy is included)\n4. score ≤30 or lower on the Patient Reported Outcome Measurement Information System Cognitive Function Short Form 8a (sr-CRCI)\n5. able to speak\u002Funderstand English\n6. have access to a computer and Wi-Fi\n7. live within the United States\n8. Identifies as female\n9. willing and able to fully participate in the study\n\nExclusion Criteria:\n\n1. type 1 diabetes\n2. actively enrolled in formal diet\u002Fweight loss program\n3. previous bariatric surgery\n4. eating disorder history\n5. night shift work\n6. pregnant, breast feeding, or trying to get pregnant\n7. dementia, psychological, psychiatric, or neurological diagnoses\n8. active brain or central nervous system disease\n9. prior or current use of memory enhancing medications\n10. history or current brain radiation\n11. frequently fasting for 12+ hours every night\n\n13\\) history of hypoglycemia 14) depression screening on PHQ9 with a score of 20 or greater across all 9 questions OR anything other than 0 on question 9","ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","The investigators are interested in finding out how Prolonged Nightly Fasting (PNF) and\u002For health education may impact health and cancer recovery for breast cancer patients and survivors.",[27,28,29,30],"Breast Cancer Survivor","Cancer Related Cognitive Difficulties","Sleep","Quality of Life",[32,33,34,35,36,37,38,39,40,41],"breast cancer","breast cancer survivor","brain fog","prolonged nightly fasting","nationwide","remote","non-invasive","health education","sleep","quality of life","RECRUITING","2026-04-27",{"date":45,"type":46},"2026-05-01","ACTUAL",{"date":48,"type":46},"2025-03-18",{"date":50,"type":21},"2026-12-31",{"name":52,"class":53},"Arizona State University","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":4,"enrollmentInfo":65,"targetDuration":4,"studyType":67,"phases":4,"briefSummary":68,"conditions":69,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":54},"100296293","effects-of-chemotherapy-on-cognitive-function-in-breast-cancer-patients--non-cancer-control-subjects-with-optional-sub-study-research-brain-mri-100296293","NCT03137095","Effects of Chemotherapy on Cognitive Function in Breast Cancer Patients & Non-Cancer Control Subjects With Optional Sub-Study Research Brain MRI","Longitudinal Pilot Mechanistic Study of the Effects of Chemotherapy on Cognitive Function in Breast Cancer Patients and Non-Cancer Control Participants - Optional Sub-Study: Research Brain MRI","Inclusion Criteria, Breast Cancer Patient Participants:\n\n* Females with a diagnosis of invasive non-metastatic breast cancer (stage I-IIIC)\n* Scheduled to begin a course of chemotherapy with Adriamycin and Cytoxan\n* Chemotherapy naïve\n* Able to speak and read English\n* 21 years or older\n* Give written informed consent\n\nExclusion Criteria, Breast Cancer Patient Participants:\n\n* Must not be currently hospitalized or have been hospitalized within the last year for a psychiatric illness\n* Must not be diagnosed with a neurodegenerative disease (e.g., Alzheimer's disease, Parkinson's disease)\n* Must not have any Central Nervous System disease (e.g., movement disorder, multiple sclerosis)\n* Subjects could have had a TIA (transient ischemic attack) or stroke in the past if the TIA or stroke was greater than 1 year ago and the subject does not have any remaining symptoms\n* Must not be scheduled to receive concurrent radiation treatment while receiving chemotherapy.\n* Must not be colorblind\n\nInclusion Criteria, Control Participants:\n\n* Must be female and within 5 years of the age of the subject receiving chemotherapy\n* Able to speak and read English\n* Give written informed consent\n* 21 years or older\n\nExclusion Criteria, Control Participants:\n\n* Must not be currently hospitalized or have been hospitalized within the last year for a psychiatric illness\n* Must not be diagnosed with a neurodegenerative disease (e.g. Alzheimer's disease, Parkinson's disease)\n* Must not have Central Nervous System disease (e.g., movement disorder, multiple sclerosis)\n* Subjects could have had a TIA (transient ischemic attack) or stroke in the past if the TIA or stroke was greater than 1 year ago and the subject does not have any remaining symptoms\n* Must not have been diagnosed with cancer or previously have received chemotherapy\n* Must not be colorblind\n\nFor optional sub-study: MR safety assessed via Rochester Center for Brain Imaging Magnetic Resonance (MR) Safety Screening Form to confirm eligibility to participate",true,"FEMALE","21 Years",{"count":66,"type":21},150,"OBSERVATIONAL","Study is enrolling newly diagnosed breast cancer patients about to start chemotherapy and age-matched control participants. The investigator is trying to better understand the prevalence of cognitive difficulties in cancer patients receiving chemotherapy compared to the general population as well as what biological mechanisms may play a role in the development of these difficulties. Patients will be asked to complete six assessments over the course of approximately 5 months. Assessments 1,3, 4.5 and 5 include computerized and paper and pencil cognitive testing as well as blood draws. Assessments 2 and 4 only involve the collection of a blood sample. An optional sub study is offered after Assessment 1. It involves a research brain MRI at Assessment 4.5 and cognitive testing and another research brain MRI at Assessment 6.",[28,70],"Breast Cancer Female","2026-04-22",{"date":73,"type":46},"2026-04-24",{"date":75,"type":46},"2017-02-20",{"date":77,"type":21},"2027-07-31",{"name":79,"class":53},"University of Rochester",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":93,"conditions":94,"keywords":98,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":54},"100464865","phase-1-modafinil-to-improve-fatiguability-100464865","NCT05333250","Modafinil to Improve Fatiguability","Modafinil to Improve Fatiguability (MODIFY): Modafinil vs. Placebo Vanguard RCT","MODIFY","Inclusion Criteria:\n\n1. 18 years of age or older with stage III or IV cancer diagnosis\n2. Estimated prognosis ≥ 3 months\n3. Eastern Cooperative Oncology Group (ECOG) Score 0-2\n4. Experiencing cancer-related fatigue, defined as a score of 4 or greater on the Fatigue item of the Edmonton Symptom Assessment System-revised-constipation\u002Fsleep (ESAS-r-cs)\n5. Ability to understand and communicate in English\n6. Ability to give first-person informed consent\n\nExclusion Criteria:\n\n* Currently receiving or have received cytotoxic chemotherapy in the last 6 weeks\n* Allergy to modafinil or placebo contents\n* Dose change of prednisone or dexamethasone in the past 7 days or planned dose change during study period\n* Blood transfusion in the last 2 weeks\n* Hemoglobin lower than 80 g\u002FL measured in the last 4 weeks\n* TSH above normal range in the last 4 weeks\n* Severe liver dysfunction (total bilirubin \\>3x upper limit of normal, or aspartate aminotransferase or alanine aminotransferase \\>5x upper limit of normal)\n* Known brain metastasis or primary brain tumor\n* Documented dementia diagnosis\n* Documented major psychiatric illness including major depressive episode, bipolar disorder, schizophrenia\n* Uncontrolled hypertension as defined by a blood pressure greater than 140\u002F90mmHg\n* Unstable angina\n* Recent (\\\u003C6 months previous) myocardial infarction\n* Evidence of left ventricular hypertrophy or ischemia on ECG\n* Arrythmia (e.g., atrial fibrillation)\n* Coronary artery disease with Canadian Cardiovascular Society Symptoms Class \\>1\n* Taking high dose selective serotonin reuptake inhibitors (SSRIs) or tricyclic antidepressants\n* Taking any benzodiazepine at any dose\n* Taking any amphetamine at any dose\n* Taking any monoamine oxidase inhibitor (MAOI) at any dose\n* Taking any azole anti-fungal medication (e.g., fluconazole, itraconazole, or ketoconazole)\n* Taking any of the following medications at any dose:\n\n  1. Methylphenidate\n  2. Cyclosporine\n  3. Propranolol\n  4. Phenytoin\n  5. S-mephenytoin\n  6. Warfarin\n  7. Triazolam\n  8. Ethinyl estradiol\n  9. Clomipramine\n  10. Midodrine\n  11. Antipyrine\n* Inability to ingest oral capsule\n* Pregnancy or lactation, or trying to conceive\n* Any other history, condition, therapy, or uncontrolled intercurrent illness which could, in the opinion of the Qualified Medical Investigator, affect compliance with study requirements or which would make the participant unsuitable for this study.\n* Simultaneous participation in another interventional clinical study (e.g., Phase 1-3 clinical studies) or treatment with any investigational medicinal product within 30 days prior to screening visit that could, in the judgment of the Qualified Medical Investigator, affect the patient's participation in or outcome of this clinical trial.",{"count":89,"type":21},40,[91,92],"PHASE1","PHASE2","Cancer-related fatigue (CRF) and cancer-related cognitive impairment (CRCI) are among the most commonly reported disabling symptoms experienced by patients with advanced cancer. However, there are currently limited evidence-based pharmacologic interventions available. The investigators will conduct a Vanguard Randomized Clinical Trial (RCT) to estimate the effect of modafinil in managing CRF and CRCI, and to test the feasibility of carrying out the study.",[95,96,97],"Cancer-related Cognitive Difficulties","Cancer-related Problem\u002FCondition","Fatigue",[99,97,100,101],"Cancer","Cognitive Impairment","Modafinil","2026-01-09",{"date":104,"type":46},"2026-01-13",{"date":106,"type":21},"2026-01-22",{"date":108,"type":21},"2028-03",{"name":110,"class":53},"Ottawa Hospital Research Institute",{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":62,"sex":63,"minAge":18,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":22,"phases":121,"briefSummary":122,"conditions":123,"keywords":127,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":54},"100505660","improve-cancer-related-cognitive-impairment-100505660","NCT05864274","Improve Cancer-related Cognitive Impairment","Using a Novel Mobile Cognitive Training Application to Improve Cancer-related Cognitive Impairment in Gynecologic Oncology Patients","Inclusion criteria are:\n\n* newly diagnosed gynecologic malignancy (uterine, cervical, ovarian, primary peritoneal, vulvar, or vaginal) and undergoing chemotherapy\n* own a smartphone or tablet with ability to download cognitive training application\n* and age \\>21 years old\n\nExclusion criteria include:\n\n* medical diagnosis of dementia\n* significant underlying mental diagnoses for which they are on more than 1 medication for (patients with depression or anxiety on single-agent therapy will be able to participate\n* age \\\u003C21","90 Years",{"count":120,"type":21},64,[24],"Cancer-related cognitive impairment (CRCI), also known as \"chemobrain,\" is the cognitive decline that negatively impacts the majority of cancer patients undergoing chemotherapy, radiation, and\u002For hormonal treatments. This application focuses on evaluating if using a cognitive mobile training application can decrease the impact of CRCI in gynecologic oncology patients through a multidisciplinary approach with patients undergoing assessments by our neurocognitive team.",[124,125,126,95],"Gynecologic Cancer","Chemotherapy Effect","Chemo-brain",[128,129,130,131],"CHEMOTHERAPY SIDE EFFECTS","GYNECOLOGIC CANCERS","CHEMO-BRAIN","CANCER-RELATED COGNITIVE IMPAIRMENT","2025-11-18",{"date":134,"type":46},"2025-11-24",{"date":136,"type":46},"2024-09-01",{"date":138,"type":21},"2027-08-01",{"name":140,"class":53},"University of Alabama at Birmingham"]