[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cancer-related-cognitive-dysfunction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cancer-related-cognitive-dysfunction":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,73],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100618396","a-physical-activity-program-compared-to-health-education-for-improving-memory-and-attention-in-hispanic-women-with-newly-diagnosed-stage-i-iiia-breast-cancer-mama-trial-100618396",false,"NCT07331077","A Physical Activity Program Compared to Health Education for Improving Memory and Attention in Hispanic Women With Newly-Diagnosed Stage I-IIIa Breast Cancer, MAMA Trial","Movement and Memory After Breast Cancer: The MAMA Trial","Inclusion Criteria:\n\n* PRE-REGISTRATION: Age \\>= 50 years at time of pre-registration visit according to participant report and\u002For clinical determination\n* PRE-REGISTRATION: Self-identifies as Hispanic (any race)\n* PRE-REGISTRATION: First time, primary diagnosis of Stage I-IIIa breast cancer according to participant report and\u002For clinical determination\n* PRE-REGISTRATION: Post-surgery and completed primary adjuvant treatment (i.e., surgery, chemotherapy, and\u002For radiation therapy) 3-36 months prior to preregistration according to participant report and\u002For clinical determination\n* PRE-REGISTRATION: Sedentary except for casual lifestyle recreation, self-reporting no more than 90 minutes per week of moderate-intensity aerobic exercise within the last 6 months\n* PRE-REGISTRATION: Self-reported ability to complete assessments by themselves or with assistance\n* REGISTRATION: Age \\>= 50 years or older as confirmed via clinical determination\n* REGISTRATION: Self-identifies as Hispanic (any race)\n* REGISTRATION: Able to provide medical record release to confirm eligibility\n* REGISTRATION: First time, primary diagnosis of Stage I-IIIa breast cancer as confirmed via clinical determination\n* REGISTRATION: Post-surgery and completed primary treatment (i.e., surgery, chemotherapy, and\u002For radiation therapy) 3-36 months prior to pre-registration as confirmed via clinical determination\n* REGISTRATION: No evidence of possible cognitive impairment as assessed using the Telephone Interview of Cognitive status (13-item modified version) (TICS-M; score \\>= 21)\n* REGISTRATION: Receive physician's clearance to participate in an exercise program\n\n  * NOTE: Individuals with conditions\u002Fdiagnoses deemed important by the primary investigator will be required to provide clearance for exercise from their cardiologist. Example conditions include:\n\n    * History of major multiple myocardial infarctions (MI)\n    * Recent electrocardiogram (ECG) changes or recent MI\n    * Resting or unstable angina\n    * Significant multivessel coronary occlusion (\\>= 70%) on angiography\n    * Uncontrolled and\u002For serious arrhythmias\n    * 3rd degree heart block\n    * Acute congestive heart failure or ejection fraction \\\u003C 30%\n* REGISTRATION: Ability to complete assessments by themselves or with assistance\n* REGISTRATION: Agree to be randomized\n\nExclusion Criteria:\n\n* PRE-REGISTRATION: Stage 0 breast cancer diagnosis OR metastatic disease\n* PRE-REGISTRATION: Currently receiving or \\\u003C 3 months since receiving chemotherapy or radiation therapy for cancer, or greater than 36 months post primary treatment\n* PRE-REGISTRATION: Planned surgery during the intervention period\n* PRE-REGISTRATION: Secondary cancer diagnosis (excluding non-invasive skin cancers, carcinoma-in-situ for any cancer)\n* PRE-REGISTRATION: Unable to regularly attend the study locations for intervention sessions and data collection\n* PRE-REGISTRATION: Unwilling to return to enrolling institution for follow-up\n* PRE-REGISTRATION: Self-reported inability to walk without assistance or devices\n* PRE-REGISTRATION: Self-reported pregnancy\n* REGISTRATION: History of stroke, transient ischemic attack, other neurological disorders, or brain surgery involving tissue removal as confirmed via clinical determination\n* REGISTRATION: Clinically significant TICS-M score (\\\u003C 21) during baseline procedures\n* REGISTRATION: Not able to provide physician re-clearance for exercise if required based upon clinically significant baseline exercise test (as determined by ECG and blood pressure monitoring)\n* REGISTRATION: Contraindications to functional magnetic resonance imaging (fMRI) in accordance with the Mayo Clinic Department of Radiology safety protocols\n* REGISTRATION: Clinically significant magnetic resonance imaging (MRI) scan as determined by physician review in which the following is advised via radiologist overread: remarkable\u002Fabnormal limited diagnostic brain image with recommended medical follow-up\n* REGISTRATION: Enrolled in another physical activity program\n* REGISTRATION: Unable to walk without assistance or devices\n* REGISTRATION: Unwilling to complete study requirements\n* REGISTRATION: Unwilling to be randomized to the exercise group or health education group\n* REGISTRATION: Unable to regularly attend study locations for intervention sessions and data collection\n* REGISTRATION: Unwilling to return to enrolling institution for follow-up\n* REGISTRATION: Unable to complete the study in English or Spanish\n* REGISTRATION: Self-reported pregnancy","FEMALE","50 Years",{"count":19,"type":20},10,"ESTIMATED","INTERVENTIONAL",[23],"NA","This clinical trial compares a physical activity program to a health education program for improving memory and attention in Hispanic women who are 50 years of age or older and are newly-diagnosed with stage I-IIIa breast cancer. Compared to non-Hispanic White breast cancer survivors (BCS), Hispanic BCS report greater depressive symptoms, emotional distress, anxiety, fear of recurrence, pain, fatigue, and financial toxicity, in addition to more cancer-related psychosocial needs and lower quality of life and social well-being. Cancer-associated cognitive decline (CACD) is a related symptom that has gained increasing attention in clinical research. Based on disparities in other outcomes, it is likely that Hispanic BCS also experience greater CACD than non-Hispanic White BCS, but interventions targeting CACD in Hispanic BCS are non-existent and critically needed. The benefits of aerobic exercise among BCS are well documented and include improvement in health outcomes that are associated with cognitive function including fatigue, anxiety, depression, and sleep. A physical activity program that includes aerobic exercise may be more effective than simple health education for improving cognitive functions like memory and attention in Hispanic women who are 50 years of age or older and are newly-diagnosed with stage I-IIIa breast cancer.",[26,27,28,29],"Anatomic Stage I Breast Cancer AJCC v8","Anatomic Stage II Breast Cancer AJCC v8","Anatomic Stage IIIA Breast Cancer AJCC v8","Cancer-related Cognitive Dysfunction","NOT_YET_RECRUITING","2026-06-15",{"date":33,"type":34},"2026-06-16","ACTUAL",{"date":36,"type":20},"2026-10-01",{"date":38,"type":20},"2027-11-30",{"name":40,"class":41},"Mayo Clinic","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":53,"briefSummary":54,"conditions":55,"keywords":58,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":42},"100425138","breast-cancer-reasoning-and-activity-intervention-100425138","NCT04816006","Breast Cancer, Reasoning, and Activity Intervention","Enhancing Cognitive Function in Breast Cancer Survivors Through Community-based Exercise Training","BRAIN","Inclusion Criteria\n\n* PRE-REGISTRATION: Age ≥50 years at time of pre-registration visit according to participant report and\u002For clinical determination\n* PRE-REGISTRATION: First, primary diagnosis of stage I-IIIa breast cancer according to participant report and\u002For clinical determination\n* PRE-REGISTRATION: Post-surgery and completed primary treatment (i.e., surgery, chemotherapy, and\u002For radiation therapy) 3-36 months prior to registration according to participant report and\u002For clinical determination\n* PRE-REGISTRATION: Sedentary except for casual lifestyle recreation defined as self-reporting no more than 90 minutes per week of moderate-intensity aerobic exercise within the last 6 months\n* PRE-REGISTRATION: Self-reported ability to complete assessments by themselves or with assistance\n* REGISTRATION: Age ≥50 years as confirmed via clinical determination\n* REGISTRATION: Able to provide medical record release to confirm eligibility\n* REGISTRATION: First, primary diagnosis of stage I-IIIa breast cancer as confirmed via clinical determination\n* REGISTRATION: Post-surgery and completed primary treatment (i.e., surgery, chemotherapy, and\u002For radiation therapy) 3-36 months prior to pre-registration as confirmed via clinical determination\n* REGISTRATION: No evidence of possible cognitive impairment as assessed using the Telephone Interview of Cognitive status (13-item modified version) (TICS-M; score \\> 21) NOTE: Only individuals who pass the TICS-M during pre-registration will be invited to participate in the urine substudy\n* REGISTRATION: Receive physician's clearance to participate in an exercise program\n\nNOTE: Individuals with conditions\u002Fdiagnoses deemed important by the primary investigator will be required to provide clearance for exercise from their cardiologist. Example conditions include:\n\n* History of major multiple myocardial infarctions (MI)\n* Recent electrocardiogram (ECG) changes or recent MI\n* Resting or unstable angina\n* Significant multivessel coronary occlusion (≥ 70%) on angiography\n* Uncontrolled and\u002For serious arrhythmias\n* 3rd degree heart block\n* Acute congestive heart failure or ejection fraction \\\u003C 30%\n\n  * REGISTRATION: Ability to complete assessments by themselves or with assistance\n\nExclusion Criteria:\n\n* PRE-REGISTRATION: Stage 0 breast cancer diagnosis OR metastatic disease\n* PRE-REGISTRATION: Currently receiving or \\\u003C 3 months since receiving chemotherapy or radiation therapy for cancer, or greater than 36 months post primary treatment\n* PRE-REGISTRATION: Planned surgery during the intervention period\n* PRE-REGISTRATION: Second cancer diagnosis (excluding non-invasive skin cancers or carcinoma-in-situ for any cancer)\n* PRE-REGISTRATION: Unable to travel regularly to the study locations for intervention sessions and data collection\n* PRE-REGISTRATION: Unwilling to return to enrolling institution for follow-up\n* PRE-REGISTRATION: Self-reported inability to walk without assistance or devices\n* REGISTRATION: History of stroke, transient ischemic attack, other neurological disorders, or brain surgery involving tissue removal as confirmed via clinical determination\n* REGISTRATION: Clinically significant TICS-M score (\\\u003C 21) during baseline procedures\n* REGISTRATION: Not able to provide physician re-clearance for exercise if required based upon clinically significant baseline exercise test (as determined by ECG and blood pressure monitoring)\n* REGISTRATION: Contraindications to functional magnetic resonance imaging (fMRI) in accordance with the Mayo Clinic Department of Radiology safety protocols\n* REGISTRATION: Clinically significant MRI scan as determined by physician review in which the following is advised via radiologist overread: remarkable\u002Fabnormal limited diagnostic brain image with recommended medical follow-up\n* REGISTRATION: Enrolled in another physical activity program\n* REGISTRATION: Unable to walk without assistance or devices\n* REGISTRATION: Unwilling to complete study requirements\n* REGISTRATION: Unwilling to be randomized to the exercise group or health education group\n* REGISTRATION: Unable or unwilling to continuously wear and regularly sync\u002Fcharge an activity tracker during the study period\n* REGISTRATION: Unable to travel regularly to the study locations for intervention sessions and data collection\n* REGISTRATION: Unwilling to return to enrolling institution for follow-up",{"count":52,"type":20},160,[23],"This phase II trial tests whether an exercise intervention works to improve cognitive function in breast cancer survivors. Many breast cancer survivors report cancer-related cognitive impairment, which this has recently become a priority in clinical research due to its dramatic impact on daily functioning, quality of life, and long-term health. Aerobic exercise has the potential to improve cognitive function and brain health in older adults and is recommended as a safe, tolerable, and accessible complementary therapy for breast cancer survivors. This study aims to understand the effects of physical activity compared with health education on memory, attention, and brain health in women with breast cancer. Study findings may help researchers design more programs that can improve memory, attention, and brain health in other women with breast cancer.",[56,57,26,27,28,29],"Breast Cancer","Breast Neoplasms",[59,60,61,62,63],"physical activity","exercise","cognition","brain health","breast cancer","RECRUITING","2026-06-11",{"date":67,"type":34},"2026-06-12",{"date":69,"type":34},"2024-02-22",{"date":71,"type":20},"2028-07-31",{"name":40,"class":41},{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":21,"phases":85,"briefSummary":86,"conditions":87,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":98},"100577529","virtual-home-based-exercise-intervention-rise-to-improve-cancer-related-cognitive-impairment-and-gut-microbiome-in-adolescent-and-young-adult-brain-tumor-survivors-100577529","NCT06799481","Virtual Home-based Exercise Intervention (RISE) to Improve Cancer-Related Cognitive Impairment and Gut Microbiome in Adolescent and Young Adult Brain Tumor Survivors","Virtually Delivered Home-Based Exercise Intervention on Cognitive Impairment and Gut Microbiome in Adolescent and Young Adult Brain Tumor Survivors: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 15-39 years\n* With primary brain tumor with cranial radiotherapy\n* 6 months to 4 years post cranial radiotherapy\n* Functional Assessment of Cancer Therapy (FACT)-Cognitive Function score \\\u003C 60 based on self-report (used among AYAs with non-neural cancer)\n* Able to provide informed consent\u002Fassent\n* Able to walk and receive clearance from a provider to participate based on the Physical Activity Readiness Questionnaire\n* Currently engaging in \\\u003C 150 minutes of physical activity per week\n* Willing to use smartphone-based applications (app)\n\nExclusion Criteria:\n\n* Secondary malignancies, germline genetic syndrome, or recurrent disease requiring re-irradiation of the brain\n* Moderate to severe traumatic brain injury with brain damage beyond that expected from brain tumor and treatment\n* Developmental disorders (e.g., autism) or major psychotic illness (e.g., schizophrenia, depression) to avoid confounding impact related to these disorders","ALL","15 Years","39 Years",{"count":84,"type":20},60,[23],"This clinical trial evaluates the impact of a research intervention of virtually supervised exercise program (RISE) on cancer-related cognitive impairment (CRCI), physical activity in adolescent and young adult (AYA) brain tumor survivors. This clinical trial also evaluates the impact of RISE on the collection of microorganisms that exist in the intestines (gut microbiome). Up to 45% of AYA brain tumor survivors experience CRCI, including issues with attention and memory. CRCI can have a negative impact on education, independent living and can worsen long-term quality of life. Moderate-intensity levels of exercise, particularly aerobic and resistance training, have been shown to improve cognitive function. Additionally, exercise can change the composition and function of the gut microbiome, which may lead to improved cognitive function. Unfortunately, only about 50% of AYAs with cancer receive exercise information or meet the physical activity recommendations. Tailoring a virtually delivered exercise intervention to meet the unique needs of AYAs may improve access to exercise. Participating in the virtual home-based exercise intervention, RISE, may improve physical activity and cognitive impairment in AYA brain tumor survivors and may also help researchers understand the relationship of exercise on the gut microbiome and cognitive function.",[29,88],"Primary Brain Neoplasm","2026-01-07",{"date":91,"type":34},"2026-01-09",{"date":93,"type":34},"2025-02-13",{"date":95,"type":20},"2027-07-31",{"name":97,"class":41},"Emory University",2]