[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cancer-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cancer-surgery":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,51,80,106,139,167,208,241,264,291],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100641106","targeted-temperature-management-on-delayed-neurocognitive-recovery-in-older-patients-after-major-cancer-surgery-100641106",false,"NCT07655687","Targeted Temperature Management on Delayed Neurocognitive Recovery in Older Patients After Major Cancer Surgery","Intraoperative Targeted Temperature Management on Delayed Neurocognitive Recovery in Older Patients After Major Cancer Surgery: a Multicenter Randomized Trial","Inclusion Criteria:\n\n1. Age ≥ 65 years.\n2. Planned potentially curative initial cancer surgery with an expected duration of 2 hours or longer under general anesthesia.\n\nExclusion Criteria:\n\n1. Preoperative fever (tympanic temperature ≥ 38℃).\n2. Known or suspected preoperative infection.\n3. Previous schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, or preexisting delirium.\n4. Inability to communicate due to coma, severe dementia, or hearing or speech impairment.\n5. Critically ill patients, defined as NYHA functional class \\> III or LVEF \\\u003C 30%, Child-Pugh class C, preoperative dialysis dependence, ASA physical status \\> IV, or expected survival \\\u003C 24 hours.\n6. Surgery for breast cancer, intracranial tumors, or rare cancers.\n7. Planned to undergo therapeutic hypothermia.\n8. Body mass index \\> 30 kg\u002Fm² (to facilitate temperature management).\n9. Previous enrollment in this study.\n10. Other conditions deemed unsuitable for study participation.",true,"ALL","65 Years",{"count":20,"type":21},1512,"ESTIMATED","INTERVENTIONAL",[24],"NA","With aging population, more older patients will receive major surgery for cancer. Older patients are at increased risk of postoperative neurocognitive complications including delayed neurocognitive recovery (dNCR), which is associated with prolonged hospital stay, raised complications, and impaired quality of life. Intraoperative hypothermia occurs in 57.1%-78.6% of patients undergoing major cancer surgery, especially in the elderly. Studies show that intraoperative hypothermia suppresses immune function, interferes with anesthetic metabolism, and delays anesthesia emergence. All these may be correlated with the occurrence of early postoperative dNCR. This study aims to verify whether intraoperative targeted temperature management (target core temperature: 36.8°C) compared with conventional temperature management (core temperature: 35.5°C) can reduce the incidence of dNCR in older patients undergoing major cancer surgery.",[27,28,29,30,31],"Elderly Patients","Cancer Surgery","Hypothermia, Accidental","Targeted Temperature Management","Delayed Neurocognitive Recovery",[33,34,35,36,37],"elderly patient","major cancer surgery","intraoperativ hypothermia","targeted temperature management","delayed neurocognitive recovery","NOT_YET_RECRUITING","2026-06-18",{"date":41,"type":42},"2026-06-23","ACTUAL",{"date":44,"type":21},"2026-06",{"date":46,"type":21},"2028-11",{"name":48,"class":49},"Peking University First Hospital","OTHER",2,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":73,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},"100535786","effects-of-intraoperative-targeted-temperature-management-on-incidence-of-postoperative-delirium-and-long-term-survival-100535786","NCT06256354","Effects of Intraoperative Targeted Temperature Management on Incidence of Postoperative Delirium and Long-term Survival","Effects of Intraoperative Targeted Temperature Management on Incidence of Postoperative Delirium and Long-term Survival in Older Patients Having Major Cancer Surgery: A Multicenter Randomized Trial","Inclusion Criteria:\n\n1. Age ≥65 years.\n2. Planned potentially curative initial cancer surgery with an expected duration of 2 hours or longer under general anesthesia.\n\nExclusion Criteria:\n\n1. Preoperative fever (tympanic temperature ≥38℃).\n2. Known or suspected preoperative infection.\n3. Previous history of schizophrenia, epilepsy, Parkinson disease, myasthenia gravis, or delirium.\n4. Unable to communicate due to severe dementia, language barrier, or coma.\n5. Critically ill (Left ventricular ejection fraction \\\u003C30%, Child-Pugh grades C, requirement of renal replacement therapy, American Society of Anesthesiologists physical status\\>IV, or expected survival \\\u003C24 hours).\n6. Scheduled surgery for breast cancer, intracranial tumors, or rare cancers.\n7. Planned to undergo therapeutic hypothermia.\n8. Body mass index \\>30 kg\u002Fm2 (to facilitate thermal management).\n9. Have participated in this study previously.\n10. Any other conditions that are considered unsuitable for study participation.",{"count":59,"type":21},3992,[24],"Intraoperative hypothermia is common in patients having major surgery and the compliance with intraoperative temperature monitoring and management remains poor. Studies suggest that intraoperative hypothermia is an important risk factor of postoperative delirium, which is associated with worse early and long-term outcomes. Furthermore, perioperative hypothermia increases stress responses and provokes immune suppression, which might promote cancer recurrence and metastasis. In a recent trial, targeted temperature management reduced intraoperative hypothermia and emergence delirium. There was also a trend of reduced postoperative delirium, although not statistically significant. This trial is designed to test the hypothesis that intraoperative targeted temperature management may reduce postoperative delirium and improves progression-free survival in older patients recovering from major cancer surgery.",[28,63,30,64,65],"Intraoperative Hypothermia","Postoperative Delirium","Long-term Survivors",[67,68,69,70,71],"Cancer surgery","Intraoperative hypothermia","Targeted temperature management","Postoperative delirium","Long-term survival","RECRUITING",{"date":41,"type":42},{"date":75,"type":42},"2024-05-29",{"date":77,"type":21},"2032-06",{"name":48,"class":49},36,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":17,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":22,"phases":92,"briefSummary":93,"conditions":94,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":105},"100622909","preoperative-physical-exercise-nutritional-support-and-psychological-intervention-multimodal-prehabilitation-to-strengthen-patients-overall-health-and-reduce-postoperative-complications-100622909","NCT07389746","Preoperative Physical Exercise, Nutritional Support, and Psychological Intervention (Multimodal Prehabilitation) to Strengthen Patients' Overall Health and Reduce Postoperative Complications","Multimodal Prehabilitation Reduces Postoperative Complications in High Risk Patients Undergoing Major Gastrointestinal Cancer Surgery","PREHAB","Inclusion Criteria:\n\n* Candidate to elective major gastrointestinal cancer surgery (pelvic exenteration, cytoreductive surgery, oesophagectomy, transhiatal gastrectomy, hepatectomy, pancreatectomy, rectum resection)\n* High risk for surgical complications defined by presence of comorbid disease such as deconditioning, heart disease, diabetes, renal impairment or morbid obesity\n* Duke Activity Status Index score (DASI) \\\u003C402\n* Schedule allowing for at least 4 weeks for intervention with multimodal prehabilitation prior to surgery \u002F willingness to exercise\n\nExclusion Criteria:\n\n* Non-elective surgery\n* Unstable cardiac or respiratory disease\n* Locomotor limitations precluding exercise training\n* Cognitive deterioration impeding adherence to the programme\n* Enrolment in other research studies affecting study endpoint","18 Years","80 Years",{"count":91,"type":21},400,[24],"In this prospective, randomized, controlled trial patients undergoing major gastrointestinal cancer surgery will be exercised (intervention group) 4 weeks before surgery with a high-intensity interval training (HIIT). They will also receive a specialized nutrition therapy and psychological support (multimodal prehabilitation). Aim of this study is to find out if the prehabilitation group is more resilient to postoperative complications when compared to the control group that will receive standard of care. Another goal is to unravel the underlying mechanisms that are stimulated by exercise like enhancing vascular function, improving immune system response, strengthen cellular tumor defense and optimizing neurological outcome.",[28,95],"Prehabilitation","2026-02-10",{"date":98,"type":42},"2026-02-13",{"date":100,"type":21},"2026-07-01",{"date":102,"type":21},"2029-01-01",{"name":104,"class":49},"University Hospital of Cologne",1,{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":17,"minAge":88,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":22,"phases":116,"briefSummary":117,"conditions":118,"keywords":124,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":105},"100617148","using-artificial-intelligence-to-guide-fluid-therapy-during-major-cancer-surgery-a-randomized-controlled-trial-100617148","NCT07314853","Using Artificial Intelligence to Guide Fluid Therapy During Major Cancer Surgery: A Randomized Controlled Trial","Fluid Optimization in Cancer Surgery With AI-Assisted Management - FOCUS-AFM Trial","FOCUS-AFM","Inclusion Criteria:\n\n* Age ≥ 18 years\n* American Society of Anesthesiologists (ASA) Physical Status II-IV\n* Undergoing major abdominal oncologic surgery (open or laparoscopic) with an expected duration \\>2 hours\n* Planned invasive arterial pressure monitoring\n* Ability to understand and sign informed consent\n\nExclusion Criteria:\n\n* Significant arrhythmias (e.g., persistent atrial fibrillation)\n* Severe aortic stenosis\n* Emergency surgery\n* Sepsis\n* End-stage renal disease on dialysis\n* Pregnancy\n* Impossibility to cannulate the radial artery\n* Refusal to participate or refusal of data processing consent",{"count":115,"type":21},176,[24],"The goal of this clinical trial is to learn if using artificial intelligence to guide intravenous fluid therapy during major cancer surgery can help keep blood pressure more stable compared with usual care in adult patients undergoing major cancer surgery. The main questions it aims to answer are:\n\n* Does artificial intelligence-guided fluid therapy reduce hypotensive events during surgery?\n* Does this approach improve recovery and reduce complications after major cancer surgery?\n\nResearchers will compare artificial intelligence-guided fluid therapy with standard fluid management to see if the artificial intelligence-guided approach provides better support during surgery.\n\nParticipants will:\n\n* Undergo major cancer surgery under general anesthesia\n* Receive either artificial intelligence-guided fluid management or standard fluid management during surgery\n* Be monitored during and after surgery as part of routine clinical care\n* Be followed after surgery to assess recovery and possible complications",[119,120,121,28,122,123],"Neoplasm","Cancer","Hemodynamic (MAP) Stability","Artificial Intelligence (AI)","Fluid Therapy DURING SURGERY",[125,126,127,128,129],"randomized controlled trial","cancer","fluid balance","fluid therapy","artificial intelligence","2026-01-07",{"date":132,"type":42},"2026-01-09",{"date":134,"type":21},"2026-02",{"date":136,"type":21},"2029-02",{"name":138,"class":49},"National Cancer Institute, Naples",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":145,"eligibilityCriteria":146,"healthyVolunteers":11,"sex":17,"minAge":88,"maxAge":4,"enrollmentInfo":147,"targetDuration":4,"studyType":22,"phases":149,"briefSummary":150,"conditions":151,"keywords":154,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":165,"locationsCount":105},"100614363","virtual-group-prehabilitation-education-surgery-school-feasibility-trial-100614363","NCT07278622","Virtual Group Prehabilitation Education (Surgery School) Feasibility Trial","Feasibility Testing and Process Evaluation of a Virtual Group Preoperative Prehabilitation Education Intervention (GoPREPARE)","GoPREPARE","Inclusion Criteria:\n\n* Adults undergoing elective surgery for any body cavity cancer with curative intent.\n* Adults with more than 3 weeks before planned surgery\n* Adults without previous experience of prehabilitation.\n\nExclusion Criteria:\n\n* Children\n* Adults who lack mental capacity.\n* Adults who do not understand spoken English.\n* Previous experience of prehabilitation.\n* Previous surgery for cancer\n* Pregnancy",{"count":148,"type":21},24,[24],"One in four patients requiring planned major surgery have complications. Prehabilitation; which involves increasing physical activity, improving nutrition and supporting emotional well-being prior to surgery can reduce these complications and improve recovery. Group preoperative prehabilitation classes (surgery schools) are advocated by the Centre for Perioperative Care and are standard care in many hospitals, despite a lack of evidence for their effectiveness in improving patient outcomes. In phase 1 an 2 of this research investigators used patient experiences and co-participatory methods to optimise an existing intervention to make it as acceptable and as engaging as possible. The resulting education package is called 'GoPREPARE'\n\nInvestigators now intend to test the practicalities of trialing GoPREPARE on preoperative patients with cancer. 24 patients awaiting surgery will be recruited from University Hospital Plymouth and randomly allocated equally to: Group - GoPREPARE and Group 2- standard care. Participants will complete lifestyle questionnaires before during and after their hospital stay. To evaluate the experience, \\~8 participants will be interviewed. 5 clinical staff involved in the trial will also take part in a focus group. The information collected will be analysed to assess if it is feasible to conduct a larger trial.",[28,152,153,95],"Elective Surgery","Patient Education",[155,156,157,158],"surgery school","prehabilitation","patient education","perioperative care","2025-12-11",{"date":161,"type":42},"2025-12-12",{"date":163,"type":42},"2025-09-02",{"date":100,"type":21},{"name":166,"class":49},"University Hospital Southampton NHS Foundation Trust",{"id":168,"slug":169,"hasResults":11,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":173,"eligibilityCriteria":174,"healthyVolunteers":11,"sex":17,"minAge":88,"maxAge":175,"enrollmentInfo":176,"targetDuration":4,"studyType":22,"phases":178,"briefSummary":179,"conditions":180,"keywords":190,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":105},"100572340","optimal-perioperative-pain-control-in-minimally-invasive-abdominal-cancer-surgery-100572340","NCT06731998","Optimal Perioperative Pain Control in Minimally Invasive Abdominal Cancer Surgery","Evaluating Optimal Perioperative Pain Management: A Prospective Randomized Control Trial of Laparoscopic Transversus Abdominis Plane Block With Local Anesthetic, Laparoscopic Transversus Abdominis Plane Block Alone, and Local Anesthetic Alone in Minimally Invasive Oncologic Surgery","LapTAP","Inclusion Criteria:\n\n1. Male and female patients age ≥ 18 - 89\n2. Patients scheduled for elective (clinically indicated) hepatic, gastric, biliary, pancreatic, gynecologic, colorectal, other GI Minimally invasive oncologic surgery.\n3. Patients who have provided informed consent to participate in the study.\n4. Patients with an American Society of Anesthesiologists (ASA) physical status classification of I, II, or III.\n5. Patients undergoing procedures anticipated to last more than 1 hour but less than 8 hours.\n6. Patients able to understand and self-report pain using the designated pain Visual Analog Scale\n\nExclusion Criteria:\n\n1. Patients age less than 18 or ≥ 90\n2. Pre-existing hepatic dysfunction, cirrhosis\n3. Patients with an ASA classification of IV or higher.\n4. Patients with chronic pain disorders or on long-term opioid or analgesic therapy.\n5. Patients with known contraindications to the study drugs or procedures (e.g., allergy to LA or contraindications to LapTAP).\n6. Patients with cognitive impairments or psychiatric conditions that could interfere with pain assessment or understanding of informed consent.\n7. Patients unable to understand the language in which consent and study-related information are provided (The study and the study-related information will be in the English Language)..\n8. Patients who have undergone major surgery within the last 6 months.\n9. Female patients who are pregnant.\n10. Patients currently enrolled in another clinical trial that might interfere with the outcome measures of this study.","89 Years",{"count":177,"type":21},48,[24],"This is a research study to evaluate the effectiveness of 3 different types of routine pain management regimens used during clinically indicated, minimally invasive oncologic (cancer) surgery. This project is considered \"Research\" and participation is voluntary. Upon enrollment in this study, the research team will collect data from the patient's medical records. The patient will undergo all of the normal testing and procedures required pre-operatively (standard of care). The study team will then randomly assign the patient (like a flip of a coin) to one of three different study arms for pain management during surgery:\n\n1. Laparoscopic Transversus Abdominis Plane Block (LapTAP) with Local Anesthetic (LA)\n2. Laparoscopic Transversus Abdominis Plane Block (LapTAP) only\n3. Local Anesthetic (LA) only The patient will receive standard pre- and post-operative care according to clinical guidelines (routine care). The study team will collect information from the patient's medical record for the first 24 hours after their surgery and upon discharge. This information will include pain scores, amount of medication required, any side effects the patient may have experienced, and satisfaction with pain control. Participation in the study will end upon discharge from the hospital.",[181,120,28,182,183,184,185,186,187,188,189],"Oncologic Surgery","Hepatic Cancer","Gastric (Cardia, Body) Cancer","Biliary Tract Cancer","Pancreatic Cancer Resectable","Gynecologic Cancers","Gastrointestinal Cancers","Colorectal Cancer","Minimally Invasive Surgical Procedures",[191,192,193,194,126,195,196,197,198],"Laparoscopic Transversus Abdominis Plane Block","Local Anesthetic","Laparoscopic Surgical Procedure","pain management","cancer surgery","oncologic surgery","perioperative pain management","minimally invasive surgical procedures","2025-09-15",{"date":201,"type":42},"2025-09-18",{"date":203,"type":42},"2025-02-05",{"date":205,"type":21},"2026-12",{"name":207,"class":49},"Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)",{"id":209,"slug":210,"hasResults":11,"nctId":211,"briefTitle":212,"officialTitle":213,"acronym":214,"eligibilityCriteria":215,"healthyVolunteers":16,"sex":17,"minAge":88,"maxAge":4,"enrollmentInfo":216,"targetDuration":4,"studyType":22,"phases":217,"briefSummary":218,"conditions":219,"keywords":220,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":240},"100576710","multimodal-prehabilitation-in-cancer-surgery-100576710","NCT06788834","Multimodal Prehabilitation in Cancer Surgery","Multimodal Prehabilitation in Cancer Surgery PROPOSE Trial (PRehabilitation in Oncological Patients undergOing SurgEry): A Randomized Trial","PROPOSE-RCT","Inclusion Criteria:\n\n* Adult patient (age \\> 18 years);\n* Scheduled for elective major abdominal (including urological), thoracic (including breast) or gynecological cancer surgery;\n* Signed informed consent.\n\nExclusion Criteria:\n\nA) Co-morbid medical, physical, and mental conditions interfering with the ability to complete study procedures, such as:\n\n* Acute or unstable cardio-respiratory conditions (e.g., unstable angina or symptomatic severe aortic stenosis);\n* Severe\u002Fend-stage organ diseases (e.g., cardiac failure NYHA functional classes III-IV, COPD FEV1 \\\u003C50% pred, end-stage kidney or liver disease);\n* American Society of Anesthesiologists (ASA) physical status classes 4-5;\n* Disabling orthopedic and neuromuscular disease;\n* Psychosis, dementia;\n* Symptomatic anemia with a hemoglobin value \\\u003C 7 gr\u002Fdl.\n\nB) Patients with both optimal functional capacity (a Duke activity status index \\[DASI\\] score \\> 45) and optimal nutritional status (NRS-nutrition screening tool-score \\\u003C 2).",{"count":91,"type":21},[24],"The PROPOSE RCT is a two-arm randomized controlled trial that will be conducted to test the efficacy of a personalized, multidisciplinary pre-operative prehabilitation program (preventive prehabilitation) to reduce serious complications and facilitate recovery after surgery in high-risk patients.\n\nThe multimodal prehabilitation program is a preoperative intervention that includes exercise training, nutritional therapy and anxiety reduction techniques, with the aim of preventing or mitigating the functional decline brought about by surgery. 400 patients scheduled for elective major abdominal (including urological), thoracic (including breast) or gynecological cancer surgery will be enrolled. They will be randomized (1:1 ratio) and assigned either to the intervention group (Prehabilitation) or to the control group, which will only be treated according to the usual standard of care within the Enhanced Recovery After Surgery (ERAS) pathways.",[28],[95,221,222,223,224,225,226,227,228,229,230],"Functional recovery","Relaxation","Exercise","Diet","Nutrition","Functional walking","Hospital stay","Multimodal prehabilitation program","Standard treatment","Anesthesiology","2025-08-05",{"date":233,"type":42},"2025-08-07",{"date":235,"type":42},"2025-01-30",{"date":237,"type":21},"2026-09",{"name":239,"class":49},"Università Vita-Salute San Raffaele",9,{"id":242,"slug":243,"hasResults":11,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":247,"eligibilityCriteria":248,"healthyVolunteers":11,"sex":17,"minAge":88,"maxAge":4,"enrollmentInfo":249,"targetDuration":4,"studyType":22,"phases":251,"briefSummary":252,"conditions":253,"keywords":254,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":256,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":262,"locationsCount":263},"100573294","prehabilitation-to-improve-heart-rate-variability-prime-100573294","NCT06744413","Prehabilitation to Improve Heart Rate Variability (PRIME)","Prehabilitation to Improve Heart Rate Variability In Surgical Cancer Patients: a randoMized controllEd Trial","PRIME","Inclusion Criteria:\n\n1. Scheduled to undergo elective major abdominal or thoracic cancer surgery;\n2. Scheduled to undergo surgery at least three weeks after enrollment;\n3. Age ≥ 18 years;\n4. Provide written informed consent;\n5. Willing and able to use smartphone application.\n\nExclusion Criteria:\n\n1. Presenting with very poor functional capacity;\n2. American Society of Anesthesiologists (ASA) physical status classes 5-6;\n3. Disabling orthopedic, neuromuscular, and psychiatric diseases or other conditions that preclude participation in a prehabilitation program.",{"count":250,"type":21},600,[24],"Cancer patients require chronic management and care. For those individuals living with cancer, a comprehensive approach that acknowledges the interdisciplinary nature of their condition can help guide appropriate care strategies and support their overall well-being. Approximately 45% of patients diagnosed with cancer undergo surgery to remove their tumor. Despite the advancements in surgical techniques, anesthesia, and perioperative care, major cancer surgeries still pose a significant challenge leading to a considerable decline in physiological and functional capacity. Traditionally, efforts focused on postoperative rehabilitation to enhance recovery. Recently, prehabilitation, a form of rehabilitation which aims to improve functional capacity before surgery, has gained attention for its potential benefits in improving surgical outcomes. However, prehabilitation lacks objective assessment measures to evaluate its effectiveness. Developing validated outcome measures is essential to enhance the impact of prehabilitation on surgical outcomes and long-term care for cancer patients. Heart rate variability (HRV) is a physiological parameter that measures the variation in time intervals between consecutive heartbeats, reflecting the autonomic nervous system activity which might serve as a valuable solution for objective outcome measures in evaluating the effectiveness of prehabilitation for cancer patients, providing an objective tool to assess and monitor physiological response to stress, recovery capacity, and autonomic nervous system activity. A multicenter randomized controlled trial will be conducted to assess the impact of a multimodal prehabilitation program on HRV. Patients aged 18 or older, scheduled for elective major cancer surgery will be randomized to receive either prehabilitation or standard care. The prehabilitation arm will receive a program involving home-based physical, nutritional, and psychological interventions for at least four weeks. Participants allocated to the control group will receive usual care. Patients will be followed throughout the study using an innovative mobile application, allowing for real-time monitoring and data collection during the prehabilitation program. The study has two primary outcomes: A) to assess the impact of prehabilitation on increasing preoperative HRV in chronic cancer patients undergoing surgery; B) to assess the effect of prehabilitation on length of hospital stay.",[28],[67,95,228,255,227,226,225,224,223,222,221,230],"Standard care treatment",{"date":257,"type":42},"2025-08-06",{"date":259,"type":42},"2024-12-20",{"date":261,"type":21},"2026-11",{"name":239,"class":49},4,{"id":265,"slug":266,"hasResults":11,"nctId":267,"briefTitle":268,"officialTitle":269,"acronym":4,"eligibilityCriteria":270,"healthyVolunteers":11,"sex":17,"minAge":271,"maxAge":4,"enrollmentInfo":272,"targetDuration":4,"studyType":22,"phases":274,"briefSummary":275,"conditions":276,"keywords":280,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":282,"lastUpdatePostDateStruct":283,"startDateStruct":285,"completionDateStruct":287,"leadSponsor":289,"locationsCount":290},"100518458","perioperative-dexmedetomidine-and-long-term-survival-after-cancer-surgery-100518458","NCT06030804","Perioperative Dexmedetomidine and Long-term Survival After Cancer Surgery","Impact of Perioperative Dexmedetomidine on Long-term Survival in Older Patients After Cancer Surgery: a Multicenter Randomized Trial","Inclusion criteria:\n\n1. Aged 60 years or older.\n2. Scheduled to undergo radical surgery for cancer under general anesthesia, with an expected surgical duration of 2 hours or longer.\n3. Required patient-controlled intravenous analgesia after surgery.\n\nExclusion criteria:\n\n1. Inability to communicate preoperatively due to visual, auditory, verbal. or other reasons.\n2. Surgery for breast cancer or intracranial tumor.\n3. Preoperative severe sinus bradycardia (\\\u003C50 beats per minute), sick sinus syndrome，or second-degree or above atrioventricular block without pacemaker.\n4. Severe hepatic dysfunction (Child-Pugh class C).\n5. Severe renal dysfunction (requirement of renal replacement therapy before surgery).\n6. Enrolled in other clinical studies.","60 Years",{"count":273,"type":21},4532,[24],"Along with aging population, cancer incidence and mortality are increasing. However, despite advances in oncology and surgery, long-term survival of cancer patients is far from optimal. Dexmedetomidine is a highly selective alpha 2 adrenergic receptor agonist with sedative, analgesic, and anxiolytic effects. Studies showed that perioperative use of dexmedetomidine reduces delirium and some non-delirium complications after surgery. In long-term follow-up studies of older patients who, for other reasons, were randomized to receive either dexmedetomidine or placebo during intra- or postoperative period, dexmedetomidine use was associated with improved long-term survival. This multicenter randomized trial aims to investigate the effect of perioperative dexmedetomidine on long-term outcomes in older patients undergoing cancer surgery.",[277,28,278,279],"Elderly","Dexmedetomidine","Long-Term Survivors",[281,67,278,71],"Older patients","2025-07-29",{"date":284,"type":42},"2025-07-31",{"date":286,"type":42},"2023-09-12",{"date":288,"type":21},"2028-10",{"name":48,"class":49},39,{"id":292,"slug":293,"hasResults":11,"nctId":294,"briefTitle":295,"officialTitle":296,"acronym":4,"eligibilityCriteria":297,"healthyVolunteers":11,"sex":17,"minAge":88,"maxAge":4,"enrollmentInfo":298,"targetDuration":4,"studyType":22,"phases":300,"briefSummary":301,"conditions":302,"keywords":303,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":312,"locationsCount":4},"100570463","landmark-versus-ultrasongraphy-guided-spinal-anesthesia-in-lower-abdominal-surgeries-in-cancer-patients-a-randomized-controlled-trial-100570463","NCT06707571","Landmark Versus Ultrasongraphy Guided Spinal Anesthesia in Lower Abdominal Surgeries in Cancer Patients: a Randomized Controlled Trial","Ultrasongraphy Guided Spinal Anesthesia Versus Landmark in Lower Abdominal Surgeries in Cancer Patients: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Age \\>18 years old\n* Both sex\n* patients with a body mass index (BMI) of 18-40 kg\u002Fm2\n* American Society of Anesthesiologists (ASA) physical status classification of I to III.\n\nExclusion Criteria:\n\n* • Patients have a contraindication for regional anesthesia, e.g. coagulopathy.\n\n  * Failed or unsatisfactory intrathecal block.\n  * Patients with known hypersensitivity to amide local anesthetics.\n  * Local injection site infection or spinal deformity.\n  * Severe hypotension.\n  * Space occupying lesions of the brain.\n  * Hypovolemia.\n  * Pregnancy.",{"count":299,"type":21},52,[24],"Spinal anesthesia is a commonly employed technique for lower abdominal surgeries, providing effective anesthesia and analgesia with minimal systemic effects. In cancer patients undergoing such procedures, careful consideration of anesthetic techniques is crucial, given their often-compromised physiological state and the need to minimize postoperative complications. Two approaches to administering spinal anesthesia are Ultrasound (US)-guided and the traditional landmark-based technique.\n\nthe aim of the study :To evaluate the efficacy, safety and feasibility of US-guided spinal anesthesia versus the landmark-based technique in cancer patients undergoing lower abdominal surgery.",[28],[304],"US-guided spinal anesthesia","2024-11-25",{"date":307,"type":42},"2024-11-27",{"date":309,"type":21},"2024-12-01",{"date":311,"type":21},"2027-01-01",{"name":313,"class":49},"Assiut University"]