[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cancer-survivorship\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cancer-survivorship":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,54,92,126,152,182,214,244,274,301,326,359,382,415,440,461],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100644472","bridging-the-gap-in-psychosocial-care-for-cancer-survivors-100644472",false,"NCT07672314","Bridging the Gap in Psychosocial Care for Cancer Survivors","Bridging the Gap in Psychosocial Care for Cancer Survivors: Integrating Digital Screening With Navigation Call","BRIDGE","Inclusion Criteria:\n\n* Adults aged ≥18 years\n* Under oncological care at the USB for ≥9 months\n* Completion of primary cancer treatment (see definition below)\n* Attendance at routine oncological follow-up at USB\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Primary brain tumors\n* Severe cognitive impairment\n* Acute psychiatric symptoms that may impair the participant's ability to provide informed consent or comply with study procedures\n* Insufficient German language skills","ALL","18 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","The study aims to assess the feasibility and acceptability of the implementation of a routine digital psychosocial screening combined with a psycho-oncological Navigation Call for cancer survivors after completion of primary treatment with the goal to improve identification of psychosocial needs and facilitate access to supportive care.",[27,28,29,30],"Cancer Survivorship","Psychological Distress","Psycho-Oncology","Supportive Care",[32,33,34,35,36,37,38,39,40],"Cancer survivors","Survivorship care","Digital screening","Psycho-oncology","Psychosocial distress","Patient-reported outcomes (PROs)","Navigation Call","Feasibility study","Acceptability","NOT_YET_RECRUITING","2026-06-26",{"date":44,"type":45},"2026-06-29","ACTUAL",{"date":47,"type":21},"2026-07",{"date":49,"type":21},"2028-05",{"name":51,"class":52},"University Hospital, Basel, Switzerland","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":22,"phases":64,"briefSummary":65,"conditions":66,"keywords":69,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":53},"100605376","sbu-reset-relaxation-stress-reduction-and-epigenetics-trial-in-cancer-survivors-100605376","NCT07161713","SBU-RESET: RElaxation, Stress Reduction and Epigenetics Trial in Cancer Survivors","Pilot Study of a Social\u002FBehavioral Intervention on Cancer Survivors, Evaluating the Effect of Mind Body Interventions on Patient Reported Outcomes, Inflammation and Epigenetics.","RESET","Inclusion Criteria:\n\n* Adults over 18 years old\n* Primary diagnosis: Lung Cancer, Colon Cancer and Non-Hodgkin's lymphoma (NHL)\n* Six months post cancer-directed treatment (chemotherapy, targeted and immunotherapy). Patients with active disease (e.g. metastatic colorectal cancer) who are not receiving any cancer-directed treatment are eligible.\n* Able to provide a saliva sample\n* Gives informed consent and agrees to be randomly assigned\n* Able to complete the questionnaire(s) in English.\n\nExclusion Criteria:\n\n* Adults with primary anal and\u002For primary rectal cancer.\n* Adult cancer survivors who are currently on an active treatment regimen.\n* Oral or any pathological conditions that can limit the ability to produce saliva.\n* Unable to participate in full length study period and follow up thereafter.\n* Is pregnant or plan to become pregnant during the study period.\n* Currently practicing yoga or SMART\n* Those on corticosteroid therapy.\n* Documented fall or syncope within the last 6 months",{"count":63,"type":21},100,[24],"Cancer survivors can experience health issues that cause chronic illness and lower quality of life. Yoga is a well-known holistic approach to health and overall well-being. Mindfulness has many benefits, including improved focus and less stress. This study aims to evaluate if yoga and\u002For mindfulness has a positive effect on cancer survivors social, emotional and physical well-being as well as their epigenetics. Epigenetics is how the environment can effect your genes; not by changing our DNA, but by turning genes on or off.",[67,68,27],"Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma)","Cancer Survivors",[70,71,72,73,74,75,76,77,78,79,80,81,82],"stony brook","survivor","yoga","mindfulness-based stress reduction","holistic","stress management","cancer survivor","long island","mindfulness","cancer","EORTC","questionnaires","surveys","RECRUITING",{"date":85,"type":45},"2026-06-30",{"date":87,"type":45},"2025-09-17",{"date":89,"type":21},"2027-09-30",{"name":91,"class":52},"Barbara Nemesure",{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":98,"eligibilityCriteria":99,"healthyVolunteers":11,"sex":17,"minAge":100,"maxAge":4,"enrollmentInfo":101,"targetDuration":4,"studyType":22,"phases":103,"briefSummary":104,"conditions":105,"keywords":110,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":53},"100640884","structured-cardio-oncology-rehabilitation-for-cardiovascular-outcomes-in-cancer-survivors-100640884","NCT07622394","Structured Cardio-Oncology Rehabilitation for Cardiovascular Outcomes in Cancer Survivors","A Multicenter, Prospective, Parallel-Group, Superiority Randomized Controlled Trial of Structured Cardio-Oncology Rehabilitation for Improving Cardiovascular Outcomes in Patients With Cancer Therapy-Related Cardiac Dysfunction or High Cardiovascular Risk","CORE-CTRCD","Inclusion Criteria:\n\n* Age 18 years or older, regardless of sex.\n* Histologically or cytologically confirmed solid tumor or hematologic malignancy.\n* Completed curative anti-cancer therapy, or receiving stable adjuvant, maintenance, or palliative anti-cancer therapy.\n* Meets at least one criterion for cancer therapy-related cardiac dysfunction (CTRCD) or high cardiovascular risk, including reduced LVEF after anti-cancer therapy, high-dose anthracycline exposure, chest radiotherapy with cardiovascular risk factors, heart failure after anti-cancer therapy, or elevated cardiac injury\u002Fheart failure biomarkers.\n* Estimated life expectancy of at least 24 months as assessed by the treating oncologist.\n* Able to complete baseline cardiopulmonary exercise testing and has no absolute contraindication to exercise training.\n* Able and willing to provide written informed consent and comply with study intervention and follow-up.\n\nExclusion Criteria:\n\n* Active progressive malignancy requiring urgent anti-cancer therapy, or estimated life expectancy less than 24 months.\n* Severe structural heart disease, including severe valvular disease, congenital heart disease, end-stage heart failure, or waiting for heart transplantation or left ventricular assist device implantation.\n* Absolute contraindications to exercise training, including uncontrolled malignant arrhythmia, acute myocarditis or pericarditis, acute coronary syndrome within 2 weeks, severe anemia, severe thrombocytopenia or neutropenia, uncontrolled hypertension, active infection, or severe musculoskeletal disease preventing exercise training.\n* Participation in a structured cardiac rehabilitation program within the previous 12 months, or regular moderate-to-vigorous aerobic or resistance training for at least 3 months before enrollment.\n* Implanted ICD or CRT, except pacemakers with exercise mode.\n* Severe psychiatric disease or cognitive impairment preventing participation.\n* Concurrent participation in another interventional clinical trial, or planned participation in another interventional clinical trial during the study period.\n* Any other condition that, in the investigator's judgment, makes the participant unsuitable for the study.","18 Months",{"count":102,"type":21},800,[24],"Cancer therapy-related cardiac dysfunction (CTRCD) has become a major cause of morbidity and mortality among cancer survivors. Although cardiac rehabilitation is recommended for cardiovascular disease prevention and management, high-quality randomized controlled evidence regarding its efficacy in cardio-oncology populations remains limited.\n\nThis multicenter, prospective, parallel-group, superiority randomized controlled trial aims to evaluate whether a structured cardio-oncology rehabilitation (CORE) program combined with usual care can improve cardiovascular outcomes in patients with CTRCD or cancer survivors at high cardiovascular risk, compared with usual care alone.\n\nA total of 800 participants will be randomized in a 1:1 ratio to receive either structured cardio-oncology rehabilitation plus usual care or usual care alone. The intervention includes individualized exercise training, nutritional management, psychosocial support, cardiovascular risk-factor optimization, and patient education. Participants will be followed for 12 months.\n\nThe primary endpoint is time to first major adverse cardiovascular event (MACE) within 12 months. Secondary endpoints include changes in cardiorespiratory fitness, cardiac function, biomarkers, quality of life, physical function, psychological status, safety outcomes, and health economic outcomes.",[106,107,27,108,109],"Cancer Therapy-Related Cardiac Dysfunction","Cardio-oncology","Cardiovascular Risk","Heart Failure",[111,112,68,113,114,115,116],"Structured Cardio-Oncology Rehabilitation","Cardiac Rehabilitation","Major Adverse Cardiovascular Events","Exercise Training","Cardiorespiratory Fitness","CTRCD","2026-06-02",{"date":119,"type":45},"2026-06-03",{"date":121,"type":21},"2026-09-01",{"date":123,"type":21},"2029-09-30",{"name":125,"class":52},"Xinjiang Medical University",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":4,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":133,"targetDuration":4,"studyType":22,"phases":135,"briefSummary":136,"conditions":137,"keywords":139,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":53},"100581028","effects-of-latin-dancing-on-sleep-quality-in-hispanic-cancer-survivors-100581028","NCT06844981","Effects of Latin Dancing on Sleep Quality in Hispanic Cancer Survivors","Moviendo Las Caderas: Effects of Latin Dancing on Sleep Quality in Hispanic Cancer Survivors","Inclusion Criteria:\n\n* Be 18 years of age or older\n* Self-identify as Hispanic and\u002For Latino(a)\n* Have a confirmed diagnosis of a solid tumor or hematologic malignancy\n* Must have completed primary cancer treatment 3+ months prior to enrollment (e.g., chemotherapy, surgery, and\u002For radiation therapy but may be on hormonal therapy and\u002For immunotherapy or other long-term therapies)\n* Have sleep disturbance (indicated by a response of 3 or more on the MD Anderson Symptom Inventory sleep question by using an 11-point scale anchored by 0 \\[no sleep disturbance\\] and 10 \\[worst possible sleep disturbance\\]\n* Be able to read and understand English and\u002For Spanish\n* Physically Inactive (\\\u003C150 minutes of vigorous exercise\u002Fweek within the past 3 months)\n\nExclusion Criteria:\n\n* Current regular Latin dancing practice within the past year (2-3 times a week over a period of two months that is not interrupted).\n* Inability to speak and read English or Spanish proficiently\n* Inability to understand informed consent\n* Medical conditions that can cause sleep impairment: sleep apnea, restless leg syndrome, shift work\n* Regular use of a walker or wheelchair\n* Healing or unhealed fractures\n* Heart failure\n* Life expectancy \\\u003C12 months\n* Unwilling to be randomized to study arms and\u002For commit to 8 weeks of classes and a follow-up assessment",{"count":134,"type":21},40,[24],"The primary objective is to assess the feasibility, acceptability and explore the impact of a culturally appropriate Latin Dance intervention vs. Usual Care on sleep quality for Hispanic cancer survivors.\n\nSecondary objectives are to examine the preliminary efficacy of a culturally appropriate Latin Dance intervention on secondary cancer- and treatment-related side effects (e.g., Quality of Life, distress, insomnia, fatigue).",[27,138],"Sleep Disturbances",[140,27,138,141,142],"Cancer","Hispanic Cancer Survivors","Latin Dancing","2026-05-19",{"date":145,"type":45},"2026-05-20",{"date":147,"type":45},"2026-04-01",{"date":149,"type":21},"2027-03",{"name":151,"class":52},"Rutgers, The State University of New Jersey",{"id":153,"slug":154,"hasResults":11,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":4,"eligibilityCriteria":158,"healthyVolunteers":11,"sex":159,"minAge":18,"maxAge":160,"enrollmentInfo":161,"targetDuration":4,"studyType":22,"phases":163,"briefSummary":164,"conditions":165,"keywords":168,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":53},"100629208","family-building-decision-support-for-female-adolescent-and-young-adult-cancer-survivors-100629208","NCT07471685","Family Building Decision Support for Female Adolescent and Young Adult Cancer Survivors","Development and Pilot Testing of a Family Building Decision Support Intervention for Female Adolescent and Young Adult Cancer Survivors","Inclusion Criteria:\n\n* Female (biological sex) AYA cancer survivor age 15-39 at original diagnosis and 18-39 at enrollment.\n* Completed cancer treatment with curative intent.\n* Prior exposure to treatments posing gonadotoxic risk (e.g., alkylating agents, total body irradiation) and\u002For treatments increasing obstetric risk (e.g., chest radiation, radiation to uterus, anthracycline exposure).\n* Has not completed family building.\n* Able to speak\u002Fread English.\n* Willing and able to complete videoconference sessions and REDCap surveys.\n\nExclusion Criteria:\n\n* Visual, hearing, or cognitive impairment or severe mental illness that would interfere with participation as determined by study staff.","FEMALE","39 Years",{"count":162,"type":21},48,[24],"This study aims to develop and pilot-test a nurse navigator-delivered behavioral program to support female adolescent and young adult (AYA) cancer survivors in making informed, values-driven family-building decisions after completion of cancer treatment. Female AYA survivors often face fertility impairments, uncertainty about reproductive potential, elevated obstetric risks during pregnancy, and significant emotional distress related to parenthood planning. Currently, few interventions address these post-treatment decision-making needs.\n\nThe intervention consists of four videoconference sessions that combine personalized, risk-based reproductive health education with coping strategies derived from Acceptance and Commitment Therapy and Patient Activation Theory. A pilot randomized controlled trial will evaluate feasibility, acceptability, and preliminary changes in knowledge, decisional conflict, self-efficacy, and reproductive-health-related distress among 48 participants randomized to the intervention or a survivorship-education control condition. Findings will inform future testing of the intervention's efficacy in a larger clinical trial.",[27,166,167],"Family Planning","Adolescent and Young Adult Cancer",[169,170,171,172],"AYA","oncofertility","fertility after cancer","survivorship","2026-05-12",{"date":175,"type":45},"2026-05-14",{"date":177,"type":45},"2026-05-11",{"date":179,"type":21},"2026-12",{"name":181,"class":52},"Duke University",{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":188,"eligibilityCriteria":189,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":190,"targetDuration":4,"studyType":22,"phases":191,"briefSummary":192,"conditions":193,"keywords":197,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":53},"100639616","hematocare-feasibility-of-a-survivorship-care-plan-for-hematologic-cancer-patients-undergoing-hsct-100639616","NCT07579065","HematoCare: Feasibility of a Survivorship Care Plan for Hematologic Cancer Patients Undergoing HSCT","Survivorship Care in Patients With Hematologic Cancer Undergoing HSCT: A Feasibility Study on Quality of Life, Unmet Needs, and Caregivers Burden","HematoCare","Inclusion Criteria:\n\n* Patients with hematologic cancer candidates for HSCT (autologous or allogeneic) and their informal caregivers\n* Able to provide informed consent\n* Able to communicate in Italian\n\nExclusion Criteria:\n\n* Patients or caregivers with comorbidities hindering participation (e.g., significant cognitive limitations)",{"count":134,"type":21},[24],"This is a feasibility study to implement a Survivorship Care (SC) Plan for patients with hematologic cancer undergoing hematopoietic stem cell transplantation (HSCT). The study evaluates if the intervention is feasible within the Italian national health system, focusing on retention rates, quality of life, unmet needs and caregiver burden",[194,195,196,27],"Hematologic Neoplasm","Hematopoietic Stem Cell Transplantation","Survivorship",[198,199,200,201,202,203,204],"Hematologic Malignancies","Survivorship Care","Quality of Life","Caregiver Burden","Unmet Needs","Feasibility Study","Patient Reported Outcome Measures (PROMs)","2026-05-06",{"date":177,"type":45},{"date":208,"type":21},"2026-06",{"date":210,"type":21},"2028-01",{"name":212,"class":213},"Azienda USL Reggio Emilia - IRCCS","OTHER_GOV",{"id":215,"slug":216,"hasResults":11,"nctId":217,"briefTitle":218,"officialTitle":219,"acronym":220,"eligibilityCriteria":221,"healthyVolunteers":11,"sex":17,"minAge":222,"maxAge":4,"enrollmentInfo":223,"targetDuration":4,"studyType":22,"phases":225,"briefSummary":226,"conditions":227,"keywords":230,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":53},"100621217","testing-the-feasibility-of-a-self-management-support-program-for-patient-with-chronic-diseases-in-israel-100621217","NCT07367750","Testing the Feasibility of a Self-Management Support Program for Patient With Chronic Diseases in Israel","Implementation of a Self-Management Support Program Among People With Kidney Transplant and Cancer Survivors in Israel: Testing Feasibility and Effects","CDSMP-IL","Inclusion Criteria:\n\n* Age 21 years or older\n* Diagnosed with at least one chronic disease (as documented in the medical record)\n* Community-dwelling\n* Fluent in Hebrew\n\nExclusion Criteria:\n\n* Documented cognitive impairment\n* Diagnosis of major depression or other psychiatric disorder (based on self-report or medical records)\n* Hospitalization in the past 3 months","21 Years",{"count":224,"type":21},45,[24],"This study explores an intervention to support people in Israel who are living with chronic health conditions such as cancer or after kidney transplantation. It focuses on a well-known international program called the Chronic Disease Self-Management Program (CDSMP), which was developed at Stanford University. The program helps individuals build confidence and skills to better manage their health, feel more in control, and improve their day-to-day quality of life.\n\nParticipants will take part in a six-week group program, delivered online, where they will learn practical strategies for managing symptoms like fatigue or pain, setting achievable health goals, communicating effectively with healthcare professionals, and staying active and engaged. The sessions are guided by trained facilitators and include support from others facing similar health challenges.\n\nThe study will involve surveys before and after the program, as well as a follow-up six months later, to understand how the program may have helped participants. Some participants will also be invited to share their experiences in small discussion groups.\n\nBy testing this program in Israel, the researchers hope to learn how it can be adapted and offered more widely to help others living with chronic conditions.",[228,229,27],"Chronic Disease","Kidney Transplantation",[228,231,232,233,234,68],"Self-Management","CDSMP","Kidney","Transplantation","2026-04-28",{"date":237,"type":45},"2026-04-29",{"date":239,"type":45},"2025-02-01",{"date":241,"type":21},"2027-03-28",{"name":243,"class":52},"University of Haifa",{"id":245,"slug":246,"hasResults":11,"nctId":247,"briefTitle":248,"officialTitle":249,"acronym":250,"eligibilityCriteria":251,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":252,"targetDuration":4,"studyType":22,"phases":254,"briefSummary":255,"conditions":256,"keywords":258,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":265,"lastUpdatePostDateStruct":266,"startDateStruct":268,"completionDateStruct":270,"leadSponsor":272,"locationsCount":53},"100571876","remote-physical-activity-programming-to-improve-outcomes-in-cancer-survivors-with-and-without-type-2-diabetes-100571876","NCT06725953","Remote Physical Activity Programming to Improve Outcomes in Cancer Survivors With and Without Type 2 Diabetes","Cerebrovascular, Cognitive, Pro-Inflammatory, and Cardiometabolic Outcomes in Cancer Survivors With and Without Type II Diabetes Reporting Chemo-Brain: Baseline Differences and Impact of Activity","CICI-PA","Inclusion Criteria:\n\n1. ≥18 years old\n2. ability to speak\u002Fread English\n3. ability to provide informed consent\n4. underwent treatment within the last three years for a non-central nervous system-related cancer with said treatment having included chemotherapy\n5. self-reported cognitive difficulties following cancer treatment\n6. For CS+T2D: current T2D diagnosis as classified by a fasted blood glucose of ≥126 mg\u002FdL, 2-hour oral glucose tolerance test of ≥200 mg\u002FdL, HbA1c level of ≥6.5%, or use of medications to treat hyperglycemia (e.g., Metformin) or For CS: no current T2D diagnosis as classified by a fasted blood glucose \\\u003C100 mg\u002FdL, 2-hour oral glucose tolerance test \\\u003C140 mg\u002FdL, or HbA1c level of \\\u003C5.7%. Presence\u002Fabsence of T2D to be confirmed preferentially via physician's documentation\n7. own smartphone and\u002For computer with internet access\n8. willing to participate in the 12-week remotely-delivered PA program\n\nExclusion Criteria:\n\n1. reporting a Physical Activity Readiness Questionnaire (2017 PAR-Q) score that indicates PA may potentially be unsafe, unless the participant produces a signed doctor's note. We will define 2017 PAR-Q+ scores as indicating that PA may potentially be unsafe as responding \"Yes\" to any of the follow-up questions except \\[1\\] if the individual indicates that they have high blood pressure but subsequent responses indicate that they do not have problems keeping it under control and that their resting blood pressure is less than 160\u002F90 mmHg, and \\[2\\] if the individual indicates that they have a metabolic condition but subsequent responses indicate that they do not have problems controlling their blood sugar levels, do not any experience signs or symptoms of hypoglycemia, and do not have any signs of symptoms of listed diabetes complications)\n2. engaging in ≥75 min\u002Fweek of vigorous-intensity PA, ≥150 min\u002Fweek of moderate-intensity PA, or an equivalent combination of both over the last 3 months\n3. currently a prisoner, pregnant, or planning to become pregnant during study.",{"count":253,"type":21},38,[24],"The growing U.S. cancer survivor population is projected to hit 26M by 2040. Chemotherapy represents an effective cancer treatment but can diminish cancer survivors' quality of life-particularly cognitive function-through select pathophysiological processes. Research on chemotherapy-induced cognitive impairment (hereafter, 'chemo-brain') is therefore critical. Chemotherapy disrupts immune system function and antioxidant regulation, causing inflammatory molecule release and damaging the brain's blood vessels. The brain's vascular function and, possibly, its neurons, are subsequently impaired-likely contributing to chemo-brain. Type 2 diabetes (T2D), a common cancer survivor comorbidity, shares underlying pathophysiology with chemo-brain. T2D-related insulin resistance can precipitate repeated high blood sugar episodes which increase inflammatory molecule release. In individuals with T2D without cancer, negative relationships are observed between inflammatory molecule concentrations and the brain's vascular and\u002For cognitive function. Cancer survivors with T2D might thus have higher chemo-brain risk than those without T2D. Yet, more research must compare how the brain's vascular function, as well as cognitive, inflammatory, and cardiometabolic indices, differ between these groups. Physical activity (PA) counteracts chemo-brain's and T2D's pathophysiology, with higher PA\u002Ffitness resulting in better vascular function of the brain, lower inflammatory molecule concentrations, and improved insulin sensitivity. We are therefore conducting a 30-participant quasi-experimental pilot study in cancer survivors with (cases) and without (controls) T2D. We will first investigate between-group differences in the brain's vascular function as well as cognitive, inflammatory, cardiometabolic, and epigenetic outcomes. We will then examine between-group changes in these outcomes and select psychosocial metrics during a 12-week technology-based PA program-potentially further elucidating involved mechanisms.",[27,257],"Chemotherapy Side Effects",[259,260,261,262,68,263,264],"Aerobic Physical Activity","Resistance Training","Wearable Devices","Smartphone Applications","Chemo-Brain","Health Outcomes","2026-04-27",{"date":267,"type":45},"2026-05-01",{"date":269,"type":45},"2025-03-10",{"date":271,"type":21},"2027-02",{"name":273,"class":52},"University of Oklahoma",{"id":275,"slug":276,"hasResults":11,"nctId":277,"briefTitle":278,"officialTitle":279,"acronym":4,"eligibilityCriteria":280,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":281,"enrollmentInfo":282,"targetDuration":4,"studyType":22,"phases":284,"briefSummary":285,"conditions":286,"keywords":288,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":295,"lastUpdatePostDateStruct":296,"startDateStruct":297,"completionDateStruct":298,"leadSponsor":299,"locationsCount":53},"100627281","bfedbwell-inspire-pilot-100627281","NCT07446595","BfedBwell INSPIRE Pilot","BfedBwell INSPIRE: Impact of an Integrated Nutrition and Exercise Program for Post-treatment Survivors on Sleep Quality, Perceived Stress, and Biomarkers of Immune Dysregulation","Inclusion Criteria:\n\n* Age 18-75 years\n* BMI 25-45 kg\u002Fm2\n* History of cancer within the past 10 years with a diagnosis of an adulthood cancer of any type\n* In maintenance or surveillance status, defined as completion of active cancer therapy (e.g., surgery, radiation, chemotherapy, immunotherapy) with curative intent at least 3 months and no more than 10 years prior to enrollment or active surveillance with no treatment; ongoing targeted or hormone therapies ≥3 months prior to intervention start date and\u002For ongoing maintenance therapy ≥1 year is permitted (exceptions to this timeframe for completion of other therapies can be made on a case-by-case basis by the PI if patients are tolerating therapy without adverse effects and will have completed active treatment or been in stable maintenance treatment prior to the intervention start date)\n* Have a primary care provider (or are willing to establish care with a primary care provider prior to study enrollment) to address medical issues which may arise during screening or study procedures\u002Finterventions and who will provide clearance to participate in a nutrition and exercise program\n* Ability and willingness to participate in a supervised exercise program; with ability assessed by the Physical Activity Readiness Questionnaire (PAR-Q+) and questions based upon National Comprehensive Cancer Network (NCCN) guidelines (note: any positive responses will trigger a required physician clearance form)\n* Speak English\n* Have access to a computer or smart phone and Internet to join Zoom meetings, complete questionnaires, and access\u002Fdownload the True Coach virtual exercise coaching sessions\n* Live or work within 30 miles of the AHWC (exceptions may be made at the discretion of the study PI on a case-by-case basis for highly motivated subjects)\n* Not be planning for major elective surgery, to travel for \\>2 consecutive weeks, or relocate\u002Fmove during the intervention (\\~6 months)\n* No nicotine or tobacco use within previous 6 months\n* Agree to refrain from use of all nutritional supplements aside from those prescribed by a physician for the duration of the study\n* Capable and willing to give informed consent and understand exclusion criteria\n* Willing to attend weekly small group education sessions, monthly behavioral skills development sessions, weekly group support sessions, and monthly 1:1 counseling sessions with a registered dietitian (RD)\n* Willing to attend up to two BfitBwell exercise sessions (one in person supervised, one virtual unsupervised) per week for first 12 weeks then once monthly supervised and once weekly unsupervised virtual sessions for second 12 weeks\n* Not meeting dietary guidelines \\[i.e., Healthy Eating Index (HEI) score \\\u003C80 as assessed via NCI DHQ III food frequency questionnaire\\] or physical activity guidelines \\[i.e., \\\u003C150 minutes moderate\u002Fvigorous activity per week via self-report on Godin-Shephard Leisure-Time Physical Activity Questionnaire\\] (exceptions may be made at the discretion of the study PI on a case-by-case basis for highly motivated subjects)\n\nExclusion Criteria:\n\n* Eastern Cooperative Oncology Group (ECOG) Performance Status 2 or higher\n* Actively undergoing chemotherapy, radiation, immunotherapy with curative intent or within 3 months of completion of surgery, chemotherapy, or radiation treatment or recent initiation of targeted\u002Fhormonal therapy (\\\u003C3 months) or maintenance therapy (\\\u003C1 year) unless well-tolerated and deemed acceptable by PI on a case-by-case basis\n* Greater than 10 years post-active or maintenance therapy\n* Plans to relocate within the next 6 months\n* Plans for extended travel (\\>2 weeks) within the next 6 months\n* For females: (1) Currently pregnant or lactating, (2) Pregnant within the past 6 months, (3) Planning to become pregnant in the next 18 months; sexually active women of childbearing potential may be enrolled if they have had a tubal ligation or use a reliable means of contraception\n* Any major surgery within the past 3 months or planned elective surgery during the intervention period, including mastectomy\n* Have completed treatment that significantly impacts digestion, metabolism, and\u002For food intake (e.g., surgical loss of esophagus, stomach, colon)\n* Recent (past 6 months) acute coronary event, unstable angina, coronary revascularization, stroke, or pulmonary embolism\n* Symptoms suggestive of cardiovascular disease (e.g., chest pain, shortness of breath at rest or with mild exertion, lightheadedness, syncope)\n* Uncontrolled hypertension, defined as diastolic blood pressure \\>100 mmHg, systolic blood pressure \\>160 mmHg, or resting heart rate \\>100 bpm as measured in duplicate on the screening visit after 5 minutes of rest in a seated position (if screening is needed due to lack of updated medical record within previous 12 months)\n* Diabetes (history of type 1 or type 2 diabetes, hemoglobin A1c ≥6.5%, or fasting glucose ≥126 mg\u002FdL as measured during the screening visit if screening is needed due to lack of updated medical record within previous 12 months) unless well controlled on metformin or DPP-V inhibitor monotherapy with hemoglobin A1c \\\u003C8%\n* History of uncontrolled thyroid disorder. History of thyroid disease or current thyroid disease treated with a stable medication regimen is acceptable\n* Triglycerides \\>500 mg\u002FdL as measured on the screening visit (if screening is needed due to lack of updated medical record within previous 12 months)\n* LDL cholesterol \\>200 mg\u002FdL as measured on the screening visit (if screening is needed due to lack of updated medical record within previous 12 months)\n* Presence or history of other metabolic or chronic health problems which would impact ability to safely participate in a weight loss intervention involving diet and exercise: significant cardiac arrhythmias or cardiac valvular disease, significant gastrointestinal, pulmonary, renal, musculoskeletal, neurologic, hematologic, or psychiatric disease\n* Have started lipid-lowering, hypertension, or oral hypoglycemic medication in previous 3 months\n* Sustained use of prescription or over-the-counter medications known to significantly impact appetite, weight, or energy metabolism (e.g., obesity pharmacotherapeutics agents, appetite suppressants, lithium, stimulants, anti-psychotics, tricyclic antidepressants) with the exception of anti-endocrine or Her2 directed treatment for breast cancer and standard of care anti-emetic or anti-diarrheal agents.\n* Sustained use of systemic glucocorticoids (current or in the past 6 months) unless physiologic replacement therapy for adrenal insufficiency\n* Previous obesity treatment with surgery or weight loss device, except: (1) liposuction and\u002For abdominoplasty if performed \\>1 year before screening, (2) lap banding if the band has been removed \\>1 year before screening, (3) intragastric balloon if the balloon has been removed \\>1 year before screening, (4) duodenal-jejunal bypass sleeve if the sleeve has been removed \\>1 year before screening, or (5) AspireAssist or other endoscopically placed weight loss device if the device has been removed \\>1 year before screening\n* Participation within previous 6 months, current participation in, or planning to participate in any formal nutrition, weight loss, or physical activity programs or clinical trials over the next 6 months\n* Previous participation the BfitBwell exercise oncology program within the previous 3 years (exceptions may be made at the discretion of the study PI)\n* Nicotine or tobacco use (current or past 6 months)\n* Current alcohol or substance abuse as assessed by the Cut down, Annoyed, Guilty, and Eye-Opener (CAGE) questionnaire (note: study PI will follow up if screener raises any concerns of substance abuse to determine final eligibility)\n* History of clinically diagnosed eating disorders including anorexia nervosa, bulimia, binge eating disorder. Score \\>20 on the Eating Attitudes Test (EATS-26) or pattern of response on the Questionnaire of Eating and Weight Patterns (QEWP-5) suggestive of possible binge eating disorder or bulimia will require further assessment by the study MD to determine if it is appropriate for the subject to participate in the study\n* Current severe depression or history of severe depression within the previous year, based on Center for Epidemiologic Studies Depression Scale (CES-D) which in the opinion of the study MD would interfere with ability to adhere to the diet and exercise interventions and provide feedback on the interventions via questionnaires and focus groups\n* History of other significant psychiatric illness (e.g., psychosis, schizophrenia, mania, bipolar disorder) which in the opinion of the study MD would interfere with ability to adhere to the diet and exercise interventions and provide feedback on the interventions via questionnaires and focus groups\n* Have medical or physical limitations or contraindications to engaging in physical activity (e.g., severe orthopedic conditions, paralysis) or are considered high-risk based on ACSM guidelines\n* Are cognitively unable to consent","75 Years",{"count":283,"type":21},25,[24],"This single-arm pilot study will evaluate the feasibility and acceptability of a comprehensive survivorship lifestyle intervention addressing nutrition, exercise, sleep health, and stress management. The intervention integrates the BfedBwell survivorship nutrition program with the BfitBwell clinical exercise oncology program. The augmented BfedBwell program includes: (1) a core education curriculum, (2) 1:1 counseling with a registered dietitian, (3) behavioral skills development, (4) group support, and (5) commercially available wearable technology and smart scales for self-monitoring of physical activity, sleep, and body weight.",[27,287],"Overweight , Obesity",[289,290,291,292,293,294],"Adult Cancer Survivor","Lifestyle Behavior","Diet, food, and nutrition","Exercise","Sleep","Stress","2026-04-22",{"date":235,"type":45},{"date":208,"type":21},{"date":149,"type":21},{"name":300,"class":52},"University of Colorado, Denver",{"id":302,"slug":303,"hasResults":11,"nctId":304,"briefTitle":305,"officialTitle":306,"acronym":307,"eligibilityCriteria":308,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":160,"enrollmentInfo":309,"targetDuration":4,"studyType":22,"phases":311,"briefSummary":312,"conditions":313,"keywords":4,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":317,"lastUpdatePostDateStruct":318,"startDateStruct":320,"completionDateStruct":322,"leadSponsor":324,"locationsCount":53},"100581298","using-tailored-mhealth-strategies-to-promote-weight-management-among-adolescent-and-young-adult-cancer-survivors-100581298","NCT06848491","Using Tailored mHealth Strategies to Promote Weight Management Among Adolescent and Young Adult Cancer Survivors","Using Tailored mHealth Strategies to Promote Weight Management Among Adolescent and Young Adult Cancer Survivors (AYA Well)","AYAWell","Inclusion Criteria:\n\n* 18-39 years old at the time of consent.\n* Diagnosed with first invasive cancer between ages 15-39 years (self-report).\n* Within 10 years of diagnosis with no evidence of progressive disease or second primary cancers (self-report).\n* Completed active cancer directed therapy (cytotoxic chemotherapy, radiation therapy and\u002For definitive surgical intervention) at least six months prior to enrollment; may be receiving \"maintenance\" therapy to prevent recurrences (self-report).\n* Body mass index (BMI) of 25-50 kg\u002Fm2\n\nExclusion Criteria:\n\n* Type 1 diabetes or currently receiving certain medical treatments for Type 2 diabetes\n* Report a history of heart attack or stroke within previous 6 months\n* Health problems which preclude ability to walk for physical activity (e.g., lower limb amputation). Participants endorsing items 1-4 on the Physical Activity Readiness Questionnaire (PAR-Q) (experience of heart problems, frequent chest pains, or faintness or dizziness) will be excluded from the study.\n* Lost 5% or more of body weight (and kept it off) in the last 3 months\n* Lifetime history of clinical diagnosis or treatment of eating disorder (anorexia nervosa or bulimia nervosa), OR report of compensatory behaviors within the previous 3 months. If participant reports a history of compensatory behaviors, the investigators will review their information to determine eligibility.\n* Currently pregnant, pregnant within the past 6 months, or planning to become pregnant within the next 12 months\n* Untreated thyroid disease or any changes (type or dose) in thyroid medication in last 6 months\n* Hospitalization for depression or other psychiatric disorder within the past 12 months.\n* History of psychotic disorder or uncontrolled bipolar disorder\n* Currently participating in a weight loss, nutrition, or physical activity study or program or other study that would interfere with this study\n* Currently using prescription medications with known effects on appetite or weight (e.g., oral steroids, weight loss medications), with the exception of individuals on a stable dose of SSRIs for 3 months)\n* Previous surgical procedure for weight loss or planned weight loss surgery in the next year\n* Inability to speak and read English\n* Does not reside in the United States\n* Do not have mobile phone with data plan or willing to be contacted by study through text messaging\n* No Internet access\n* Not willing to be randomized to either intervention arm",{"count":310,"type":21},240,[24],"The AYA WELL study is a 2-arm randomized clinical trial to test the efficacy of a theory-based, mHealth weight management intervention adapted specifically for adolescent and young adult cancer survivors compared to a self-guided arm. Participants, diagnosed with cancer between ages 15-39, currently age 18-39, post-treatment at least 6 months, and who have overweight or obesity will be randomized to receive either: 1) a comprehensive mHealth weight management program (intervention) or 2) digital tools + health education + peer support (self-guided) over 12 months. Outcomes will be assessed at 3, 6, and 12 months.",[314,140,315,27,316],"Obesity","Physical Activity","Diet","2026-03-20",{"date":319,"type":45},"2026-03-23",{"date":321,"type":45},"2025-10-27",{"date":323,"type":21},"2028-10-31",{"name":325,"class":52},"UNC Lineberger Comprehensive Cancer Center",{"id":327,"slug":328,"hasResults":11,"nctId":329,"briefTitle":330,"officialTitle":331,"acronym":332,"eligibilityCriteria":333,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":334,"targetDuration":4,"studyType":22,"phases":335,"briefSummary":336,"conditions":337,"keywords":342,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":350,"lastUpdatePostDateStruct":351,"startDateStruct":353,"completionDateStruct":355,"leadSponsor":357,"locationsCount":53},"100618496","mhealth-intervention-for-pain-self-management-100618496","NCT07332377","mHealth Intervention for Pain Self Management","PsyMINT: Mobile Health (mHealth) Intervention to Support Self-Management of Pain and Symptoms for Cancer Survivors","PsyMINT","Inclusion Criteria:\n\n* In a post-treatment stage with no evidence of disease (complete remission)\n* Diagnosed with cancer in the past three years\n* Experiencing cancer\u002Ftreatment-related pain\n* ≥ 18 years of age at the time of first diagnosis\n* Cognitively able to actively participate in an online-based study\n* Able to read, write, and understand English\n\nExclusion Criteria:\n\n* Individuals who currently use any medication for psychiatric reasons (including stimulants, and mood stabilizers)\n* Patients with major psychotic disorders (bipolar disorder or schizophrenia) and\u002For substance use disorders.\n* Those who are currently pregnant or plan to become pregnant in the next three months",{"count":283,"type":21},[24],"This is a feasibility pilot test of a single-arm intervention to evaluate the beta version of an mHealth app-based behavioral intervention prior to scaling for a randomized controlled trial (RCT). This mHealth intervention is designed to enhance self-efficacy and support pain and symptom self-management among post-treatment cancer survivors.",[338,339,340,341,27],"Pain","Pain Management","Symptom Monitoring","Symptom Management",[343,344,345,346,347,348,349],"cancer survivorship","pain management","mHealth","behavioral intervention","nonpharmacologic intervention","app","digital health","2026-03-16",{"date":352,"type":45},"2026-03-18",{"date":354,"type":45},"2026-02-23",{"date":356,"type":21},"2027-03-31",{"name":358,"class":52},"Virginia Commonwealth University",{"id":360,"slug":361,"hasResults":11,"nctId":362,"briefTitle":363,"officialTitle":363,"acronym":364,"eligibilityCriteria":365,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":366,"targetDuration":4,"studyType":22,"phases":368,"briefSummary":369,"conditions":370,"keywords":371,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":372,"lastUpdatePostDateStruct":373,"startDateStruct":375,"completionDateStruct":377,"leadSponsor":379,"locationsCount":381},"100563971","exercise-and-nutrition-for-older-cancer-survivors-and-their-support-person-the-vitality-study-100563971","NCT06623097","Exercise and Nutrition for Older Cancer Survivors and Their Support Person: The Vitality Study","VITALITY","Inclusion Criteria for Survivor Participants:\n\n* Ability to understand and the willingness to sign informed consent prior to any study- related procedures.\n* Older adults (≥65 years of age); cancer survivors who are at higher risk for developing comorbid conditions related to physical and cognitive function due to age declines.\n* Completed chemotherapy and\u002For targeted therapy in the previous 36 months; said treatment exposure negatively impacts cognitive and physical function.\n* Diagnosed with breast, lung, prostate, or colorectal cancer which are obesity-related cancers with higher risk for developing comorbid conditions related to physical and cognitive function.\n* No detection of dementia as measured by scoring ≥ 23\u002F41 on the Telephone Interview for Cognitive Status (TICS); it may be unsafe for individuals with dementia to participate in the intervention, and they may not be able to experience measurable cognitive improvement. Additionally, scores on cognitive measures could reflect task comprehension failure - not actual cognitive ability - as individuals with dementia may not be able to comprehend or follow the test instructions\n* Overweight\u002Fobese: BMI ≥25 kg\u002Fm2 (calculated using height and weight) or body fat \\>35% for people assigned female at birth and \\>25% for people assigned male at birth (estimated by bioelectrical impedance); higher body weight negatively impacts cognitive and physical function.\n* Currently participating in \\\u003C60 minutes of structured moderate-to-vigorous exercise per week (determined by screening questionnaire); sedentary cancer survivors have a higher need and are more likely to benefit from exercise exposure.\n* No history of disordered eating; to avoid triggering of past eating disorders with a diet intervention program.\n* Reside with an (≥18 years of age) informal support person willing to participate; survivor\u002Fsupport person dyads will participate in the trial together per the goals of the trial and finding mechanism.\n* Speak English or Spanish; the study teams will only be able to accommodate for these two languages at this time.\n* Willing to travel to the respective site for necessary data collection.\n\nInclusion Criteria for Support Person:\n\n* Adults ≥18 years of age; the intervention is not designed for adolescent and pediatric populations.\n* No detection of dementia as measured by scoring ≥ 23\u002F41 on the Telephone Interview for Cognitive Status (TICS); it may be unsafe for individuals with dementia to participate in the intervention, and they may not be able to experience measurable cognitive improvement. Additionally, scores on cognitive measures could reflect task comprehension failure - not actual cognitive ability - as individuals with dementia may not be able to comprehend or follow the test instructions\n* No history of disordered eating; to avoid triggering of past eating disorders with a diet intervention program.\n* Speak English or Spanish; the study teams will only be able to accommodate for these two languages at this time.\n\nExclusion Criteria for Survivor Participants:\n\n* Adult cancer survivors less than 65 years of age.\n* Survivors with a TICS score ≤ 22\u002F41\n* Survivors with a BMI \\\u003C25 kg\u002Fm2 and body fat \\\u003C35% for people assigned female at birth and \\\u003C25% for people assigned male at birth.\n* Survivors currently consuming a Mediterranean Diet or meeting 2 or more out of the following 3 Mediterranean eating pattern goals in the prior 6 weeks: ≥3 servings of vegetables per day, ≥ 3 servings of beans and legumes per week, or ≥ 1 serving of nuts per day.\n* Survivors with unstable comorbidities that prevent participation in moderate-to-vigorous intensity exercise. Persons with unstable comorbidities may develop unexpected adverse events from exercise. For the purpose of participant safety, as well as because this study involves remote, home-based exercise where close supervision is not possible, participants with unstable medical conditions will be excluded. This will be evaluated through the PAR- Q.\n* Subjects with severe psychiatric conditions such as Active Major Depression, Bipolar Disorder, significant Suicidal ideation, and an active substance use and\u002For substance abuse disorder; these conditions can 1) adversely affect important cognitive test measures and 2) the ability to complete certain circumscribed interventions in the study.\n* Subjects who in the opinion of the investigator may not be able to comply with the safety monitoring requirements of the study.\n* Survivors receiving treatment for an active malignancy (exceptions are treatment for basal cell carcinoma. They may receive long term treatments for their diagnosed breast, lung, prostate or colorectal cancer including hormone therapy). This study is exclusively targeting survivors post-primary cancer treatment.\n\nExclusion Criteria for Support Person:\n\n* Support persons less than 18 years of age.\n* Support persons with a TICS score ≤ 22\u002F41\n* Given the age range of support persons include those in childbearing years, people who are pregnant, or plan to become pregnant during study duration will be excluded due to the unknown nature of exercise on developing fetuses.\n* Support persons with unstable comorbidities that prevent participation in moderate-to- vigorous intensity exercise. Persons with unstable comorbidities may develop unexpected adverse events from exercise. For the purpose of participant safety, as well as because this study involves remote, home-based exercise where close supervision is not possible, participants with unstable medical conditions are excluded.\n* Support persons with severe psychiatric conditions such as Active Major Depression, Bipolar Disorder, significant Suicidal ideation, and an active substance use and\u002For substance abuse disorder; these conditions can 1) adversely affect important cognitive test measures and 2) the ability to complete certain circumscribed interventions in the study.\n* Support persons receiving treatment for an active malignancy or are less than 10 years from the completion of any cancer treatment (exceptions are treatment for basal cell carcinoma). This is to preserve the \"role\" of the cancer survivor in the dyad.",{"count":367,"type":21},1528,[24],"This research study will compare the impact of virtually supervised and unsupervised home-based exercise and diet programs on cognitive and physical function among cancer survivors and support persons. This study will involve a 6-month home-based virtually supervised or unsupervised exercise and diet intervention.\n\nThe names of the study interventions involved in this study are:\n\n* Virtually supervised exercise and healthy diet care\n* Unsupervised exercise and healthy diet care",[27],[27],"2026-02-27",{"date":374,"type":45},"2026-03-02",{"date":376,"type":45},"2025-07-23",{"date":378,"type":21},"2030-04-30",{"name":380,"class":52},"Dana-Farber Cancer Institute",2,{"id":383,"slug":384,"hasResults":11,"nctId":385,"briefTitle":386,"officialTitle":387,"acronym":388,"eligibilityCriteria":389,"healthyVolunteers":11,"sex":17,"minAge":390,"maxAge":4,"enrollmentInfo":391,"targetDuration":4,"studyType":22,"phases":393,"briefSummary":394,"conditions":395,"keywords":397,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":407,"lastUpdatePostDateStruct":408,"startDateStruct":410,"completionDateStruct":412,"leadSponsor":413,"locationsCount":53},"100620369","finding-my-way-uk-promoting-positive-psychological-outcomes-in-people-living-with-and-beyond-curatively-treated-cancer-100620369","NCT07356726","Finding My Way-UK: Promoting Positive Psychological Outcomes in People Living With and Beyond Curatively Treated Cancer","Finding My Way-UK: Promoting Positive Psychological Outcomes in People Living With and Beyond Curatively Treated Cancer: A Pilot Randomised Trial","FMW-UK","Inclusion Criteria:\n\n* Diagnosed with any cancer within the past 12 months;\n* Cancer is being (or, indeed, was) treated with curative intent;\n* Aged 16 years or older;\n* Possess sufficient English proficiency to provide informed consent and use the program;\n* Able to access the internet and have access to an email address (or are willing to set an email address up with our help).\n\nExclusion Criteria:\n\n* Diagnosis of cancer not being treated with curative intent (for example, metastatic, stage IV, or otherwise advanced-stage disease);\n* And\u002FOr have a severe comorbidity that may hinder their ability to participate fully (such as being unable to complete study procedures or provide informed consent).","16 Years",{"count":392,"type":21},60,[24],"The goal of this pilot randomised trial is to evaluate whether an online psychosocial intervention (Finding My Way-UK) is feasible and acceptable for individuals living with and beyond curatively treated cancer. The main questions it aims to answer are:\n\n1. Is Finding My Way-UK feasible and acceptable for individuals living with and beyond curatively treated cancer?\n2. Are there preliminary signals of efficacy in benefit finding and other well-being outcomes (hope, resilience, and subjective well-being)?\n3. What is the potential role of information-seeking styles and self-management self-efficacy?\n\nParticipants will be randomly assigned to one of two groups:\n\n1. Finding My Way-UK Intervention group: access a four-week, self-guided online program with six modules covering coping with treatment side effects, managing emotions, social support, body image, and post-treatment adjustment.\n2. Control group: receive a digital information pack listing national psychological support resources.\n\nAll study activities will take place online. Participants will complete questionnaires before the program, after four weeks, and three months later.",[27,140,396],"Neoplasms",[27,398,399,40,400,401,402,403,404,405,406,29],"Benefit Finding","Psychosocial Intervention","Feasibility","Pilot Randomised Trial","Resilience","Hope","Subjective Well-Being","Curatively Treated","Online Intervention","2026-01-15",{"date":409,"type":45},"2026-01-21",{"date":411,"type":21},"2026-01",{"date":47,"type":21},{"name":414,"class":52},"Edge Hill University",{"id":416,"slug":417,"hasResults":11,"nctId":418,"briefTitle":419,"officialTitle":420,"acronym":421,"eligibilityCriteria":422,"healthyVolunteers":11,"sex":159,"minAge":423,"maxAge":4,"enrollmentInfo":424,"targetDuration":4,"studyType":22,"phases":426,"briefSummary":427,"conditions":428,"keywords":430,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":431,"lastUpdatePostDateStruct":432,"startDateStruct":434,"completionDateStruct":436,"leadSponsor":438,"locationsCount":381},"100573353","making-healthy-habits-stick-100573353","NCT06745180","Making Healthy Habits Stick","Making Healthy Habits Stick: Extended Contact Interventions to Promote Long-Term Physical Activity in Cancer Survivors","HABITS","Inclusion Criteria:\n\n* woman age of 19 or older\n* identifies as African American or Black\n* have a history of cancer\n* have completed post-primary treatment for cancer (i.e., chemotherapy, radiation)\n* agree to allow research team to confirm cancer diagnosis with your physician\n* If received surgery, must be at least 8 weeks post-surgery\n* willing to have regular physician provide medical clearance for study participation\n* willing to provide home address if qualified for the study\n* willing and able to use videoconference platform such as Zoom for study activities (must be both willing and able)\n* willing and able to send and\u002For receive text messages (must be both willing and able)\n* has US phone number\n* has an email address\n* if has no email address, must be willing to create one\n* English speaking\n* Able to ambulate without assistance (does not need to use a cane, a walker, or a wheelchair)\n* willing and able to complete 3-5 exercise session per week on their own for the duration of the study; if answered no, please explain\n* willing to attend individual and group sessions via videoconferences during study participation; if answered no, please explain.\n* willing to attend assessments via videoconference during study participation; if answered no, please explain.\n* willing to complete surveys during study participation; if answered no, please explain.\n\nExclusion Criteria:\n\n* Metastatic or recurrent cancer\n* another cancer diagnosis in the past 5 years (not including skin or cervical cancer in situ)\n* have severe orthopedic, joints or any other condition that stops individual from being active\n* unstable angina\n* have paint, tightness, or heaviness in chest EITHER when resting OR then physically active\n* have New York Heart Association class II, III, OR IV congestive heart failure\n* blood pressure has been over 160\u002F100 at least twice in the past 6 months (either number; 160 or 100)\n* have uncontrolled asthma\n* have interstitial lung disease that requires extra oxygen\n* have dementia or organize brain syndrome\n* have schizophrenia or active psychosis\n* have had a stroke or other problem that left individual disables or with paralysis (unable to move or feel any part of body)\n* have hearing problems that make it hard to carry on a phone conversation\n* blind or partially blind\n* planned surgery during the first 6 month of study participation (if unapproved by PI)\n* planned knee or hip surgery during the first 6 month of study participation\n* anticipate changes in usual medications during the first 6 months of study participation (if unapproved by PI)\n* have been told by a physician to only do exercise prescribed by a physician\n* have been told by a physician to limit physical activity\n* have a contraindication to engaging in moderate intensity aerobic exercise\n* have completed on average, more than 90 min\u002Fweek of moderate-intensity or more that 30 min\u002Fweek of vigorous exercise in the past 6 months\n* trouble with balance or moving around safely\n* are currently pregnant or anticipate pregnant during study participation\n* currently participating in another exercise study\n* have BMI ≥ 50","19 Years",{"count":425,"type":21},260,[24],"The aim of this project is to help increase physical activity maintenance in cancer survivors.",[140,315,429,27],"Cancer Survivor",[315,140,429,292,27],"2025-09-26",{"date":433,"type":45},"2025-10-01",{"date":435,"type":45},"2025-01-27",{"date":437,"type":21},"2028-03-31",{"name":439,"class":52},"University of Tennessee",{"id":441,"slug":442,"hasResults":11,"nctId":443,"briefTitle":444,"officialTitle":445,"acronym":446,"eligibilityCriteria":447,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":448,"targetDuration":4,"studyType":22,"phases":450,"briefSummary":451,"conditions":452,"keywords":4,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":453,"lastUpdatePostDateStruct":454,"startDateStruct":456,"completionDateStruct":458,"leadSponsor":460,"locationsCount":53},"100582914","cooperative-extension-and-cancer-survivorship-100582914","NCT06869512","Cooperative Extension and Cancer Survivorship","Cooperative Extension and Cancer Survivorship: Supportive Care Via Cooperative Extension Services (SUCCESS)","SUCCESS","Inclusion Criteria:\n\n* Previous adult-diagnosed cancer\n* Post active cancer treatment\n* No current active treatment, hormonal therapy permitted\n* Ability to get to group sessions\n* In Oklahoma\n\nExclusion Criteria:\n\n* Current palliative or hospice care\n* Surgical or medical history that precludes participation\n* Positive screen on the Physical Activity Readiness Questionnaire+ (PAR-Q+) without a doctor's note approving study participation",{"count":449,"type":21},80,[24],"The goal of this clinical trial is to learn if a cancer survivor program, delivered via Cooperative Extension, is feasible and if it can improve health outcomes in cancer survivors who are post-active treatment.\n\nAim 1: Evaluate the feasibility and acceptability of SUCCESS. Hypothesis 1: SUCCESS will be feasible and acceptable as evidenced by delivery of the intervention among Educators (implementation), including in agreement with the curriculum in Phase 1 (fidelity) with \\>85% attendance (demand) among participants with \\>80% rating the intervention as acceptable or highly acceptable on 5-point Likert-type scale (acceptability).\n\nAim 2: Determine the preliminary efficacy of SUCCESS for improving HRQOL (primary outcome) and other psychosocial and health-related endpoints (e.g., financial toxicity) (secondary outcomes). Hypothesis 2: Compared to matched controls, adults LWBC who complete SUCCESS will have significant improvements in HRQOL per the PROMIS Global Health v1.2 at follow-up (i.e., after 6 weeks).\n\nAim 3: Examine changes in conserved transcriptional response to adversity (CTRA) gene expression in a subset of interventions participants at follow-up. Hypothesis 3: Adults LWBC who complete SUCCESS will experience significant CTRA down-regulation.\n\nThis is a single arm trial and there is no comparison group.\n\nParticipants will be asked to do survey- and Zoom-based data collection before and after completing the 6-week program.",[27],"2025-06-25",{"date":455,"type":45},"2025-06-26",{"date":457,"type":45},"2025-02-24",{"date":459,"type":21},"2026-12-31",{"name":273,"class":52},{"id":462,"slug":463,"hasResults":11,"nctId":464,"briefTitle":465,"officialTitle":466,"acronym":4,"eligibilityCriteria":467,"healthyVolunteers":11,"sex":159,"minAge":222,"maxAge":4,"enrollmentInfo":468,"targetDuration":4,"studyType":470,"phases":4,"briefSummary":471,"conditions":472,"keywords":475,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":483,"lastUpdatePostDateStruct":484,"startDateStruct":486,"completionDateStruct":488,"leadSponsor":490,"locationsCount":53},"100573982","breast-cancer-rehabilitation-needs-and-service-uptake-100573982","NCT06753357","Breast Cancer Rehabilitation Needs and Service Uptake","Prevalence of Cancer Rehabilitation Needs and Drivers of Rehabilitation Service Uptake in Breast Cancer Survivors","Inclusion Criteria:\n\n1. Female patients\n2. Age 21yrs old and above\n3. Histological diagnosis of breast cancer at any stage (or clinical consensus at a Tumour Board meeting, for example if the condition is metastatic and biopsy is not indicated for any reason)\n4. Started treatment (surgical, medical, radiotherapeutic, or otherwise) with curative or palliative intent\n5. Speak English, Mandarin, or Malay, or Tamil, and are able to understand a verbally-translated version of the questionnaire\n6. Able to provide informed consent\n\nExclusion Criteria:\n\n1. Unable to answer the questionnaire for any reasons such as cognitive impairment or sensory dysfunction\n2. Declined participation",{"count":469,"type":21},376,"OBSERVATIONAL","The investigators are attempting to verify the prevalence of cancer rehabilitation needs at our institution in breast cancer patients. The investigators also want to assess 1) self-perceived needs for cancer rehabilitation services, 2) awareness, willingness, and patient health beliefs as determinants for cancer rehabilitation-seeking behaviour, and 3) the modifiable patient factors driving the mismatch between needs and uptake in our population.\n\nPatients attending outpatient clinics in our hospital will be approached to answer a questionnaire designed to find out this information. The investigators hope that the results will ultimately inform the design of better triage and referral systems that match patients to services based on their rehabilitation needs.\n\nThe investigators believe that local survivors of breast cancer have unmet rehabilitation needs and that it is possible to evaluate their readiness to seek access to rehabilitation services as well as identify mismatches between provided and desired services through the administration of a cancer rehabilitation questionnaire (CRQ).",[473,27,474],"Breast Cancer","Health Attitude",[476,477,478,479,480,481,482],"Breast cancer","Cancer rehabilitation","Rehabilitation needs","Rehabilitation service uptake","Cancer survivorship","Health Belief Model","Technological enablers","2024-12-22",{"date":485,"type":45},"2024-12-31",{"date":487,"type":21},"2025-01",{"date":489,"type":21},"2025-12",{"name":491,"class":52},"Changi General Hospital"]