[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"canine-retraction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:canine-retraction":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100640184","comparison-of-rate-of-tooth-movement-between-mops-vs-mops--lllt-combined-100640184",false,"NCT07626580","Comparison of Rate of Tooth Movement Between MOPs vs MOPs & LLLT Combined","Comparison of Rate of Tooth Movement Between Micro-osteoperforations Versus Micro-osteoperforations and Low Level Laser Therapy Combined","Inclusion Criteria:\n\n* • Patients aged 12-30 years requiring fixed orthodontic treatment.\n\n  * Patients with Class I or mild-to-moderate Class II malocclusion requiring canine retraction.\n  * No history of previous orthodontic treatment.\n  * Patients with indications for the extraction of the first premolars on both sides of the maxilla.\n\nExclusion Criteria:\n\n* • Patients with systemic conditions affecting bone metabolism (e.g., osteoporosis, diabetes).\n\n  * Smokers and individuals with poor oral hygiene.\n  * Pregnant or lactating women.",true,"ALL","18 Years","30 Years",{"count":21,"type":22},33,"ESTIMATED","INTERVENTIONAL",[25],"NA","Orthodontic treatment is often prolonged, requiring years to achieve desirable outcomes. The prolonged duration of treatment increases the risk of complications such as root resorption, periodontal damage, and patient non-compliance.\n\nTo address these concerns, various methods have been explored to accelerate orthodontic tooth movement, including pharmacological agents, mechanical vibration, corticotomies, and minimally invasive techniques like Micro-Osteoperforations (MOPs) and Low-Level Laser Therapy (LLLT). Micro-Osteoperforations (MOPs) have gained popularity as a minimally invasive technique that enhances bone remodeling by inducing a localized inflammatory response, thereby accelerating tooth movement.\n\nStudies have shown that MOPs can effectively stimulate the expression of cytokines, increasing osteoclastic activity and facilitating rapid orthodontic tooth movement. However, the extent of its effectiveness varies among individuals, necessitating additional interventions to maximize efficiency. Low-Level Laser Therapy (LLLT), also known as photobiomodulation, is another promising adjunct in orthodontics. LLLT has been reported to enhance cellular activity, promote osteoblastic and osteoclastic function, and improve tissue healing, leading to accelerated tooth movement. Several studies suggest that LLLT alone can expedite orthodontic treatment, but its combination with MOPs has not been extensively explored.\n\nThis study aims to compare the rate of orthodontic tooth movement between MOPs alone and MOPs combined with LLLT. By evaluating these two techniques, this research seeks to determine whether LLLT enhances the effectiveness of MOPs in accelerating tooth movement. The findings of this study could provide valuable insights into optimizing orthodontic treatment duration while minimizing potential risks and discomfort for patients.",[28,29,30],"Orthodontic Tooth Movement","Low Level Laser Therapy","Canine Retraction",[29,32,33,30,34],"LLLT","Micro-Osteoperforations","Maxillary Scan","NOT_YET_RECRUITING","2026-06-01",{"date":38,"type":39},"2026-06-04","ACTUAL",{"date":41,"type":22},"2026-06",{"date":43,"type":22},"2026-12",{"name":45,"class":46},"Riphah International University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":16,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":47},"100627978","assessment-of-the-locally-administrated-vitamin-d3-and-corticision-efficacy-on-orthodontic-canine-retraction-100627978","NCT07455656","Assessment of the Locally Administrated Vitamin D3 and Corticision Efficacy on Orthodontic Canine Retraction","Assessment of the Locally Administrated Vitamin D3 and Corticision Efficacy on Orthodontic Canine Retraction: A Prospective Clinical Study","Inclusion criteria:\n\n1. Orthodontic patients referred for therapeutic extraction of bilateral maxillary first premolars (Angle Class II division 1 cases, with crowding and bimaxillary protrusion).\n2. Fully erupted permanent teeth (except third molar).\n3. Age 13-20 patients.\n4. No previous orthodontic treatment.\n5. Good oral and general health.\n6. No systemic disease or regular medication that could interfere with and\u002For affect orthodontic teeth movement.\n\nExclusion criteria:\n\n1. Patients with impacted canines.\n2. Patients with severe crowding.\n3. Patients with untreated decay or any endodontic lesions.\n4. Patients with thyroid, parathyroid, or renal and liver disease.","13 Years","20 Years",{"count":58,"type":22},16,[25],"To study the effect vitamin D effect on orthodontic tooth movement when used in combination with coticision technique, independent t test or an equivalent non-parametric test will be used for comparison. According to a previous study by (S. T. Varughese, et al. (2019) , \"Effect of vitamin D on canine distalization and alveolar bone density using multi-slice spiral CT: a randomized controlled trial",[62,30],"Malocclusions",[64,65,66],"Orhodontic tooth movement","Canine retraction","Extraction first premolars","RECRUITING","2026-03-03",{"date":70,"type":39},"2026-03-06",{"date":72,"type":39},"2025-08-01",{"date":74,"type":22},"2027-08-01",{"name":76,"class":46},"Al-Azhar University",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":84,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":23,"phases":87,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":47},"100597799","comparing-ligation-methods-during-canine-retraction-stage-using-conventional-brackets-100597799","NCT07063186","Comparing Ligation Methods During Canine Retraction Stage Using Conventional Brackets","Comparing Ligation Methods During Canine Retraction Stage Using Conventional Brackets: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 16 years and above.\n* Patients who require extraction of one or both maxillary first premolars as part of their orthodontic treatment.\n* Patient who are planned for maximum anchorage using Nance appliance.\n* Patients who require at least 4mm of maxillary canine retraction as part of their orthodontic treatment.\n* Patients with good oral hygiene.\n\nExclusion Criteria:\n\n* Patients with craniofacial anomalies.\n* Patients with systemic or bone diseases that could affect tooth movement (e.g., osteopetrosis, osteogenesis imperfecta, Paget's disease).\n* Patients on medications that may affect tooth movement.\n* Patients with hypodontia.\n* Patients with poor dental health where orthodontic treatment is not feasible.","16 Years",{"count":86,"type":22},60,[25],"The goal of this Randomized Controlled Trial (RCT) is to determine the most effective way to tie the main wire to the regular orthodontic brackets during the stage of orthodontic treatment where the canines are retracted. This study is for orthodontic patients aged 16 years and older who need to have their canines retracted into spaces where other teeth have been removed.\n\nThe main questions it aims to answer are:\n\n1. What is the effect of different ways of tying the wire to the braces on how much the maxillary canine moves back using conventional brackets?\n2. How do various ways of tying the wire influence unwanted movements of the maxillary canines-specifically rotation, tipping, and extrusion?\n3. What is the effect of these different tying methods on how much the back molar teeth shift forward (this is called \"anchorage loss\") while the maxillary canine is being pulled back?\n\nResearchers will compare three different ways of tying the wire to the braces to see if they differ in the amount of maxillary canine retraction, three-dimensional positional changes (rotation, tipping, and extrusion), and anchorage loss of maxillary first molars:\n\n* Group A: Uses an elastic power chain that wraps around all four parts (wings) of the brace.\n* Group B: Uses thin stainless-steel wires (ligatures) to tie the brace first, then an elastic power chain is placed over these wires, also wrapping around all four parts of the brace.\n* Group C: Uses small elastic rings on the two front parts (mesial wings) of the brace, and an elastic power chain on the two back parts (distal wings) of the brace.\n\nParticipants will consist of orthodontic patients aged 16 years and above from the Postgraduate Orthodontic Clinic, Kulliyyah of Dentistry, IIUM, Kuantan, who require extraction of one or both maxillary first premolars, are planned for maximum anchorage using a Nance appliance, need at least 4mm of maxillary canine retraction, and have good oral hygiene.\n\nParticipants will:\n\n* Undergo screening and provide written informed consent for participation.\n* Receive a comprehensive orthodontic examination, including photographic records, impressions, and radiographs.\n* Have molar bands fitted and a Nance button fabricated and cemented, followed by dental extractions of maxillary first premolars.\n* Undergo bond-up with conventional stainless-steel brackets and initial archwire placement.\n* Progress through an alignment and levelling phase using progressively larger archwires, culminating in a 0.019 x 0.025-inch stainless steel archwire.\n* At baseline (T0) and subsequent 4-week follow-up intervals (T1, T2, T3), have intraoral three-dimensional scans taken after archwire removal.\n* Receive canine retraction using elastomeric power chains delivering a standardized 150g force. This is done as a two-step retraction, where the canine is retracted in isolation.\n* Continue to receive full orthodontic treatment to completion even after the data collection period ends at T3.",[90,30],"Malocclusion",[92,30,93,94,95,96,97,98,99,100,101],"Ligation Methods","Conventional Brackets","3D Superimposition","Two-step Retraction","Anchorage Loss","Three-dimensional Positional Change","Canine Rotation","Canine Tipping","Canine Extrusion","Intraoral Scanners","2025-07-12",{"date":104,"type":39},"2025-07-16",{"date":106,"type":22},"2025-11-01",{"date":108,"type":22},"2027-12-31",{"name":110,"class":46},"International Islamic University Malaysia"]