[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"canvas-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:canvas-syndrome":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100604953","pathogenic-insights-and-search-for-biomarkers-in-rfc1-ataxiacanvas-100604953",false,"NCT07156214","Pathogenic Insights and Search for Biomarkers in RFC1-ataxia\u002FCANVAS","Pathogenic Insights and Search for Biomarkers in RFC1-ataxia\u002FCANVAS: a Model to a Deeper Understanding of Molecular Mechanisms Underlying Late-onset Neurodegeneration","INSIDE-CANVAS","Inclusion Criteria:\n\n* Molecular diagnosis of RFC1-ataxia\n* age \\>18 years and \\\u003C80 years\n* ability to sign informed consent\n\nExclusion Criteria:\n\n* Diagnosis of other degenerative and\u002For non-degenerative neurological diseases\n* Not signed informed consent",true,"ALL","18 Years","80 Years",{"count":22,"type":23},50,"ESTIMATED","INTERVENTIONAL",[26],"NA","CANVAS (Cerebellar Ataxia, Neuropathy, Vestibular Areflexia Syndrome), also referred to as RFC1-ataxia, is a recently molecularly characterized neurodegenerative disorder caused by a biallelic expansion of an AAGGG pentanucleotide repeat in intron 2 of the Replication Factor C subunit 1 (RFC1) gene.\n\nThis adult-onset condition presents with a variable combination of cerebellar ataxia, peripheral neuropathy, and vestibular dysfunction. Currently, limited data are available regarding its natural history and the molecular mechanisms by which this dynamic mutation leads to neurodegeneration of selective neuronal populations.\n\nGiven that recent literature identifies RFC1\u002FCANVAS as a relatively common genetic cause of late-onset ataxia, elucidation of its underlying pathogenic mechanisms may offer insights into the molecular pathways implicated in more prevalent late-onset neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease.",[29],"CANVAS Syndrome","RECRUITING","2025-09-02",{"date":33,"type":34},"2025-09-05","ACTUAL",{"date":36,"type":34},"2024-10-14",{"date":38,"type":23},"2026-07-31",{"name":40,"class":41},"Catholic University of the Sacred Heart","OTHER",2]