[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"carbapenem-resistant-enterobacteriaceae\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:carbapenem-resistant-enterobacteriaceae":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":5},"100644401","tackling-resistance-and-healthcare-economics-through-cpe-screening-100644401",false,"NCT07663110","Tackling Resistance And HealthCare Economics Through CPE Screening","Multi-centre Evaluation of Carbapenemase-producing Enterobacterales (CPE) Prevalence and Transmission Dynamics, Recommendations on Screening Strategies, and Health Economics Outcomes Research Impact to Inform Policy Change","TRACE-CPE","Inclusion Criteria:\n\n* All adult (18 years or older) medical patients admitted to the acute medical unit during the implementation period who undergo routine rectal CPE testing as per local Trust policy and test positive for CPE colonisation through either the rapid test or culture-based methods.\n\nExclusion Criteria:\n\n* Patient refusal for rectal screening or\n* Clinical contraindication to rectal swab collection","ALL","18 Years",{"count":20,"type":21},16000,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical study is to learn if it is possible to reduce the spread of resistant bacteria called CPEs (Carbapenemase producing Enterobacterales) between patients admitted to hospital.\n\nCPEs can be carried in the gut of people without making them ill. Normally when patients come into hospital, they may undergo a swab test on their bottom to see if CPEs can be grown. This test can take up to 24 hours to produce a result.\n\nThe investigators want to use a faster test which takes 2 hours to produce a result, and whether this can make a difference to CPE spread between person to person.\n\nThe main questions it aims to answer are:\n\n1. Why do people carry, transmit or get infected with CPE?\n2. If a faster test was used to look for CPE, would this be better at reducing patient spread in hospital?\n3. Is a faster test also more cost effective?\n\nParticipants will:\n\n1. Be tested by both the usual and faster test when they come into hospital by a swab on their bottom\n2. Where they test positive for CPE they will be asked to answer some questions about their health",[27,28],"Carbapenem-Resistant Enterobacteriaceae","Colonisation",[30,31,32,33,34,35,36,37],"infection prevention and control","health economics","rapid molecular diagnostics","carbapenem-resistant Enterobacterales","CPEs","CROs","MDROs","hospital transmission","NOT_YET_RECRUITING","2026-06-16",{"date":41,"type":42},"2026-06-23","ACTUAL",{"date":44,"type":21},"2026-08-01",{"date":46,"type":21},"2028-03-31",{"name":48,"class":49},"Imperial College London","OTHER",{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":5},"100516193","efficacy-and-safety-of-fmt-for-the-decolonization-of-mdros-in-the-intestinal-tract-100516193","NCT06001333","Efficacy and Safety of FMT for the Decolonization of MDROs in the Intestinal Tract","Efficacy and Safety of Fecal Microbiota Transplantation for the Decolonization of Multidrug-Resistant Organisms in the Intestinal Tract: An Unblinded Randomized Controlled Trial","Inclusion Criteria:\n\n1. Individuals aged 20 and older.\n2. Those with confirmed carbapenemase-producing Enterobacteriaceae (CPE) from a rectal swab culture within the past week (class A, B, or D CPE).\n3. Those with confirmed vancomycin-resistant Enterococci (E. fecalis or E. faecium) from a rectal swab culture within the past week.\n4. Individuals who have agreed to undergo Fecal Microbiota Transplantation (FMT) procedures and to provide pre- and post-procedure stool samples.\n5. Individuals who have discontinued antibiotics for a period of 3 to 7 days prior to FMT procedure.\n\nExclusion Criteria:\n\n1. Patients with ongoing or anticipated acute treatment, including antibiotic therapy.\n2. Individuals with severe immunodeficiency.\n3. Cases where there is a risk due to upper gastrointestinal endoscopy or colonoscopy.\n4. Pregnant individuals, those who could become pregnant, and breastfeeding women.\n5. Cases where participation in the study is determined by the researcher not to be beneficial.","20 Years",{"count":59,"type":21},240,[24],"The goal of this unblinded randomized controlled trial is to evaluate the efficacy and safety of fecal microbiota transplantation for the decolonization of carbapenemase-producing carbapenem-resistant Enterobacteriaceae (CP-CRE) or vancomycin-resistant Enterococci (VRE) in the intestinal tract. The study is planned to be conducted to test the superiority hypothesis that the decolonization success rate in the FMT group is higher compared to the non-FMT group. Outcome analysis will be conducted through intention-to-treat analysis, modified intention-to-treat analysis, and per-protocol analysis.\n\nThe main questions it aims to answer are:\n\n* primary endpoint: Rate of Decolonization of Multidrug-Resistant Organisms (CP-CRE or VRE) at 1 Month After Fecal Microbiota Transplantation (FMT).\n* secondary endpoint: Rates of Multidrug-Resistant Organism decolonization at 3 months, 6 months, and 1 year after FMT \u002F Post-FMT Multidrug-Resistant Organism Recolonization Rate and Infection Rate.\n\nPatients colonized with multidrug-resistant organisms in the gastrointestinal tract are divided into two groups through obtaining written consent from the patients and random allocation: the Fecal Microbiota Transplantation group (FMT group), which receives FMT, and the control group (non-FMT group), which is observed without FMT. The decolonization status of multidrug-resistant organisms will be monitored every 3-7 days after FMT until three consecutive negative results.",[27,63],"Vancomycin (Glycopeptide) Resistant Enterococcus (VRE)",[27,65,66,67],"Vancomycin-Resistant Enterococci","Fecal Microbiota Transplantation","Gastrointestinal Microbiome","RECRUITING","2025-06-16",{"date":71,"type":42},"2025-06-19",{"date":73,"type":42},"2023-09-18",{"date":75,"type":21},"2026-12-31",{"name":77,"class":49},"Chuncheon Sacred Heart Hospital"]