[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"carbapenemase-producing-enterobacterales-cpe-colonization\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:carbapenemase-producing-enterobacterales-cpe-colonization":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100623498","impact-of-implementing-a-rapid-pcr-based-algorithm-for-carbapenemase-producing-enterobacterales-cpe-and-infection-control-bundle-in-a-tertiary-hospital-100623498",false,"NCT07397416","Impact of Implementing a Rapid PCR-based Algorithm for Carbapenemase-producing Enterobacterales (CPE) and Infection Control Bundle in a Tertiary Hospital","Intervention in the CPE Surveillance Algorithm and Isolation Re-evaluation With the Addition of PCR vs. Culture-based Protocol: Real-life Time Differences","Inclusion Criteria:\n\n* Adult patients aged ≥18 years\n* Patients screened for carbapenemase-producing Enterobacterales (CPE) carriage by perianal swab within the first 5 days of hospital admission\n* Patients newly identified as CPE-colonized, leading to initiation of contact isolation\n* Patients found to be decolonized, leading to discontinuation of contact isolation\n* Patients with indication for active surveillance at hospital admission:\n\n  * Transfer from another healthcare facility\n  * Hospitalization in another healthcare center within the previous month\n* Patients undergoing active surveillance during hospitalization:\n\n  * First surveillance swab in high-risk neutropenic patients (HAR flag)\n  * First surveillance swab in immunosuppressed units, such as hematopoietic stem-cell transplant wards\n* Patients evaluated for discontinuation of contact precautions who meet all of the following:\n\n  * Prior CPE-positive surveillance sample\n  * At least 3 months since the last positive result and last hospitalization\n  * No systemic antibiotic exposure during that period\n\nExclusion Criteria:\n\n* Lost samples\n* Insufficient samples\n* Invalid laboratory test results requiring repeat sampling","ALL","18 Years",{"count":19,"type":20},800,"ESTIMATED","INTERVENTIONAL",[23],"NA","Purpose:\n\nCarbapenemase-producing Enterobacterales (CPE) are a growing cause of healthcare-associated infections, linked to high morbidity, mortality, and cost. Current screening methods rely mainly on culture, which can take up to 48 hours and delay infection control actions.\n\nThis study aims to evaluate the real-life impact of implementing a rapid PCR-based algorithm for CPE detection compared with the standard culture-based protocol, focusing on time differences in isolation and de-isolation decisions in hospitalized patients.\n\nDesign:\n\nA quasi-experimental, before-and-after, retrospective study conducted at Hospital Italiano de Buenos Aires (HIBA).\n\nPrimary Outcome:\n\nTime (in hours) between rectal swab request and change in isolation status (application or removal of isolation label) before and after PCR implementation.\n\nPopulation:\n\nAdult patients (≥18 years) admitted between October 2023-April 2024 (pre-intervention) and October 2024-April 2025 (post-intervention), who had contact isolation initiated or discontinued based on CPE surveillance results.\n\nRationale:\n\nThe introduction of rapid molecular testing could reduce operational delays and unnecessary isolation days, optimizing resource use in a setting with high CPE endemicity.",[26],"Carbapenemase-Producing Enterobacterales (CPE) Colonization",[28,29,30,31,32],"Healthcare-Associated Infections","Antimicrobial Resistance","Enterobacteriaceae Infections","Nosocomial Colonization","Infection Control","NOT_YET_RECRUITING","2026-02-04",{"date":36,"type":37},"2026-02-09","ACTUAL",{"date":39,"type":20},"2026-03-01",{"date":41,"type":20},"2026-05-01",{"name":43,"class":44},"Hospital Italiano de Buenos Aires","OTHER"]