[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"carbohydrate-loading\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:carbohydrate-loading":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100497676","intermittent-fasting-versus-carbohydrate-drinks-before-surgery-100497676",false,"NCT05760339","Intermittent Fasting Versus Carbohydrate Drinks Before Surgery","Preoperative Intermittent Fasting Versus Carbohydrate Loading to Reduce Insulin Resistance: a Randomised Controlled Trial","PRINCESS","Inclusion Criteria:\n\n* Undergoing elective orthopaedic surgery;\n* Intermediate, major or complex surgery according to the Surgical Outcome Risk Tool (SORT; http:\u002F\u002Fwww.sortsurgery.com\u002F) severity of surgery classification;\n* Scheduled for surgery at least 17 days from the date of screening;\n* Motivated to follow a time restricted feeding regimen.\n* Willing and able to provide written informed consent.\n\nExclusion Criteria:\n\n* History of diabetes mellitus;\n* History of feeding or eating disorders;\n* History of delayed gastric emptying or gastro-oesophageal reflux\n* Active malignancy\n* Patients classified as ASA IV by the attending anaesthetist;\n* BMI \\\u003C 18.5 or ≥ 35;\n* Outpatient or day case surgery;\n* Palliative surgery;\n* Participation in another clinical trial that is interfering with the procedures or outcomes of the PRINCESS trial;\n* Patients unable to fully comply to study needs (e.g. legally incapable patients or patients unable to communicate in Dutch).","ALL","18 Years",{"count":20,"type":21},75,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this study is to investigate whether time-restricted feeding, a form of intermittent fasting, before surgery improves insulin resistance around the time of surgery, compared to carbohydrate drinks and standard fasting before surgery.",[27,28,29,30,31,32],"Perioperative Care","Intermittent Fasting","Carbohydrate Loading","Preoperative Fasting","Orthopedic Surgery","Insulin Resistance",[27,29,31,32,34,35],"HOMA-IR","Time Restricted Feeding","RECRUITING","2024-10-18",{"date":39,"type":40},"2024-10-22","ACTUAL",{"date":42,"type":40},"2023-03-20",{"date":44,"type":21},"2025-09",{"name":46,"class":47},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","OTHER"]