[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"carbon-dioxide-lasers\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:carbon-dioxide-lasers":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100620022","prp-plus-fractional-co-laser-for-acne-scars-100620022",false,"NCT07352215","PRP Plus Fractional CO₂ Laser for Acne Scars","Evaluating the Effectiveness of Platelet-Rich Plasma as an Adjunct to Fractional Carbon Dioxide Laser Therapy in Improving Facial Acne Scar Appearance: A Randomized Controlled Trial","PRPLT","Inclusion Criteria:Adults aged 18 to 40 years\n\nMale and female participants\n\nFitzpatrick skin types I to V\n\nPresence of moderate-to-severe acne scars\n\nWilling to undergo 3 treatment sessions and follow-up visits\n\nAble to provide informed consent -\n\nExclusion Criteria:Use of topical anti-acne medications in the past 1 month\n\nHistory of keloid formation or hypertrophic scarring\n\nActive acne or active skin inflammation at treatment area\n\nDiabetes mellitus\n\nPhotosensitive disorders (e.g., lupus, dermatomyositis)\n\nMelasma\n\nActive infections (e.g., Herpes simplex)\n\nRecent laser resurfacing or similar procedures\n\nOutdoor workers with high sun exposure\n\nVitiligo\n\nPregnancy or breastfeeding\n\nBleeding disorders or anticoagulant therapy\n\nUnrealistic expectations or inability to comply with follow-up\n\n\\-","ALL","18 Years","40 Years",{"count":21,"type":22},70,"ESTIMATED","INTERVENTIONAL",[25],"NA","This randomized controlled trial aims to evaluate whether adding platelet-rich plasma (PRP) to fractional CO₂ laser resurfacing improves the treatment of moderate-to-severe acne scars compared with laser alone. Seventy adults aged 18-40 years will be recruited from the Dermatology Department of Gujranwala Medical College Teaching Hospital. Participants will be randomly assigned to receive either fractional CO₂ laser combined with topical PRP or fractional CO₂ laser alone, with three treatment sessions delivered four weeks apart.\n\nThe primary outcome is the change in acne scar severity measured using the Goodman and Baron Quantitative Acne Scar Scale. Secondary outcomes include redness, edema, pain scores, and patient satisfaction assessed using Likert and numeric rating scales. The study is single-blinded, with patients unaware of treatment allocation. PRP will be prepared using a standardized double-spin centrifugation process. Data will be analyzed using appropriate statistical tests with a significance level of p \\\u003C 0.05. The study aims to determine whether PRP enhances laser efficacy, reduces side effects, and improves patient-reported outcomes.",[28,29,30],"Post-Acne Atrophic Scars","Carbon Dioxide Lasers","Platelet-Rich Plasma",[32,33,34,35],"Post-acne Scarring","Fractional CO₂ Laser","PRP Therapy","Skin Resurfacing","RECRUITING","2026-01-11",{"date":39,"type":40},"2026-01-20","ACTUAL",{"date":42,"type":40},"2025-10-31",{"date":44,"type":22},"2026-04-30",{"name":46,"class":47},"Gujranwala medical college District Headquarters Hospital, Gujranwala","OTHER"]