[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"carbon-dioxide\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:carbon-dioxide":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,52,87,115],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100443207","phase-2-co2-modulation-in-endovascular-thrombectomy-for-acute-ischemic-stroke-100443207",false,"NCT05051397","CO2 Modulation in Endovascular Thrombectomy for Acute Ischemic Stroke","Evaluation of the Effect of Moderate and Controlled Hypercapnia on Ischemic Penumbra Vascular Collaterality During General Anesthesia for Anterior Circulation Acute Ischemic Stroke Mechanical Thrombectomy","COMET-AIS","Inclusion Criteria:\n\n• Large vessel occlusion anterior circulation stroke (terminal carotid artery and\u002For middle cerebral artery M1-M2 segment) eligible to mechanical thrombectomy under general anesthesia\n\nExclusion Criteria :\n\n* Active smoker\n* Chronic respiratory failure with ambulatory oxygen supplementation\n* Obesity with BMI\\>40Kg\u002F m2\n* Intubation before the procedure\n* Heart failure with intolerance to decubitus\n* Severe renal failure\n* Suspected elevated intracranial pressure\n* Pregnant or breastfeeding women","ALL","18 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","Acute ischemic stroke due to large vessel occlusion is responsible of cerebral blood flow impairment with a progressive and extensive ischemic process. Cerebral collateral circulation may preserve an ischemic penumbra that could recover providing timely reperfusion of the occluded vessel. Mechanical thrombectomy is the standard of care for anterior circulation large vessel reperfusion. Strategy to promote cerebral blood flow in collateral circulation before reperfusion is scarce and rely mainly on blood pressure maintenance. Carbon dioxide is a potent cerebral vasodilator that could enhance collateral circulation blood flow and cerebral protection before reperfusion. General anesthesia with endotracheal mechanical ventilation could be used for thrombectomy and give the opportunity to modulate and control carbon dioxide tension in the blood. This study will test the effect of moderate hypercapnia on penumbral collateral circulation before reperfusion during mechanical thrombectomy for anterior circulation acute ischemic stroke under general anesthesia.",[27,28,29,30,31],"Ischemic Stroke, Acute","Thrombectomy","Anesthesia, General","Cerebrovascular Circulation","Carbon Dioxide",[33,34,35,36,37,38],"mechanical thrombectomy","large vessel occlusion stroke","carbon dioxide tension","cerebral blood flow","general anesthesia","cerebral collateral circulation","RECRUITING","2025-09-30",{"date":42,"type":43},"2025-10-06","ACTUAL",{"date":45,"type":43},"2022-07-20",{"date":47,"type":21},"2026-10-19",{"name":49,"class":50},"University Hospital, Clermont-Ferrand","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":64,"conditions":65,"keywords":70,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":51},"100522179","ischemia-detection-during-development-of-acute-compartment-syndrome-100522179","NCT06079255","Ischemia Detection During Development of Acute Compartment Syndrome","Early Ischemia Detection by a Tissue CO2-sensor During Development of Acute Compartment Syndrome","IDEA","Inclusion Criteria:\n\n* Must have a leg fracture that, perceived by the clinician, could give rise to later developing acute compartment syndrome condition.\n* Subject must be 18 years or more.\n* Able to sign informed consent.\n* Expected cooperation of the patients for the treatment and follow up\n\nExclusion Criteria:\n\n* Another study interfering with current study\n* Any reason why, in the opinion of the investigator, the patient should not participate.\n* Patients where a fasciotomy has already been decided should be performed","110 Years",{"count":62,"type":21},60,"OBSERVATIONAL","This is an open, observational, prospective, descriptive, single-centre study including 60 patients. The study is designed to investigate if IscAlert sensor system can be used for reliable and continuous tissue carbon dioxide (pCO2)- and temperature monitoring in muscular tissue in lower extremity in patients at risk of developing acute compartment syndrome.",[66,67,31,68,69],"Ischemia Limb","Blood Circulation Disorder","Biosensing Techniques","Compartment Syndrome of Leg",[71,72,73,74,75,76],"Ischemia","Biosensor","Carbon dioxide","Orthopedic surgery","Limb","Acute compartment syndrome","NOT_YET_RECRUITING","2025-03-21",{"date":80,"type":43},"2025-03-25",{"date":82,"type":21},"2025-10-15",{"date":84,"type":21},"2027-10-30",{"name":86,"class":50},"Oslo University Hospital",{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":94,"sex":17,"minAge":95,"maxAge":96,"enrollmentInfo":97,"targetDuration":4,"studyType":22,"phases":99,"briefSummary":101,"conditions":102,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":51},"100558153","effects-of-different-anesthesia-machine-modalities-on-bariatric-surgery-patients-a-prospective-randomized-controlled-study-100558153","NCT06547411","Effects of Different Anesthesia Machine Modalities on Bariatric Surgery Patients: a Prospective Randomized Controlled Study","Effects of Different Ventilation Modes on Intracranial Pressure and Carbon Dioxide Partial Pressure During Bariatric Surgery: a Prospective, Randomized, Controlled Study","Inclusion Criteria:\n\n* Patients scheduled for elective bariatric surgery.\n* Age between 16 and 65 years.\n* Continuous weight gain for more than 5 years with a BMI ≥ 35.\n* ASA-PS (American Society of Anesthesiologists Physical Status) categorization of Grade II or III.\n\nExclusion Criteria:\n\n* Patients who were dependent on alcohol or opioids.\n* Patients with severe mental or intellectual disabilities.\n* Patients with severe ocular conditions, such as ocular trauma, optic nerve tumors, or those wearing ocular prostheses.",true,"16 Years","65 Years",{"count":98,"type":21},90,[100],"NA","The goal of this clinical trial is to explore the clinical significance and value of the PRVC ventilation mode in Bariatric Surgery Patients. The main questions it aims to answer are：\n\n* Do different ventilation patterns affect intracranial pressure and partial pressure of carbon dioxide in bariatric surgery patients?\n* Does PRVC mode reduce intracranial pressure and partial pressure of carbon dioxide in bariatric surgery patients?\n* Whether intracranial pressure can be quickly measured by monitoring a patient's optic nerve sheath diameter (ONSD)？ Researchers randomized bariatric surgery patients into PC, VC, and PRVC groups for comparison, looking at breathing mechanics, PaCO2, and ICP.\n\nParticipants will:\n\n* take PC mode ventilation, VC mode ventilation, and PRVC mode ventilation\n* monitor Respiratory mechanics, PaCO2, and ONSD",[103,104,105,31],"Ventilation","Bariatric Surgery","Intracranial Pressure","2025-02-28",{"date":108,"type":43},"2025-03-05",{"date":110,"type":43},"2024-03-01",{"date":112,"type":21},"2025-03-30",{"name":114,"class":50},"Yu-Long Jia",{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":122,"enrollmentInfo":123,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":125,"conditions":126,"keywords":127,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":51},"100396730","validation-of-continuous-transcutaneous-carbon-dioxide-monitoring-in-va-ecmo-patients-100396730","NCT04445909","Validation of Continuous Transcutaneous Carbon Dioxide Monitoring in VA-ECMO Patients","Validation of Continuously Determined Transcutaneous Carbon Dioxide Partial Pressures in Patients Supported with Veno-arterial Extracorporeal Membrane Oxygenation","Inclusion Criteria:\n\n* Low cardiac output requiring VA-ECMO support.\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years","90 Years",{"count":124,"type":21},30,"Carbon dioxide in patients on veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is eliminated via respirator as well as via the oxygenator's membrane of the ECMO machine. Consequently, monitoring of end-tidal carbon dioxide tensions is limited, which can result in marked swings towards non-physiological values. Hyper- and hypocapnia, however, can have detrimental effects on organ perfusion in a great number of patients supported with VA-ECMO. Continuous, rapidly applicable monitoring of reliable carbon dioxide measures would therefore be extremely helpful to prevent harmful deviations from the norm. The investigators therefore try to assess the accuracy and the precision of continuously measured non-invasive transcutaneous carbon dioxide partial pressures when compared with tensions determined by blood gas analysis.",[31],[128,129,130,131,132,133],"ECMO","Carbon dioxide elimination","Organ perfusion","Low cardiac output","Monitoring","Critical Care","2024-12-01",{"date":136,"type":43},"2024-12-04",{"date":138,"type":43},"2019-11-18",{"date":140,"type":21},"2025-12-31",{"name":142,"class":50},"Medical University of Vienna"]