[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"carbon-monoxide-poisoning\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:carbon-monoxide-poisoning":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,45,75,101,131,155,180],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100608409","maternal-smoking-exposure-and-newborn-outcomes-a-study-using-cord-blood-cotinine-100608409",false,"NCT07201181","Maternal Smoking Exposure and Newborn Outcomes: A Study Using Cord Blood Cotinine","Association of Prenatal Tobacco Exposure, Classified by Cord Blood Cotinine (Active, Passive, None), With Neonatal Metabolic and Physiologic Indices: A Single-Center Prospective Cohort Study","Inclusion Criteria:\n\n* Liveborn neonate delivered at the study hospital, aged 0-72 hours at assessment.\n* Routine umbilical cord blood gas available at birth (pH, base excess, lactate).\n* Cord blood cotinine available or obtainable at delivery for exposure classification.\n* Singleton live birth at ≥35 weeks of gestation.\n* Availability of routine umbilical cord blood gas parameters at birth, including at minimum pH, base excess, and lactate, with FCOHb recorded where available.\n* Availability of routine first postnatal day clinical and laboratory data according to unit practice.\n* Parent\u002Fguardian provides informed consent for use of neonatal data obtained from routine care.\n* Standard newborn assessments obtainable within 72 hours (e.g., birthweight, \\~6-hour vitals\u002FBP, TSH at 24-48 h, hearing screen ≤72 h per unit practice).\n\nExclusion Criteria:\n\n* Emergent clinical scenarios where any research step could delay urgent care.\n* Major congenital anomaly, known chromosomal\u002Fgenetic disorder, or major metabolic disease likely to affect neonatal adaptation or study outcomes.\n* Severe perinatal condition preventing acquisition of core study data or making outcome interpretation unreliable, including major birth trauma or prolonged intensive care requirement.\n* Missing cord blood cotinine measurement or missing core primary outcome data.\n* Multiple gestation.\n* Prior enrollment of the same neonate (no re-enrollment).",true,"ALL","0 Minutes","72 Hours",{"count":21,"type":22},126,"ESTIMATED","OBSERVATIONAL","Prenatal exposure to tobacco smoke, whether from active maternal smoking or secondhand exposure, has been associated with adverse neonatal adaptation, metabolic stress, and impaired fetal oxygenation. This single-center prospective observational cohort study will quantify prenatal tobacco exposure using cord blood cotinine measured at delivery and examine its association with early neonatal biochemical, metabolic, and physiologic outcomes.\n\nParticipants will consist of mother-newborn dyads recruited consecutively at a tertiary academic hospital. After informed consent, cord blood obtained at delivery will be used for cotinine measurement. Based on pre-specified cotinine thresholds and maternal smoking history, newborns will be classified into three exposure groups: active exposure, passive exposure, or no exposure. No experimental intervention will be administered, and neonatal assessments will be based on routine perinatal and postnatal care.\n\nNeonatal data collected will include umbilical cord blood gas parameters (pH, pCO2, pO2, base excess, bicarbonate, and lactate), fetal carboxyhemoglobin (FCOHb), birthweight and anthropometric measurements, Apgar scores, oxygen saturation, heart rate, blood pressure, and routine laboratory indices obtained during the first postnatal day. These laboratory measures may include complete blood count parameters, inflammatory and hematologic ratios such as NLR and PLR, metabolic markers including albumin and lactate-to-albumin ratio, lipid parameters such as HDL and LDL, thyroid-stimulating hormone from the standard newborn screening program, and hearing screening results. Early follow-up data, including postnatal weight loss and bilirubin measurements at routine visits, will also be recorded where available. Maternal and perinatal covariates, including maternal age, parity, gestational age, delivery mode, intrapartum factors, smoking history, and relevant maternal comorbidities, will be collected to support adjusted analyses.\n\nThe primary objective is to determine whether higher cord blood cotinine-defined exposure is associated with greater metabolic stress and impaired fetal oxygenation at birth, particularly as reflected by cord lactate, related blood gas parameters, and FCOHb. Secondary objectives include evaluating associations with early neonatal hematologic, metabolic, endocrine, and clinical indices, including birthweight, blood pressure, bilirubin levels, thyroid screening results, and hearing screening outcomes.\n\nThe study will recruit consecutive eligible dyads in a prospective manner. Statistical analyses will follow a pre-specified plan and will include multivariable regression models to adjust for potential confounding factors. Sensitivity and subgroup analyses, including analyses by delivery mode and other clinically relevant strata, will be performed when feasible.\n\nThis study is designed to provide prospectively collected, biochemically verified evidence on how prenatal tobacco exposure, classified by cord blood cotinine, relates to immediate neonatal metabolic, hematologic, and physiologic outcomes using measurements that are feasible within routine clinical care.",[26,27,28,29],"Tobacco Smoke Pollution","Maternal Exposure During Pregnancy","Infant, Newborn","Carbon Monoxide Poisoning",[31,32],"Prenatal Tobacco Exposure","Maternal Smoking","NOT_YET_RECRUITING","2026-04-23",{"date":36,"type":37},"2026-04-29","ACTUAL",{"date":39,"type":22},"2026-05-04",{"date":41,"type":22},"2026-10-01",{"name":43,"class":44},"Haseki Training and Research Hospital","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100560200","phase-1-carbon-monoxide-hyperbaric-oxygen-with-steroid-therapy-100560200","NCT06574048","Carbon Monoxide Hyperbaric Oxygen With Steroid Therapy","Trial of Dexamethasone vs Placebo as an Adjunctive Therapy to Hyperbaric Oxygen Treatment HBO in Patients With Acute Carbon Monoxide Poisoning","CODex","Inclusion Criteria:\n\n* Acute CO poisoning, intentional or non-intentional exposure, receiving HBO treatment during hospitalization\n* Age \\>18 years\n* Nebraska Medicine admission\n\nExclusion Criteria:\n\n* Mechanical ventilation\n* No hospital admission or admission to hospital Critical Care Medicine Service\n* Allergy to dexamethasone\n* Pre-Existing neurological condition confounding outcome determination","19 Years",{"count":55,"type":22},20,"INTERVENTIONAL",[58,59],"PHASE1","PHASE2","Hyperbaric Oxygen Therapy (HBO) is routine treatment of carbon monoxide (CO) poisoning to prevent delayed neurological sequelae. This study looking to see if neurologic outcomes are improved with the addition of dexamethasone. CO poisoning can initiate a free radical mediated process that can instigate a demyelinating process resulting in long term neurological sequelae in some, but not all patients. In other demyelinating disorders, steroids are a part of first line treatment. HBO is already used for acute CO poisoning, so this pilot study will try to ascertain if the addition of steroids in concert with each hyperbaric oxygen session will yield improved outcomes.",[29,62,63,64],"Carbon Monoxide Intoxication","Carbon Monoxide Encephalopathy","Carbon Monoxide-induced Parkinsonism","2026-04-13",{"date":67,"type":37},"2026-04-17",{"date":69,"type":22},"2026-07",{"date":71,"type":22},"2028-01",{"name":73,"class":44},"University of Nebraska",1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":81,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":56,"phases":84,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":97,"leadSponsor":99,"locationsCount":74},"100578467","phase-4-the-efficacy-of-dexamethasone-in-combination-with-n-acetylcysteine-in-preventing-neurocognitive-sequelae-due-to-carbon-monoxide-poisoning-100578467","NCT06811675","The Efficacy of Dexamethasone in Combination With N-acetylcysteine in Preventing Neurocognitive Sequelae Due to Carbon Monoxide Poisoning","Inclusion Criteria:\n\n* History and clinical symptoms consistent with CO poisoning (initial blood carboxyhemoglobin (COHb) levels \\>5%, or \\>10% for smokers).\n\nExclusion Criteria:\n\n* Concurrent use of other potentially lethal toxins. Severe trauma or burns that could be fatal. No spontaneous heartbeat or blood pressure before arrival. Poisoning time exceeding 24 hours before hospital arrival. Minors (under 18 years of age). Pregnant women. Patients or their families refuse to sign the consent form. Contraindications for the use of Dexamethasone or N-acetylcysteine (such as severe allergies) or when the physician assesses the risks outweigh the benefits.","18 Years",{"count":83,"type":22},128,[85],"PHASE4","Background and Aim: Carbon monoxide (CO) poisoning is a significant public health issue that can cause delayed neuropsychological sequelae (DNS). DNS mechanisms involve oxidative stress, inflammation, and immune injury. Although hyperbaric oxygen therapy is widely used, its efficacy in preventing DNS remains inconclusive. Preclinical and retrospective studies suggest that Dexamethasone (anti-inflammatory and immunosuppressive) and N-acetylcysteine (antioxidant) may reduce DNS risk. This study hypothesizes that their combination can effectively prevent DNS.\n\nMethods: This prospective pre-post intervention study will enroll CO poisoning patients into treatment (Dexamethasone + N-acetylcysteine) and control groups. The primary outcome is the incidence of DNS within six weeks post-treatment.\n\nObjective: To determine whether combining Dexamethasone and N-acetylcysteine reduces the incidence of DNS following CO poisoning.",[29,88],"Delayed Neurocognitive Sequelae",[29,90,91,88],"Dexamethasone","N-acetylcysteine","RECRUITING","2025-03-23",{"date":95,"type":37},"2025-03-26",{"date":93,"type":37},{"date":98,"type":22},"2027-09-30",{"name":100,"class":44},"China Medical University Hospital",{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":105,"acronym":106,"eligibilityCriteria":107,"healthyVolunteers":16,"sex":17,"minAge":81,"maxAge":108,"enrollmentInfo":109,"targetDuration":111,"studyType":23,"phases":4,"briefSummary":112,"conditions":113,"keywords":114,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":74},"100484687","microparticles-blood-level-in-acute-carbon-monoxide-poisoning-100484687","NCT05591300","Microparticles Blood Level in Acute Carbon Monoxide Poisoning","COMPs","Inclusion Criteria:\n\n* Age \\> 18 years\n* Acute carbon monoxide poisoning\n* Need for treatment with hyperbaric oxygen\n\nExclusion Criteria:\n\n* Patient reject to consent","99 Years",{"count":110,"type":22},108,"45 Days","The goal of this pilot, clinical, experimental, biological and prospective study with uso of biological material (venous blood sampling), in patient with acute carbon monoxide (CO) intoxication and in a group of healthy non-intoxicated subject (group of control) is the research of a possible increase of circulating microparticles level in human blood with an acute carbon monoxide intoxication.\n\nThe main question to answer is:\n\nIs there an increase of circulating microparticles levels in subjects with acute carbon monoxide poisoning? Two blood samples will be withdrawn from patients with acute carbon monoxide poisoning, one before and one after hyperbaric oxygen treatment.\n\nResearchers will compare a group of healthy volunteers to see if there is a different in circulating microparticles blood level compared to patients with intoxication.",[29],[115,116,117,118,119,120,121],"Carbon monoxide intoxication","Microparticles","Microvesicles","Carbon monoxide poisoning","CO","Delayed neurological syndrome","Hyperbaric Oxygen","2024-11-13",{"date":124,"type":37},"2024-11-14",{"date":126,"type":37},"2022-11-15",{"date":128,"type":22},"2025-11",{"name":130,"class":44},"Azienda Ospedaliero Universitaria Maggiore della Carita",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":17,"minAge":81,"maxAge":138,"enrollmentInfo":139,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":141,"conditions":142,"keywords":143,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":74},"100558323","cardiotoxicity-of-carbon-monoxide-in-patients-treated-with-hyperbaric-oxygen-therapy-100558323","NCT06549621","Cardiotoxicity of Carbon Monoxide in Patients Treated With Hyperbaric Oxygen Therapy","COCARDIOTOX","Inclusion Criteria:\n\nPatients treated for CO poisoning with HBOT in the hyperbaric and underwater medicine department of the Brest University hospital from 2015\u002F01\u002F01 to 2021\u002F12\u002F31\n\nExclusion Criteria:\n\n* refusal","100 Years",{"count":140,"type":22},66,"Carbon monoxide poisoning is a frequent domestic accident and the leading cause of death from unintentionnal poisoning. Its toxicity is based on the CO binding to hemoglobin and myoglobin, inhibition of mitochondrial cytochrome oxidase, resulting in tissue hypoxia and reduced adenosine triphosphate synthesis and ischemia-reperfusion injury.\n\nThis study aims to investigate the early and late cardiologic effects of CO in patients treated with hyperbaric oxygen (HBOT) for CO poisoning",[29],[144,145],"cardiac injury","cardiac toxicity","2024-08-08",{"date":148,"type":37},"2024-08-12",{"date":150,"type":37},"2022-07-25",{"date":152,"type":22},"2024-10-25",{"name":154,"class":44},"University Hospital, Brest",{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":159,"acronym":4,"eligibilityCriteria":160,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":161,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":163,"conditions":164,"keywords":4,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":74},"100400137","carbon-monoxide-intoxication-in-korea-prospective-cohort-care-co-cohort-100400137","NCT04490317","CARbon monoxidE intoxiCatiOn in Korea: Prospective Cohort (CARE CO Cohort)","Inclusion Criteria:\n\n* Acute CO poisoning\n\nExclusion Criteria:\n\n* Declined to enrollment in the study",{"count":162,"type":22},1500,"This prospective cohort study enrolls subjects who experience carbon monoxide (CO) poisoning. The purpose of the study is to evaluate therapeutic effects of various treatments and short and long-term outcomes in CO poisoned patients. In addition, complications of brain and heart susceptible to CO are investigated through various ways and the association between complications and the patient's prognosis is also investigated. All subjects will be regularly monitored by physicians participating in this study.",[29,165,166,167,168,169,170],"Myocardial Injury","Neurologic Deficits","Image, Body","Therapy","Prognostic Factors","Complications","2024-07-22",{"date":173,"type":37},"2024-07-23",{"date":175,"type":37},"2020-07-29",{"date":177,"type":22},"2035-12",{"name":179,"class":44},"Wonju Severance Christian Hospital",{"id":181,"slug":182,"hasResults":11,"nctId":183,"briefTitle":184,"officialTitle":185,"acronym":4,"eligibilityCriteria":186,"healthyVolunteers":11,"sex":17,"minAge":187,"maxAge":4,"enrollmentInfo":188,"targetDuration":190,"studyType":23,"phases":4,"briefSummary":191,"conditions":192,"keywords":193,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":74},"100433528","neurological-sequelae-in-patients-with-acute-carbon-monoxide-poisoning-100433528","NCT04925297","Neurological Sequelae in Patients With Acute Carbon Monoxide Poisoning","The Characteristics of Neurological Sequelae in Patients With Acute Carbon Monoxide Poisoning","Inclusion Criteria:\n\n* patients present within 12 hours after acute carbon monoxide poisoning;\n* age older than 16 years.\n\nExclusion Criteria:\n\n* pregnant women；\n* patients receive oxygen therapy before presentation;\n* have history of acute carbon monoxide poisoning within 1 year;\n* have been diagnosed any of the following disease: Parkinson disease; cognitive disorder, psychiatric disorders, sequelae of cerebral infarction or hemorrhage, chronic kidney disease and receive hemodialysis, congestive heart failure ( NYHA class III-IV)","16 Years",{"count":189,"type":22},1250,"1 Year","The purpose of this study is to access the clinical characteristics and risk factors for neurological sequelae after acute carbon monoxide poisoning.",[29],[194,195],"carbon monoxide poisoning","neurological sequelae","2021-06-07",{"date":198,"type":37},"2021-06-14",{"date":200,"type":22},"2021-08-01",{"date":202,"type":22},"2027-05-01",{"name":204,"class":44},"The First Hospital of Jilin University"]