[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiac-ageing\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiac-ageing":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100498840","exercise-to-slow-cardiovascular-ageing-progression-100498840",false,"NCT05775484","Exercise to Slow Cardiovascular Ageing Progression","Inclusion Criteria:\n\n* Age \\>=21 years old\n* Outdoor ambulant\n\nExclusion Criteria:\n\n* Wheelchair or bed-bound\n* Dementia\n* Residing in sheltered or nursing home\n* Cancer\n* Participation in ongoing clinical trials that involve interventional drugs or devices\n* Aneurysms\n* Acute infections (in the last six months)\n* Uncontrolled thyrotoxicosis\n* Neuromuscular, musculoskeletal or rheumatoid disorders that are exacerbated by exercise\n* Uncontrolled asthma or chronic lung disease\n* Restrictive lung disease",true,"ALL","21 Years","100 Years",{"count":20,"type":21},450,"ESTIMATED","OBSERVATIONAL","In ageing, deleterious alterations in cardiovascular (CV) structure and function increase risks of ageing-related cardiovascular disease (CVD). Investigators found that these CV alterations were associated with circulating serum metabolites, suggesting a metabolic basis to CV ageing. Investigators hypothesize that modification of these metabolites by intervention, such as exercise, may retard CV alterations and reduce CVD in ageing.",[25,26,27],"Cardiac Ageing","Exercise","Cardiovascular","RECRUITING","2025-06-03",{"date":31,"type":32},"2025-06-05","ACTUAL",{"date":34,"type":32},"2023-05-01",{"date":36,"type":21},"2050-12-31",{"name":38,"class":39},"National Heart Centre Singapore","OTHER"]