[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiac-anaesthesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiac-anaesthesia":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,51,79,105,128,156],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100630652","intraoperative-ketamine-for-chronic-postoperative-pain-after-open-heart-surgery-100630652",false,"NCT07490457","Intraoperative Ketamine for Chronic Postoperative Pain After Open-Heart Surgery","Effect of Intraoperative Ketamine Administration on Postoperative Chronic Pain in Patients Undergoing Open Cardiac Surgery","Inclusion Criteria:\n\n* ASA II-III,\n* Patients scheduled for elective on-pump open cardiac surgery via median sternotomy.\n\nExclusion Criteria:\n\n* Emergency surgery requirement\n* Need for reoperation\n* Requirement for postoperative re-intubation\n* History of opioid use\n* Preoperative diabetic neuropathy or autonomic dysfunction\n* Hepatic or renal dysfunction\n* History of neuropathic pain\n* Neurocognitive disorders such as psychosis or dementia\n* Use of antidepressants or antipsychotics\n* Body mass index (BMI) \\> 40","ALL","18 Years","80 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this interventional study is to determine whether a single intraoperative IV dose of ketamine can reduce postoperative chronic and acute pain and postoperative opioid requirements in adult patients undergoing open-heart surgery under general anesthesia. The main questions it aims to answer are:\n\nPrimary outcome: Does a single-dose intraoperative IV ketamine reduce the presence and severity of pain at 3 and 6 months after surgery ? Secondary outcomes: Does it reduce acute postoperative pain scores, opioid consumption, and other recovery-related outcomes in the early postoperative period ? Researchers will compare a single-dose IV ketamine arm to a placebo arm to see if ketamine decreases chronic pain incidence at 3 and 6 months and improves acute pain\u002Fopioid-related outcomes.\n\nParticipants will:\n\nBe randomized to receive either a single IV bolus of ketamine or placebo during surgery.\n\nUndergo standard general anesthesia and open cardiac surgery per protocol. Have postoperative pain assessed using Numeric Rating Scale (NRS) at extubation, 0, 3, 6, 12, 24, and 48 hours.\n\nHave opioid and additional analgesic use recorded, time to first rescue analgesic noted, and ICU\u002Fhospital length of stay tracked.\n\nBe evaluated for ICU delirium (CAM-ICU) and complete Quality of Recovery-15, Brief Pain Inventory-Short Form, and Pain Self-Efficacy questionnaires.\n\nBe followed up at 3 and 6 months for assessment of chronic postoperative pain.",[27,28,29,30,31,32],"Cardiac Anaesthesia","Chronic Pain","Post Operative Pain, Chronic","Post Operative Pain, Acute","Ketamine","Pain",[34,35,36,37],"Postoperative chronic pain","ketamine","Open-heart surgery","Intraoperative ketamine","NOT_YET_RECRUITING","2026-03-18",{"date":41,"type":42},"2026-03-24","ACTUAL",{"date":44,"type":21},"2026-04-15",{"date":46,"type":21},"2027-05",{"name":48,"class":49},"Bursa City Hospital","OTHER_GOV",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":22,"phases":62,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":4},"100604034","comparison-of-milrinone-and-epinephrine-on-tapse-100604034","NCT07144267","Comparison of Milrinone and Epinephrine on TAPSE","Milrinone Versus Epinephrine for Right Ventricular Dysfunction After Cardiac Surgery in Adults: A Randomized Double-Blinded Trial","Milrinone","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status II \\& III\n* Age between 18 and 70 years\n* Both Gender\n* Body mass index less than 40 kg\u002Fm2\n* Ejection fraction of \\>40%\n* Tricuspid annular plane systolic excursion (TAPSE) \\\u003C 1.7cm\n\nExclusion Criteria:\n\n* Patient refusal.\n* Preoperative RV impairment\n* Pulmonary hypertension (estimated pulmonary artery systolic pressure \\> 50 mmHg)\n* Patients with any contraindications to Transesophageal echocardiography (TEE)\n* Redo or Re-exploration surgery\n* Patients with chronic kidney disease (serum creatinine \\> 1.5 mg\u002F dl)\n* Patients with chronic liver disease (child pugh B and C)","70 Years",{"count":61,"type":21},102,[24],"Cardiopulmonary bypass (CPB) is a critical technology in cardiac surgery, allowing for the temporary replacement of the heart and lung functions during intricate surgical procedures. it has significant post-surgical complications, the most important complications of CPB is right ventricle (RV) dysfunction. Diagnosis and management of RV dysfunction is crucial for maintenance of hemodynamic stability and organ function in early post-operation period and prognostic for later phase.",[27,65],"Cardiopulmonary Bypass",[67,68],"Cardiopulmonary bypass (CPB) -Tricuspid annular plane systolic excursion (TAPSE)-","Epinephrine - Milrinone","2026-02-23",{"date":71,"type":42},"2026-02-25",{"date":73,"type":21},"2026-03-01",{"date":75,"type":21},"2028-03-30",{"name":77,"class":78},"Mansoura University","OTHER",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":90,"conditions":91,"keywords":95,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":50},"100612618","anesthesia-perfusion-and-surgical-practices-in-cardiac-surgery-100612618","NCT07255924","Anesthesia, Perfusion, and Surgical practicEs in Cardiac Surgery","Anesthesia, Perfusion, and Surgical practicEs in Cardiac Surgery: an Adaptive, Prospective, International, Multicenter, Observational Study.","APECx","Inclusion Criteria:\n\n* 18 years or older\n* Undergoing cardiac surgery at a participating center\n\nExclusion Criteria:\n\n\\- Transcatheter cardiac interventions or endovascular procedures",{"count":88,"type":21},15000,"OBSERVATIONAL","Perioperative management in cardiac surgery, particularly the use of anesthesia, cardiopulmonary bypass (CPB), and surgical techniques, remains highly variable across institutions. Current international guidelines lack clear recommendations due to insufficient high-quality comparative data. APECx is an adaptive, international, multicenter, prospective, observational study designed to address multiple of these evidence gaps. The adaptive design allows the study to proceed through subsequent phases. Each phase will collect comprehensive global data on specific peri-operative practices and their associated patient outcomes, all within a single, continuously evolving study.",[27,92,93,94],"Cardiac Surgery","Perfusion","Anesthesia",[92,27,94,93],"2025-11-27",{"date":98,"type":42},"2025-12-01",{"date":100,"type":21},"2026-04-01",{"date":102,"type":21},"2036-01",{"name":104,"class":78},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":114,"conditions":115,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":4},"100607041","impact-of-fluid-resuscitation-on-venous-congestion-in-cardiac-critically-ill-patients-100607041","NCT07183397","Impact of Fluid Resuscitation on Venous Congestion in Cardiac Critically-ill Patients","VExUS-CS","Inclusion Criteria:\n\n* Age above 18 years\n* Admission to cardiac intensive care unit",{"count":113,"type":21},250,"The objective of this study is to assess how fluid resuscitation, in the context of fluid responsiveness, affects the incidence and progression of systemic venous congestion in critically ill cardiac patients. Additionally, the study aims to evaluate the impact on clinical outcomes, with a particular focus on acute kidney dysfunction. This assessment will utilize the VExUS score in conjunction with comprehensive bedside echocardiographic evaluations.",[116,27,117,118],"Cardiac and Aortic Surgery","Venous Congestion","Fluid Resuscitation","2025-09-14",{"date":121,"type":42},"2025-09-19",{"date":123,"type":21},"2025-09-15",{"date":125,"type":21},"2027-12",{"name":127,"class":78},"Medical University of Vienna",{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":11,"sex":16,"minAge":135,"maxAge":136,"enrollmentInfo":137,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":139,"conditions":140,"keywords":141,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":50},"100560756","cardiac-anesthesia-registry-including-biosignal-database-for-prognostication-of-postoperative-renal-outcome-100560756","NCT06581289","Cardiac Anesthesia Registry Including Biosignal Database for Prognostication of Postoperative Renal Outcome","Cardiac Anesthesia Registry Including Biosignal Database for Prognostication of Postoperative Renal Outcome: Cardiac Anesthesia Renal Outcome in Severance Cardiovascular Hospital - DataBase (CARS-DB)","Inclusion Criteria:\n\n* Aged 19 years and older scheduled for cardiac surgery using CPB\n\nExclusion Criteria:\n\n* emergency operation, the patient is foreigner or illiterate and unable to read the consent form","19 Years","90 Years",{"count":138,"type":21},10000,"AKI(Acute Kidney Injury) is a common complication after cardiac surgery which is associated with increased mortality and morbidity. Collecting perioperative biosignal data and studying their association with renal outcomes can help improve kidney injury, mortality, and morbidity in cardiac surgical patients. Furthermore, the occurrence of AKI, length of hospital stay, and recovery of renal function after discharge are closely associated with the development of chronic kidney disease (CKD). Therefore, regular monitoring of renal function and related indicators in cardiac surgical patients can help improve long-term outcomes.",[27],[142,143,65,144,145,146],"Acute Kidney Injury","Cardiovascular Surgical Procedures","Biomarker","Biosignal data","Renal outcome","2024-08-29",{"date":149,"type":42},"2024-09-03",{"date":151,"type":21},"2024-09",{"date":153,"type":21},"2034-09-30",{"name":155,"class":78},"Yonsei University",{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":16,"minAge":135,"maxAge":4,"enrollmentInfo":163,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":164,"conditions":165,"keywords":166,"overallStatus":170,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":50},"100426495","registry-of-cardioneurovascular-anesthesia-including-the-database-of-biological-signals-during-anesthesia-preoperative-assessment-and-prognosis-in-patients-100426495","NCT04833751","Registry of Cardio\u002FNeurovascular Anesthesia Including the Database of Biological Signals During Anesthesia, Preoperative Assessment and Prognosis in Patients","Registry of Cardiovascular Anesthesia Including the Database of Biological Signals During Anesthesia, Preoperative Assessment and Prognosis in Patients: Severance Cardiovascular Surgery Prospective (SECURE) Database","Inclusion Criteria:\n\n1. Adults age 19 and older\n2. Patients scheduled for anesthesia at a cardiovascular hospital for cardiovascular surgery or procedures\n\nExclusion Criteria:\n\n1\\) Emergency (surgery\u002Fprocedure room transfer within 1 hour of visit) where there is insufficient time for the subject (adult 19 years of age or older) or his\u002Fher representative (adult incapable of consent) to decide whether to participate in the study",{"count":138,"type":21},"The purpose of this study is to establish a registry database for patients undergoing anesthesia for cardiovascular surgery or procedures in our operating or hybrid room. The following information will be collected:\n\n1. Preoperative patient assessment\n2. All monitored perioperative biosignal data\n3. Intraoperative and immediate postoperative hemodynamic information, input\u002Foutput balance, and medication usage\n4. Short- and long-term prognosis from electronic medical records This database will be used to develop a vigilant monitoring system that integrates multiple biosignal data simultaneously, contributing to the improvement of anesthesia care.",[27],[167,145,168,143,169],"Cardiac Diseases","Cardiac Surgical Procedures","Heart Valve Prosthesis Implantation","RECRUITING","2024-07-22",{"date":173,"type":42},"2024-07-24",{"date":175,"type":42},"2018-12-14",{"date":177,"type":21},"2028-12-31",{"name":155,"class":78}]