[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiac-arrest-out-of-hospital\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiac-arrest-out-of-hospital":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,47,60,95,122,154,178,209,235,262,287,314,334,360,382,409],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100054239","pediatric-influence-of-cooling-duration-on-efficacy-in-cardiac-arrest-patients-p-icecap-100054239",false,"NCT05376267","Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)","Inclusion criteria:\n\n* Age 2 days to \\\u003C 18 years with corrected gestational age of at least 38 weeks\n* Chest compressions for at least 2 minutes\n* Coma or encephalopathy after resuscitation from Out-of-Hospital Cardiac Arrest (OHCA)\n* Requires continuous mechanical ventilation through endotracheal tube or tracheostomy\n* Definitive temperature control device initiated\n* Randomization within 6 hours of Return of Spontaneous Circulation (ROSC)\n* Informed consent from Legally Authorized Representative (LAR) including intent to maintain life support for 120 hours\n\nExclusion criteria:\n\n* Glasgow Coma Motor Score (GCMS) = 6\n* LAR does not speak English or Spanish\n* Duration of Cardiopulmonary Resuscitation (CPR) \\> 60 minutes\n* Severe hemodynamic instability with continuous infusion of epinephrine or norepinephrine of 2 micrograms per kilogram per minute (μg\u002Fkg\u002Fminute) or initiation of Extracorporeal membrane oxygenation (ECMO)\n* Pre-existing severe neurodevelopmental deficits with Pediatric Cerebral Performance Category (PCPC) =5 or progressive degenerative encephalopathy\n* Pre-existing terminal illness, unlikely to survive to one year\n* Cardiac arrest associated with brain, thoracic, or abdominal trauma\n* Active and refractory severe bleeding prior to randomization\n* Extensive burns or skin lesions incompatible with surface cooling\n* Planned early withdrawal of life support before 120 hours\n* Sickle cell anemia\n* Pre-existing cryoglobulinemia\n* Non-fatal drowning in ice covered water\n* Central nervous system tumor with ongoing chemotherapy\n* Previous enrollment in P-ICECAP trial\n* Prisoner\n* Chronic hypothermia\n* New post-cardiac arrest diabetes insipidus\n* Pregnancy","ALL","2 Days","17 Years",{"count":19,"type":20},900,"ESTIMATED","INTERVENTIONAL",[23],"NA","This is a multicenter trial to establish the efficacy of cooling and the optimal duration of induced hypothermia for neuroprotection in pediatric comatose survivors of cardiac arrest.\n\nThe study team hypothesizes that longer durations of cooling may improve either the proportion of children that attain a good neurobehavioral recovery or may result in better recovery among the proportion already categorized as having a good outcome.",[26,27,28],"Cardiac Arrest, Out-Of-Hospital","Hypothermia, Induced","Hypoxia-Ischemia, Brain",[30,31,32,33],"Bayesian Adaptive Clinical Trial","Hypothermia, therapeutic","Coma","Pediatric","RECRUITING","2026-07-10",{"date":37,"type":38},"2026-07-13","ACTUAL",{"date":40,"type":38},"2022-08-05",{"date":42,"type":20},"2028-03-31",{"name":44,"class":45},"University of Michigan","OTHER",62,{"id":48,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":49,"targetDuration":4,"studyType":21,"phases":50,"briefSummary":24,"conditions":51,"keywords":52,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":56,"completionDateStruct":57,"leadSponsor":58,"locationsCount":59},"100468168",{"count":19,"type":20},[23],[26,27,28],[30,31,32,33],"2026-06-03",{"date":55,"type":38},"2026-06-05",{"date":40,"type":38},{"date":42,"type":20},{"name":44,"class":45},61,{"id":61,"slug":62,"hasResults":11,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":11,"sex":15,"minAge":68,"maxAge":4,"enrollmentInfo":69,"targetDuration":4,"studyType":21,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":94},"100624099","phase-4-medical-treatment-in-idiopathic-ventricular-fibrillation-patients-100624099","NCT07405229","MEdical Treatment in Idiopathic Ventricular Fibrillation Patients","Investigation of RIsk Factors in Out-of-hospital-cardiac-arrest Patients, and MEdical Treatment in Idiopathic Ventricular Fibrillation Patients","RIME-IVF","Inclusion Criteria:\n\nResuscitated OHCA patients admitted to one of the participating hospitals.\n\n1. Age ≥18 years\n2. Suspected cardiac cause of cardiac arrest\n\nExclusion Criteria:\n\nOHCA patients\n\n1. With Ischemic heart disease.\n2. Obvious non-cardiac cause of cardiac arrest\n3. Congenital heart disease\n4. Do not speak or understand Danish\n5. Foreigners -","18 Years",{"count":70,"type":20},218,[72],"PHASE4","A person who has experienced a cardiac arrest with no apparent cause is at risk of having recurrent cardiac arrest. Hence an implantable cardioverter-defibrillator (ICD) is recommended on empirical grounds. Today, there is no uniform way of approaching prevention of recurrence in idiopathic ventricular fibrillation (IVF) patients, beside ICD implantation. Better reatment and risk stratification tools are needed Medical treatment in these patients has never been assessed systematically, but at least some patients with no apparent diagnosis are on betablocker treatment. It is not known if low-doselow dose betablocker treatment is beneficial in these patients.\n\nThis study investigates the effect of betablocker treatment to reduce arrhythmic burden in IVF patients.\n\nNo predictors for appropriate ICD therapy have been identified in patients with IVF. It is also explored if toxicological and\u002For genetic profiles, together with in depth machine learning simulation data on repolarization patterns from IVF-ECGs compared to controls, can be used as risk stratification tools.\n\nLastly, QOL in IVF patients and the impact of beta blocker treatment will be investigated.",[75,26],"Idiopathic Ventricular Fibrillation",[75,77,78,79,80,81,82,83,84],"IVF","cardiac arrest","beta-blocker","treatment","ventricular tachyarrhythmias","Risk markers","quality of life","QoL","2026-02-11",{"date":87,"type":38},"2026-02-12",{"date":89,"type":38},"2018-05-01",{"date":91,"type":20},"2035-12-31",{"name":93,"class":45},"Bo Gregers Winkel",2,{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":101,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":15,"minAge":68,"maxAge":103,"enrollmentInfo":104,"targetDuration":4,"studyType":106,"phases":4,"briefSummary":107,"conditions":108,"keywords":109,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":94},"100596102","prehospital-ecpr-in-moravia-silesia-region-100596102","NCT07041086","Prehospital ECPR in Moravia Silesia Region","Prehospital ECPR in Moravia Silesia Region - Assessing the Effectiveness, Feasibility and Time of ECPR by Simulating Connections and Real Interventions.","01-Pain","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Observed collapse and presumption of cardiac cause of cardiac arrest\n* Estimated age up to 70 years\n* Baseline rhythm of ventricular fibrillation or pulseless electrical activity (PEA)\n* Basic bystander cardiopulmonary resuscitation (CPR), \"bystander CPR\", telephone assisted CPR (TANR)\n\nExclusion Criteria:\n\n* Children or adults with estimated weight below 40 kg\n* Known major comorbidities of the patient suggesting low rehabilitation potential (e.g. chronic obstructive pulmonary disease (COPD) IV, malignancy in tertiary phase)","70 Years",{"count":105,"type":20},100,"OBSERVATIONAL","Cardiopulmonary resuscitation (CPR) for out-of-hospital cardiac arrest (OHCA) in specific cases could be improved by Extracorporeal membrane oxygenation (ECMO; ECPR). ECPR could be introduced in hospital after retrieval of an OHCA patient and also faster by implantation on scene. The aim is to verify the effectiveness of ECPR on scene in the Moravian-Silesian region.",[26],[110,111,112],"ECMO","Cardiac arrest","Cardiopulmonary resuscitation","2026-01-13",{"date":115,"type":38},"2026-01-15",{"date":117,"type":38},"2025-06-17",{"date":119,"type":20},"2028-12-31",{"name":121,"class":45},"University Hospital Ostrava",{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":128,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":15,"minAge":68,"maxAge":4,"enrollmentInfo":130,"targetDuration":132,"studyType":106,"phases":4,"briefSummary":133,"conditions":134,"keywords":139,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":153},"100437150","resuscitative-tee-collaborative-registry-100437150","NCT04972526","Resuscitative TEE Collaborative Registry","Evaluation of the Clinical Impact and Safety of Focused Transesophageal Echocardiography During Resuscitation of Critically Ill Patients in the Emergency Department and Intensive Care Settings","rTEECoRe","Inclusion Criteria:\n\n* Adult critically-ill patients who as part of their routine clinical care receive focused TEE in the emergency department of intensive care setting.\n\nExclusion Criteria:\n\n* Children (age under 18 years)\n* Vulnerable populations",{"count":131,"type":20},1000,"1 Month","The general objective of this study is to evaluate the clinical impact and safety of focused, point-of-care transesophageal echocardiography (TEE) used during the evaluation of critically-ill patients in the emergency and intensive care settings. The target population for this study are critically-ill patients over the age of 18 who as part of their routine clinical care are receiving a focused TEE.\n\nThe primary objective of this study is to determine the clinical impact and safety of TEE performed during the evaluation of critically-ill patients in the emergency department and intensive care settings.\n\nThe secondary objective(s) of this study are to characterize the use of this imaging modality in the subsets of critically-ill patients in shock and cardiac arrest; including but not limited to; description of the frequency of studies, clinical indications, clinician characteristics, echocardiography findings, timing of studies, procedure-related complications and patient outcomes.",[135,136,26,137,138],"Cardiac Arrest","Cardiac Arrest Circulatory","Shock","Hemodynamic Instability",[140,141,135,142,143],"Transesophageal Echocardiography","Resuscitation","Point-of-care Ultrasound","Focused Cardiac Ultrasound","2026-01-12",{"date":146,"type":38},"2026-01-14",{"date":148,"type":38},"2020-12-01",{"date":150,"type":20},"2027-12-15",{"name":152,"class":45},"University of Pennsylvania",1,{"id":155,"slug":156,"hasResults":11,"nctId":157,"briefTitle":158,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":161,"sex":15,"minAge":162,"maxAge":163,"enrollmentInfo":164,"targetDuration":166,"studyType":106,"phases":4,"briefSummary":167,"conditions":168,"keywords":169,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":176,"locationsCount":153},"100339491","cardiac-arrest-pursuit-trial-with-unique-registration-and-epidemiologic-surveillance-100339491","NCT03700203","Cardiac Arrest Pursuit Trial With Unique Registration and Epidemiologic Surveillance","CAPTURES","Inclusion Criteria:\n\n* 19 to 79 years old\n* Out-of-hospital-cardiac arrest providing resuscitation at the site and visiting the emergency department of the participating hospital or transporting from another hospital emergency room (EMS-treated OHCA)\n* The cardiac arrest event must not have been predicted for 24 hours before the incident\n\nExclusion Criteria:\n\n* People who do not consent to personal information and blood supply for research\n* Trauma, submersion, poisoning, hanging, suffocation, or other causes of external causes directly contribute to the cardiac arrest\n* Patients with a terminal condition known to have no further treatment plans due to malignancy, neurological disease, respiratory disease, rheumatic disease, hematologic disease, renal disease or infectious disease. The terminal condition had to be checked by a doctor or recorded in medical records.\n* \"Do not have a resuscitation\" card or record issued by a doctor.\n* Hospice setting at the time of acute cardiac arrest for terminal illness or other reasons.\n* pregnant patient\n* With a family cannot provide information about patient\n* Without a family\n* Patients who were transported after admission at the other hospital\n* Foreign patients",true,"19 Years","79 Years",{"count":165,"type":20},5340,"12 Months","Identification of Causes and Risk Factors for Out-of-Hospital Cardiac Arrest through Development of Prediction Model and Novel Biomarkers\n\nStudy Objectives:\n\n1. To identify causes and risk factors of OHCA incidence that are associated with chronic diseases and health behaviors\n2. To identify high risk population for OHCA incidence through development of a prediction model\n3. To develop novel biomarkers associated with OHCA incidence, survival, and disabilities",[26],[135],"2026-01-04",{"date":172,"type":38},"2026-01-07",{"date":174,"type":38},"2017-09-07",{"date":119,"type":20},{"name":177,"class":45},"Seoul National University Hospital",{"id":179,"slug":180,"hasResults":11,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":184,"eligibilityCriteria":185,"healthyVolunteers":11,"sex":15,"minAge":68,"maxAge":4,"enrollmentInfo":186,"targetDuration":4,"studyType":21,"phases":188,"briefSummary":189,"conditions":190,"keywords":194,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":208},"100349185","phase-4-epinephrine-dose-optimal-versus-standard-evaluation-trial-100349185","NCT03826524","Epinephrine Dose: Optimal Versus Standard Evaluation Trial","CanROC Epinephrine Dose: Optimal Versus Standard Evaluation Trial (CanROC EpiDOSE Trial)","EpiDOSE","Inclusion Criteria:\n\n* Out-of-hospital cardiac arrest treated by paramedics\n* Initial recorded cardiac rhythm of VF or pulseless VT, or, AED shock on first analysis administered or witnessed by EMS (paramedic or fire)\n* Established intravenous vascular access\n\nExclusion Criteria:\n\n* Known or apparent age \\\u003C18 years\n* Initial recorded cardiac rhythm of VF or pulseless VT, or, AED shock on first analysis administered or confirmed by paramedics\n* Cardiac arrest due to an obvious non-cardiac primary cause (e.g. blunt or penetrating trauma, exsanguination, burns, drug overdose, drowning, anaphylaxis, sudden asphyxiation, etc.)\n* Administration of intramuscular, endotracheal tube, or intraosseous epinephrine\n* Prisoners or persons in police custody\n* Known allergy or sensitivity to epinephrine",{"count":187,"type":20},3790,[72],"The objective of this randomized controlled trial is to evaluate the effectiveness of a low cumulative dose of epinephrine compared to a standard cumulative dose of epinephrine during resuscitation from ventricular fibrillation (VF) or ventricular tachycardia (VT) in adult out-of-hospital cardiac arrest (OHCA) patients.",[26,191,192,193],"Sudden Cardiac Arrest","Ventricular Fibrillation","Ventricular Tachycardia-Pulseless",[195,196,197,198],"out-of-hospital cardiac arrest","sudden cardiac arrest","epinephrine","randomized controlled trial","2025-12-09",{"date":201,"type":38},"2025-12-11",{"date":203,"type":38},"2023-05-24",{"date":205,"type":20},"2028-12",{"name":207,"class":45},"Unity Health Toronto",8,{"id":210,"slug":211,"hasResults":11,"nctId":212,"briefTitle":213,"officialTitle":213,"acronym":214,"eligibilityCriteria":215,"healthyVolunteers":11,"sex":15,"minAge":68,"maxAge":4,"enrollmentInfo":216,"targetDuration":4,"studyType":21,"phases":218,"briefSummary":220,"conditions":221,"keywords":223,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":234},"100476362","phase-2-cardiopulmonary-resuscitation-with-argon-cpar-trial-100476362","NCT05482945","CardioPulmonary Resuscitation With Argon (CPAr) Trial","CPAr","Inclusion Criteria:\n\n* ICU admission after resuscitation from witnessed non-traumatic out-of-hospital cardiac arrest (OHCA) of presumably cardiac etiology with a presenting shockable rhythm;\n* age ≥ 18 years;\n* unconsciousness after return of spontaneous circulation (ROSC);\n* duration of CPR ≤ 40 mins;\n* initiation of study intervention ≤ 4 hrs from ROSC;\n* stable SaO2 ≥ 94% with a FiO2 of 30%.\n\nExclusion Criteria:\n\n* Non-witnessed CA;\n* CA of traumatic origin or from a non-presumably cardiac cause;\n* CA with a non-shockable presenting rhythm (pulseless electrical activity and asystole);\n* female of childbearing potential defined as younger of 50 years;\n* pregnancy;\n* known terminal illness;\n* pre-CA cerebral performance category (CPC) ≥ 3;\n* initiation of the study intervention \\> 4 hrs from ROSC;\n* participation to another clinical trial",{"count":217,"type":20},120,[219],"PHASE2","Preclinical studies suggest that argon (Ar) might diminish the neurological and myocardial damage after any hypoxic-ischemic insult. Indeed, Ar has been tested in different models of ischemic insult, at concentrations ranging from 20% up to 80%. Overall, Ar emerged as a protective agent on cells, tissues and organs, showing less cell death, reduced infarct size and faster functional recovery. More specifically, encouraging data has been reported in animal studies on cardiac arrest (CA) in which a better and faster neurological recovery was achieved when Ar was used in the post-resuscitation ventilation. More importantly, these benefits have been replicated in different studies, enrolling both small and large animals. Finally, ventilation with Ar in O2 has been demonstrated to be safe both in animals and humans. Based on this evidence, a clinical translation is advocated. Thus, the CardioPulmonary resuscitation with Argon - CPAr trial has been conceived. The trial initially started as phase I-II trial to specifically address the question about the safety of the post resuscitation Ar-treatment. The available data on the first 30 randomized patients, evaluated by the Data Safety Monitoring Board (DSMB), were considered absolutely reassuring with regard to the safety of the experimental treatment. In this perspective, the DSMB supported the continuation of the study as a phase II trial, maintaining the study protocol in all its aspects. Thus, the aim of the CPAr trial is now to evaluate efficacy in reducing post-CA neurological injury of Ar\u002FO2 ventilation in patients resuscitated from CA.",[26,222],"Cardiac Arrest With Successful Resuscitation",[224],"Cardiac arrest; Cardiopulmonary resuscitation; Argon.","2025-09-11",{"date":227,"type":38},"2025-09-17",{"date":229,"type":38},"2022-05-30",{"date":231,"type":20},"2026-06-30",{"name":233,"class":45},"Mario Negri Institute for Pharmacological Research",9,{"id":236,"slug":237,"hasResults":11,"nctId":238,"briefTitle":239,"officialTitle":239,"acronym":240,"eligibilityCriteria":241,"healthyVolunteers":11,"sex":15,"minAge":68,"maxAge":4,"enrollmentInfo":242,"targetDuration":4,"studyType":106,"phases":4,"briefSummary":244,"conditions":245,"keywords":247,"overallStatus":252,"whyStopped":4,"lastUpdateSubmitDate":253,"lastUpdatePostDateStruct":254,"startDateStruct":256,"completionDateStruct":258,"leadSponsor":260,"locationsCount":4},"100575086","aid-omie---artificial-intelligence-in-detection-of-occlusive-myocardial-infarction-in-emergency-medicine-100575086","NCT06767709","AID-OMIE - Artificial Intelligence in Detection of Occlusive Myocardial Infarction in Emergency Medicine","AID-OMIE","Inclusion Criteria:\n\n* OHCA from with ROSC in the Province of Bolzano, Italy\n* Coronary angiography (CAG) within 7 days post-OHCA\n* Age \\> 18 years\n* Available prehospital post-ROSC ECG\n* Available CAG report\n\nExclusion Criteria:\n\n* In-Hospital Cardiac Arrest (IHCA)\n* Age \\\u003C 18 years\n* Traumatic cardiac arrest\n* Cardiac arrest from a clear non-cardiac cause\n* Corrupted ECG images\n* Poor ECG digitalization quality",{"count":243,"type":20},200,"Study Objective and Hypothesis The study hypothesizes that artificial intelligence (AI)-assisted interpretation of the 12-lead electrocardiogram (ECG) can improve the care of patients resuscitated after out-of-hospital cardiac arrest (OHCA) by enabling faster and more accurate detection of occlusion myocardial infarction (OMI). This enhanced diagnostic approach could reduce the time required for revascularization, improve patient outcomes, and decrease unnecessary activations of cardiac catheterization laboratories. The primary objective of the study is to assess the effectiveness of an AI-powered ECG model in identifying acute OMI in OHCA patients whose post-return of spontaneous circulation (ROSC) ECG does not show ST-elevation.\n\nMethods\n\nThis is a retrospective observational study involving OHCA patients in Bolzano, Italy, who meet the following inclusion criteria:\n\nAged 18 years or older. Achieved ROSC after cardiac arrest. Underwent coronary angiography (CAG) within seven days post-OHCA. Prehospital post-ROSC ECG and CAG reports available.\n\nExclusion criteria include in-hospital cardiac arrest (IHCA), traumatic cardiac arrest, cardiac arrest from a non-cardiac cause, and poor-quality or corrupted ECG images. Post-ROSC ECGs will be analyzed using the PMcardio App, an AI tool for ECG interpretation. The data will be fully anonymized before storage. Coronary angiography charts will be reviewed for the presence of atherosclerotic lesions, the degree of arterial narrowing, and Thrombolysis in Myocardial Infarction (TIMI) flow, which assesses blood flow in coronary arteries.\n\nStudy Outcomes The primary outcome is the sensitivity and specificity of the AI-assisted ECG in detecting OMI in patients whose post-ROSC ECG does not show ST-elevation. Secondary outcomes include the frequency of OMI in OHCA patients without ST-elevation and the ability of the AI model to rule out OMI accurately in these cases.",[26,246],"Cardiac Arrest Due to Underlying Cardiac Condition",[111,248,249,250,251],"OHCA","Occlusion myocardial infarction","OMI","Artificial intelligence","NOT_YET_RECRUITING","2025-08-05",{"date":255,"type":38},"2025-08-08",{"date":257,"type":20},"2025-09-01",{"date":259,"type":20},"2026-05-31",{"name":261,"class":45},"Institute of Mountain Emergency Medicine",{"id":263,"slug":264,"hasResults":11,"nctId":265,"briefTitle":266,"officialTitle":266,"acronym":4,"eligibilityCriteria":267,"healthyVolunteers":11,"sex":15,"minAge":68,"maxAge":4,"enrollmentInfo":268,"targetDuration":4,"studyType":106,"phases":4,"briefSummary":270,"conditions":271,"keywords":272,"overallStatus":252,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":286},"100561253","late-biomarkers-in-adult-survivors-after-out-of-hospital-cardiac-arrest-100561253","NCT06587763","Late Biomarkers in Adult Survivors After Out-of-hospital Cardiac Arrest","Inclusion Criteria:\n\n* Survivors of out-of-cardiac arrest who participate in the extended follow-up study of the STEPCARE trial at selected sites only\n\nExclusion Criteria:\n\n* Patients not participating in the extended follow-up at participating sites",{"count":269,"type":20},400,"Blood samples are collected at six months follow-up from adult survivors after out-of-hospital cardiac arrest. Patients will be informed about the study and if they consent to participation, venous blood will be drawn by authorised medical personnel. Plasma, serum and PAX-RNA will be collected (ca 15 ml in total), processed and frozen for analysis after trial completion.",[26],[273,274,275,276],"Biomarkers","Brain injury","Inflammation","Dementia","2025-06-23",{"date":279,"type":38},"2025-06-27",{"date":281,"type":20},"2025-10-01",{"date":283,"type":20},"2032-12-31",{"name":285,"class":45},"Region Skane",3,{"id":288,"slug":289,"hasResults":11,"nctId":290,"briefTitle":291,"officialTitle":291,"acronym":292,"eligibilityCriteria":293,"healthyVolunteers":11,"sex":15,"minAge":68,"maxAge":4,"enrollmentInfo":294,"targetDuration":4,"studyType":106,"phases":4,"briefSummary":295,"conditions":296,"keywords":297,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":312,"locationsCount":234},"100595001","validity-of-icu-clinicians-appraisal-of-proportionality-in-cpr-100595001","NCT07026773","Validity of ICU Clinician's Appraisal of Proportionality in CPR","VICAP-CPR","Inclusion Criteria:\n\n* Doctors and nurses working in the Intensive Care Unit treating patients included in the STEPCARE study (NCT 05564754)\n\nExclusion Criteria:\n\n* Doctors and nurses who do not have a direct treatment relationship with a patient included in the STEPCARE study",{"count":131,"type":20},"The VICAP-CPR study investigates whether doctors and nurses working in Intensive Care can determine neurological outcome and future quality of life after six months in patients treated for cardiac arrest outside the hospital based on clinical assessment in the first 24 hours after admission to Intensive Care. To conduct this study, the results of the questionnaire offered to Intensive Care doctors and nurses regarding the estimation of long-term neurological outcome and quality of life will be compared with the neurological outcome and quality of life as recorded in the STEPCARE study (NCT 05564754). The aim of the international STEPCARE study is to determine the best combination of post-resuscitation care to favourably influence survival and neurological outcome in patients treated for cardiac arrest outside hospital.",[26],[78,195,298,299,300,301,302,303,83,304],"cardiopulmonary resuscitation","appropriateness of care","frailty","perception","prognostication","outcome","Intensive Care","2025-06-10",{"date":307,"type":38},"2025-06-18",{"date":309,"type":38},"2025-05-18",{"date":311,"type":20},"2026-12-30",{"name":313,"class":45},"University Hospital, Ghent",{"id":315,"slug":316,"hasResults":11,"nctId":317,"briefTitle":318,"officialTitle":318,"acronym":4,"eligibilityCriteria":319,"healthyVolunteers":11,"sex":15,"minAge":68,"maxAge":4,"enrollmentInfo":320,"targetDuration":322,"studyType":106,"phases":4,"briefSummary":323,"conditions":324,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":325,"lastUpdatePostDateStruct":326,"startDateStruct":328,"completionDateStruct":330,"leadSponsor":332,"locationsCount":153},"100484436","international-device-assisted-controlled-sequential-elevation-cpr-registry-100484436","NCT05588024","International Device Assisted Controlled Sequential Elevation CPR Registry","Inclusion Criteria\n\n1. Patient is at least 18 years of age\n2. Patient is in active cardiac arrest, as defined by presence of either ventricular fibrillation or ventricular tachycardia, or pulseless electrical activity, or asystole at time of enrollment.\n3. Patient receives either a) active-compression decompression cardiopulmonary resuscitation b) automated suction-cup based CPR with an impedance threshold device (ITD) c) manual CPR with an ITD\n4. Subject receives device assisted controlled elevation of the head and thorax.\n\nExclusion Criteria\n\n1\\. Prisoners",{"count":321,"type":20},5000,"30 Days","The purpose of this prospective observational cardiopulmonary resuscitation (CPR) registry is to track the use and clinical outcomes from emergency medical systems across the US and Europe that have implemented a system of care approach applied rapidly to cardiac arrest that includes using the combination of an impedance threshold device (ITD), and either manual active compression-decompression (ACD) CPR device or automated compression device, with a Head Up CPR device.",[26],"2025-06-09",{"date":327,"type":38},"2025-06-12",{"date":329,"type":38},"2020-03-23",{"date":331,"type":20},"2027-06",{"name":333,"class":45},"Hennepin Healthcare Research Institute",{"id":335,"slug":336,"hasResults":11,"nctId":337,"briefTitle":338,"officialTitle":339,"acronym":4,"eligibilityCriteria":340,"healthyVolunteers":161,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":341,"targetDuration":4,"studyType":21,"phases":343,"briefSummary":344,"conditions":345,"keywords":346,"overallStatus":252,"whyStopped":4,"lastUpdateSubmitDate":351,"lastUpdatePostDateStruct":352,"startDateStruct":354,"completionDateStruct":356,"leadSponsor":358,"locationsCount":153},"100509059","gathering-evidence-on-best-practices-for-lay-rescuer-cpr-training-100509059","NCT05908500","Gathering Evidence on Best Practices for Lay Rescuer CPR Training","Generating Evidence to Optimize Lay Rescuer Cardiopulmonary Resuscitation (CPR) Training: a Longitudinal Study of Frequency, Modality, and Design Features Impacting Skill Retention","Inclusion Criteria:\n\n* All students at participating schools\n\nExclusion Criteria:\n\n* Previous CPR training (will be included in the CPR training but excluded from analysis)\n* Physical injury which prevents performing CPR\n* Student or parent opt-out",{"count":342,"type":20},2100,[23],"The goal of this prospective trial is to compare CPR skill and attitudes in lay rescuers. The main question\\[s\\] it aims to answer are:\n\n* What is the optimal training timing, duration, and frequency for lay rescuers that leads to CPR skill retention?\n* What is the impact of CPR manikin type (high-fidelity, inflatable, nontraditional objects) on skill retention?\n* How do specific features of training modality -- such as contextualization, gamification, and emotional engagement -- impact skill proficiency, knowledge retention, and attitudes about CPR?\n\nParticipants will\n\n* Answer pre-training questionnaires\n* Participate in CPR training\n* Participate in CPR skills testing\n* Answer post-training questionnaires\n\nResearchers will compare different methods of training, different frequencies of training, and different manikin types.",[26],[347,348,349,350],"Cardiopulmonary Resuscitation","cardiopulmonary resuscitation training","Lay Rescuer cardiopulmonary resuscitation","lay rescuer cardiopulmonary resuscitation training","2025-05-29",{"date":353,"type":38},"2025-06-04",{"date":355,"type":20},"2026-04-01",{"date":357,"type":20},"2031-03-31",{"name":359,"class":45},"University of Nevada, Reno",{"id":361,"slug":362,"hasResults":11,"nctId":363,"briefTitle":364,"officialTitle":365,"acronym":366,"eligibilityCriteria":367,"healthyVolunteers":11,"sex":15,"minAge":68,"maxAge":368,"enrollmentInfo":369,"targetDuration":4,"studyType":106,"phases":4,"briefSummary":371,"conditions":372,"keywords":4,"overallStatus":252,"whyStopped":4,"lastUpdateSubmitDate":373,"lastUpdatePostDateStruct":374,"startDateStruct":376,"completionDateStruct":378,"leadSponsor":380,"locationsCount":153},"100562475","evaluation-of-updated-procedure-for-management-of-refractory-out-of-hospital-cardiac-arrests-100562475","NCT06603649","Evaluation of Updated Procedure for Management of Refractory Out-of-hospital Cardiac Arrests","Evaluation of the Updated Procedure for the Management of Refractory Out-of-hospital Cardiac Arrests with SAMU 54 : the Revised ACEP Protocol in 02\u002F2024","ACEP-V2","Inclusion Criteria:\n\n* Out-of-hospital cardiac arrest\n* enrolled in the ECPR program\n* 18 years old or more\n* Low-flow estimated \\\u003C60minutes\n\nExclusion Criteria:\n\n* traumatic cardiac arrest\n* major comorbidities","65 Years",{"count":370,"type":20},150,"ECPR is a technique that has been rapidly developed in many cardiac arrest specialized centers In 2013, a specific management protocol was developed for patients in refractory out-of-hospital cardiac arrest around Nancy, France. To select patients with the best prognosis, the inclusion criteria defined were strict. This led to an over-selection of patients and a significant reduction in the number of eligible patients. A balance needed to be struck between over-selecting patients and maintaining the expertise of medical and paramedical teams in the field. In addition, it has also been shown that ECPR also increases the number of organs and transplants.\n\nIn February 2024, the criteria for inclusion in the protocol were redefined to include any witnessed non-traumatic cardiac arrest, whatever the initial rhythm. This simplification should enable more patients to be included in the procedure.\n\nThe aim of the study is to assess the patient's outcome",[26],"2024-09-16",{"date":375,"type":38},"2024-09-19",{"date":377,"type":20},"2024-10-01",{"date":379,"type":20},"2030-12-31",{"name":381,"class":45},"Central Hospital, Nancy, France",{"id":383,"slug":384,"hasResults":11,"nctId":385,"briefTitle":386,"officialTitle":387,"acronym":388,"eligibilityCriteria":389,"healthyVolunteers":11,"sex":15,"minAge":68,"maxAge":4,"enrollmentInfo":390,"targetDuration":4,"studyType":21,"phases":392,"briefSummary":393,"conditions":394,"keywords":397,"overallStatus":252,"whyStopped":4,"lastUpdateSubmitDate":400,"lastUpdatePostDateStruct":401,"startDateStruct":403,"completionDateStruct":405,"leadSponsor":407,"locationsCount":153},"100557390","synergy-of-elevation-of-the-head-and-thorax-and-reboa-during-out-of-hospital-cardiac-arrest-100557390","NCT06537492","Synergy of Elevation of the Head and Thorax and REBOA During Out-of-Hospital Cardiac Arrest","Synergy of Elevation of the Head and Thorax and Resuscitative Endovascular Balloon Occlusion of the Aorta During Out-of-Hospital Cardiac Arrest: a Pilot Study","GRAVITY2","Inclusion Criteria:\n\n* Patient with age over or equal to 18 years old\n* Patient with a witnessed medical cardiac arrest and with a no-flow duration under 10 min\n* Patient with EtCO2 greater than 20 mmHg at REBOA team arrival\n* Patient located in the Grenoble Metropolitan area\n* Patient affiliated to French social security\n\nExclusion Criteria:\n\n* Patient with ROSC before REBOA placement.\n* Patient eligible to extracorporeal life support (according to local guidelines).\n* CA of traumatic origin (including drowning or hanging).\n* Patients whose size is not adapted to the LUCAS device: height of the sternum from 170 to 303 mm or maximum chest width of 449 mm. The use of the LUCAS device is not subject to a patient weight condition.\n* Cardiac arrest for which resuscitation seems unjustified (inevitable death, terminally ill irreversible condition, too long duration of cardiac arrest, advance personal directives of no-resuscitation).\n* Obvious pregnancy at inclusion.\n* Subject in a period of exclusion from another clinical investigation.\n* Patients with a femoral arterial access site that cannot accommodate an 8 Fr (minimum) introduces sheath",{"count":391,"type":20},35,[23],"Long-term neurological outcome after successful resuscitation of cardiac arrest remains poor, mainly due to cerebral hypoperfusion and severe hypoxic-ischemic brain injuries. Automated head and chest elevation during cardiopulmonary resuscitation (AHUP-CPR) improves cerebral perfusion by decreasing the intracranial pressure and increasing cerebral perfusion in experimental pig studies. The addition of an impedance threshold device (ITD) and active chest compression-decompression device (ACD) improved hemodynamics and cerebral perfusion. In addition, early implementation of AHUP-CPR in patients with out-of-hospital cardiac arrest (OHCA) was associated with improved survival to hospital discharge, in a multicenter observational study. A 2-year prospective clinical trial in Grenoble evaluating this combination was just completed. This study showed for the first time that the value of end-tidal CO2 (EtCO2), a surrogate for cardiopulmonary resuscitation (CPR) quality and cardiac output, measured with this combination therapy, was significantly higher than with standard CPR.\n\nResuscitative endovascular balloon occlusion of the aorta (REBOA) has recently been proposed during CPR. This technique temporarily diverts blood flow to the coronary and cerebral circulation. Its beneficial effect on hemodynamics, cerebral blood flow and survival has been experimentally validated. In several feasibility studies, encouraging results were observed by slightly optimizing cerebral perfusion and coronary pressure when REBOA was used in combination with standard CPR.\n\nIn a porcine model of cardiac arrest, the addition of REBOA to AHUP CPR was associated with a marked improvement in coronary perfusion pressure and near-normalization of cerebral perfusion pressure. These two interventions act synergistically. REBOA directs flow and pressure to the heart and brain, while AHUP CPR improves preload on the right side of the heart and reduces intracranial pressure.\n\nThe aims of this clinical investigation are to assess the feasibility of placing a REBOA catheter combined with automated CPR with head and chest elevation, and to quantify the associated changes in clinical parameters for OHCA.",[395,26,396,347],"Heart Arrest","Cardiopulmonary Arrest",[398,399],"Resuscitative endovascular balloon","Head-up cardiopulmonary resuscitation","2024-07-31",{"date":402,"type":38},"2024-08-05",{"date":404,"type":20},"2024-10",{"date":406,"type":20},"2026-01",{"name":408,"class":45},"University Hospital, Grenoble",{"id":410,"slug":411,"hasResults":11,"nctId":412,"briefTitle":413,"officialTitle":414,"acronym":4,"eligibilityCriteria":415,"healthyVolunteers":11,"sex":15,"minAge":68,"maxAge":4,"enrollmentInfo":416,"targetDuration":4,"studyType":106,"phases":4,"briefSummary":418,"conditions":419,"keywords":420,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":430,"lastUpdatePostDateStruct":431,"startDateStruct":433,"completionDateStruct":435,"leadSponsor":437,"locationsCount":153},"100553830","pulse-checks-using-femoral-artery-b-mode-ultrasound-with-compressibility-assessment-100553830","NCT06491186","Pulse Checks Using Femoral Artery B-Mode Ultrasound With Compressibility Assessment","Femoral Artery Ultrasound With Compressibility Assessment as a Method for Pulse Checks in Out-of-Hospital Cardiac Arrest: A Prospective Exploratory Study.","Inclusion Criteria:\n\n* Out-of-hospital cardiac arrest treated by EMS\n* Minimum age of 18 years\n\nExclusion Criteria:\n\n* Pregnancy or suspected pregnancy\n* Disapproval of the treating EMS team\n* Adults under legal guardianship\n* Inability to perform femoral artery doppler ultrasound due to limited access to the patient and possible interference with the treating EMS team\n* Inability to perform femoral artery doppler ultrasound due to injuries or anatomic abnormalities in the femoral region or necessary emergent medical interventions in the femoral region\n* Decision to transfer the patient to the hospital with ongoing CPR for emergent procedures such as extracorporeal CPR before femoral artery doppler ultrasound could be attempted\n* Inability to safely perform femoral artery doppler ultrasound due to environmental hazards",{"count":417,"type":20},69,"The goal of this prospective observational study is to investigate B-mode point-of care ultrasound with arterial compressibility assessment on the femoral artery as a method to determine the presence of a pulse and to compare it with concurrently conducted manual pulse checks.",[26],[135,421,248,422,423,424,425,426,427,428,429],"Out-of-hospital Cardiac Arrest","Ultrasound","Point-Of-Care Ultrasound","POCUS","Pulse Check","POCUS Pulse Check","B-mode Ultrasound","Femoral Artery","Arterial Compressibility Assessment","2024-06-29",{"date":432,"type":38},"2024-07-09",{"date":434,"type":38},"2024-05-02",{"date":436,"type":20},"2024-12-31",{"name":438,"class":45},"Medical University of Vienna"]