[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiac-arrest-with-successful-resuscitation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiac-arrest-with-successful-resuscitation":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,43,73,99],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100476362","phase-2-cardiopulmonary-resuscitation-with-argon-cpar-trial-100476362",false,"NCT05482945","CardioPulmonary Resuscitation With Argon (CPAr) Trial","CPAr","Inclusion Criteria:\n\n* ICU admission after resuscitation from witnessed non-traumatic out-of-hospital cardiac arrest (OHCA) of presumably cardiac etiology with a presenting shockable rhythm;\n* age ≥ 18 years;\n* unconsciousness after return of spontaneous circulation (ROSC);\n* duration of CPR ≤ 40 mins;\n* initiation of study intervention ≤ 4 hrs from ROSC;\n* stable SaO2 ≥ 94% with a FiO2 of 30%.\n\nExclusion Criteria:\n\n* Non-witnessed CA;\n* CA of traumatic origin or from a non-presumably cardiac cause;\n* CA with a non-shockable presenting rhythm (pulseless electrical activity and asystole);\n* female of childbearing potential defined as younger of 50 years;\n* pregnancy;\n* known terminal illness;\n* pre-CA cerebral performance category (CPC) ≥ 3;\n* initiation of the study intervention \\> 4 hrs from ROSC;\n* participation to another clinical trial","ALL","18 Years",{"count":19,"type":20},120,"ESTIMATED","INTERVENTIONAL",[23],"PHASE2","Preclinical studies suggest that argon (Ar) might diminish the neurological and myocardial damage after any hypoxic-ischemic insult. Indeed, Ar has been tested in different models of ischemic insult, at concentrations ranging from 20% up to 80%. Overall, Ar emerged as a protective agent on cells, tissues and organs, showing less cell death, reduced infarct size and faster functional recovery. More specifically, encouraging data has been reported in animal studies on cardiac arrest (CA) in which a better and faster neurological recovery was achieved when Ar was used in the post-resuscitation ventilation. More importantly, these benefits have been replicated in different studies, enrolling both small and large animals. Finally, ventilation with Ar in O2 has been demonstrated to be safe both in animals and humans. Based on this evidence, a clinical translation is advocated. Thus, the CardioPulmonary resuscitation with Argon - CPAr trial has been conceived. The trial initially started as phase I-II trial to specifically address the question about the safety of the post resuscitation Ar-treatment. The available data on the first 30 randomized patients, evaluated by the Data Safety Monitoring Board (DSMB), were considered absolutely reassuring with regard to the safety of the experimental treatment. In this perspective, the DSMB supported the continuation of the study as a phase II trial, maintaining the study protocol in all its aspects. Thus, the aim of the CPAr trial is now to evaluate efficacy in reducing post-CA neurological injury of Ar\u002FO2 ventilation in patients resuscitated from CA.",[26,27],"Cardiac Arrest, Out-Of-Hospital","Cardiac Arrest With Successful Resuscitation",[29],"Cardiac arrest; Cardiopulmonary resuscitation; Argon.","RECRUITING","2025-09-11",{"date":33,"type":34},"2025-09-17","ACTUAL",{"date":36,"type":34},"2022-05-30",{"date":38,"type":20},"2026-06-30",{"name":40,"class":41},"Mario Negri Institute for Pharmacological Research","OTHER",9,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100593685","optimization-of-transport-and-use-of-a-mobile-ecmo-team-in-patients-with-sudden-cardiac-arrest-in-the-moravian-silesian-region-100593685","NCT07009652","Optimization of Transport and Use of a Mobile ECMO Team in Patients With Sudden Cardiac Arrest in the Moravian-Silesian Region","Proposal for the Organisation of the Procedure for Extracorporeal Cardiopulmonary Resuscitation of Patients With Sudden Cardiac Arrest in the Pre-hospital Environment of the Moravian-Silesian Region","Inclusion Criteria:\n\n* out-of-hospital cardiac arrest\n* indication for ECPR\n\nExclusion Criteria:\n\n* death at the scene of the accident\n* withdrawal of the informed consent","3 Years","60 Years",{"count":53,"type":20},100,"OBSERVATIONAL","This study evaluates the feasibility of implementing a mobile extracorporeal membrane oxygenation (ECMO) team and optimizing patient transport logistics.",[27,57],"Cardiac Arrest, Cause Unspecified",[59,60,61,62],"cardiac arrest","extracorporeal membrane oxygenation","out-of-hospital cardiac arrest","extracorporeal cardiopulmonary resuscitation","2025-05-29",{"date":65,"type":34},"2025-06-06",{"date":67,"type":34},"2025-05-01",{"date":69,"type":20},"2028-05-01",{"name":71,"class":41},"University Hospital Ostrava",2,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":21,"phases":82,"briefSummary":84,"conditions":85,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":98},"100532064","stepcare-extended-follow-up-substudy-100532064","NCT06207942","Stepcare Extended Follow-up Substudy","Extended Follow-up Substudy of the Sedation, Temperature and Pressure After Cardiac Arrest and Resuscitation -STEPCARE Trial","All OHCA participants randomized in the STEPCARE trial at the extended follow-up participating sites, who survive and provide consent, with no further inclusion or exclusion criteria.\n\nThe inclusion and exclusion criteria for the STEPCARE trial are:\n\n* Inclusion criteria: out-of-hospital cardiac arrest of non-traumatic origin, minimum of 20 minutes without chest compressions (defined as stable return of spontaneous circulation. ROSC), unconsciousness (defined as not being able to obey verbal commands equal to a FOUR-score motor response of \\\u003C4, or being intubated and sedated because of agitation after sustained ROSC, eligible for intensive care without restrictions or limitation, inclusion within 4 hours (240 minutes) of ROSC (or 220 minutes of stable ROSC).\n* Exclusion criteria: on ECMO prior to randomization, pregnancy, suspected or confirmed intracranial hemorrhage, previously randomized in the STEPCARE trial.\n\nFor caregivers, the eligibility will be that they live with, or have weekly or more frequent contact (in person or over the telephone) with the post OHCA survivor. Only one nominated caregiver per post OHCA survivor will be able to be included in the study. This would typically be the caregiver that would identify as the primary caregiver of the post OHCA survivor if needed, but may also be another close family member.",{"count":81,"type":20},600,[83],"NA","To provide detailed information on long-term outcomes in relation to potential neuroprotection and improvements in recovery for different targets of sedation, temperature, and pressure management in post out of hospital cardiac arrest survivors at 6 and 12 months. In addition, the impact of caring for a post OHCA survivor will be explored.",[27,86,87,88],"Hypoxia, Brain","Cognitive Impairment","Caregiver Burden","2025-04-17",{"date":91,"type":34},"2025-04-23",{"date":93,"type":34},"2023-08-01",{"date":95,"type":20},"2027-07-31",{"name":97,"class":41},"Region Skane",34,{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":124},"100551968","study-of-ventilator-associated-event-during-intensive-care-after-resuscitated-cardiac-arrest-100551968","NCT06466980","Study of Ventilator Associated Event During Intensive Care After Resuscitated Cardiac Arrest.","VAE-ACR","Inclusion Criteria:\n\n* Adult male or female\n* Non-pregnant female\n* Successfully resuscitated from cardiac arrest during primary care\n* Invasive mechanical ventilation initiated during resuscitation and continued for at least 4 days\n* No decision to limit life-sustaining therapies within 24 hours following admission to intensive care\n* No requirement of arteriovenous circulatory support during intensive care management\n\nExclusion Criteria\n\n\\- patients who opposed to the use of their data",{"count":107,"type":20},150,"The aim is to describe the incidence, characteristics, risk factors and outcome of complications acquired under mechanical ventilation (called ventilator-associated events) according to the new CDC criteria, in a population of patients admitted in intensive care unit after cardiac arrest.",[27,110],"Mechanical Ventilation",[112,59,113,114],"Ventilator associated event","ventilator-acquired pneumonia","ventilator associated pneumonia","2025-03-12",{"date":117,"type":34},"2025-03-14",{"date":119,"type":34},"2024-06-27",{"date":121,"type":20},"2025-12-31",{"name":123,"class":41},"Centre Hospitalier Sud Francilien",1]