[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiac-arrest\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiac-arrest":32},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,75,0,25,[9,52,85,108,129,157,178,217,242,267,293,315,341,365,398,426,448,474,499,520,547,568,596,622,644],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":35,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100524838","phase-4-prevention-of-infection-of-the-respiratory-tract-through-application-of-non-invasive-methods-of-secretion-suctioning-100524838",false,"NCT06113939","Prevention of Infection of the Respiratory Tract Through Application of Non-Invasive Methods of Secretion Suctioning","Prevention of Infection of the Respiratory Tract by Applying Methods That Are Non-Invasive for Extraction of Secretions. An Open Label, Randomized, Assessor-blinded, Pilot Trial.","PIRAMIDES","Inclusion criteria\n\n1. Endotracheal intubation with an anticipated duration \\> 48 hours.\n2. High risk of early respiratory infection associated with a diagnosis of:\n\n   1. Severe trauma.\n   2. Severe traumatic brain injury.\n   3. Ischaemic or haemorrhagic stroke.\n   4. Other causes of impaired consciousness: post-resuscitated cardiac arrest status, intoxications, acute infections or diseases of the central nervous system, seizures.\n3. Informed consent signed by the patient or, when impossible due to clinical status, by their legal representative, with re-consent by the patients themselves upon regaining capacity (section 15).\n\nExclusion criteria\n\n1. Intubation with an anticipated duration \\\u003C 48 hours.\n2. Foreseeable ominous prognosis within \\\u003C 7 days.\n3. Already established indication for systemic antibiotic therapy, either for suspected aspiration pneumonia with radiological pulmonary infiltrate or for suspected non-respiratory source infection.\n4. Active haemoptysis or pulmonary haemorrhage.\n5. Unstable chest.\n6. Undrained pneumothorax (inclusion may be considered once drained).\n7. Known allergy or intolerance to beta-lactam antibiotics.","ALL","18 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","Adults who are unconscious or severely ill and need a breathing tube connected to a ventilator are at high risk of developing a lung infection (pneumonia) within the first few days in the intensive care unit. This early pneumonia affects up to 30 to 50 % of certain high-risk patients, prolongs the time on the ventilator and in hospital, and increases the use of antibiotics.\n\nTwo strategies are commonly used today to try to prevent this infection: a short, three-day course of an intravenous antibiotic, and removal of secretions from the airway with a sterile suction catheter. Both have limitations - antibiotics can favour the growth of resistant bacteria, and catheter suctioning is uncomfortable and may injure the airway.\n\nPIRÁMIDES is a small (60-patient) pilot study that compares the current practice with two non-invasive, mechanical alternatives for keeping the airway clear: a continuous low-pressure suction system built into a special breathing tube, and a device that produces a gentle, programmed \"artificial cough\" through the ventilator. Adult patients who are intubated for severe trauma, severe brain injury, stroke, resuscitated cardiac arrest or other causes of decreased consciousness are randomly assigned, in equal numbers, to one of the three approaches and followed for 14 days, with a final visit at day 90.\n\nThe main goal is to find out which of the three strategies best prevents early pneumonia, and which provides the best overall result for patients when survival, severity of infection, need for additional antibiotics and side effects are considered together. To make these comparisons as fair as possible in an open-label study, an independent committee of doctors not involved in patient care reviews each suspected pneumonia case without knowing which strategy the patient received. The results will help design a larger trial to confirm which approach is safest and most effective for preventing early pneumonia in critically ill patients on a ventilator.",[28,29,30,31,32,33,34],"Intubation Complication","Stroke, Ischemic","Stroke Hemorrhagic","Head Trauma","Cardiac Arrest","Ventilator Associated Pneumonia","Airway Clearance Impairment",[36,37,38],"ventilator-associated pneumonia","prevention","airway clearance","NOT_YET_RECRUITING","2026-06-25",{"date":42,"type":43},"2026-06-29","ACTUAL",{"date":45,"type":22},"2026-09-15",{"date":47,"type":22},"2029-06-30",{"name":49,"class":50},"Hospital San Carlos, Madrid","OTHER",1,{"id":53,"slug":54,"hasResults":12,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":23,"phases":62,"briefSummary":64,"conditions":65,"keywords":69,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":51},"100563531","combined-whole-brain-structural-and-functional-mri-for-the-prediction-of-neurological-recovery-after-cardiac-arrest-100563531","NCT06617377","Combined Whole-brain Structural and Functional MRI for the Prediction of Neurological Recovery After Cardiac Arrest","Use of Brain Structural and Functional Connectomes for the Prediction of Neurological Recovery in Coma Patients After Cardiac Arrest","ARISE","Inclusion Criteria:\n\n* Adult patients (male or female ≥ 18 years).\n* Coma, as indicated by a Glasgow Coma Scale (GCS) ≤ 8 (motor score ≤ 2) immediately after CA resuscitation and before sedation onset.\n* Persisting unconsciousness, defined as the inability to obey verbal commands, after at least 72 hours from complete withdrawal of sedation in normothermia conditions.\n* Written informed consent from patient's legal representative.\n* Affiliation or beneficiary to the French social security system.\n\nExclusion Criteria:\n\n* Brain death.\n* Coma explained by other cause than CA.\n* Likely poor neurological outcome based on early predictors, following ERC-ESCIM 2021 recommendations. In a comatose patient with GCS motor score ≤ 3 at ≥ 72 h from ROSC, in the absence of confounders, the identification of at least two of the following: bilaterally absent pupillary light and corneal reflexes at ≥ 72h, bilaterally absent N20 SSEP ≥ 24h; neuron-specific enolase (NSE) \\> 60 μg\u002Fl at 48h and\u002For 72h, status myoclonus ≤72h.\n* Decision of WLST previous to patient recruitment, based on early predictors of poor neurological outcome, age, co-morbidity, general organ function and patient's preferences.\n* Life expectancy shorter than 6 months based on pre-morbid conditions.\n* Former neurological functional disability (mRS \\> 2 before CA).\n* MRI contraindication: medical material not MRI compatible, claustrophobia\n* Known hypersensitivity to gadoteric acid, meglumin or any drug containing gadolinium\n* Severe kidney failure defined as a KDIGO score \\> 3 (glomerular filtration rate \\\u003C 30 ml\u002Fmin\u002F1.73 m2 or renal replacement therapy).\n* Hemodynamic shock or severe respiratory failure precluding patient's transport and MRI scanning.\n* Pregnancy or nursing woman.\n* Patient under juridical protection.",{"count":61,"type":22},263,[63],"NA","To assess the performance of a predictive model resulting from the analysis of sMRI\u002FfMRI\u002Fcontrast-enhanced MRI-derived personalized connectomic data, as compared with standard predictors (clinical examination, electrophysiology, serum biomarker, standard neuroimaging) collected ≥ 72h from sedation withdrawal and in normothermia condition, to predict anoxoischemic coma neurological outcome at 6 months.",[66,32,67,68],"Coma","Disorder of Consciousness","Neurologic Disorder",[70,71,72,73,74,75],"prognosis","coma","cardiac arrest","Structural MRI","resting-state","cognitive motor dissociation","RECRUITING","2026-06-24",{"date":42,"type":43},{"date":80,"type":43},"2026-03-16",{"date":82,"type":22},"2029-09",{"name":84,"class":50},"University Hospital, Toulouse",{"id":86,"slug":87,"hasResults":12,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":93,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":96,"conditions":97,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":107},"100576087","study-of-the-occurrence-of-cardiocirculatory-arrest-as-a-function-of-the-level-of-hypoxemia-during-a-maastricht-3-procedure-100576087","NCT06780722","Study of the Occurrence of Cardiocirculatory Arrest as a Function of the Level of Hypoxemia During a Maastricht 3 Procedure","Study of the Occurrence of Cardiocirculatory Arrest as a Function of the Level of Hypoxemia During a Maastricht 3 Procedure. Prospective Observational Multicenter Study","HEPHAISTOS","FOR THE DONORS :\n\nInclusion Criteria :\n\n* Patient over 18 years of age\n* Organ donation procedure initiated in accordance with the legislation and procedures in force in France for the Maastricht III category\n* No opposition formulated by the relative to the patient's participation in the study\n\nExclusion Criteria :\n\n* Patient registered on the national register of refusals or living refusal of donation\n* Pregnant or breast-feeding women\n* Patients under guardianship, curatorship or legal protection\n* Medical contraindication to organ donation according to the recommendations of the Agence de Biomédecine currently in force in France\n\nFOR THE RECEIVER\n\nInclusion Criteria :\n\n* No opposition to the collection of data concerning him\u002Fher\n* Patient over 18 at pre-transplant consultation\n* Patient who has received an organ from a donor participating in the HEPHAISTOS protocol\n\nExclusion Criteria :\n\n\\- Patients under guardianship, curatorship or legal protection",{"count":94,"type":22},50,"OBSERVATIONAL","Evaluation of the level of hypoxemia during the occurrence of cardiocirculatory arrest during a Maastricht III organ donation procedure.",[32,98],"Reanimation","2026-06-22",{"date":40,"type":43},{"date":102,"type":43},"2025-12-19",{"date":104,"type":22},"2027-06-19",{"name":106,"class":50},"Nantes University Hospital",12,{"id":109,"slug":110,"hasResults":12,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":116,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":118,"conditions":119,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":128},"100548651","fmri-in-cardiac-arrest-with-uncertain-prognosis-100548651","NCT06423768","fMRI in CardiaC arrEst With Uncertain Prognosis","The fMRI in CardiaC arrEst With Uncertain Prognosis (FACE-UP) Study","FACE-UP","Inclusion Criteria:\n\n* survive of an in or out of hospital cardiac arrest\n\nExclusion Criteria:\n\n* Drug overdose\n* Opinion of medical team patient unlikely to survive more than 24 hours (severe concurrent medical illness, dilated and unreactive pupils, etc..)\n* Following verbal commands (MD or RN note) once TTM is complete and normothermia is achieved (Day 2 or 3; Day of admission is Hospital Day 0). If no TTM is administered, this can be assessed on Hospital Day 2.\n* Following verbal commands (study team assessment) at time of MRI\n* Family planning to WLST at time of enrollment\n* Non English speaker (okay if English not primary language, as long as they can understand it)\n* Permanent Contraindication to MRI (some kind of implanted metal)\n* Pregnant",true,{"count":94,"type":22},"The goal of this observational study is to determine whether specific advanced MRI measures are associated with functional outcomes in patients who are comatose after cardiac arrest. The main question\\[s\\] it aims to answer are:\n\nAim 1: Determine if stimulus-based functional MRI (fMRI)-measured activations are independently associated with favorable neurological outcomes after cardiac arrest\n\nAim 2: Determine if resting state functional MRI (rs-fMRI)-measured functional network connectivity is independently associated with favorable neurological outcomes after cardiac arrest.\n\nAim 3: Determine if diffusion tensor imaging (DTI)-measured white matter integrity is associated with favorable neurological outcomes after cardiac arrest.\n\nParticipants will undergo advanced MRI sequences at time of clinical MRI, and will be followed for 6 months post-arrest.",[32],"2026-06-18",{"date":99,"type":43},{"date":123,"type":43},"2024-05-16",{"date":125,"type":22},"2027-12-01",{"name":127,"class":50},"Brigham and Women's Hospital",2,{"id":130,"slug":131,"hasResults":12,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":135,"eligibilityCriteria":136,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":137,"enrollmentInfo":138,"targetDuration":4,"studyType":23,"phases":140,"briefSummary":141,"conditions":142,"keywords":143,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":128},"100570728","target-directed-management-of-cerebral-oxygenation-in-patients-after-receiving-ecpr-100570728","NCT06711016","Target-directed Management of Cerebral Oxygenation in Patients After Receiving ECPR","Efficacy and Safety of Target-directed Management of Cerebral Oxygenation in Patients Undergoing Extracorporeal Cardiopulmonary Resuscitation: A Multicenter, Pragmatic, Randomized, Controlled Clinical Trial","TDMCO-ECPR","Inclusion criteria:\n\n1. 18-75 years old\n2. Witnessed in-hospital or out-of-hospital cardiac arrest\n3. Patients who did not achieve return of spontaneous circulation (ROSC) after 15 minutes of conventional cardiopulmonary resuscitation (CPR), or whose ROSC cannot be maintained, and who received ECPR\n4. Time from cardiac arrest to initiation of CPR \\\u003C 10 minutes\n5. The cause of cardiac arrest is expected to be reversible (e.g., hypothermia, acute myocardial infarction\u002Fmyocardial ischemia, malignant arrhythmia, pulmonary embolism, electrolyte abnormalities, hypoxia, anaphylactic shock, hemorrhage\u002Fhypovolemia, drug poisoning, electric shock, etc.)\n\nExclusion criteria:\n\n1. Aortic dissection\n2. Participants with active gastrointestinal bleeding or other conditions with contraindications to anticoagulation\n3. Pregnancy\n4. Severe trauma\n5. Cerebral Performance Category (CPC) score \\> 2 before cardiac arrest, or acute cerebrovascular disease (e.g., suspected or confirmed acute stroke, subarachnoid hemorrhage, etc.)\n6. Terminal diseases, such as malignant tumors, end-stage liver and kidney diseases, severe heart failure (NYHA class III or IV), severe COPD (GOLD class III or IV), etc.\n7. Transfer time from cardiac arrest to extracorporeal membrane oxygenation (ECMO) \\> 90 minutes\n8. Previous history of bilateral femoral artery bypass grafting or artificial vascular replacement, unsuitable for ECMO catheterization","75 Years",{"count":139,"type":22},654,[63],"Neurological injury remains an important cause of morbidity and mortality in patients with ECPR. At present, the results of three prospective randomized controlled studies on ECPR are inconsistent, and it is inconclusive whether ECPR can improve the neurological outcomes of patients with refractory cardiac arrest. Several study found that extracorporeal membrane oxygenation nonsurvivors can lead toacute brain injury.Further research with a systematic neurologic monitoring is necessary to define the timing of acute brain injury in patients with extracorporeal membrane oxygenation.Moreover, brain injury that occurs during extracorporeal membrane oxygenation therapy is not easy to detect in time because of the use of analgesics, sedatives, and muscle relaxants. Surprisingly, little attention has been paid to the role of cerebral perfusion and oxygenation. Moreover,the features of cerebrovascular pathophysiology and optimal management strategies are still vague.\n\nTherefore multimodal neuromonitoring may be a valuable tool for detecting brain injury in patients with extracorporeal membrane oxygenation and providing early intervention guidance.\n\nMultimodal neuromonitoring, integrating tools such as near-infrared spectroscopy (NIRS), transcranial Doppler, and continuous electroencephalography, may enable early detection of brain injury and guide targeted interventions.\n\nHypothesis: Multimodal neuromonitoring combined with a standard care management will increase the proportion of patients achieving survival with favorable neurological outcome (Cerebral Performance Category \\[CPC\\] 1-2) at 30 days compared with standard care without protocolized neuromonitoring.\n\nPrimary Objective: To test whether a multimodal neuromonitoring strategy improves 30-day survival with favorable neurological outcome (CPC 1-2) in adult patients with refractory cardiac arrest treated with ECPR.",[32],[144,145,146,147],"Multimodality Neuromonitoring","ECPR","Out-of-hospital Caridac arrest","In-Hospital Cardiac Arrest","2026-06-03",{"date":150,"type":43},"2026-06-08",{"date":152,"type":43},"2025-04-22",{"date":154,"type":22},"2028-07-30",{"name":156,"class":50},"Qilu Hospital of Shandong University",{"id":158,"slug":159,"hasResults":12,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":164,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":165,"conditions":166,"keywords":167,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":51},"100555431","continuous-jugular-venous-oxygen-saturation-sjo2-measurement-after-cardiac-arrest-100555431","NCT06511999","Continuous Jugular Venous Oxygen Saturation (SjO2) Measurement After Cardiac Arrest","Feasibility and Validation of Continuous Measurement of Jugular Venous Oxygen Saturation in Comatose Patients After Cardiac Arrest","Inclusion Criteria:\n\n• Adults (\\>=18 years old) resuscitated from out-of-hospital or in-hospital cardiac arrest who remain comatose (motor Glasgow coma scale \\\u003C=4) for at least 30 minutes when examined off sedation\u002Fneuromuscular blockade.\n\nExclusion Criteria:\n\n* Cardiac arrest due to traumatic brain injury, intracranial bleeding, or ischemic stroke\n* Cervical spine fracture\n* Need for immediate prone positioning for severe hypoxemic respiratory failure\n* Marked hemodynamic instability precluding priority of any neuromonitoring (multiple recurrent cardiac arrests, norepinephrine equivalents \\> 1.5 mcg\u002Fkg\u002Fmin)\n* Moribund neurological status based upon initial clinical, radiographic and historical assessment (e.g. diffuse cerebral edema or herniation on head computed tomography)\n* Pregnancy\n* Prisoners",{"count":7,"type":22},"Patients successfully resuscitated from sudden cardiac arrest are often comatose, having suffered a period of low blood flow and oxygen delivery to the brain. They are also at risk of suffering further brain injury during the immediate period after resuscitation, in which the brain's normal regulatory functions are impaired. To diagnose and treat secondary brain injury in comatose patients after cardiac arrest, doctors use a variety of neurological monitoring techniques. One of these methods involves measuring the oxygen saturation of blood going into and out of the brain to determine whether the brain is receiving and utilizing oxygen in an optimal manner. The oxygen saturation of blood exiting the brain is called the jugular venous oxygen saturation (SjO2). It is measured by inserting a catheter into the jugular vein in the neck and sampling blood as it exits the skull. The blood sample is sent to the hospital laboratory and the oxygen saturation is measured on a blood gas machine. This method of SjO2 measurement has limitations, particularly that blood must be taken out of the patient and sent to the lab for analysis, which can only be done feasibly every few hours. Special catheters exist that can measure the oxygen saturation of blood passing by the tip of the catheter inside the patient on a second-by-second basis, without needing to withdraw blood and send it to the laboratory. With such rapidly available data, doctors may be able to better diagnose and treat brain oxygen abnormalities in post cardiac arrest patients.\n\nIn this study, the investigators plan to determine the accuracy of an existing, Food and Drug Administration (FDA)-cleared catheter capable of continuous, indwelling measurement of venous blood oxygen saturation for SjO2 monitoring in comatose patients early after cardiac arrest. The SjO2 measurements from the study catheter will be compared with standard SjO2 measurements made by withdrawing blood and analyzing it in the laboratory to determine if the new catheter is accurate. The investigators will also collect blood samples using the study catheter to measure levels of specific proteins that indicate damage to brain tissue. The study will enroll 25 participants admitted to the intensive care unit at one hospital cared for by a group of doctors that specialize in the neurological care of patients after cardiac arrest. The investigators hypothesize that the study catheter will accurately measure SjO2 compared to the standard laboratory method.",[32],[168,169],"Jugular venous oxygen saturation","Neuromonitoring",{"date":171,"type":43},"2026-06-05",{"date":173,"type":43},"2025-09-20",{"date":175,"type":22},"2027-12-31",{"name":177,"class":50},"Byron Drumheller",{"id":179,"slug":180,"hasResults":12,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":4,"eligibilityCriteria":184,"healthyVolunteers":12,"sex":18,"minAge":185,"maxAge":186,"enrollmentInfo":187,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":189,"conditions":190,"keywords":195,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":215,"locationsCount":51},"100637740","brain-blood-flow-and-cerebral-autoregulation-monitoring-in-critically-ill-children-100637740","NCT07613918","Brain Blood Flow and Cerebral Autoregulation Monitoring in Critically Ill Children","Transcranial Doppler Assessment of Cerebral Autoregulation and Blood Flow Velocity Patterns in Critically Ill Children: A Prospective Observational Study","Inclusion Criteria:\n\n* Has at least one Parent or Legal Guardian who is willing and able to provide informed consent in English\n* Mechanically ventilated (Endotracheal tube)\n* Indwelling arterial catheter\n* Current patient in the American Family Children's Hospital PICU.\n* 1 day to 17.5 years of age\n\nExclusion Criteria:\n\n* Subjects with a known or obvious anatomic barrier preventing safe application of the transcranial Doppler probe (e.g., cranial dressings, cranial fixation hardware, ventricular access devices positioned over insonation sites, or bilateral craniectomies)\n* Patient with known chronic hypertension\n* Admission FSS score \\> 16\n* Tracheostomized patient\n* The designated sub-investigator (Dr. Talal Al Hendawi) and PI (Dr. Neil Munjal) are unavailable to perform the Transcranial Doppler scan at the time of eligibility. All study scans are performed by either Dr. Al Hendawi or Dr.Munjal to ensure standardization and data integrity. Therefore, if they are unavailable (e.g., due to clinical service, leave, or other scheduling constraints), the patient will not be enrolled in the study.\n* Not suitable for study participation due to other reasons at the discretion of the investigators","1 Day","17 Years",{"count":188,"type":22},125,"This study uses a non-invasive (external) ultrasound test called Transcranial Doppler (TCD) to measure how blood flows through the major arteries of the brain of children receiving care in the Pediatric Intensive Care Unit (PICU). TCD is already used for clinical reasons in many children, but it is not part of routine monitoring for every critically ill child. By using TCD, the investigators hope to better understand how brain blood flow changes during illness. They will also track children's functional status from before their illness to the time of PICU discharge to explore how brain blood flow patterns relate to neurological outcomes.125 participants will be enrolled and will be on study while in the PICU, estimated to be 3-14 days.",[191,192,193,194,32],"Critical Illness","Pediatric Critical Illness","Respiratory Failure","Traumatic Brain Injury",[196,197,198,199,200,201,202,203,204,205,206,207],"PICU","infant","Transcranial Doppler Assessment","Cerebral Autoregulation","Blood Flow Velocity","children","mechanical ventilation","neurocritical care","pulsatility index","Mean flow index","neonate","pediatric critical care","2026-06-02",{"date":210,"type":43},"2026-06-04",{"date":212,"type":22},"2026-06",{"date":214,"type":22},"2028-05",{"name":216,"class":50},"University of Wisconsin, Madison",{"id":218,"slug":219,"hasResults":12,"nctId":220,"briefTitle":221,"officialTitle":221,"acronym":222,"eligibilityCriteria":223,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":224,"targetDuration":4,"studyType":23,"phases":226,"briefSummary":227,"conditions":228,"keywords":230,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":233,"lastUpdatePostDateStruct":234,"startDateStruct":236,"completionDateStruct":238,"leadSponsor":240,"locationsCount":51},"100533715","developing-and-testing-drone-delivered-aeds-for-cardiac-arrests-in-rural-america-100533715","NCT06229418","Developing and Testing Drone-Delivered AEDs for Cardiac Arrests In Rural America","RESTORe-CARE","Inclusion Criteria:\n\n* Patients 18 years of age or older in the CARES registry who suffer cardiac arrest before arrival of a 911-responder of non-traumatic cause, including patients who receive an AED shock by a bystander prior to the arrival of 911 responders.\n\nExclusion Criteria:\n\n* Patients in the CARES registry who have a traumatic cause of cardiac arrest.",{"count":225,"type":22},128,[63],"The overall goal of this project is to design, develop, and pilot test an emergency healthcare drone delivery system suitable for rural communities that can deliver AEDs to out-of-hospital cardiac arrest (OHCA) locations more rapidly than can be achieved with current first responder and EMS systems. The goal is to determine whether this method of AED delivery can be achieved rapidly enough to justify a future clinical trial directly testing its ability to improve OHCA survival.",[32,229],"Sudden Cardiac Arrest",[231,232],"Drone","Automated External Defibrillator","2026-05-13",{"date":235,"type":43},"2026-05-14",{"date":237,"type":43},"2025-09-08",{"date":239,"type":22},"2027-03-31",{"name":241,"class":50},"Duke University",{"id":243,"slug":244,"hasResults":12,"nctId":245,"briefTitle":246,"officialTitle":247,"acronym":248,"eligibilityCriteria":249,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":250,"targetDuration":4,"studyType":23,"phases":252,"briefSummary":254,"conditions":255,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":266},"100502099","phase-2-efficacy-of-early-intravenous-high-dose-vitamin-c-in-post-cardiac-arrest-shock-100502099","NCT05817851","Efficacy of Early Intravenous High-dose Vitamin C in Post-cardiac Arrest Shock.","Efficacy of Early Intravenous High-dose Vitamin C in Post-cardiac Arrest Shock: a Multicenter, Randomized Controled Trial.","VICEPAC","Inclusion Criteria:\n\n* patients still comatose (Glasgow coma scale \\\u003C 8) after an OHCA of presumed cardiac origin with ROSC \\\u003C 60 min;\n* and treated with a norepinephrin or an epinephrin continuous infusion during at least 30 min before randomization to maintain mean arterial pressure (MAP) ≥ 65 mmHg.\n\nExclusion Criteria:\n\n* patients still comatose (Glasgow coma scale \\\u003C 8) after an OHCA of presumed cardiac origin with ROSC \\\u003C 60 min;\n* and treated with a norepinephrin or an epinephrin continuous infusion ≥ 0.2µg\u002Fkg\u002Fh, within 4 hours after OHCA, during at least 30 min\u002Fh to maintain mean arterial pressure (MAP) ≥ 65 mmHg.\n\nExclusion criteria:\n\n* minor or pregnant women;\n* OHCA from evident extracardiac cause (trauma, bleeding, poisoning, etc.);\n* interval between RACS and randomization \\> 6 hours;\n* extracorporeal circulatory assistance requirement in the first 4 hours after OHCA;\n* history of urolithiasis, oxalate nephropathy or hemochromatosis;\n* glucose-6-phosphate deshydrogenase deficiency; nephrolithiasis, hyperoxalyurie\n* patients already treated with vit-C; known vit-C deficit;\n* inclusion in another study;\n* pre-existent severe chronic kidney disease (glomerular filtration rate \\\u003C 30ml\u002Fmin);\n* treatment limitationsor moribound\n* Patient with derpived freedom or with legal protective measures.\n* Patient not covered by French national health insurance",{"count":251,"type":22},234,[253],"PHASE2","Among patients admitted after an out-of-hospital cardiac arrest (OHCA) in intensive care unit (ICU), almost two thirds of patients will develop in the first hours a post-cardiac arrest (CA) shock. This post-CA shock, combines cardiac and hemodynamic failure, generally resulting in multi-organ failure and early death in up to 35% of patients. Experimental data suggest that intravenous ascorbic acid (vitamin C) may attenuate inflammation and vascular injury related to sepsis or surgery. Preclinical and clinical studies also provide safety data of high dose intravenous vitamin C (\\> 200mg\u002Fkg\u002Fday) with no significant adverse event reported and favorable impact on outcome. Experimental data also suggest beneficial effect of vitamin C in post-CA management with improvement of shock and multi-organ failure with potential benefit on neuroprotection and outcome.\n\nThe study is a phase II multicenter prospective controlled open-label trial randomized in two parallel groups :\n\n* Expérimental group: Standard of care care for post-CA shock + Vitamin C (Vit-C) 200mg\u002Fkg\u002Fd IV (started as early as possible, no later than 1 h after randomization + thiamin (Vit B1) 200mg every 12 h during 3 days.\n* Control group: Standard of care care for post CA shock according international guidelines.\n\nPatient number to be enrolled : 234, Study duration :24 months and 28 days, Inclusion duration : 24 months, Patient participation : duration : 28 days",[32],"2026-05-05",{"date":258,"type":43},"2026-05-08",{"date":260,"type":43},"2023-12-27",{"date":262,"type":22},"2028-01-24",{"name":264,"class":265},"Centre Hospitalier de Bethune","NETWORK",14,{"id":268,"slug":269,"hasResults":12,"nctId":270,"briefTitle":271,"officialTitle":272,"acronym":273,"eligibilityCriteria":274,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":275,"targetDuration":4,"studyType":23,"phases":277,"briefSummary":278,"conditions":279,"keywords":282,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":285,"lastUpdatePostDateStruct":286,"startDateStruct":287,"completionDateStruct":289,"leadSponsor":291,"locationsCount":128},"100361050","compression-only-cpr-versus-standard-cpr-in-out-of-hospital-cardiac-arrest---a-randomized-survival-study-100361050","NCT03981107","Compression Only CPR Versus Standard CPR in Out-Of-Hospital Cardiac Arrest - A Randomized Survival Study","A Randomized Trial Comparing Survival After of a Simplified Form of Cardiopulmonary Resuscitation (CPR) Consisting of Compressions Only Compared to CPR With Compressions and Rescue Breaths","TANGO2","Inclusion Criteria:\n\n* Unconsciousness with no, abnormal or agonal breathing (suspected OHCA)\n* The suspected OHCA is witnessed (seen or heard)\n* Any Bystander at the scene has previous training in CPR\n\nExclusion Criteria:\n\n* Age below 18 years\n* Collapse is not witnessed\n* Bystander has no prior CPR training\n* Obvious asphyxia (i.e. hanging, foreign body, suffocation, strangulation)\n* Obvious drug overdose \u002F intoxication\n* Pregnancy\n* Trauma (penetrating, blunt, burn injury)\n\nPost randomisation exclusion Criteria from data analysis:\n\n* Not EMS-verified cardiac arrest\n* Previous do not resuscitate (DNR) decision",{"count":276,"type":22},3260,[63],"Out-of-hospital cardiac arrest (OHCA) is one of the leading causes of mortality in the industrialized world. Bystander CPR before arrival of the Emergency Medical Service (EMS) is associated with an increased chance of survival.\n\nDuring the last decade, the best form of bystander CPR has been debated. Chest Compression Only CPR (CO-CPR) has been advocated as a preferable method in situations where the bystander has no previous knowledge in CPR, both because its believed to be equally efficient but also a simplified form of CPR that could lead to a higher incidence of bystander-CPR.\n\nIn an initiative to increase CPR rates the American Heart Association has launched public campaigns such as the \"hands-only CPR\" promoting CO-CPR as an option to S-CPR for adult non-asphyxic cardiac arrest. In the 2015 updates of the European resuscitation council guidelines it states that the confidence in the equivalence between the two methods is not sufficient to change current practice.\n\nWhether CO-CPR leads to a survival rate no worse than, or even superior to standard CPR in situations where the bystander has previous CPR training remains unclear. This clinical question remains unanswered while millions of people are trained in CPR worldwide each year.\n\nTo investigate whether CO-CPR is non-inferior to standard CPR (S-CPR) when performed by a bystander with previous CPR training in witnessed, non-asphyxic cases of OHCA. Superiority testing will also be performed for the purpose of demonstrating a possible increase in survival with CO-CPR.",[280,32,281],"Out-Of-Hospital Cardiac Arrest","Cardiopulmonary Resuscitation",[281,283,284,32],"Chest compressions only CPR","Dispatcher assisted CPR","2026-05-04",{"date":258,"type":43},{"date":288,"type":43},"2017-01-01",{"date":290,"type":22},"2028-12-31",{"name":292,"class":50},"Karolinska Institutet",{"id":294,"slug":295,"hasResults":12,"nctId":296,"briefTitle":297,"officialTitle":298,"acronym":299,"eligibilityCriteria":300,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":301,"enrollmentInfo":302,"targetDuration":4,"studyType":23,"phases":304,"briefSummary":305,"conditions":306,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":309,"completionDateStruct":311,"leadSponsor":313,"locationsCount":51},"100560490","sustained-inflation-and-chest-compression-vs-31-cv-ratio-in-asphyxiated-newborns-100560490","NCT06577818","Sustained Inflation and Chest Compression vs 3:1 C:V Ratio in Asphyxiated Newborns","Sustained Inflation and Chest Compression Versus 3:1 Chest Compression to Ventilation Ratio During Cardiopulmonary Resuscitation of Asphyxiated Newborns - a Multi-centre, International Cluster Randomized Control Trial","SUR1VE-2","Inclusion Criteria:\n\n* Newborns with gestational age born between 28 to 43 weeks based on best available obstetrical estimate\n* Newborns designated to receive full resuscitation, i.e., parental request or pre-determined decision to provide only comfort care at birth\n* No known major congenital or chromosomal malformation. All newborns who meet inclusion criteria will be enrolled as the centres agreed to change their local hospital policy during the trial. The inclusion criteria are designed to be pragmatic and provide useful knowledge translation for most of the patient population in the future.\n\nExclusion Criteria:\n\n\\- Newborns born outside of study centers and transported to centers after delivery.\n\nSex, race, and ethnicity are not part of the exclusion criteria for this trial, and as such it should represent the combined demographics of all centers involved.","40 Minutes",{"count":303,"type":22},554,[63],"Newborn infants who require cardiopulmonary resuscitation at birth receive chest compression using a 3-Compression to 1-Ventilation (3:1 C:V) ratio. However, the optimal chest compression technique during cardiopulmonary resuscitation is uncertain and identified as a critical gap in evidence.\n\nThe International Consensus Statement advises to use the 3:1 C:V ratio based on animal studies, and states that there are no clinical trials to support this approach and called for more research. There continues to be uncertainty about the optimal chest compression technique during cardiopulmonary resuscitation.\n\nThis trial will compare if in newborn infants with cardiac arrest in the delivery room does providing CC+SI (a new chest compression technique) compared to 3:1 C:V decreases the incidence of all mortality within the initial hospital stay.\n\nThis will be a multi-centre international cluster randomized trial.",[32],"2026-04-28",{"date":285,"type":43},{"date":310,"type":22},"2026-09-01",{"date":312,"type":22},"2033-07-01",{"name":314,"class":50},"University of Alberta",{"id":316,"slug":317,"hasResults":12,"nctId":318,"briefTitle":319,"officialTitle":320,"acronym":321,"eligibilityCriteria":322,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":323,"targetDuration":4,"studyType":23,"phases":325,"briefSummary":326,"conditions":327,"keywords":328,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":51},"100626368","in-hospital-cardiopulmonary-resuscitation-with-balloon-occlusion-of-the-descending-aorta-100626368","NCT07434726","In-hospital Cardiopulmonary Resuscitation With Balloon Occlusion of the Descending Aorta","CPReboa: In-hospital Cardiopulmonary Resuscitation With Balloon Occlusion of the Descending Aorta","CPReboa","Inclusion criteria:\n\n* patients suffering from in hospital cardiac arrest (IHCA), including patients with out of hospital cardiac arrest (OHCA) and return of spontaneous circulation (ROSC), transported to the emergency department, where they suffer a second arrest (IHCA)\n* successful placement of a femoral artery introducer sheath\n* any electrical cardiac activity seen in the initial rhythm analysis\n* ongoing effort of resuscitation as determined by study-independent resuscitation lead\n\nExclusion criteria:\n\n* IHCA in the operating room, on intensive care unit or in the cardiac catheter laboratory\n* hospital visitors suffering from cardiac arrest\n* asystole seen in the initial rhythm analysis\n* (presumed) age under 18 years\n* known \"do not resuscitate\"-order\n* known or obvious pregnancy\n* traumatic cardiac arrest\n* known aortic pathologies that render cannulation impossible\n* known allergies to radiographic contrast agents",{"count":324,"type":22},98,[63],"This study will test if a sustained Return of Spontaneous Circulation (ROSC) in patients with cardiac arrest is more frequent when patients receive advanced cardiac life support (ACLS) alone or when they receive ACLS plus a balloon occlusion of the thoracic aorta.",[32],[32,329,330,331],"resuscitative endovascular occlusion of the aorta REBOA","cardio pulmonary resuscitation CPR","advanced cardiac life support ACLS","2026-04-20",{"date":334,"type":43},"2026-04-23",{"date":336,"type":43},"2026-04-14",{"date":338,"type":22},"2030-12",{"name":340,"class":50},"Insel Gruppe AG, University Hospital Bern",{"id":342,"slug":343,"hasResults":12,"nctId":344,"briefTitle":345,"officialTitle":346,"acronym":4,"eligibilityCriteria":347,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":348,"enrollmentInfo":349,"targetDuration":4,"studyType":23,"phases":351,"briefSummary":353,"conditions":354,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":356,"lastUpdatePostDateStruct":357,"startDateStruct":359,"completionDateStruct":361,"leadSponsor":363,"locationsCount":51},"100551086","phase-1-post-ca-neuroprotection-with-magnesium-100551086","NCT06455514","Post-CA Neuroprotection With Magnesium","Neuroprotection Following Cardiac Arrest: A Randomized Control Trial of Magnesium","Inclusion Criteria:\n\n* Documented post-cardiac arrest patient with Return of Spontaneous Circulation (ROSC) achieved \\\u003C2 hours prior to recruitment\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years or \\> 85 years\n* Traumatic cardiac arrests\n* Unsustained ROSC (\\\u003C20 minutes)\n* Patient who is responsive\u002Fable to follow motor commands within 1 hour of achieving ROSC\n* Plan for withdrawal of life support within 72 hours of ROSC\n* Known pregnant women at the time of the cardiac arrest\n* Known prisoners at the time of the cardiac arrest\n* Subjects who have a medical o social condition that would make them inappropriate for the study based on the PI's or clinical team judgement.","85 Years",{"count":350,"type":22},178,[352],"PHASE1","The purpose of this pilot interventional study is to collect preliminary data on administering magnesium sulfate as a neuroprotective medication in patients who achieved Return of Spontaneous Circulation (ROSC) following Cardiac Arrest (CA). The primary aims are to assess the feasibility and safety of administering magnesium and measure serum markers of neuronal injury at prespecified time points in the post-cardiac arrest period. Because this is a pilot study with a limited sample size, the primary objective is to evaluate the precision and stability of the collected measures to inform the design and formal analysis in a larger trial.",[32,355],"Return of Spontaneous Circulation","2026-04-01",{"date":358,"type":43},"2026-04-07",{"date":360,"type":43},"2025-03-25",{"date":362,"type":22},"2026-06-30",{"name":364,"class":50},"NYU Langone Health",{"id":366,"slug":367,"hasResults":12,"nctId":368,"briefTitle":369,"officialTitle":370,"acronym":371,"eligibilityCriteria":372,"healthyVolunteers":116,"sex":18,"minAge":373,"maxAge":4,"enrollmentInfo":374,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":376,"conditions":377,"keywords":381,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":388,"lastUpdatePostDateStruct":389,"startDateStruct":391,"completionDateStruct":393,"leadSponsor":395,"locationsCount":266},"100507694","ai-powered-ecg-analysis-using-willem-software-in-high-risk-cardiac-patients-willem-100507694","NCT05890716","AI-powered ECG Analysis Using Willem™ Software in High-risk Cardiac Patients (WILLEM)","Evaluation of Electrocardiographic Data From High-risk Cardiac Patients Using Willem™ Cardiologist-level Artificial Intelligence Software. WILLEM Trial.","WILLEM","Inclusion Criteria:\n\n* Patient presenting relevant cardiac arrhythmias and cardiac patterns (including supraventricular tachycardias, abnormal ECG patterns, ventricular tachycardias, ventricular fibrillation, pulseless electrical activity or asystole among others) that have been recorded with at least one short-term ECG medical device according to guidelines with ≥1 signal-channel.\n* Patient with suspected or diagnosed acute\u002Fchronic cardiac diseases (including patients with heart failure, patients with history of cardiac arrhythmias, patients with probable coronary artery diseases, patients with cardiomyopathies, patients with pacemakers or implantable cardioverter-defibrillators (ICD), patients with indication of pacemaker or ICD in current or short-term phase, patients participating in other interventional clinical investigation, patients with hemodynamic instability or acute coronary syndromes, pregnant patients, patients with cancer and chemotherapy, patients with life-expectancy lower than 24 months, patients with in or out-of-hospital cardiac arrest with ventricular fibrillation as first documented rhythm).\n* At least one ECG tracing that can be exported in raw data.\n* Signed informed consent. Patients unable to consent, it will be requested to an authorized relative.\n\nExclusion Criteria:\n\n* Unwillingness or inability to sign study written informed consent.\n* Unavailable or suboptimal quality of the electrocardiographic signal in raw data.","4 Years",{"count":375,"type":22},5342,"WILLEM is a multi-center, prospective and retrospective cohort study.\n\nThe study will assess the performance of a cloud-based and AI-powered ECG analysis platform, named Willem™, developed to detect arrhythmias and other abnormal cardiac patterns. The main questions it aims to answer are:\n\n1. A new AI-powered ECG analysis platform can automatice the classification and prediction of cardiac arrhythmic episodes at a cardiologist level.\n2. This AI-powered ECG analysis can delay or even avoid harmful therapies and severe cardiac adverse events such as sudden death.\n\nThe prerequisites for inclusion of patients will be the availability of at least one ECG record in raw data, along with patient clinical data and evolution data after more than 1-year follow-up.\n\nCardiac electrical signals from multiple medical devices will be collected by cardiology experts after obtaining the informed consent. Every cardiac electrical signal from every subject will be reviewed by a board-certified cardiologist to label the arrhythmias and patterns recorded in those tracings. In order to obtain tracings of relevant information, \\>95% of the subjects enrolled will have rhythm disorders or abnormal ECG's patterns at the time of enrollment.",[378,32,379,380],"Cardiomyopathies","Cardiac Arrhythmias","Sudden Cardiac Death",[382,383,384,385,386,387],"Artificial intelligence","Cardiac arrhythmias","Heart disease","Cardiac electrical signals","Electrocardiogram","Electrogram","2026-03-30",{"date":390,"type":43},"2026-04-03",{"date":392,"type":43},"2023-04-04",{"date":394,"type":22},"2026-11",{"name":396,"class":397},"Idoven 1903 S.L.","INDUSTRY",{"id":399,"slug":400,"hasResults":12,"nctId":401,"briefTitle":402,"officialTitle":403,"acronym":404,"eligibilityCriteria":405,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":406,"enrollmentInfo":407,"targetDuration":4,"studyType":23,"phases":409,"briefSummary":410,"conditions":411,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":417,"lastUpdatePostDateStruct":418,"startDateStruct":419,"completionDateStruct":421,"leadSponsor":423,"locationsCount":128},"100546486","internet-based-interventions-for-cardiac-arrest-survivors-100546486","NCT06395558","intErnet-based iNterventions FOR Cardiac arrEst suRvivors","Internet-Based Interventions for Cardiac Arrest Survivors","ENFORCER","Inclusion Criteria:\n\n* Hospital discharge after out-of-hospital cardiac arrest with Cerebral Performance Category 1 or 2\n* Informed consent for participation in the study\n* Native Italian speaker or adequate understanding of the Italian language\n* Adequate ability to use the web to guarantee access to the contents\n\nExclusion Criteria:\n\n* Previous cognitive dysfunction\n* Previous psychiatric disease\n* Previous episode of out-of-hospital cardiac arrest","80 Years",{"count":408,"type":22},106,[63],"This randomized clinical trial will test whether an internet-based lifestyle intervention administered through a web app can foster Health Related Quality of Life in patients who survived an out-of-hospital cardiac arrest and suffer from these symptoms",[412,413,32,414,415,416],"Cognitive Impairment","Depression, Anxiety","Quality of Life","Social Functioning","Sexual Dysfunction","2026-03-25",{"date":388,"type":43},{"date":420,"type":43},"2024-08-05",{"date":422,"type":22},"2027-10-01",{"name":424,"class":425},"Azienda Usl di Bologna","OTHER_GOV",{"id":427,"slug":428,"hasResults":12,"nctId":429,"briefTitle":430,"officialTitle":431,"acronym":145,"eligibilityCriteria":432,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":433,"targetDuration":435,"studyType":95,"phases":4,"briefSummary":436,"conditions":437,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":439,"lastUpdatePostDateStruct":440,"startDateStruct":442,"completionDateStruct":444,"leadSponsor":446,"locationsCount":51},"100601690","plasma-biomarkers-and-platelet-morphology-of-extracorporeal-cardiopulmonary-resuscitation-100601690","NCT07113769","Plasma Biomarkers and Platelet Morphology of Extracorporeal CardioPulmonary Resuscitation","Explore Plasma Biomarkers and Platelet Morphological Signatures for Predicting Prognosis in Patients With Extracorporeal CardioPulmonary Resuscitation (ECPR) Using Multi-omics and Platelet Morphology Analysis","Inclusion Criteria:\n\n1. Age between 18 and 70 years old (the age limit can be relaxed if the patient has good organ function and a good neurological prognosis after evaluation).\n2. The cardiac arrest is witnessed, and bystanders perform traditional cardiopulmonary resuscitation (CPR), and the time interval from the occurrence of cardiac arrest to the start of traditional CPR is no more than 5 minutes.\n3. The causes of cardiac arrest are reversible, such as cardiogenic, pulmonary embolism, severe hypothermia, drug poisoning, trauma, acute respiratory distress syndrome, etc.\n4. After 20 minutes of traditional CPR, there is no restoration of spontaneous circulation or hemodynamic instability, or the restoration of spontaneous circulation occurs, but the spontaneous heart rhythm cannot be maintained.\n5. The informed consent has been signed.\n\nExclusion Criteria:\n\n1. Infectious diseases, such as hepatitis B, hepatitis C, AIDS, syphilis, etc.\n2. Hematological diseases, such as hematological malignancies, aplastic anemia, idiopathic thrombocytopenic purpura (ITP), etc.\n3. Malignant tumors in other systems except the hematological system.\n4. Patients who have received massive plasma or platelet transfusions during hospitalization or recently.",{"count":434,"type":22},130,"1 Month","Extracorporeal cardiopulmonary resuscitation (ECPR) constitutes a pivotal emergency intervention for cardiac arrest (CA) patients. However, current eligibility criteria and prognostic assessment metrics remain substantially limited, relying predominantly on clinical symptoms and physical signs while lacking objective biomarker data. Integrating reproducible, highly sensitive, and specific proteinaceous and metabolic indicators with ultrastructural platelet alterations may hold significant implications for both ECPR administration and prognostication in CA. Therefore, the purpose of this study is to identify the plasma proteomic and metabolomic characteristics of patients with refractory cardiac arrest before and after ECPR treatment, as well as the characteristics of platelet morphological and structural changes, to search for potential specific markers that can predict CA patients who may benefit from ECPR so as to optimize treatment selection.",[438,32],"ExtraCorporeal Membrane Oxygenation (ECMO)","2026-03-19",{"date":441,"type":43},"2026-03-23",{"date":443,"type":43},"2025-09-01",{"date":445,"type":22},"2026-12-30",{"name":447,"class":50},"Central China Fuwai Hospital of Zhengzhou University",{"id":449,"slug":450,"hasResults":12,"nctId":451,"briefTitle":452,"officialTitle":453,"acronym":454,"eligibilityCriteria":455,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":456,"targetDuration":4,"studyType":23,"phases":458,"briefSummary":459,"conditions":460,"keywords":461,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":465,"lastUpdatePostDateStruct":466,"startDateStruct":468,"completionDateStruct":470,"leadSponsor":472,"locationsCount":51},"100629835","optimizing-ventilation-to-improve-survival-from-out-of-hospital-cardiac-arrest-the-optivo-randomized-controlled-trial-100629835","NCT07479836","Optimizing Ventilation to Improve Survival From Out-of-hospital Cardiac Arrest: the OPTIVO Randomized Controlled Trial","OPTImizing Ventilation to Improve Survival From Out-of-Hospital Cardiac Arrest: The OPTIVO Randomized Controlled Trial","OPTIVO","Inclusion Criteria:\n\n* Adult (\\>=18 years of age)\n* presumed cardiac etiology\n* treated by paramedics\n* Ventilation monitor utilized\n\nExclusion Criteria:\n\n* Do Not Resuscitate (DNR) order\n* No use of ventilation monitor\n* Traumatic cardiac arrest\n* Pregnant patients\n* Prisoners\n* Respiratory cause of cardiac arrest (e.g. drowning, hanging, suffocation, opioid-related)",{"count":457,"type":22},1656,[63],"When the heart stops pumping during cardiac arrest, cardiopulmonary resuscitation (CPR) is used to continue pushing blood and providing oxygen to vital organs. CPR involves a combination of chest compressions (to push the blood) and ventilations (to provide oxygen and gas exchange). There is a lot of research that has helped to optimize the provision of chest compressions, however there is considerably less research available to guide ventilations. The current guideline recommendations are based on limited data, and no data that is specific to cardiac arrest patients. There is a recognized need for research to better guide ventilation during CPR. This research will help to better define appropriate ventilation targets for cardiac arrest patients.",[32],[462,463,281,464],"Resuscitation","Ventilation","Out-of-Hospital Cardiac Arrest","2026-03-15",{"date":467,"type":43},"2026-03-18",{"date":469,"type":22},"2026-03",{"date":471,"type":22},"2028-03",{"name":473,"class":50},"Sunnybrook Health Sciences Centre",{"id":475,"slug":476,"hasResults":12,"nctId":477,"briefTitle":478,"officialTitle":478,"acronym":479,"eligibilityCriteria":480,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":406,"enrollmentInfo":481,"targetDuration":4,"studyType":23,"phases":483,"briefSummary":484,"conditions":485,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":490,"lastUpdatePostDateStruct":491,"startDateStruct":493,"completionDateStruct":495,"leadSponsor":497,"locationsCount":51},"100521616","emergency-resuscitative-endovascular-balloon-occlusion-of-the-aorta-in-out-of-hospital-cardiac-arrest-100521616","NCT06071910","Emergency Resuscitative Endovascular Balloon Occlusion of the Aorta in Out of Hospital Cardiac Arrest","ERICA-ARREST","Inclusion criteria\n\n* Non-Traumatic OHCA in patients within the East of England area AND with a East Anglian Air Ambulance (EAAA) REBOA team in attendance\n* Patients below or equal to 80yrs of age and above or equal to 18yrs of age, according to available information\u002Festimate at scene\n* No flow \\\u003C10 mins from data available (i.e. total period in OHCA with no CPR)\n* In cardiac arrest (with no sustained ROSC) on arrival of the EAAA REBOA team\n\nExclusion criteria\n\n* Patients aged less than 18 or above 80 years\n* Known terminal illness\n* Multiple severe co-morbidities\n* Traumatic Cardiac Arrest (TCA)\n* Inability to deploy mechanical CPR (e.g. LUCAS Device)\n* Pregnancy, obvious or suspected",{"count":482,"type":22},40,[63],"This study will assess the feasibility of performing pre-hospital resuscitative endovascular balloon occlusion of the aorta (REBOA) as an adjunct to conventional Advanced Life Support (ALS) in patients suffering from non-traumatic out of hospital cardiac arrest (OHCA). As well as providing valuable insights into the technical feasibility of performing this procedure as part of a resuscitation attempt, the study will also document the beneficial physiological effects of REBOA in this group of patients.",[280,32,486,487,488,489],"Cardiac Arrhythmia","Ventricular Fibrillation","Ventricular Arrythmia","Pulseless Electrical Activity","2026-02-26",{"date":492,"type":43},"2026-03-02",{"date":494,"type":43},"2024-06-04",{"date":496,"type":22},"2026-12-31",{"name":498,"class":50},"Queen Mary University of London",{"id":500,"slug":501,"hasResults":12,"nctId":502,"briefTitle":503,"officialTitle":503,"acronym":504,"eligibilityCriteria":505,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":506,"targetDuration":4,"studyType":23,"phases":508,"briefSummary":509,"conditions":510,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":511,"lastUpdatePostDateStruct":512,"startDateStruct":514,"completionDateStruct":516,"leadSponsor":518,"locationsCount":519},"100599608","targeted-temperature-management-at-33c-versus-controlled-normothermia-for-in-hospital-cardiac-arrest-100599608","NCT07086703","Targeted Temperature Management at 33°C Versus Controlled Normothermia for In-hospital Cardiac Arrest","IH-TTM","Inclusion Criteria:\n\n* IHCA (unwitnessed IHCA with initial asystole; these patients may still be eligible if visible or audible signs of life were witnessed within 10 minutes after IHCA (no-flow duration ≤10 minutes, in keeping with the non-inclusion criteria for HYPERION study).\n* Sustained ROSC (Return Of Spontaneous Circulation) defined as signs of circulation for 20 minutes without chest compressions\n* At least 1 mg of epinephrine\n* Coma defined as an inability to obey verbal commands (Glasgow Coma Scale motor response \\\u003C6 or Full Outline of UnResponsiveness (FOUR) score motor response \\\u003C4) after sustained ROSC\n* Eligible for intensive care without restrictions or limitations\n* Inclusion within 90 minutes of ROSC\n* Age 18 years or older\n* Next of kin informed about the trial and having consented to participation of the patient in the trial (patients with coma are unable to consent). If no next of kin can be contacted during screening for the study, trial inclusion will be completed as an emergency procedure by the ICU physician, in compliance with Country of inclusion law.\n* Healthcare costs covered by the French statutory healthcare insurance system\n\nExclusion Criteria:\n\n* Temperature at admission \\\u003C30°C\n* Obvious or suspected pregnancy\n* Intracranial bleeding\n* Dependent on others for activities of daily living before hospitalization\n* Patient under curators, guardianship or under protection of justice\n* Correctional facility inmate\n* Patient who does no speak French",{"count":507,"type":22},788,[63],"The IH-TTM trial is designed to determine whether survival with a favorable neurological outcome is improved by induced hypothermia at 33°C in comatose critically ill patients admitted after resuscitated in-hospital cardiac arrest (IHCA). Recent evidence suggests that targeted temperature management (TTM) at 33°C may provide no survival benefits compared to controlled normothermia in unselected patients with out-of-hospital cardiac arrest (OHCA). However, this evidence is relevant only to OHCA of presumed cardiac origin, chiefly witnessed and immediately followed by resuscitation efforts. Only scant data are available for cardiac arrest (CA) of other origins and for IHCA.\n\nIn a randomized clinical trial of patients with CA in an initial non-shockable rhythm, the subgroup with IHCA had significantly better outcomes when treated with TTM at 33°C versus controlled normothermia; nevertheless, the sample size was limited. Another randomized controlled trial done specifically in patients with IHCA failed to show benefits of TTM at 33°C compared to controlled normothermia but was underpowered. Thus, whether therapeutic hypothermia is indicated after IHCA remains unclear. IH-TTM will be the largest trial assessing TTM after IHCA.",[32],"2026-01-26",{"date":513,"type":43},"2026-01-28",{"date":515,"type":22},"2026-05-01",{"date":517,"type":22},"2029-05-01",{"name":106,"class":50},32,{"id":521,"slug":522,"hasResults":12,"nctId":523,"briefTitle":524,"officialTitle":525,"acronym":4,"eligibilityCriteria":526,"healthyVolunteers":12,"sex":18,"minAge":527,"maxAge":4,"enrollmentInfo":528,"targetDuration":4,"studyType":23,"phases":530,"briefSummary":531,"conditions":532,"keywords":536,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":539,"lastUpdatePostDateStruct":540,"startDateStruct":542,"completionDateStruct":544,"leadSponsor":545,"locationsCount":51},"100611332","serious-game-for-improving-targeted-temperature-management-knowledge-and-situational-awareness-in-critical-care-nurses-100611332","NCT07239206","Serious Game for Improving Targeted Temperature Management Knowledge and Situational Awareness in Critical Care Nurses","Effectiveness of Serious Game on Facilitating Targeted Temperature Management Knowledge and Situational Awareness Among Critical Care Nurses","Inclusion Criteria:\n\n* Registered nurses currently working in adult intensive care units (medical, surgical, or mixed ICUs).\n* Able to read and understand Chinese.\n* Willing to participate and provide informed consent.\n* Available to complete pre-test, post-test, and follow-up assessments.\n\nExclusion Criteria:\n\n* Nurses working in pediatric or neonatal ICUs.\n* Nurses holding administrative or supervisory positions (non-clinical).\n* Nurses currently participating in other TTM-related educational or research programs.\n* Individuals unable to complete the intervention or evaluation schedule.","20 Years",{"count":529,"type":22},120,[63],"This randomized controlled trial aims to evaluate the effectiveness of a serious game in improving targeted temperature management (TTM) knowledge and situational awareness among critical care nurses. A total of 120 nurses from adult intensive care units will be randomly assigned to either a control group receiving traditional lecture-based teaching or an experimental group receiving lecture-based teaching combined with a digital serious game. Outcomes will be measured using a TTM knowledge test, a situational awareness scale, and a system usability scale. The findings will provide evidence for the use of serious games as an innovative educational strategy to enhance post-resuscitation care quality and patient safety.",[533,534,535,32],"Targeted Temperature Management","Nursing Education","Serious Game",[537,538],"Targeted temperature management","Serious game","2026-01-20",{"date":541,"type":43},"2026-01-22",{"date":543,"type":43},"2026-01-19",{"date":496,"type":22},{"name":546,"class":50},"National Taiwan University Clinical Trial Center",{"id":548,"slug":549,"hasResults":12,"nctId":550,"briefTitle":551,"officialTitle":551,"acronym":4,"eligibilityCriteria":552,"healthyVolunteers":12,"sex":18,"minAge":553,"maxAge":4,"enrollmentInfo":554,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":556,"conditions":557,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":560,"lastUpdatePostDateStruct":561,"startDateStruct":562,"completionDateStruct":564,"leadSponsor":566,"locationsCount":51},"100377765","predictors-for-survival-and-good-neurological-outcome-in-e-cpr-and-non-cpr-treated-patients-100377765","NCT04198792","Predictors for Survival and Good Neurological Outcome in E-CPR and Non CPR Treated Patients","Inclusion Criteria:\n\n* ECMO-treated patients.\n\nExclusion Criteria:\n\n* None","16 Years",{"count":555,"type":22},700,"In ECPR, where CPR times often range from 30 to 120 minutes, only patients with good circulation during CPR survive, while non-survivors commonly suffer from anoxic brain injury. The selection process during CPR is challenging causing a general survival rate of just 2 out of 10, and the urgent need for better selection criteria has been emphasized. It it crucial to keep cardiac arrest times as short as possible, pre primed-ECMO can facilitate this.\n\nThe ECMO treatment and the long CPR times of ECPR can also affect the measurements of the neurologic prognostication guidelines after cardiac arrest, making its validity uncertain in this specific cohort. Further, the long-term neuropsychological follow-up is limited to a few patients, making it uncertain if ECPR gives the survivors good long-term life satisfaction or just a prolonged life.\n\nOur overall aim is to optimize and improve the care pathway for ECPR patients by refining patient selection, assessing pre-primed ECMO, validating neurological prognostication guidelines, and understanding long-term outcomes and challenges faced by survivors.\n\nSpecific Aim 1: Evaluating predictors for good neurological outcomes in ECPR and to develop and validate (internally and externally) an evidence-based selection tool for ECPR.\n\nSpecific aim 2: To assess the sterility and function of pre-primed ECMO.\n\nSpecific aim 3: To evaluate the applicability of current guidelines for neurological prognostication after cardiac arrest in ECPR patients, and to assess the predictive value of individual and combined neurological tests in this specific patient population.\n\nSpecific aim 4: To determine the long-term neuropsychological outcomes, identify the problems survivors experience in daily life, and assess life satisfaction - by comprehensive follow-up visits with validated questionnaires and neuropsychology testing up to 12 years after the ECMO-treated cardiac arrest.",[32,558,559],"Extracorporeal Membrane Oxygenation","Hypoxia-Ischemia, Brain","2026-01-14",{"date":539,"type":43},{"date":563,"type":43},"2010-01-01",{"date":565,"type":22},"2030-01-01",{"name":567,"class":50},"Sahlgrenska University Hospital",{"id":569,"slug":570,"hasResults":12,"nctId":571,"briefTitle":572,"officialTitle":573,"acronym":574,"eligibilityCriteria":575,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":576,"targetDuration":435,"studyType":95,"phases":4,"briefSummary":578,"conditions":579,"keywords":584,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":588,"lastUpdatePostDateStruct":589,"startDateStruct":590,"completionDateStruct":592,"leadSponsor":594,"locationsCount":51},"100437150","resuscitative-tee-collaborative-registry-100437150","NCT04972526","Resuscitative TEE Collaborative Registry","Evaluation of the Clinical Impact and Safety of Focused Transesophageal Echocardiography During Resuscitation of Critically Ill Patients in the Emergency Department and Intensive Care Settings","rTEECoRe","Inclusion Criteria:\n\n* Adult critically-ill patients who as part of their routine clinical care receive focused TEE in the emergency department of intensive care setting.\n\nExclusion Criteria:\n\n* Children (age under 18 years)\n* Vulnerable populations",{"count":577,"type":22},1000,"The general objective of this study is to evaluate the clinical impact and safety of focused, point-of-care transesophageal echocardiography (TEE) used during the evaluation of critically-ill patients in the emergency and intensive care settings. The target population for this study are critically-ill patients over the age of 18 who as part of their routine clinical care are receiving a focused TEE.\n\nThe primary objective of this study is to determine the clinical impact and safety of TEE performed during the evaluation of critically-ill patients in the emergency department and intensive care settings.\n\nThe secondary objective(s) of this study are to characterize the use of this imaging modality in the subsets of critically-ill patients in shock and cardiac arrest; including but not limited to; description of the frequency of studies, clinical indications, clinician characteristics, echocardiography findings, timing of studies, procedure-related complications and patient outcomes.",[32,580,581,582,583],"Cardiac Arrest Circulatory","Cardiac Arrest, Out-Of-Hospital","Shock","Hemodynamic Instability",[585,462,32,586,587],"Transesophageal Echocardiography","Point-of-care Ultrasound","Focused Cardiac Ultrasound","2026-01-12",{"date":560,"type":43},{"date":591,"type":43},"2020-12-01",{"date":593,"type":22},"2027-12-15",{"name":595,"class":50},"University of Pennsylvania",{"id":597,"slug":598,"hasResults":12,"nctId":599,"briefTitle":600,"officialTitle":601,"acronym":602,"eligibilityCriteria":603,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":604,"enrollmentInfo":605,"targetDuration":607,"studyType":95,"phases":4,"briefSummary":608,"conditions":609,"keywords":610,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":612,"lastUpdatePostDateStruct":613,"startDateStruct":615,"completionDateStruct":617,"leadSponsor":619,"locationsCount":621},"100305812","neuroprognostication-bias-a-collaboration-to-reduce-the-impact-of-self-fulfilling-prophecy-in-cardiac-arrest-100305812","NCT03261089","Neuroprognostication Bias: A Collaboration to Reduce the Impact of Self-fulfilling Prophecy in Cardiac ARrEst","Addressing an Inherent Bias in Neuroprognostication: A Collaboration to Reduce the Impact of Self-fulfilling Prophecy in Cardiac ARrEst","SPARE","Inclusion Criteria:\n\n* Initially unconscious following cardiac arrest from any non-perfusing rhythm (i.e., ventricular tachycardia, ventricular fibrillation, pulseless electrical activity, asystole)\n* Sustained return of spontaneous circulation (ROSC) as defined by maintained spontaneous circulation for at least 20 minutes after cardiopulmonary resuscitation.\n\nExclusion Criteria:\n\n\\- Isolated respiratory arrest without concomitant or ensuing cardiac arrest","89 Years",{"count":606,"type":22},600,"5 Years","Cardiovascular disease remains the leading cause of death in the United States. Mortality rates of cardiac arrest range from 60-85%, and approximately 80% of survivors are initially comatose. Of those who survive, 50% are left with a permanent neurological disability, and only 10% are able to resume their former lifestyle. Early prognosis of comatose patients after cardiac arrest is critical for management of these patients, yet predicting outcome for these patients remains quite challenging.\n\nThe primary study objective of SPARE is to assess the value of using a systematic, multi-modal approach for neuroprognostication in the unconscious post-cardiac arrest population. We hypothesize that prognostication using this approach will be significantly improved compared to historical controls. This approach will be novel because:\n\nAll patients who are unconscious at least 24 hours post-cardiac arrest, whereas previous studies on neurologic outcome tended to have restrictive inclusion criteria, such as no pre-existing neurologic impairment (e.g. dementia or prior cerebrovascular injury), or included an unduly restrictive population, such as patients with a strictly comatose state.\n\nThe prognostic modalities used to assess patients will be applied at specific time points that will maximize their utility.\n\nPatients' families and clinicians will be encouraged to provide adequate time to allow for a delayed recovery, especially in cases of uncertain outcome, thus minimizing the self-fulfilling prophesy bias of early withdrawal of life-sustaining therapies (WLST). This will be particularly pertinent in the comparison of US and Brazil\u002FItaly patients, as the Brazilian and Italian populations are not commonly exposed to premature WLST (as can be the case in the US), one of the major sources of biases in prognostication studies of cardiac arrest due to the self-fulfilling prophecy.",[32],[72,611,71],"neuroprognostication","2025-12-22",{"date":614,"type":43},"2025-12-24",{"date":616,"type":43},"2017-08-02",{"date":618,"type":22},"2027-08",{"name":620,"class":50},"Boston Medical Center",8,{"id":623,"slug":624,"hasResults":12,"nctId":625,"briefTitle":626,"officialTitle":627,"acronym":628,"eligibilityCriteria":629,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":630,"targetDuration":4,"studyType":23,"phases":632,"briefSummary":634,"conditions":635,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":636,"lastUpdatePostDateStruct":637,"startDateStruct":638,"completionDateStruct":640,"leadSponsor":642,"locationsCount":51},"100568411","phase-3-early-amiodarone-in-shockable-cardiac-arrest-100568411","NCT06680869","Early Amiodarone in Shockable Cardiac Arrest","Early Amiodarone in Shockable Cardiac Arrest (Early-Amio) Study","Early-Amio","Inclusion Criteria:\n\n* Emergency medical services (EMS)-treated non-traumatic out-of-hospital cardiac arrest\n* Initial rhythm on EMS rhythm assessment of ventricular fibrillation or ventricular tachycardia\n* Recurrence or persistence of ventricular fibrillation or ventricular tachycardia after one defibrillation attempt\n\nExclusion Criteria:\n\n* Known allergy to amiodarone\n* EMS-assessed contraindication to amiodarone\n* Pre-existing \"do-not-attempt-resuscitation\" orders\n* Inter-facility transportations\n* Initial care by a non-participating EMS agency able to perform advanced life support interventions\n* Pediatric patient as determined by EMS\n* Prisoners\n* Pregnant patients",{"count":631,"type":22},585,[633],"PHASE3","The primary objective of this pilot, pragmatic stepped-wedge cluster randomized trial is to evaluate if a modified cardiac arrest treatment algorithm calling for the administration of the initial amiodarone dose one 2-minute cycle earlier than current guidelines (during the same cycle as the initial dose of epinephrine) improves the time to amiodarone delivery in those with out-of-hospital cardiac arrest due to refractory ventricular fibrillation or ventricular tachycardia compared to usual care.",[32],"2025-12-17",{"date":102,"type":43},{"date":639,"type":43},"2025-01-01",{"date":641,"type":22},"2028-01-31",{"name":643,"class":50},"Oregon Health and Science University",{"id":645,"slug":646,"hasResults":12,"nctId":647,"briefTitle":648,"officialTitle":649,"acronym":4,"eligibilityCriteria":650,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":651,"enrollmentInfo":652,"targetDuration":4,"studyType":23,"phases":654,"briefSummary":655,"conditions":656,"keywords":663,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":668,"lastUpdatePostDateStruct":669,"startDateStruct":671,"completionDateStruct":673,"leadSponsor":675,"locationsCount":51},"100452609","phase-4-rehabilitation-for-survivors-of-out-of-hospital-cardiac-arrest-100452609","NCT05173740","Rehabilitation for Survivors of Out-of-hospital Cardiac Arrest","The ROCK Trial. A Multidisciplinary Rehabilitation Intervention Targeted Return-to-work in Sudden Out-of-hospital Cardiac Arrest Survivors A Pragmatic Randomised Controlled Trial","Inclusion criteria:\n\n* All adult survivors with first time out-of-hospital cardiac arrest\n* Discharged from the Hospitals will be assessed eligible for inclusion\n\nExclusion criteria:\n\n* Survivors who prior to the cardiac arrest were not part of the labour force with at least two years until they are qualified to receive retirement state pensions\n* Patients that cannot understand and fulfil the study surveys (in Danish)\n* Patients with short witnessed cardiac arrests with return of spontaneous circulation estimated less than 4 minutes and immediate awakening without ICU treatment","65 Years",{"count":653,"type":22},214,[25],"This study is a parallel group multicentre investigator-initiated clinical randomised controlled superiority trial that will include a total of 214 survivors of OHCA.\n\nParticipants will to be randomized with a 1:1 allocation ratio to either a intervention consisting of a comprehensive initiated tailored rehabilitation intervention focusing on supporting RTW plus usual care compared to usual care alone.",[32,657,281,658,659,660,661,662],"Heart Arrest","Return to Work","Return-to-work","Rehabilitation","Recovery of Function","Cardiac Rehabilitation",[664,665,657,281,666,659,667,660,661,662],"Labour marked","Cardiac arrest","Return to work","Back to Work","2025-12-01",{"date":670,"type":43},"2025-12-08",{"date":672,"type":43},"2022-02-01",{"date":674,"type":22},"2028-07-31",{"name":676,"class":50},"Rigshospitalet, Denmark"]