[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiac-conduction-system\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiac-conduction-system":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":5},"100477030","high-intensity-his-bundle-pacing-in-heart-failure-patients-with-narrow-qrs-outcome-study-100477030",false,"NCT05491655","High Intensity His Bundle Pacing in Heart Failure Patients With Narrow QRS Outcome Study","HIPPOS","Inclusion Criteria:\n\n* Aged 18 or above\n* Ventricular Ejection Fraction (EF) \\\u003C 50%; BNP needs to be ≥250ng\u002FL or N Terminal-pro BNP≥600ng\u002FL for patients with EF 36-50% and they should have an ICD indication\n* New York Heart Association (NYHA) class I-IV\n* Narrow QRS duration (≤110ms) on 12 lead ECG\n\nExclusion Criteria:\n\n* Other serious medical condition with life expectancy of less than 1 year\n* Lack of capacity to consent\n* Pregnancy\n* Previous aortic valve surgery","ALL","18 Years","90 Years",{"count":20,"type":21},34,"ESTIMATED","INTERVENTIONAL",[24],"NA","Cardiac Resynchronization Therapy (CRT) decreases heart failure hospitalizations and mortality and increases left ventricular Ejection Fraction (EF) in patients with dilated cardiomyopathy, left bundle branch block and QRS duration \\>130msec. His bundle pacing has a similar effect in this category of patients. However, CRT is not beneficial in heart failure (HF) patients with narrow QRS. His-bundle pacing delivers physiological ventricular activation and has been shown to improve acute hemodynamic function in patients with heart failure, a prolonged PR interval, and either a narrow QRS or RBBB through AV delay optimization. We observed an acute hemodynamic effect during application of higher pacing output (3.5 Volts\u002F1 msec) in HF patients with dilated or ischemic cardiomyopathy and narrow QRS independently of the paced QRS duration or AV delay shortening.\n\nThis is a single-center, prospective randomized single-blinded study, recruiting a sub-population of patients with heart failure (dilated or ischemic cardiomyopathy, EF\\\u003C50%, narrow QRS (\\\u003C110 msec), in optimal medical treatment who have an indication for ICD.",[27,28,29,30],"Cardiac Conduction System","His Bundle Pacing","Heart Failure","Cardiomyopathies",[32,33,34,35,36,37],"His bundle pacing","conduction system pacing","Heart failure","Cardiomyopathy","narrow QRS","Ejection Fraction","RECRUITING","2025-12-15",{"date":41,"type":42},"2025-12-22","ACTUAL",{"date":44,"type":42},"2023-03-29",{"date":46,"type":21},"2026-05",{"name":48,"class":49},"Miulli General Hospital","OTHER"]