[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiac-insufficiency\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiac-insufficiency":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100635035","bachmann-bundle-pacing-for-prevention-of-new-onset-atrial-fibrillation-in-patients-with-heart-failure-100635035",false,"NCT07547449","Bachmann Bundle Pacing for Prevention of New-Onset Atrial Fibrillation in Patients With Heart Failure","Clinical Efficacy of Bachmann Bundle Pacing on New-Onset Atrial Fibrillation in Patients With Cardiac Insufficiency","Inclusion Criteria:\n\n1. Aged between 18 and 70 years old;\n2. Diagnosis of chronic cardiac insufficiency according to current guidelines, and received guideline-directed medical therapy (GDMT) for at least 3 months;\n3. Have indications for CRT\u002FLBBP or ICD implantation, and expected atrial pacing ratio \\> 20%, including: Sinus rhythm, QRS duration \\> 120ms, LBBB, LVEF ≤ 35% with symptomatic heart failure; Sinus rhythm, QRS duration ≥ 150ms, non-LBBB, LVEF ≤ 35% with symptomatic heart failure; Sinus rhythm, QRS duration \\> 120ms, LBBB, LVEF 36%-50% with symptomatic heart failure; Symptomatic heart failure with LVEF ≤ 50% and expected ventricular pacing ratio \\> 20%; Symptomatic heart failure with LVEF ≤ 50% requiring ICD implantation for primary or secondary sudden death prevention, with atrial pacing indication due to sinus bradycardia or expected atrial pacing ratio \\> 20%;\n4. Patients with pacing-induced cardiomyopathy requiring upgrade therapy, in sinus rhythm, and requiring reimplantation of atrial lead;\n5. Signed written informed consent form approved by the ethics committee.\n\nExclusion Criteria:\n\n1. Expected survival time less than 12 months;\n2. Status after mechanical tricuspid valve replacement, or congenital heart disease (including dextrocardia, transposition of great arteries, single left persistent superior vena cava);\n3. Previous history of atrial fibrillation;\n4. Previous cardiac surgery, or requiring surgical treatment for severe structural heart disease within 1 year;\n5. Pregnancy, planned pregnancy, or heart transplantation;\n6. Patient refusal to participate in the study.","ALL","18 Years","70 Years",{"count":20,"type":21},140,"ESTIMATED","INTERVENTIONAL",[24],"NA","This is a multi-center, prospective, single-blind, randomized controlled clinical trial to evaluate the efficacy and safety of Bachmann bundle pacing (BBP) in preventing new-onset atrial fibrillation (AF) in patients with chronic cardiac insufficiency who have indications for cardiac resynchronization therapy with left bundle branch pacing (CRT\u002FLBBP) or implantable cardioverter defibrillator (ICD) implantation.\n\nA total of 110 eligible patients will be randomly assigned 1:1 to the BBP group or the traditional right atrial appendage (RAA) pacing group. All patients will receive guideline-directed medical therapy (GDMT) for at least 3 months and standardized follow-up for 12 months after device implantation. The primary endpoint is the incidence of new-onset AF within 12 months after implantation. Secondary endpoints include time to first new-onset AF, procedural success rate, changes in cardiac function parameters, and incidence of adverse events. This study aims to provide high-level evidence-based medical evidence for BBP as a new atrial pacing strategy to prevent AF in heart failure patients.",[27,28,29],"Heart Failure","Atrial Fibrillation (AF)","Cardiac Insufficiency",[31,32,33,34,35,36],"Bachmann Bundle Pacing","Right Atrial Appendage Pacing","Cardiac Resynchronization Therapy","Implantable Cardioverter Defibrillator","Physiological Pacing","New-Onset Atrial Fibrillation","NOT_YET_RECRUITING","2026-04-16",{"date":40,"type":41},"2026-04-23","ACTUAL",{"date":43,"type":21},"2026-04",{"date":45,"type":21},"2028-04",{"name":47,"class":48},"Fu Wai Hospital, Beijing, China","OTHER"]