[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiac-rehabilitation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiac-rehabilitation":38},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,35,0,25,[9,57,83,110,139,171,209,236,270,297,326,350,375,396,419,457,480,502,534,560,584,608,637,659,683],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":41,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100638424","ecardiacrehab---a-hybrid-patient-centered-ehealth-programme-100638424",false,"NCT07590635","eCardiacRehab - a Hybrid Patient-Centered eHealth Programme","eCardiacRehab - a Randomized Controlled Trial on a Hybrid Home-Based Patient-Centered eHealth Programme With Tailored Solutions","eCardiacRehab","Inclusion Criteria:\n\n* Adult Norwegian (or Scandinavian) speaking patients (≥ 18 years) who have a Norwegian national identification number\n* With coronary artery disease after percutaneous coronary intervention\n* Living at home\n* Have internet available\n* Provide signed informed consent\n\nExclusion Criteria:\n\n* Patients with cognitive impairment that may interfere with the ability to comply with the study protocol\n* Severe aortic stenosis\n* Severe arrhythmias\n* Expected lifetime less than one year as determined by study personnel\n* Otherwise clinically unstable\n* Not fully revascularized\n* Awaits percutaneous coronary intervention or coronary artery bypass graft surgery\n* Inability to comply with the study protocol due to any physical disability, somatic disease, or mental problems as determined by study personnel","ALL","18 Years",{"count":21,"type":22},1000,"ESTIMATED","INTERVENTIONAL",[25],"NA","The overall aim of eCardiacRehab trial is to meet rehabilitation needs of patients with coronary artery disease (CAD) regardless of their access to traditional place-based rehabilitation by developing and evaluating the efficacy and cost effectiveness of an interdisciplinary and comprehensive home-based hybrid programme. eCardiacRehab address patient- and system level challenges to increase access to cardiac rehabilitation (CR). We give particular attention to older patients, women, and those with comorbidities or mental health challenges. The vision of the hybrid home-based eCardiacRehab programme is to make CR available to all.\n\neCardiacRehab is a prospective, multicentre randomized open-label blinded end point evaluation (PROBE) trial. The primary endpoint is a hierarchical composite endpoint using a win-ratio framework combining cardiovascular (CV) death, unplanned contacts to the Emergency Department (ED) for observation or admission (\\>24 hours) for CV disease, and quality of life. Inclusion criteria are adult Scandinavian speaking patients (≥ 18 years) who have a Norwegian national identification number, with CAD treated with Percutaneous Coronary Intervention (PCI), are living at home, and have internet available to them and providing signed informed consent. Exclusion criteria are patients with severe aortic stenosis, severe arrhythmias, expected lifetime less than one year as determined by study personnel, otherwise clinically unstable, not fully revascularized, awaits PCI or coronary artery bypass graft operation (CABG) or inability to comply with the study protocol due to any physical disability, somatic disease, cognitive impairment or mental health challenges as determined by study personnel.",[28,29,30,31,32,33,34,35,36,37,38,39,40],"Comorbidities and Coexisting Conditions","Ethics","Continuity of Patient Care","Older Adults (65 Years and Older)","Cost-Benefit Analysis","Adherence, Medication","Secondary Prevention of Coronary Heart Disease","Health Literacy","eHealth Literacy","Mental Health","Cardiac Rehabilitation","Womens's Health","Coronary Artery Disease (CAD)",[38,42,43],"Coronary Artery Disease","Percutaneous Coronary Intervention","RECRUITING","2026-06-18",{"date":47,"type":48},"2026-06-23","ACTUAL",{"date":50,"type":48},"2026-05-21",{"date":52,"type":22},"2037-12-31",{"name":54,"class":55},"Haukeland University Hospital","OTHER",1,{"id":58,"slug":59,"hasResults":12,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":64,"targetDuration":4,"studyType":23,"phases":66,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":82},"100599043","improving-veteran-referral-to-cardiac-rehabilitation-100599043","NCT07079358","Improving Veteran Referral to Cardiac Rehabilitation","Improving Veteran Referral to Cardiac Rehabilitation: A Hybrid Effectiveness-Implementation Trial","Inclusion Criteria:\n\n* All Veterans hospitalized with acute myocardial infarction, percutaneous coronary intervention, cardiac valve surgery, coronary artery bypass grafting, or systolic heart failure at the three participating VA medical centers (Nashville, Dallas, and Gainesville).\n\nExclusion Criteria:\n\n* No exclusion criteria during the intervention period\n\n  * however, post-hoc analysis will exclude Veterans with documented reasons preventing CR attendance including death during hospitalization or within 30 days of discharge, discharge to inpatient rehabilitation or skilled nursing facilities, significant cognitive impairment, high-risk ventricular arrhythmias, or explicit refusal of CR services.",{"count":65,"type":22},816,[25],"This study will test whether the Veterans Cardiac Rehabilitation Referral Program (VCR2P) improves cardiac rehabilitation participation by studying 816 Veterans across three VA medical centers in Nashville, Dallas, and Gainesville over 12 months. The trial compares referral rates from the 6 months before implementing the program to 6 months after, using a \"before and after\" design since randomization would be impractical. The study will measure whether the program increases the proportion of eligible Veterans who receive cardiac rehabilitation referrals and whether more Veterans actually attend rehabilitation sessions. Additionally, focus groups with physicians, nurses, and Veterans will identify what helps or hinders the program's success, providing essential insights for expanding this intervention to other VA facilities nationwide if it proves effective.",[69,38],"Cardiovascular Disease",[38,71],"Hybrid Effectiveness-Implementation Trial","2026-06-15",{"date":74,"type":48},"2026-06-17",{"date":76,"type":48},"2026-02-23",{"date":78,"type":22},"2029-12-31",{"name":80,"class":81},"VA Office of Research and Development","FED",3,{"id":84,"slug":85,"hasResults":12,"nctId":86,"briefTitle":87,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":92,"phases":4,"briefSummary":93,"conditions":94,"keywords":95,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":56},"100642668","barriers-and-facilitators-to-psychosocial-management-in-cardiac-rehabilitation-at-the-south-francilien-hospital-center-chsf-100642668","NCT07651501","Barriers and Facilitators to Psychosocial Management in Cardiac Rehabilitation at the South Francilien Hospital Center (CHSF)","PSYRCV","Inclusion Criteria:\n\n* Male and female, legally adult patients, participating in a cardiac rehabilitation program in day hospital at the CHSF\n* Active in the workforce\n* Planning to return to work\n* Patients informed of the study and who did not object to it\n\nExclusion Criteria:\n\n* Patient under legal guardianship\n* Presence of cognitive impairments\n* Patients who do not speak nor understand French.",{"count":91,"type":22},20,"OBSERVATIONAL","The goal of this observational study is to describe the barriers to psychosocial management in cardiac rehabilitation patients at the south francilien hospital center (CHSF) and understand how to improve it, in order to facilitate their return to work.\n\nThe main questions it aims to answer are :\n\n* What are the perceived barriers to psychosocial management among the male and female cardiac rehabilitation patients at the CHSF ?\n* What are the perceived barriers to psychosocial management among the medical, paramedical and administrative staff members of the cardiac rehabilitation service at the CHSF ?",[38],[96,97,98,99],"cardiac rehabilitation","Psychosocial intervention","Occupational health","Return to work","NOT_YET_RECRUITING","2026-06-11",{"date":103,"type":48},"2026-06-16",{"date":105,"type":22},"2026-09-01",{"date":107,"type":22},"2026-12-31",{"name":109,"class":55},"Centre Hospitalier Sud Francilien",{"id":111,"slug":112,"hasResults":12,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":12,"sex":18,"minAge":118,"maxAge":4,"enrollmentInfo":119,"targetDuration":4,"studyType":23,"phases":121,"briefSummary":122,"conditions":123,"keywords":127,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":82},"100469858","behavioral-exposure-for-introceptive-tolerance-rct-100469858","NCT05398276","Behavioral Exposure for Introceptive Tolerance RCT","A Tailored Exposure Intervention for Exercise Anxiety and Avoidance in Cardiac Rehabilitation","BE-FIT","Inclusion Criteria:\n\n1. ≥ 40 years of age\n2. Elevated exercise anxiety (score of ≥ 30 on ESQ-18)\n3. Low active (\\\u003C 90 min self-reported moderate-to-vigorous intensity physical activity\u002Fday in past three months)\n4. Medically approved cardiac rehabilitation\n5. English proficiency\n\nExclusion Criteria:\n\n1. Evidence of cognitive impairment (≤ 23 on Montreal Cognitive Assessment; MoCA)\n2. Severe disabling chronic medical and\u002For psychiatric comorbidities determined on a case-by-case basis that prevents safe or adequate participation\n3. Expectation that patient will not live through study periods","40 Years",{"count":120,"type":22},146,[25],"Behavioral Exposure for Interoceptive Tolerance (BE-FIT) is a mechanism-informed behavioral intervention to target exercise anxiety. The three primary components of BE-FIT include: (1) exposure to feared bodily sensations and exercise; (2) prevention of safety behavior use before\u002Fduring\u002Fafter exercise, and (3) use of a wrist-worn activity monitor for physical activity (PA) feedback and activity goal setting. Evidence from the investigators' Stage I trial indicated that BE-FIT is feasible, acceptable, and safe and produced reductions in exercise anxiety and increased exercise outcomes (short-term moderate-to-vigorous intensity physical activity and steps\u002Fday). The investigators' present aim is to conduct a Stage II randomized-controlled trial to further evaluate the efficacy of BE-FIT in decreasing exercise anxiety in cardiac rehabilitation (CR) patients and examine whether changes in this target yield successive changes in exercise adherence outcomes.",[124,125,126,38],"Exercise Sensitivity","Introceptive Exposure","Anxiety",[124,125,128,129],"Kinesiophobia","Acceptance and Commitment Therapy","2026-06-10",{"date":132,"type":48},"2026-06-12",{"date":134,"type":48},"2022-05-03",{"date":136,"type":22},"2027-02-28",{"name":138,"class":55},"Rutgers, The State University of New Jersey",{"id":140,"slug":141,"hasResults":12,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":146,"targetDuration":4,"studyType":23,"phases":148,"briefSummary":149,"conditions":150,"keywords":153,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":56},"100639519","high-flow-nasal-cannula-on-exercise-tolerance-in-heart-failure-patients-undergoing-cardiac-rehabilitation-100639519","NCT07613762","High-Flow Nasal Cannula on Exercise Tolerance in Heart Failure Patients Undergoing Cardiac Rehabilitation","Effect of High-Flow Nasal Cannula Use on Exercise Tolerance and Physical Performance in Heart Failure Patients Enrolled in a Cardiac Rehabilitation Program: A Randomized Crossover Trial","Inclusion Criteria:\n\n* Age 18 years or older\n* Medical diagnosis of heart failure (documented in clinical record or referral)\n* Electrocardiogram performed within the last 6 months\n* Functional capacity class II or III according to the New York Heart Association (NYHA) classification\n* Stable pharmacological treatment\n* Stable and controlled comorbidities\n* Available to complete two evaluation sessions\n* Able and willing to provide written informed consent\n\nExclusion Criteria:\n\n* Diagnosis of respiratory disease (chronic obstructive pulmonary disease, interstitial lung disease, or pulmonary hypertension)\n* Myocardial infarction within the past 3 months\n* Hospitalization due to heart failure within the past 4 weeks\n* Cognitive impairment or inability to follow the study protocol\n* Neuromuscular or osteoarticular conditions that limit treadmill test performance",{"count":147,"type":22},28,[25],"The goal of this clinical trial is to learn if a high-flow nasal cannula (HFNC) - a device that delivers warm, humidified air through a small tube placed in the nostrils - can improve exercise tolerance in adults with heart failure (HF) who are entering a cardiac rehabilitation program. The main questions it aims to answer are: Can HFNC help people with heart failure exercise for a longer time during a treadmill test? and does HFNC lower how hard people feel they are working during exercise?\n\nResearchers will compare exercise performance with HFNC to exercise performance without HFNC to see if HFNC helps people with HF tolerate exercise better. Participants will:\n\nComplete two treadmill exercise tests, one with HFNC and one without, in a randomly assigned order.\n\nWait 48 to 72 hours between the two tests to allow full recovery. Have their heart rate, blood pressure, oxygen level, and breathing rate measured before and after each test.",[151,152,38],"Heart Failure","Exercise Tolerance (Measured in Minutes)",[154,155,151,38,156,157,158,159,160,161],"High-Flow Nasal Cannula","HFNC","Exercise Tolerance","Incremental Treadmill Test","Crossover Trial","Dyspnea","Physical Performance","Cardiopulmonary Rehabilitation","2026-05-30",{"date":164,"type":48},"2026-06-02",{"date":166,"type":22},"2026-06-01",{"date":168,"type":22},"2027-03",{"name":170,"class":55},"Universidad de Santiago de Chile",{"id":172,"slug":173,"hasResults":12,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":177,"eligibilityCriteria":178,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":179,"targetDuration":4,"studyType":23,"phases":181,"briefSummary":182,"conditions":183,"keywords":196,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":208},"100640479","reaction-vad-trial-remote-exercise-training-via-telemedicine-in-patients-with-long-term-ventricular-assist-devices-100640479","NCT07611188","REACTION-VAD Trial: Remote Exercise Training Via Telemedicine in Patients With Long-Term Ventricular Assist Devices","Efficacy and Safety of a Remote Conditioning Program in Patients Supported With a Ventricular Assist Device: THE RE-ACTION-VAD TRIAL.","REACTION-VAD","Inclusion Criteria (must meet all):\n\n* Recent LVAD Implantation (\\\u003C6 months)\n* Clinical stability (defined as meeting all of the following criteria): discharge from the LVAD implantation hospitalization, absence of inotropic medication, hemoglobin \\>9 g\u002FdL, and no active infection.\n* Inability to participate in a supervised rehabilitation program (due to lack of availability, or inability because geographical reasons).\n\nExclusion Criteria (any):\n\n* Functional Inability to Perform Cardiopulmonary Exercise Testing\n* Prior Participation in a Supervised Rehabilitation Program (after the LVAD implantation)",{"count":180,"type":22},78,[25],"Current international guidelines recommend that patients with a heart pump (left ventricular assist device, LVAD) participate in supervised exercise cardiac rehabilitation programs. However, not all patients with a heart pump are able to attend to a supervised program on a daily basis.\n\nThe goal of this clinical trial is to determine whether a home-based exercise program helps patients with a heart pump improve their exercise capacity and quality of life, guided by telemedicine tools including a mobile app, smartwatch, and remote medical checkups. The study will also provide information about the safety of this program by monitoring for any issues or symptoms during home activity.\n\nThe trial aims to answer the following questions:\n\n* Does a 12-week remote exercise program improve patients' exercise capacity? This will be measured using the 6-minute walk test and a cardiopulmonary exercise test.\n* Is it safe for patients to follow this exercise plan at home while being monitored through a mobile app and smartwatch?\n* Does the program improve quality of life and reduce feelings of anxiety or depression? This will be assessed using widely validated questionnaires, such as the Kansas City Cardiomyopathy Questionnaire.\n\nResearchers will compare the remote exercise program to standard care, which usually does not include exercise for patients who are unable to attend the hospital daily.\n\nParticipants will:\n\n* Join the study voluntarily after signing a consent form.\n* Be randomly assigned, with a 50% chance of being in either the exercise group (following a structured plan with a mobile app) or the usual care group (receiving general written advice), to see which approach works best for recovery.\n* Follow a 12-week home-based routine if in the exercise group, including warm-up routine, walking or cycling, respiratory exercises, and light strength training, all supported by the mobile app, smartwatch, and professional monitoring.\n* Visit the hospital three times over six months for medical checkups, including walking and exercise tests, blood analyses, and questionnaires about physical and emotional health.",[151,184,185,186,38,187,188,189,190,191,192,193,194,195],"Advanced Heart Failure","Left Ventricular Assist Device","LVAD","Telemedicine","Remote Exercise","Ventricular Assist Device","Exercise Training","Conditioning Therapy","Cardiopulmonary Exercise Test","Six Minute Walk Test","Quality of Life","Telerehabilitation",[185,184,151,38,197,187,198,194,192,195],"Remote rehabilitation","6 minute walking test","2026-05-20",{"date":201,"type":48},"2026-05-28",{"date":203,"type":22},"2026-05",{"date":205,"type":22},"2030-12",{"name":207,"class":55},"Puerta de Hierro University Hospital",10,{"id":210,"slug":211,"hasResults":12,"nctId":212,"briefTitle":213,"officialTitle":214,"acronym":215,"eligibilityCriteria":216,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":217,"targetDuration":4,"studyType":23,"phases":219,"briefSummary":220,"conditions":221,"keywords":223,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":233,"locationsCount":235},"100609186","monitoring-and-guidance-of-physical-activity-during-the-maintenance-phase-of-cardiac-rehabilitation-the-antwerp-activity-index-100609186","NCT07211282","Monitoring and Guidance of Physical Activity During the Maintenance Phase of Cardiac Rehabilitation: the Antwerp Activity Index","Transmural Physical Activity Monitoring and Guidance During Phase 3 Cardiac Rehabilitation: the Antwerp Activity Index","AMAAI","Inclusion Criteria:\n\n1. Age ≥ 18 years,\n2. Patients in the last phase of phase 2 CR,\n3. Having a smartphone available,\n4. Being capable of signing the informed consent.\n\nExclusion Criteria:\n\n1. Patients with high-risk criteria for safe exercise participation following a cardiac event, including:\n\n   1. Ejection fraction less than 30%\n   2. Decrease in systolic blood pressure of more than 15 mmHg with exercise\n   3. Serious arrhythmias at rest or exercise-induced\n   4. Exercise-induced ischemia indicated by angina more than 2 mm ST segment depression on the ECG\n2. Patients with severe heart failure (NYHA III-IV),\n3. Patients with implantable devices (e.g. pacemakers),\n4. Patients diagnosed with permanent AF,\n5. Patients who do not speak and read Dutch or English,\n6. Patients who have cognitive impairment (e.g. severe dementia).",{"count":218,"type":22},318,[25],"The goal of this clinical trial is to determine whether the AAI activity score can help cardiac rehabilitation patients adhere to physical activity guidelines after participating in an in-hospital cardiac rehabilitation program. The main questions it aims to answer are:\n\n1. Does the AAI activity score have an impact on adherence to physical activity maintenance during phase 3 CR?\n2. Does the AAI activity score predict changes in cardiorespiratory fitness? Researchers will compare participants who use the AAI activity score with those who do not to determine if there are differences in physical activity adherence.\n\nParticipants will:\n\n* Wear a smartwatch to continuously measure heart rate for 4 months;\n* Perform an exercise stress test at the end of the study;\n* Fill in several questionnaires at the end of the study.",[38,222],"Cardiovascular Disease Prevention",[224,96,225],"physical activity","heart rate monitor","2026-04-30",{"date":228,"type":48},"2026-05-06",{"date":230,"type":48},"2025-02-17",{"date":232,"type":22},"2029-01",{"name":234,"class":55},"University Hospital, Antwerp",2,{"id":237,"slug":238,"hasResults":12,"nctId":239,"briefTitle":240,"officialTitle":241,"acronym":242,"eligibilityCriteria":243,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":244,"targetDuration":4,"studyType":23,"phases":246,"briefSummary":247,"conditions":248,"keywords":250,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":264,"completionDateStruct":266,"leadSponsor":268,"locationsCount":56},"100584242","smart-to-optimize-an-intervention-to-maintain-health-improvements-after-cardiac-rehabilitation-100584242","NCT06886789","SMART to Optimize an Intervention to Maintain Health Improvements After Cardiac Rehabilitation","An Application of SMART Methodology to Optimize an Intervention to Maintain Improvements in Health Behaviors in Under-resourced Patients After Phase II Cardiac Rehabilitation","EMPOWER ME","Inclusion Criteria:\n\n* ≥18 years of age or older\n* Have completed at least 6 CR sessions\n* Must enroll within 6 weeks of their final CR session\n* BMI ≥27\n* Own an internet-connected device\n* Home internet access\n* English proficiency\n* Able to walk ≥1 block without stopping\n\nLastly, the participant MUST belong to ≥1 of the following groups or identities:\n\n* Identifies as a woman\n* Identifies as LGBTQIA+\n* Identifies as a racial or ethnic minority\n* Insecure transportation for medical appointments\n* Self-reported trouble paying for healthcare needs (e.g., copays)\n* Receive income-based subsidized benefits (e.g., state-funded health insurance for low-income residents)\n* Reside in a small town or rural area per 2010 United States Department of Agriculture Rural-Urban Commuting Area zip code or the Distressed Communities Index\n* Low educational attainment (≤high school diploma)\n* Low household income (less than twice the Federal Poverty Level) or meeting federal poverty guidelines per the National Committee on Vital and Health Statistics and the Department of Health and Human Services)\n\nExclusion Criteria:\n\n* New York Heart Association Class IV heart failure\n* Heart transplant in the last 5 months\n* Left ventricular assist device in the last 4 months\n* Physician diagnosis of dementia\n* Physician prescription for 24 hours of oxygen therapy daily\n* Coronary artery bypass surgery in the last 3 months\n* Current dialysis\n* Chronic gait or balance disturbances that would make unsupervised exercise unsafe\n* Current pregnancy\n* Report of conditions that the investigators believe would render them potentially unlikely to follow the protocol including terminal illness, active substance dependence, or other significant psychiatric problems that require inpatient hospitalization",{"count":245,"type":22},400,[25],"The study is sponsored by the National Heart, Lung, and Blood Institute, which is part of the National Institutes of Health. The study expects to enroll 400 subjects. The research team will recruit research participants that are finishing or will finish cardiac rehabilitation soon. Participants belong to one or more groups of people who are less often studied in cardiac rehabilitation research, may have less access to a formal cardiac rehabilitation maintenance program, or they may especially benefit from additional support after cardiac rehabilitation ends. The main purposes of this study are to evaluate which treatments work the best after cardiac rehabilitation, which order to deliver the treatments in, and which treatments are as minimally burdensome as possible while still working well. This study will make two comparisons (one comparison between a set of low-intensity interventions and another between a set of higher-intensity interventions) to determine which produces the best behavioral adherence immediately after Phase II (outpatient) cardiac rehabilitation",[249,38],"Cardiovascular Diseases",[251,252,253,254,255,256,257,258,259,260],"Cardiovascular disease","Cardiac rehabilitation","Medication adherence","Weight loss","Weight management","Weight maintenance","Physical activity","Intervention optimization","Sequential, multiple assignment, randomized trials","Digital health","2026-04-27",{"date":263,"type":48},"2026-04-28",{"date":265,"type":48},"2026-04-01",{"date":267,"type":22},"2030-08",{"name":269,"class":55},"The Miriam Hospital",{"id":271,"slug":272,"hasResults":12,"nctId":273,"briefTitle":274,"officialTitle":275,"acronym":4,"eligibilityCriteria":276,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":277,"enrollmentInfo":278,"targetDuration":4,"studyType":23,"phases":280,"briefSummary":281,"conditions":282,"keywords":286,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":265,"lastUpdatePostDateStruct":289,"startDateStruct":291,"completionDateStruct":293,"leadSponsor":295,"locationsCount":56},"100570192","healthrelated-quality-of-life-and-experiences-of-a-heart-rehabilitation-programme-after-care-for-infective-endocarditis-100570192","NCT06704048","Healthrelated Quality of Life and Experiences of a Heart Rehabilitation Programme After Care for Infective Endocarditis.","Healthrelated Quality of Life and Experiences of a Heart Rehabilitation Programme After Care for Infective Endocarditis. A Quantitave and Qualitative Study With Mixed Methods.","Inclusion Criteria:\n\n* Diagnosis of infective endocarditis (IE) based on Dukes ISCVID criteria and discharged after treatment for IE from the Department of Infectious Diseases, Hospital of Halmstad, Region Halland, Sweden.\n\nExclusion Criteria:\n\n* Not able to do a bicycle ergometer test or training.","90 Years",{"count":279,"type":22},50,[25],"How does health develop after Infective endocarditis (IE)? Can the health of patients with IE be improved by participation in the physical exercise training within cardiac rehabilitation program?\n\nParticipants will:\n\n* Answer digitally surveys on the perceived health for 4 times during 1 year\n* Participate in interviews on patient's experiences of health and rehabilitation 1 time before and 2 times after the training program during I year.\n* Be physically evaluated by a physiotherapist before and after the progam of physical exercise training within cardiac rehabilitation.\n* Do individual exercises in a group led by a physiotherapist 2 times weekly during 12 weeks.",[283,284,38,285],"Infective Endocarditis","Bacterial Infections","Patient Participation",[283,284,285,287,288,252],"Interview","Qualitative Research",{"date":290,"type":48},"2026-04-07",{"date":292,"type":48},"2024-08-22",{"date":294,"type":22},"2035-08",{"name":296,"class":55},"Region Halland",{"id":298,"slug":299,"hasResults":12,"nctId":300,"briefTitle":301,"officialTitle":302,"acronym":4,"eligibilityCriteria":303,"healthyVolunteers":12,"sex":18,"minAge":304,"maxAge":305,"enrollmentInfo":306,"targetDuration":4,"studyType":23,"phases":308,"briefSummary":309,"conditions":310,"keywords":312,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":318,"lastUpdatePostDateStruct":319,"startDateStruct":321,"completionDateStruct":323,"leadSponsor":324,"locationsCount":56},"100631392","strength-and-balance-integration-in-maintenance-cardiac-rehabilitation-for-older-adults-100631392","NCT07500077","Strength and Balance Integration in Maintenance Cardiac Rehabilitation for Older Adults","Exploring the Addition of Strength and Balance Exercise Into Traditional Community-based Maintenance Cardiac Rehabilitation Classes in Older Adults: A Pilot Cluster Randomised Controlled Trial","Inclusion Criteria:\n\n* English-speaking older adults\n* Aged ≥50 years old\n* Able to provide written informed consent\n* Currently engaged with community-based Maintenance Cardiac Rehabilitation exercise classes within Scotland for at least 6 months\n\nExclusion Criteria:\n\n* Show symptoms of an unstable cardiovascular medical condition\n* Have moderate or severe cognitive impairment (can neither understand nor write the informed consent form, and\u002For cannot follow instructions)\n* Have upper or lower limb amputation\n* Have had upper or lower limb fractures in the past six months.","50 Years","100 Years",{"count":307,"type":22},53,[25],"The goal of this cluster randomised clinical trial is to investigate the impact of adding strength and balance exercises into traditional aerobic-based Cardiac Rehabilitation Community\u002FMaintenance classes on the functional fitness of older adults.\n\nThe main questions it aims to answer are:\n\n1. To explore participants' functional fitness changes,\n2. Confidence in balance,\n3. Concerns about falling compared to those participating in traditional aerobic-based cardiac rehabilitation only.\n4. Understand the perceptions of participants regarding the addition of strength and balance into classes.\n5. Understand the views of exercise professionals delivering the classes with additional strength and balance.\n\nParticipants:\n\n1. Will get their Functional fitness measured using the Functional Fitness MOT at baseline, and carry out questionnaires on their current physical activity levels, confidence in balance and concerns about falling.\n2. The traditional aerobic-based cardiac rehabilitation classes (Clusters) will be randomised into Intervention Groups (additional strength and balance added) and usual care (Control Groups).\n3. After 12 weeks, Functional Fitness and the questionnaires will be reassessed.\n4. Two weeks after the 12-week follow-up, participants will be invited to an online focus group on Microsoft Teams to understand their perceptions of strength and balance.\n5. Additionally, exercise Leaders will be invited to an interview on Microsoft Teams to discuss their views on strength and balance incorporation into maintenance cardiac rehabilitation classes.",[38,311],"Older Adults (50-94 Years)",[313,38,314,315,316,317],"Strength and Balance","Functional Fitness","Community-based","Maintenance Phase","Older Adults (50-94 years)","2026-03-25",{"date":320,"type":48},"2026-03-30",{"date":322,"type":48},"2026-02-02",{"date":166,"type":22},{"name":325,"class":55},"Glasgow Caledonian University",{"id":327,"slug":328,"hasResults":12,"nctId":329,"briefTitle":330,"officialTitle":330,"acronym":331,"eligibilityCriteria":332,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":333,"targetDuration":4,"studyType":23,"phases":335,"briefSummary":336,"conditions":337,"keywords":338,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":341,"lastUpdatePostDateStruct":342,"startDateStruct":344,"completionDateStruct":346,"leadSponsor":348,"locationsCount":82},"100554901","optimizing-cardiac-rehabilitation-by-refining-sleep-and-stress-100554901","NCT06505109","OPTImizing CArdiac REhabilitation by REfining Sleep and STress","OPTICARE-RESST","Inclusion Criteria:\n\n* Participate in CR at one of the study centres for any cardiac diagnosis or reason as stated in the Dutch guidelines\n* Age at or above 18 years\n* Proficient in the Dutch language\n* Experiencing sleep and\u002For stress problems as indicated by a high score on the Pittsburgh Sleep Quality Index (PSQI score \\>5) or Perceived Stress Scale-10 (PSS-10 score \\>13)\n* Signed informed consent\n\nExclusion Criteria:\n\n* Severe psychiatric, cognitive or physical comorbidity that would impede CR participation\n* Active treatment for sleep disorders, stress, or other forms of (behavioural) therapy at the start of the study or expected to start within the first 6 months of the study, that could interfere with the RESST intervention. Note: Participants with previously diagnosed sleep disorders are eligible if they still experience sleep or stress problems, unless they fall under the above criteria. Participants who received a prior treatment that is still ongoing but has resulted in a stable sleep and stress condition in the 3 months before the cardiovascular event (e.g., Continuous Positive Airway Pressure (CPAP)) are eligible.",{"count":334,"type":22},200,[25],"The primary objective of this project is to investigate the effectiveness and costs of integrating a behavioural program targeting sleep and stress (the RESST intervention) into cardiac rehabilitation (CR). In addition, the investigators will also study whether parameters regarding diversity (e.g., sex, ethnicity, socioeconomic position) are associated with intervention effectiveness. Furthermore, the investigators aim to explore the (bidirectional) relation between sleep and stress on the one hand, and other lifestyle components and health outcomes on the other hand.",[249,38],[249,38,339,340],"Sleep","Stress","2026-03-11",{"date":343,"type":48},"2026-03-13",{"date":345,"type":48},"2024-08-28",{"date":347,"type":22},"2027-01",{"name":349,"class":55},"Erasmus Medical Center",{"id":351,"slug":352,"hasResults":12,"nctId":353,"briefTitle":354,"officialTitle":355,"acronym":4,"eligibilityCriteria":356,"healthyVolunteers":357,"sex":18,"minAge":358,"maxAge":4,"enrollmentInfo":359,"targetDuration":4,"studyType":23,"phases":361,"briefSummary":362,"conditions":363,"keywords":4,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":367,"startDateStruct":369,"completionDateStruct":371,"leadSponsor":373,"locationsCount":4},"100535126","reducing-heart-failure-risk-in-late-life-with-physical-activity-100535126","NCT06247774","Reducing Heart Failure Risk in Late-Life With Physical Activity","Reducing Heart Failure Risk in Late-Life With Physical Activity: Impact on Cardiac Structure and Function and Proteomic Signatures","Inclusion Criteria:\n\n* Hypertension (controlled on stable medication regimen)\n* Structural heart abnormality (LVH or LA enlargement)\n* LVEF \\> 50%\n* Sedentary\n* BMI \\\u003C30\n\nExclusion Criteria:\n\n* Diabetes\n* Unable to exercise\n* Supplemental oxygen use\n* Pulmonary hypertension\n* Sleep apnea\n* Regular exercise training\n* Devices that limit ability to achieve target heart rate\n* Moderate to severe valve disease\n* Recent (within 3 months) major CV event or planned procedures (within 6 months)\n* Terminal illness, life expectancy \\\u003C6 months\n* Inability or unwillingness to comply with study requirements\n* No access to smart phone\u002Ftablet",true,"65 Years",{"count":360,"type":22},42,[25],"The goal of this clinical trial is to learn about the molecular pathways associated with the benefit of a regular exercise program in patients with high blood pressure and who don't already participate in regular exercise.\n\nThe main question it aims to answer is to identify protein signatures associated with the benefits of a cardiac rehabilitation exercise program.\n\nThe trial will enroll 42 participants, who will be randomized to a 12 week cardiac rehabilitation exercise program versus control arm and asked to participate in the following at the beginning and end of study:\n\n* Cardiopulmonary exercise test (CPET)\n* Echocardiogram\n* Physical function test\n* 6-minute walk test\n* Hand grip strength\n* Quality of life questionnaire\n* Blood draws\n\nResearchers will compare results between those who do and don't participate in the exercise program.",[364,190,38,365],"Hypertension","Proteomics","2026-03-10",{"date":368,"type":48},"2026-03-12",{"date":370,"type":22},"2026-06",{"date":372,"type":22},"2029-05",{"name":374,"class":55},"Brigham and Women's Hospital",{"id":376,"slug":377,"hasResults":12,"nctId":378,"briefTitle":379,"officialTitle":380,"acronym":4,"eligibilityCriteria":381,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":382,"targetDuration":4,"studyType":23,"phases":384,"briefSummary":385,"conditions":386,"keywords":4,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":387,"lastUpdatePostDateStruct":388,"startDateStruct":390,"completionDateStruct":392,"leadSponsor":394,"locationsCount":235},"100502771","cardiac-rehabilitation-mobile-health-fall-risk-prevention-intervention-100502771","NCT05826587","Cardiac Rehabilitation Mobile-Health Fall Risk Prevention Intervention","A Mobile-Health (mHealth) Fall Risk Prevention Intervention in Cardiac Rehabilitation: A Randomized Control Trial","Inclusion Criteria:\n\n* All patients referred to and who undergo early outpatient CR irrespective of diagnosis will be eligible for the study.\n* All participants must have access to a smart mobile device.\n\nExclusion Criteria:\n\n* Advanced dementia.\n* Wheelchair bound.\n* Vision loss.\n* Patients that underwent sternotomy within 12-weeks will be excluded from the upper body muscular strength\u002Fpower assessment and associated upper body training. At the time of enrollment into CR, balance, upper body muscular fitness, and lower body muscular fitness will be assessed in each subject before they are randomized at a 1:1 allocation ratio into one of two parallel groups:\n* Standard early outpatient center-based supervised CR only (control; CR); or\n* Early outpatient center-based supervised CR plus individualized, home-based, m-Health delivered physical function training (experimental group; CR+PFt). Balance, upper body muscular fitness, and lower body muscular fitness and gait will be reassessed in each participant after 5-to-6 weeks of CR and again upon completion of the CR program. Patient reported measures of fall risk will be measured at baseline with the Stop Elderly Accidents, Deaths, and Injuries (STEADI) tool kit. Balance confidence, health-related quality of life, physical activity level, and functional capacity will be evaluated before and after CR and CR+PFt using the Activities-Specific Balance Confidence (ABC) Scale, the Dartmouth Primary Care Cooperative Information Project (COOP) charts, and the Duke Activity Status Index (DASI).",{"count":383,"type":22},128,[25],"The purpose of this research is to see if taking part in a structured exercise plan that is designed to improve balance and muscle strength and one that can done at home helps to improve the ability to perform standard physical tasks, confidence in balance, and health-related quality-of-life",[38],"2026-01-15",{"date":389,"type":48},"2026-01-20",{"date":391,"type":48},"2023-10-09",{"date":393,"type":22},"2026-12",{"name":395,"class":55},"Mayo Clinic",{"id":397,"slug":398,"hasResults":12,"nctId":399,"briefTitle":400,"officialTitle":401,"acronym":402,"eligibilityCriteria":403,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":404,"targetDuration":4,"studyType":23,"phases":406,"briefSummary":407,"conditions":408,"keywords":4,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":409,"lastUpdatePostDateStruct":410,"startDateStruct":412,"completionDateStruct":414,"leadSponsor":416,"locationsCount":56},"100615307","effectiveness-of-home-based-cardiac-rehabilitation-100615307","NCT07290907","Effectiveness of Home-Based Cardiac Rehabilitation","EFFECTIVENESS OF HOME-BASED CARDIAC REHABILITATION TO IMPROVE QUALITY OF LIFE AND HEALTH BEHAVIOR OF PATIENTS WITH CARDIOVASCULAR DISEASES IN LOW-RESOURCE SETTINGS IN PAKISTAN","NCD CVD HBCR","Inclusion Criteria:\n\nDiagnosed with coronary artery disease, myocardial infarction and heart failure Diagnosed with cardiovascular diseases based on clinical history and diagnosis, including electrocardiogram (ECG), biochemical markers, or non-invasive tests like, echocardiography, exercise tolerance test (ETT), Thallium stress test, and selected for procalcitonin PCI, a biomarker for the diagnosis of the infection Either gender included Found medically stable and discharged from the hospital. Resident of the surrounding areas other than the sectors of Islamabad as defined by the Capital Development Authority (CDA) of Pakistan.\n\n\\-\n\nExclusion Criteria:\n\n\\-",{"count":405,"type":22},92,[25],"Statement of the Problem WHO stated that the average life expectancy has been recorded as 40 years among these in South Asian countries and 98 million people relate to Pakistan. Wang pointed out that the significant difference has been seen regarding provision of the health care facilities being provided in the rural and urban settings, called as health poverty in rural area as compared to urban areas. Therefore, accessibility of essential healthcare facilities such as experienced staff, vaccination and necessarily supply of medicines in rural population would be supporting reducing health poverty and will maintain equal and equitable opportunities. Andersen and Newman argued that there are main factors such as distance, time and travel costs that affect health accessibility for the poor people living in rural settings which are deprived of emergency care and common in developing economies.\n\nCardiac Rehabilitation is a efficient, safe and affordable intervention that lowers overall health service financial burden. Additionally, CR are planned to optimize and restore physical, psychological, and social functioning by combining medical consultation, individualized exercise sessions, education, cardiac risk factor modification, and health counseling. CR is highly and mostly suggested as the key multicomponent and multi-dimensional intervention for the prevention of death by cardiac attacks, the lowering chances of hospital readmissions, and the enhancement of quality of life (QoL) of the people. Therefore, CR is one of the effective techniques to decrease the increasing number of cases and provide an efficient cardiac health intervention program with appropriate planning and organization.\n\nDespite the evidence of cost-effective rehabilitation program to optimize cardiac functioning at the hospital-based settings but the participation in cardiac rehabilitation, traditionally delivered in hospital outpatient departments or community, Despite the evidence of cost-effective rehabilitation program to optimize cardiac functioning at the hospital-based settings but the participation in cardiac rehabilitation, traditionally delivered in hospital outpatient departments or community centers, has remained low, with average participation rates \\\u003C 20% recorded in the United States and similarly in the Europe. Low participation has predominantly recorded mostly in few groups like women, elder population, ethnic minorities, and those living in rural settings or who are socioeconomically and financially resource constrained. Subsequently, these patients were contacted through calls for alternative options to center-based cardiac rehabilitation. Recommended interventions included cardiac rehabilitation at home transited by healthcare professionals with the support of telehealth technologies to maximize participation. Thus, the home-based cardiac rehabilitation program was recommended by the American Heart Association and the American College of Cardiology in 2019 through a scientific statement. Guidelines from NICE on chronic heart failure in the UK in 2018 said that \"delivery of home-based rehabilitation may enhance the accessibility and participation. For changing behavior and improving quality of life, HBCR is an essential component of secondary prevention and an important alternative technique, for those patients who suffered a cardiac incident or experienced any other cardiac event. Hence, HBCR is one of the effective t strategies to reduce the higher number of cases. HBCR contains techniques for secondary prevention that facilitate cardiac patients to rebuild their functional cardiac capacity and decrease the magnitude of hospital visits and workload in emergency management in coronary critical areas.\n\nMost of the studies were done on cardiovascular disease and on the conventional approach of hospital-based cardiac rehabilitation, but rare literature in the context of Pakistan, especially Islamabad, was found on home-based cardiac rehabilitation to improve the quality of life and behavior of the patients. Thus, the study aims to evaluate the effectiveness of home-based cardiac rehabilitation to improve the quality of life and health behavior of patients with cardiovascular disease in low resource settings in Islamabad.",[38],"2025-12-17",{"date":411,"type":48},"2025-12-18",{"date":413,"type":22},"2025-12-15",{"date":415,"type":22},"2026-03-15",{"name":417,"class":418},"Pakistan Institute of Medical Sciences","OTHER_GOV",{"id":420,"slug":421,"hasResults":12,"nctId":422,"briefTitle":423,"officialTitle":424,"acronym":425,"eligibilityCriteria":426,"healthyVolunteers":12,"sex":18,"minAge":118,"maxAge":427,"enrollmentInfo":428,"targetDuration":430,"studyType":92,"phases":4,"briefSummary":431,"conditions":432,"keywords":437,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":448,"lastUpdatePostDateStruct":449,"startDateStruct":451,"completionDateStruct":453,"leadSponsor":455,"locationsCount":56},"100605622","predictive-factors-of-response-to-phase-ii-cardiac-rehabilitation-in-heart-failure-with-reduced-ejection-fraction-100605622","NCT07164911","Predictive Factors of Response to Phase II Cardiac Rehabilitation in Heart Failure With Reduced Ejection Fraction","Prédiction Des réponses du Patient Porteur d'Une Insuffisance Cardiaque à Fraction d'éjection altérée à Une Phase II de réadaptation Cardiaque","PrédicRéa","Inclusion Criteria:\n\n* Heart failure with reduced ejection fraction \\\u003C 40%\n* NYHA functional class ≥ II\n* Clinically stable for at least 6 weeks\n* On optimized medical therapy for at least 6 weeks\n* Prescription for phase II cardiac rehabilitation\n* BMI between 20-30 kg·m-²\n* Physical activity level: sedentary or physically active but untrained\n* Signed informed consent to participate in the study\n* Affiliation to the French national health insurance system\n\nExclusion Criteria:\n\n* Contraindication to regular adapted physical activity\n* Uncontrolled arterial hypertension\n* Secondary respiratory disease such as emphysema or chronic obstructive pulmonary disease (COPD)\n* Secondary cardiovascular disease\n* Individuals under legal protection or deprived of liberty\n* Pregnant or breastfeeding women","75 Years",{"count":429,"type":22},62,"1 Month","Exercise intolerance, measured as peak oxygen consumption (VO₂peak) during exercise in patients with heart failure with reduced ejection fraction (HFrEF). Change in VO₂peak (ΔVO₂peak), which serves as a prognostic marker for HFrEF engaged in exercise based cardiac rehabilitation program (ExCR). Responders to ExCR generally show improved cardiac function but some patients with HFrEF do not respond to ExCR. VO₂peak depends on three major components of oxygen transport: Pulmonary (lungs), circulatory (heart and vessels) and skeletal muscle (oxygen utilization) functions. These physiological responses to ExCR may be influenced by epigenetic regulation, specifically the expression of circulating microRNAs (c-miRNAs).\n\nLinking non-invasive measurements and epigenetic markers could 1) identify which component of the oxygen transport chain is most impaired and 2) allow personalized interventions to maximize VO₂peak improvements.\n\nThe primary objective of this stidy is to assess the association between changes in VO₂peak during exercise training and circulating microRNA expression (miR-146a, miR-191, miR-23a, miR-140, miR-1, miR-21, miR-133a, miR-17-5p, miR-3200-3p).\n\nThe secondary objective is to examine the relationship between pulmonary, cardiovascular, and neuromuscular adaptations to exercise and circulating microRNA expression.",[433,38,190,434,435,436],"HFrEF - Heart Failure With Reduced Ejection Fraction","Exercise Adaptations","Exercise Intolerance","Exercise Intervention",[438,439,440,441,442,443,444,445,446,447],"Exercise-based cardiac rehabilitation in patients with reduced left ventricular ejection fraction","VO2peak","MicroRNA","Muscle Oxygenation","arterial stiffness","cardiac output","stroke volume","Oxygen alveolar-arterial gradient","alveolar ventilation","minute ventilation","2025-12-08",{"date":450,"type":48},"2025-12-16",{"date":452,"type":48},"2025-11-25",{"date":454,"type":22},"2027-11-30",{"name":456,"class":418},"Centre Hospitalier de Corbie",{"id":458,"slug":459,"hasResults":12,"nctId":460,"briefTitle":461,"officialTitle":462,"acronym":4,"eligibilityCriteria":463,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":464,"enrollmentInfo":465,"targetDuration":4,"studyType":23,"phases":467,"briefSummary":468,"conditions":469,"keywords":4,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":472,"lastUpdatePostDateStruct":473,"startDateStruct":474,"completionDateStruct":476,"leadSponsor":478,"locationsCount":4},"100615223","construction-and-application-of-an-intelligent-collaborative-cardiac-rehabilitation-app-for-middle-aged-and-young-patients-with-myocardial-infarction-100615223","NCT07289815","Construction and Application of an Intelligent Collaborative Cardiac Rehabilitation App for Middle-aged and Young Patients With Myocardial Infarction","Construction and Application of an Intelligent Collaborative Cardiac Rehabilitation Management Model for Young and Middle-aged Patients With Myocardial Infarction Based on Intervention Mapping","Inclusion Criteria:\n\n* Patients in Ward 1 were assigned to the intervention group, and patients in Ward 2 served as the control group. The inclusion criteria were as follows: ① aged 18-60 years; ② diagnosed by cardiologists as meeting the clinical diagnostic criteria for myocardial infarction (MI) established by the Cardiology Branch of the Chinese Medical Association; ③ having basic smartphone operation skills to use the App normally; ④ providing informed consent and signing the research consent form.\n\nExclusion Criteria:\n\n* ① Complicated with severe hepatic or renal insufficiency, malignant tumors, cognitive impairment, or mental illnesses; ② Patients with NYHA class Ⅳ or definite exercise contraindications (e.g., those assessed as high-risk in exercise risk evaluation) who are unable to participate in exercise prescription intervention; ③ Patients who have difficulty completing follow-up or withdraw midway.","60 Years",{"count":466,"type":22},232,[25],"This study is guided by the intervention mapping theory, combined with Fogg's behavior model and digital health technologies, focusing on the key rehabilitation obstacles and behavioral characteristics of young and middle-aged MI patients. It constructs a \"smart + collaborative\" out-of-hospital rehabilitation management model. This model, through systematic needs assessment and problem logical modeling \\[11\\], develops individualized rehabilitation paths covering multiple dimensions of intervention such as exercise, diet, medication, and psychological regulation. It relies on digital means such as mobile terminals, online education, behavior check-ins, real-time feedback, and remote follow-ups to achieve intelligent rehabilitation management. At the same time, it emphasizes the multi-disciplinary collaboration mechanism, integrating team members from cardiology, nursing, nutrition, rehabilitation, and psychology, forming a collaborative work system with information sharing, task complementarity, and consistent goals. Together, they promote the activation of patient motivation, improvement of behavioral ability, and improvement of rehabilitation compliance. The study will also verify its feasibility and initial effects in a real clinical environment, and evaluate its practical value in improving rehabilitation behaviors, promoting functional recovery, and enhancing quality of life. This study not only innovatively integrates intervention mapping and behavioral science models into the rehabilitation management of young and middle-aged MI patients in theory, filling the gap in existing rehabilitation models for this group, but also explores the path of digital rehabilitation intervention that can be promoted and replicated in grassroots clinical practice. The research results can provide practical basis for the construction of the smart rehabilitation service system under the background of \"Healthy China 2030\", and have important practical significance and social value.",[470,38,471],"Myocardial Infarction","APP","2025-12-04",{"date":409,"type":48},{"date":475,"type":22},"2026-01-01",{"date":477,"type":22},"2028-12-31",{"name":479,"class":55},"The Fourth Affiliated Hospital of Zhejiang University School of Medicine",{"id":481,"slug":482,"hasResults":12,"nctId":483,"briefTitle":484,"officialTitle":484,"acronym":485,"eligibilityCriteria":486,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":487,"targetDuration":4,"studyType":92,"phases":4,"briefSummary":489,"conditions":490,"keywords":492,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":495,"lastUpdatePostDateStruct":496,"startDateStruct":498,"completionDateStruct":499,"leadSponsor":500,"locationsCount":56},"100609420","sex-differences-in-barriers-and-participation-in-physical-activity-during-and-following-cardiac-rehabilitation-100609420","NCT07214350","Sex Differences in Barriers and Participation in Physical Activity During and Following Cardiac Rehabilitation","SPARC","Inclusion Criteria:\n\n* Age \\> 18 years\n* Enrolled in cardiac rehabilitation within the last month\n* Own a smartphone or tablet for mobile application download\n\nExclusion Criteria:\n\n* Planned relocation during the study period out of the local area\n* Planned medical procedure within the study period that may limit physical activity (i.e., joint replacement)\n* End-stage kidney disease\n* Impairment from stroke, injury, or other medical conditions that would prevent participation in or completion of the protocol\n* Heart transplant\n* Use of a left ventricular assist device\n* Pregnant or intending to become pregnant during the study period\n* Any other illness that, in the opinion of the study physician, would negatively impact or mitigate participation in or completion of the protocol",{"count":488,"type":22},150,"The SPARC study will measure physical activity and functional fitness during cardiac rehabilitation, right after completion of cardiac rehabilitation, and 6 months later. This will help investigators learn if men and women maintain physical activity levels and functional fitness differently during and after they complete cardiac rehabilitation. Participants in this study will have three in-person study visits and may complete two qualitative interviews over a 10-month study period. The greatest risks during the study include physical discomfort, falling, and\u002For shortness of breath during the fitness testing.",[38,491],"Heart Disease",[493,494],"Physical Activity","Sex Differences","2025-12-02",{"date":497,"type":48},"2025-12-03",{"date":495,"type":48},{"date":267,"type":22},{"name":501,"class":55},"Duke University",{"id":503,"slug":504,"hasResults":12,"nctId":505,"briefTitle":506,"officialTitle":507,"acronym":4,"eligibilityCriteria":508,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":358,"enrollmentInfo":509,"targetDuration":4,"studyType":23,"phases":511,"briefSummary":513,"conditions":514,"keywords":522,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":526,"lastUpdatePostDateStruct":527,"startDateStruct":528,"completionDateStruct":530,"leadSponsor":532,"locationsCount":56},"100452609","phase-4-rehabilitation-for-survivors-of-out-of-hospital-cardiac-arrest-100452609","NCT05173740","Rehabilitation for Survivors of Out-of-hospital Cardiac Arrest","The ROCK Trial. A Multidisciplinary Rehabilitation Intervention Targeted Return-to-work in Sudden Out-of-hospital Cardiac Arrest Survivors A Pragmatic Randomised Controlled Trial","Inclusion criteria:\n\n* All adult survivors with first time out-of-hospital cardiac arrest\n* Discharged from the Hospitals will be assessed eligible for inclusion\n\nExclusion criteria:\n\n* Survivors who prior to the cardiac arrest were not part of the labour force with at least two years until they are qualified to receive retirement state pensions\n* Patients that cannot understand and fulfil the study surveys (in Danish)\n* Patients with short witnessed cardiac arrests with return of spontaneous circulation estimated less than 4 minutes and immediate awakening without ICU treatment",{"count":510,"type":22},214,[512],"PHASE4","This study is a parallel group multicentre investigator-initiated clinical randomised controlled superiority trial that will include a total of 214 survivors of OHCA.\n\nParticipants will to be randomized with a 1:1 allocation ratio to either a intervention consisting of a comprehensive initiated tailored rehabilitation intervention focusing on supporting RTW plus usual care compared to usual care alone.",[515,516,517,518,519,520,521,38],"Cardiac Arrest","Heart Arrest","Cardiopulmonary Resuscitation","Return to Work","Return-to-work","Rehabilitation","Recovery of Function",[523,524,516,517,99,519,525,520,521,38],"Labour marked","Cardiac arrest","Back to Work","2025-12-01",{"date":448,"type":48},{"date":529,"type":48},"2022-02-01",{"date":531,"type":22},"2028-07-31",{"name":533,"class":55},"Rigshospitalet, Denmark",{"id":535,"slug":536,"hasResults":12,"nctId":537,"briefTitle":538,"officialTitle":539,"acronym":540,"eligibilityCriteria":541,"healthyVolunteers":12,"sex":542,"minAge":118,"maxAge":543,"enrollmentInfo":544,"targetDuration":4,"studyType":23,"phases":546,"briefSummary":547,"conditions":548,"keywords":549,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":553,"lastUpdatePostDateStruct":554,"startDateStruct":555,"completionDateStruct":557,"leadSponsor":558,"locationsCount":56},"100576407","designing-and-assessing-a-women-only-cardiac-rehabilitation-care-program-100576407","NCT06784895","Designing and Assessing a Women Only Cardiac Rehabilitation (CARE) Program","Designing and Assessing a Women Only Cardiac Rehabilitation Program","CARE","Inclusion Criteria:\n\n* Provision of signed and dated informed consent form\n* Stated willingness to comply with all study procedures and availability to participate in study procedures for the duration of the study\n* Identify as a female\n* Be between the ages of 40-80 years, inclusive\n* Documented diagnosis of CR indications of stable angina pectoris, acute myocardial infarction (MI) within the preceding 6 months, percutaneous coronary interventions (PCI), surgical and transvalvular aortic valve replacement, post-aortic surgery with or without aortic valve, coronary artery bypass grafting (CABG) and mitral valve replacement or repair with or without CABG\n* Referred to outpatient CR at the University of Michigan, Domino's Farms or Brighton Center for Specialty Care Cardiac Rehabilitation site based on Michigan Medicine's Division of Cardiovascular Medicine Policy and Procedure.\n\nExclusion Criteria:\n\n* Not being \"cleared\" for CR based on Michigan Medicine's Division of Cardiovascular Medicine Policy and Procedures\n* Prior participation in CR\n* Inability to understand spoken and written English, either due to language barrier or cognitive limitation for any reason, including deaf or blind\n* Frailty, fall risk, or muscle, joint or back pain as defined as the inability to perform activities of daily living without limitations and engage in mild physical activity (i.e. unable to walk up 1 flight of stairs unaided)\n* Any of the following as the indication for CR: aortic repair or replacement for aortic dissection, untreated or greater than New York Heart Association (NYHA) class II congestive heart failure, coronary artery dissection without coronary artery disease, fibromuscular hyperplasia, stress cardiomyopathy, cardiac transplant candidate or recipient\n* Life threatening ventricular arrythmias without an implanted defibrillator; very frequent premature ventricular contraction or premature atrial contractions symptomatic or not; poorly controlled atrial fibrillation\n* Associated more than mild valvular heart disease, untreated congestive heart failure; unstable angina or heart pain with minimal activity; angina or congestive heart failure limiting ability to climb one flight of stairs without help (NHYA Functional Classification \\>2)\n* Severe pulmonary hypertension (right heart systolic pressure greater than 60 millimeters of mercury); clot in the heart; treated venous thrombosis with or without pulmonary embolism in past 6 months; more than mild dyspnea related to chronic lung disease or asthma\n* Chronic kidney disease (creatinine \\>2 milligrams per deciliter (mg\u002Fdl)); symptomatic active liver disease (infectious or inflammatory), symptomatic chronic liver disease (except for nonalcoholic fatty liver disease), kidney dialysis or kidney transplant recipient, active or chronic renal disease (rise by 0.5mg\u002FdL in past 3 months or chronic elevated serum creatinine 2.0 milligrams per milliliter (mg\u002FmL) or greater.\n* Poorly controlled diabetes defined as uninterrupted HbA1c \\>8.0% for ≥1 year despite standard care, baseline HbA1c prior to CR \\> 8.5%.\n* Immunosuppressive drug requirement, acute anemia, chronic anemia with Hemoglobin \\\u003C 10mg\u002FmL\n* Limiting chronic muscle, joint, or back pain; identified as fall risk from poor balance or neurologic syndromes; frailty defined as the inability to perform activities of daily living in older adults that carries an increased risk for poor health outcomes including falls, incident disability, hospitalization, and mortality\n* Untreated or active substance abuse\u002Faddiction including alcohol and drugs; depression (defined as a score ≥ 15 or depression positive answer to #8 or #9 on Patient Health Questionnaire-9) unless deemed acceptable by mental health care provider; severe anxiety\n* Severe obesity (Body mass index ≥ 40 kilograms\u002Fmeters squared), on weight loss drugs (unless target body weight has been achieved or use is for glycemic control in diabetes), history of bariatric surgery; chronic venous insufficiency with cellulitis or \\> 1+ edema unless controlled with support hose.","FEMALE","80 Years",{"count":545,"type":22},60,[25],"The purpose of this randomized controlled study is to investigate the effect(s) of a pilot women-only cardiac rehabilitation (CR) program. The study team will be testing the effectiveness, compliance and enjoyment of this women's only cardiac rehabilitation (CR) program by comparing outcomes to those randomized to receive Michigan Medicine's current CR program (standard care), which includes people of all genders.\n\nStudy hypotheses:\n\n* Women randomized to women-specific CR programming will have superior attendance and completion rates compared to women attending mixed-sex CR programming.\n* Women randomized to women-specific CR programming will experience greater improvement in clinical outcomes in comparison to those in mixed-sex CR programming.",[38,249],[550,551,552],"Female only CR program","Standard of care rehab program","Education sessions","2025-11-26",{"date":472,"type":48},{"date":556,"type":48},"2025-05-05",{"date":168,"type":22},{"name":559,"class":55},"University of Michigan",{"id":561,"slug":562,"hasResults":12,"nctId":563,"briefTitle":564,"officialTitle":564,"acronym":565,"eligibilityCriteria":566,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":567,"targetDuration":4,"studyType":23,"phases":569,"briefSummary":570,"conditions":571,"keywords":573,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":576,"lastUpdatePostDateStruct":577,"startDateStruct":579,"completionDateStruct":581,"leadSponsor":583,"locationsCount":235},"100534851","transition-to-cardiac-rehabilitation-t2cr-to-address-barriers-of-multimorbidity-and-frailty-100534851","NCT06244199","Transition to Cardiac Rehabilitation (T2CR) to Address Barriers of Multimorbidity and Frailty","T2CR","Inclusion Criteria:\n\n* Eligible candidates will consist of male and female Veterans hospitalized with:\n\n  * ischemic heart disease (acute myocardial infarction or stable ischemia)\n* revascularization (coronary artery bypass grafting or percutaneous coronary intervention)\n* valvular heart disease (surgical or percutaneous intervention for mitral regurgitation or aortic stenosis)\n* or heart failure (with reduced or preserved ejection fraction)\n* All will be recruited while initially hospitalized and must express willingness to consider cardiac rehabilitation as a treatment option, including the possibility of the intervention which could possibly extend the length of their hospitalization (for 2 days maximum).\n* Study candidates must also be English speaking and able to provide written informed consent\n\nExclusion Criteria:\n\n* Veterans with unstable medical condition as indicated by history, physical exam, and\u002For laboratory findings end-stage disease likely to be fatal within 12 months\n* severe cognitive impairment (MiniCog score 0-2)\n* history of addictive or behavioral issues that confound safe administration of HBCR\n* hearing loss that interferes with participation in the trial\n* living in a long-term care living situation prior to the time of hospitalization, no plans to return to independent living after the hospitalization",{"count":568,"type":22},250,[25],"Cardiac rehabilitation (CR) is a secondary prevention program for patients with cardiovascular disease (CVD). It is especially valuable as CVD increasingly occurs in combination with comorbidity, frailty, and complexities of care that predispose patients to functional decline, disability, and high costs. Still, few Veterans participate in CR, in part because of the difficult logistics to attend. Promising Practice home-based CR (HBCR) was developed to increase CR participation, but many Veterans remain too limited by comorbidity and frailty for participation. A Transition to CR (T2CR) intervention is a face-to-face program that fosters vital skills, education, insights, motivation, and patient-provider relationships conducive to successful HBCR thereafter. This study compares Veterans eligible for CR who are randomized to T2CR intervention versus usual care. Differences in functional capacity, HBCR participation, and healthy days at home are compared over one year. Patients' experiences and providers' perspectives of barriers and facilitators to T2CR are also compared.",[249,38,572],"Transition of Care",[574,96,575],"cardiovascular diseases","transition of care","2025-10-21",{"date":578,"type":48},"2025-10-22",{"date":580,"type":48},"2024-11-01",{"date":582,"type":22},"2027-08-31",{"name":80,"class":81},{"id":585,"slug":586,"hasResults":12,"nctId":587,"briefTitle":588,"officialTitle":588,"acronym":589,"eligibilityCriteria":590,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":591,"targetDuration":4,"studyType":23,"phases":593,"briefSummary":594,"conditions":595,"keywords":596,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":599,"lastUpdatePostDateStruct":600,"startDateStruct":602,"completionDateStruct":604,"leadSponsor":606,"locationsCount":56},"100605130","the-heart-health-after-cardiac-treatment-study-100605130","NCT07158515","The Heart Health After Cardiac Treatment Study","HEART-ACT","Inclusion Criteria:\n\n1. Age 18+\n2. Referred for cardiac rehabilitation for a covered indication:\n\n   1. Acute myocardial infarction\n   2. Percutaneous coronary intervention\n   3. Coronary artery bypass surgery\n   4. Heart valve repair or replacement\n   5. Heart transplant\n   6. Chronic stable angina\n   7. Chronic systolic heart failure (EF \\\u003C=35%)\n3. Able to communicate in English, Spanish, or Cantonese\n4. Able to consent for self\n\nExclusion Criteria:\n\n1. Currently enrolled in hospice.\n2. Provider says patient may not be approached for participation in this study.",{"count":592,"type":22},100,[25],"The goal of this study is to determine whether participation in a tailored cardiac rehabilitation program delivered in a safety net setting, compared to usual care referral to an outside cardiac rehabilitation program, results in greater participation in cardiac rehabilitation.",[38],[597,598],"comparative effectiveness","safety net","2025-09-16",{"date":601,"type":48},"2025-09-18",{"date":603,"type":48},"2023-11-28",{"date":605,"type":22},"2027-12-31",{"name":607,"class":55},"University of California, San Francisco",{"id":609,"slug":610,"hasResults":12,"nctId":611,"briefTitle":612,"officialTitle":612,"acronym":613,"eligibilityCriteria":614,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":615,"targetDuration":617,"studyType":92,"phases":4,"briefSummary":618,"conditions":619,"keywords":627,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":628,"lastUpdatePostDateStruct":629,"startDateStruct":631,"completionDateStruct":633,"leadSponsor":635,"locationsCount":56},"100600398","cardiac-rehabilitation-cohort-at-the-medicine-campus-davos-to-investigate-recovery-100600398","NCT07096973","Cardiac REhabilitation COhort at the Medicine Campus DaVos to invEstigate Recovery","RECOVER","Inclusion Criteria:\n\n* Patients undergoing CR at the HGK\n* Written informed consent\n* Age ≥ 18 years\n\nExclusion Criteria:\n\n* Insufficient knowledge of the German language to understand study documents, the interview, or questionnaires interview without translation\n* Physical or psychological incapability to participate in the study",{"count":616,"type":22},10000,"10 Years","The RECOVER study, titled Cardiac Rehabilitation Cohort at the Medicine Campus Davos for Exploration of Recovery, is a prospective, non-interventional, monocentric cohort study conducted at the Hochgebirgsklinik Davos. The study is sponsored by Medicine Campus Davos AG and the Kühne Foundation, with an estimated start date in July 2025 and planned completion by December 2034, with the possibility of extension.\n\nThe principal investigator of the study is PD Dr. David Niederseer from Hochgebirgsklinik Davos, who also represents the study. The research team includes co-investigators such as Prof. Dr. Stefan Blankenberg and Prof. Dr. Andreas Ziegler from Cardio-CARE, Medicine Campus Davos, as well as Dr. Jan Vontobel from Hochgebirgsklinik Davos.\n\nThe study will enroll patients referred to Hochgebirgsklinik Davos for cardiac rehabilitation who provide informed consent. Cardiac rehabilitation is an evidence-based therapy for patients with heart disease, including those who have undergone cardiac procedures or surgeries.\n\nThe primary objectives are to evaluate baseline patient characteristics, rehabilitation strategies, predictors of recovery, and clinical outcomes during and after rehabilitation. To support this, a detailed database and biobank will be established to allow for comprehensive phenotyping, extensive clinical assessments, and long-term follow-up.\n\nRECOVER seeks to gain translational insights into how patient-specific factors - such as genetics, plasma, digital and clinical biomarkers, and comorbidities - influence long-term clinical outcomes. The goal is to identify modifiable risk factors to optimize individualized therapeutic approaches in cardiac rehabilitation.",[38,151,620,621,622,623,624,625,626],"Cardiac Arrest (CA)","ACS (Acute Coronary Syndrome)","CABG","Valve Anomalies","LVAD (Left Ventricular Assist Device)","Heart Transplantation","Arrhythmia",[574,96],"2025-09-11",{"date":630,"type":48},"2025-09-17",{"date":632,"type":48},"2025-08-05",{"date":634,"type":22},"2040-08-05",{"name":636,"class":55},"Hochgebirgsklinik Davos",{"id":638,"slug":639,"hasResults":12,"nctId":640,"briefTitle":641,"officialTitle":642,"acronym":4,"eligibilityCriteria":643,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":644,"targetDuration":4,"studyType":23,"phases":646,"briefSummary":647,"conditions":648,"keywords":649,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":652,"lastUpdatePostDateStruct":653,"startDateStruct":654,"completionDateStruct":656,"leadSponsor":657,"locationsCount":56},"100540731","implementation-and-evaluation-of-telemedicine-in-cardiac-rehabilitation-100540731","NCT06320652","Implementation and Evaluation of Telemedicine in Cardiac Rehabilitation","Implementation and Evaluation of Telemedicine in Cardiac Rehabilitation - a Study on Health Literacy, Health Related Quality of Life, and Family Support","Inclusion Criteria:\n\n* Patients and their family members affiliated with the Department of Cardiology at Amager and Hvidovre Hospital and attending cardiac rehabilitation.\n* Patients diagnosed with ischemic heart disease, heart failure, persistent atrial fibrillation, and cardiac valve surgery.\n\nExclusion Criteria:\n\n* Patients with substantial language barriers and limited cognitive function.\n* Patients who can't use a smart phone, tablet, or computer.",{"count":645,"type":22},140,[25],"The overall aim is to develop and test the effect of a tailored patient and family focused cardiac tele rehabilitation intervention on health literacy by comparing it to standard care. Furthermore, to evaluate health-related quality of life, family support, and how the patients experience the communication and relationship with outpatient clinic nurses.",[38],[252,187,650,651],"Video consultation","Home monitoring","2025-07-31",{"date":632,"type":48},{"date":655,"type":48},"2024-05-02",{"date":582,"type":22},{"name":658,"class":55},"Copenhagen University Hospital, Hvidovre",{"id":660,"slug":661,"hasResults":12,"nctId":662,"briefTitle":663,"officialTitle":663,"acronym":664,"eligibilityCriteria":665,"healthyVolunteers":12,"sex":18,"minAge":666,"maxAge":543,"enrollmentInfo":667,"targetDuration":4,"studyType":23,"phases":668,"briefSummary":669,"conditions":670,"keywords":672,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":674,"lastUpdatePostDateStruct":675,"startDateStruct":677,"completionDateStruct":679,"leadSponsor":681,"locationsCount":56},"100600480","cardio-fit2-impact-of-a-cardiac-rehabilitation-program-in-patients-with-cardiovascular-disease-100600480","NCT07098039","Cardio-Fit2: Impact of a Cardiac Rehabilitation Program in Patients With Cardiovascular Disease","Cardio-Fit2","Inclusion Criteria:\n\n1. Patients between the ages of 20 and 80.\n2. Have suffered an acute event or have chronic cardiovascular disease with decreased\u002Flimited functional capacity.\n3. Reside in the provinces of Cuenca, Toledo, or Albacete.\n4. Willingness to participate voluntarily and acceptance of the conditions.\n5. Must report the ability to access new technologies.\n\nExclusion Criteria:\n\n1. Have a physical or mental condition that prevents participation.\n2. Inability to adhere to the entire program, as reported in the initial consultation.\n3. Are outside the age criteria defined above.","20 Years",{"count":545,"type":22},[25],"Cardiovascular diseases (CVD) are the main cause of morbidity and mortality in the world, being responsible for 17.9 million deaths annually, according to the World Heart Federation (WHF), which represents a significant social and health cost both due to direct expenses derived from admissions and diagnostic-therapeutic methods, as well as indirect expenses secondary to work incapacity, disability and loss of autonomy that this generates. Although advanced diagnostic and therapeutic techniques have been incorporated in recent years in the acute phase of ischemic heart disease, interventions during hospitalization and after hospital discharge remain insufficient in terms of secondary prevention, a paradoxical fact, since increasingly, the available evidence, as well as the recommendation guidelines, focus on the modification of lifestyle habits and control of cardiovascular risk factors (CVRF), fundamental pillars of cardiac rehabilitation programs (PRC) as a preventive measure both in the appearance of new adverse events and in the reduction of disease progression and improvement of the functional capacity of the patient. Cardiac rehabilitation (CR) was defined by the World Health Organization (WHO) in the 1960s as \"the set of activities necessary to ensure that heart patients have an optimal physical, mental and social condition, allowing them to occupy, by their own means, as normal a place as possible in society.\" The scientific evidence is more than consistent regarding the benefits that multidisciplinary CRP provides in terms of cardiovascular mortality and quality of life (QoL) of our patients and how these results are maintained despite changes in patient characteristics and risk, or the incorporation of new pharmacological treatments. Therefore, if we deprive our patients of these therapies, we are indirectly acting negatively on their cardiovascular prognosis, especially within the field of ischemic heart disease, although it is increasingly being extended to other areas of Cardiology such as heart failure (HF), pulmonary hypertension (PH), valvular disease,7 etc. So much so that it is already included in the latest clinical practice guidelines of the main scientific societies at European and American level, establishing participation in a CR program after acute coronary syndrome or coronary revascularization and those patients with HF as a \"level of recommendation I evidence A\"",[671,38],"Cardiovascular Diseases (CVD)",[96,574,673],"wearables","2025-07-24",{"date":676,"type":48},"2025-08-01",{"date":678,"type":22},"2025-09-01",{"date":680,"type":22},"2025-12-31",{"name":682,"class":55},"Hospital Virgen de la Luz",{"id":684,"slug":685,"hasResults":12,"nctId":686,"briefTitle":687,"officialTitle":688,"acronym":689,"eligibilityCriteria":690,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":691,"targetDuration":693,"studyType":92,"phases":4,"briefSummary":694,"conditions":695,"keywords":699,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":702,"lastUpdatePostDateStruct":703,"startDateStruct":705,"completionDateStruct":707,"leadSponsor":708,"locationsCount":56},"100600226","the-italian-alliance-for-cardiovascular-rehabilitation-and-prevention-itacare-p-registry-an-observational-study-on-cardiac-rehabilitation-in-patients-with-coronary-disease-or-heart-failure-100600226","NCT07094737","The Italian Alliance for Cardiovascular Rehabilitation and Prevention (ITACARE-P) Registry: An Observational Study on Cardiac Rehabilitation in Patients With Coronary Disease or Heart Failure","The ITACARE-P CardioRehab Registry","CardioRehab","Inclusion Criteria:\n\n* Patients with coronary artery disease and\u002For heart failure who meet the current regulatory requirements for appropriateness of referral to cardiac rehabilitation are eligible for enrollment. These patients may be included regardless of whether they are referred to inpatient or outpatient cardiac rehabilitation programs, depending on the clinical setting and care pathway.\n\nExclusion Criteria:\n\n* Explicit refusal to participate in the study by the patient;\n* Planned hospital readmission within six months after completion of the cardiac rehabilitation program.",{"count":692,"type":22},1600,"12 Years","ITACARE-P CardioRehab Registry is a nationwide observational study conducted in Italy and coordinated by the Fondazione Don Carlo Gnocchi in Milan. It involves multiple hospitals and rehabilitation centers across the country and aims to better understand how cardiac rehabilitation (CR) is delivered to patients recovering from heart conditions (coronary deseases and\u002For heart failure). CR is a structured program that includes exercise, lifestyle education, and psychological support, and is known to improve recovery, reduce future cardiac events, lower hospital readmissions, and enhance quality of life. Despite strong recommendations from international guidelines, not all eligible patients are referred to CR, and its delivery varies. This study collects real-world data to describe how CR programs are implemented, evaluate patient outcomes, identify subgroups needing tailored care, and support improvements in cardiac care services in Italy. Adults who recently experienced a qualifying heart condition are enrolled and followed during their standard rehabilitation, without any changes to treatment. Data on medical history, risk factors, quality of life, functional improvements, and medication use are collected, with follow-up at 6 and 12 months. Participation involves no added risks, and personal health data is securely managed according to EU GDPR regulations using the REDCap system. The study aims to enhance the quality, consistency, and equity of cardiac rehabilitation across the country.",[696,151,697,698,520,38,195],"Cardiac Rehab","Coronary Disease","Heart Conditions",[696,151,700,701,520,252,195],"Coronary disease","Heart conditions","2025-07-23",{"date":704,"type":48},"2025-07-30",{"date":706,"type":48},"2025-05-01",{"date":605,"type":22},{"name":709,"class":55},"Fondazione Don Carlo Gnocchi Onlus"]