[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiac-resynchronisation-therapy-crt\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiac-resynchronisation-therapy-crt":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100630846","conduction-system-pacing-vs-biventricular-pacing-for-cardiac-resynchronization-therapy-100630846",false,"NCT07492979","Conduction System Pacing vs. Biventricular Pacing for Cardiac Resynchronization Therapy","Nordic-CSP - a Randomized Nordic Study - Is Conduction System Pacing Superior Compared to Conventional BIV-CRT in Reducing the Death or Heart Failure-related Hospitalization in Patients With Heart Failure and Bundle Branch Block?","Nordic-CSP","Inclusion Criteria:\n\n* ≥18 years of age,\n* LVEF ≤ 35%,\n* NYHA Class II-IV (IV only outpatients),\n* optimized in medical treatment (OMT)\n\nAND one of the following:\n\n. LBBB according to AHA\u002FACC\u002FHRS Scientific Statement from 2009 and ≥130ms or\n\n* LBBB-like intraventricular conduction delay (IVCD) \\> 150ms or RV paced QRS and indication for upgrade to CRT (\\> 40% RV pacing) OR\n* ≥18 years of age,\n* LVEF ≤ 40 %\n* pacing indicated by AV-block and, thus, expected large percentage of ventricular pacing.\n\nExclusion Criteria:\n\n* recent acute myocardial infarction (AMI)\n* coronary artery bypass graft (CABG) (\\\u003C3 months)\n* life expectancy \\\u003C2 years, patients in hemodialysis\n* treatment with a cardiac implantable electronic device (CIED) is contraindicated.\n* Patients are excluded with regards to the MRI sub study if eGFR \\> 35 ml\u002Fmin, in case or contrast allergy or certain metal implants.","ALL","18 Years","99 Years",{"count":21,"type":22},1100,"ESTIMATED","INTERVENTIONAL",[25],"NA","The NORDIC-CSP trial is an investigator-initiated, blinded, nordic RCT aimed at evaluating whether using direct pacing of the HIS bundle (HIS)-pacing or left bundle branch (LBB) pacing is superior to conventional biventricular pacing in reducing the incidence of the composite endpoint of death and non-planned HF hospitalization. The study will be conducted in the 4 CRT-centres in Denmark and 6-8 centres from countries Sweden, Norway and Finland.",[28,29,30],"Cardiac Resynchronisation Therapy (CRT)","Heart Failure","Conduction System Pacing",[15,32,33,34,35,36],"conduction system pacing","His-pacing","LBB-pacing","Biventricular pacing","Cardiac Resynchronization Therapy","NOT_YET_RECRUITING","2026-03-20",{"date":40,"type":41},"2026-03-25","ACTUAL",{"date":43,"type":22},"2026-03-01",{"date":45,"type":22},"2031-07-01",{"name":47,"class":48},"Rigshospitalet, Denmark","OTHER",4,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":49},"100612471","left-bundle-branch-area-pacing-lbbap-monitoring-assistant-evaluation-of-portable-ecg-solution-100612471","NCT07254013","Left Bundle Branch Area Pacing (LBBAP) Monitoring Assistant: Evaluation of Portable ECG Solution","LBBOT","Inclusion Criteria:\n\n* Subject with indication for LBBAP using an Electrophysiology ECG monitoring system (EP System) as part of pacemaker or CRT-P or CRT-D implant procedure (de novo implant, device revision or upgrade including LOT-CRT)\n* Subject signed and dated the ICF\n\nExclusion Criteria:\n\n* Incapacitated subject or under guardianship\n* inability to understand the purpose of the study\n* Minor subjects\n* Non menopausal women\n* Patients implanted with other electrically active non cardiac devices.",true,{"count":59,"type":22},55,[25],"To evaluate the capability to monitor LBB success criteria with the use of a Smart ECG system (ECG monitor, 12 leads ECG cable, ECG viewer software ) during a cardiac device implantation involving the placement of a pacing lead in interventricular septum area",[63,64,28,65],"Bradycardia","Left Bundle Branch Area Pacing","ECG",[67],"LBBAP ECG MONITORING ASSISTANT","RECRUITING","2025-11-27",{"date":71,"type":41},"2025-12-05",{"date":73,"type":41},"2025-11-14",{"date":75,"type":22},"2026-03-31",{"name":77,"class":78},"MicroPort CRM","INDUSTRY",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":23,"phases":89,"briefSummary":90,"conditions":91,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":101},"100599436","a-study-testing-a-new-heart-scan-method-to-improve-pacemaker-treatment-for-heart-failure-100599436","NCT07084467","A Study Testing a New Heart Scan Method to Improve Pacemaker Treatment for Heart Failure","Evaluation of First-Phase Ejection Fraction to Guide Cardiac Resynchronization Therapy - A Randomised Controlled Trial","EFFECT-CRT","Inclusion Criteria:\n\n* Age 18 years or older\n* On optimal medical therapy for heart failure\n* Meets standard guideline criteria for CRT (including conduction system pacing), specifically:\n\n  * NYHA class II to IV\n  * Left ventricular ejection fraction (EF) ≤ 35%\n  * QRS duration \\> 130 ms\n\nExclusion Criteria:\n\n* Co-morbidities likely to reduce life expectancy to less than 6 months\n* Major cardiovascular event within the past 6 weeks\n* More than mild aortic stenosis\n* Receiving continuous or intermittent infusion therapy for heart failure\n* Poor ultrasound acoustic window preventing adequate imaging\n* Unable to give informed consent\n* Currently participating in another interventional study",{"count":88,"type":22},400,[25],"Cardiac resynchronization therapy (CRT) is a device treatment for patients with heart failure which cannot be managed by medications alone. CRT can help the heart contract more efficiently and improve the pumping function. However, many patients do not benefit from this treatment. Therefore, a better selection tool will help us to determine the most suitable patients to receive this treatment. A new measure of pumping function of the heart called: first-phase ejection fraction or EF1 has been shown a good tool to select suitable patients for CRT. EF1 is a sensitive measurement of heart function and can be easily measured by echocardiography (an ultrasound heart scan).\n\nThe purpose of this study is to examine whether this new measurement (EF1) can predict outcomes and response to CRT treatment.",[28,29],"2025-07-30",{"date":94,"type":41},"2025-08-03",{"date":96,"type":22},"2025-08-01",{"date":98,"type":22},"2030-07-31",{"name":100,"class":48},"King's College London",1]