[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiac-risk-factors\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiac-risk-factors":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":4,"leadSponsor":41,"locationsCount":44},"100142856","imaging-techniques-in-mri-100142856",false,"NCT01130545","Imaging Techniques in MRI","* INCLUSION CRITERIA:\n\nA. Volunteer individuals\n\nB. Lab Eligibility parameters (for contrast scans within 4 weeks of gadolinium injection):\n\nC. Creatinine below upper normal limit\n\nD. eGFR \\>= 60 mL\u002Fmin\u002F1.73m2\n\nE. Age \\>= 60 or history of renal disease: test GFR within 1 week prior to contrast\n\nF. Willing to travel to the NIH for follow-up visits.\n\nG. 18 years old\n\nH. Able to understand and sign informed consent\n\nI. No MRI scan with gadolinium injection in the last 6 months under this protocol.\n\nEXCLUSION CRITERIA:\n\nA. Implanted metal clips or wires of the type which may concentrate radiofrequency fields or cause tissue damages from twisting in a Magnetic field. Examples:\n\n* Aneurysm clip, implanted neural stimulator,\n* Implanted cardiac pacemaker, defibrillator, or certain other implanted electrical or metallic devices,\n* Cochlear implant, ocular foreign body (metal shavings),\n* Any implanted device (pumps, infusion devices, etc.),\n* Shrapnel injuries,\n* History of metal in head or eyes or other parts of the body.\n\nB. Pregnant women\n\nC. Paralyzed hemidiaphragm\n\nD. Over 500 lbs and\u002For a body circumference that prevents the study subject from laying flat in the scanner\n\nE. Surgery of uncertain type\n\nF. Untreatable claustrophobia otherwise requiring anesthesia.\n\nG. Any contraindications that the Physician identifies from the subject, MRI Safety Questionnaire, and\u002For History and Physical.\n\nEXCLUSION FOR PARTICIPANTS FOR GADOLINIUM CONTRAST:\n\n(Inclusive of the above exclusion criteria):\n\nA. Allergy to gadolinium for scans using contrast; will be eligible for non-contrast scans.\n\nB. Acute renal failure, renal transplant, dialysis and renal failure individuals (eGFR \\\u003C60 mL\u002Fmin\u002F1.73m2 and\u002For clinically diagnosed).\n\nC. Individuals with a history of liver transplant or severe liver disease.\n\nD. Lactating women\n\nE. Individuals with hemoglobinopathies or severe asthma.\n\nF. Patient preference to not undergo intravenous line placement and\u002For receive gadolinium contrast. Contrast administration is optional and participants may still undergo a non-contrast study.\n\nG. GBCA with an MRI scan in the last 6 months. This includes scan performed with GBCA at any outside institution and \u002F or at the clinical center .In addition, they cannot have reached their maximum of 4 GBCA imaging studies under this protocol. They will be excluded from having a contrast enhanced MRI, but will not be excluded from the protocol for non-contrast MRI studies.",true,"ALL","18 Years","100 Years",{"count":20,"type":21},1000,"ESTIMATED","OBSERVATIONAL","Background:\n\n\\- Magnetic resonance imaging (MRI) scans must be performed according to specified sets of parameters that provide optimal images of each organ and each area of the body. These scanning parameters are often specific to the institution or organization at which they are employed, and may also depend on the manufacturer of the MRI scanning equipment. Because MRI scanning equipment is always being updated and upgraded, researchers are interested in developing new and optimized scanning parameters for MRI scans.\n\nObjectives:\n\n\\- To improve current methods and develop new techniques for magnetic resonance imaging.\n\nEligibility:\n\n* Individuals 18 years of age and older who are either volunteers or current NIH protocol participants.\n* Participants must not have any medical history factors (e.g., extreme claustrophobia, history of metal implants) that would prevent them from receiving MRI scans.\n\nDesign:\n\n* Participants will have at least one MRI scan that will last from 20 minutes to 2 hours (most scans will last between 45 and 90 minutes). The total time commitment for most visits will be approximately 4 hours from start to finish.\n* Some MRI techniques require standard monitoring equipment or specific procedures during the scanning, such as an electrocardiogram.\n* Participants will have blood samples taken at the time of the scan. Some MRI studies will require the use of a contrast agent that will be administered during the scan.\n* Volunteers may be asked to return for additional MRI scans over the course of a few years. Follow-up scans may be done on the same part of the body or on different parts of the body. No more than one MRI scan will be performed in any 4-week period for this protocol....",[25,26,27],"Cardiac Risk Factors","Healthy","Healthy Volunteers",[29,30,31,32,33],"Healthy Volunteer","Magnetic Resonance Imaging","Gadolinium","Natural History","HV","RECRUITING","2026-06-23",{"date":37,"type":38},"2026-06-24","ACTUAL",{"date":40,"type":38},"2010-06-05",{"name":42,"class":43},"National Institutes of Health Clinical Center (CC)","NIH",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":4},"100625797","focused-echocardiography-for-primary-care-physicians-100625797","NCT07427303","Focused Echocardiography for Primary Care Physicians","CLINICAL FEASIBILITY OF ULTRAPORTABLE CARDIAC ULTRASOUND PERFORMED IN THE GENERAL PRACTITIONER'S OFFICE TO IDENTIFY CARDIOVASCULAR ABNORMALITIES","UPCOMING","Inclusion Criteria:\n\n* Men and women aged 65 or older with no cardiac symptoms and presenting with a treated or untreated cardiovascular risk factor (hypertension and\u002For diabetes and\u002For dyslipidemia) or\n* Adult men and women presenting with one of the following signs:\n\n  * Stage I-II exertional dyspnea\n  * Lower limb edema\n  * Unexplained fatigue\n  * Weight gain\n  * Unexplained cough\n  * History of carpal tunnel surgery (search for signs of myocardial infiltration by cardiac amyloidosis)\n\nExclusion Criteria:\n\n* Patients with arrhythmia or ventricular or supraventricular hyper excitability.\n* Symptomatic patients:\n\n  * exertional dyspnea (NYHA \\>2)\n  * palpitations\n  * malaise\n  * chest pain\n* Obese individuals with a BMI \\>35\n* Patients with breast implants\n* Patients under guardianship, conservatorship, or legal protection\n* Patients without health insurance coverage or equivalent\n* Patients known to have heart disease\n* Patients who have had a cardiology consultation within the last 5 years\n* Subjects with known heart disease, whether monitored or not.\n* Known valvular heart disease (whether monitored or not)\n* Known coronary artery disease (whether monitored or not)","65 Years","120 Years",{"count":56,"type":21},300,"INTERVENTIONAL",[59],"NA","Our society is characterized by a steady improvement in the standard of living of its inhabitants, which is reflected, among other things, in improved healthcare and quality of life (longer life expectancy, lower infant mortality, treatment of chronic diseases, cancer plan). Many factors contribute to this, but technological innovations and therapeutic advances are the main ones. This positive overall picture should not obscure the fact that there are significant regional disparities.\n\nFor more than 15 years, the former Lower Normandy region (Calvados, Manche, and Orne), like many other regions in France, has been marked by increasingly complex access to healthcare, whether for primary care or for so-called specialty disciplines. This situation is gradually leading to the creation of medical deserts. There are many reasons for this (numerus clausus, sociological changes, urbanization of young practitioners, attraction of small rural towns by medium-sized cities), which are chronic and have no clearly identified solution.\n\nThis situation complicates patient care and, in some cases, represents a major public health challenge, such as in the treatment of heart failure (HF), which affects more than one million people in France, or 2.3% of the adult population. For 2.3 times more deaths each year than strokes and five times more than myocardial infarctions.\n\nSome healthcare innovations can reduce the consequences of these areas of stress. In the field of cardiology, recent initiatives based on the creation of specialized cardiology and telemedicine care teams have been proposed. In primary care, point-of-care solutions enable many tests to be performed on an outpatient basis. Imaging plays a central role in patient care, and ultrasound is often the first-line modality in cardiology. Technological innovations in this field have made it possible to miniaturize ultrasound machines to such an extent that some of them can now be considered POCUS (point-of-care ultrasound). Their reduced manufacturing costs, combined with the maturity of the technique, make it possible to offer simplified acquisition protocols adapted to specific questions, known as targeted clinical ultrasound.\n\nThis simplification\u002Fminiaturization of ultrasound equipment has facilitated the spread of this technique outside the field of cardiology and now allows for its use by general practitioners close to patients, specifically for screening purposes. Many diseases would benefit from early screening in order to reduce hospitalizations, mortality, and societal costs. In cardiology, this approach remains difficult because the majority of patients admitted to healthcare facilities have already developed the disease. HF is characterized by an initial silent phase which, if left untreated, inevitably leads to complications and death. It is responsible for 200,000 hospitalizations per year in France, causing the deaths of 70,000 people. Certain signs, grouped under the French acronym EPOF, appear early on and can be warning signs, but they are often vague and unfamiliar to the general public. This fact is well illustrated by the results of a survey conducted by the Heart Failure and Cardiomyopathy Group (GICC) of the French Society of Cardiology (SFC) in 2017 (5,000 subjects representative of the French population aged 18 to 80). This survey noted that two-thirds of subjects presenting four of these signs (EPOF) had not consulted a cardiologist in the 12 months prior to the questionnaire. In the majority of cases, these patients, whether asymptomatic or paucisymptomatic (EPOF), have morphological and functional abnormalities of the heart, which are the first step toward more severe complications and can be detected by cardiac echocardiography.\n\nThere is currently a favorable alignment between echocardiography as a public health need (early detection of conditions that can lead to heart failure) and frontline practitioners (general practitioners). This alignment could lead to the definition of new practices and a new care pathway. While echocardiography is technically feasible in a general practitioner's office, its implementation remains to be evaluated (HAS report). This report emphasizes the lack of data in the literature to identify use cases and clinical impact in general medicine in France.",[62,25,63,64,65,66,67],"Age 65 and Older","Dyspnea; Cardiac","Oedema","Fatigability","Cough","Weight Gain","NOT_YET_RECRUITING","2026-02-16",{"date":71,"type":38},"2026-02-23",{"date":73,"type":21},"2026-03-01",{"date":75,"type":21},"2027-05-31",{"name":77,"class":78},"University Hospital, Caen","OTHER"]