[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiac-surgery-requiring-cardiopulmonary-bypass\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiac-surgery-requiring-cardiopulmonary-bypass":23},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,39,64,89],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":16,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100585254","the-association-between-tau--gfap-and-postoperative-neurological-impairment-in-patients-undergoing-cardiac-surgery-100585254",false,"NCT06899971","The Association Between Tau & GFAP and Postoperative Neurological Impairment in Patients Undergoing Cardiac Surgery","Inclusion Criteria:\n\n* less than 18 years old\n* undergoing cardiac surgery with cardiopulmonary bypass at Boston Children's Hospital\n\nExclusion Criteria:\n\n* undergoing an emergent procedure and do not have more than 1 hour ahead of time to review the consent\n* patient in a moribund condition American Society of Anesthesiology (ASA 5)\n* patient with a hematological and\u002For oncological disease\n* Jehovah witnesses\n* patient on preoperative mechanical ventilation","ALL","18 Years",{"count":18,"type":19},100,"ESTIMATED","OBSERVATIONAL","Patients born with heart defects often undergo surgical procedures on a heart lung machine. With improvements in medical and surgical management, their survival has significantly improved, but their brain insult has not been paid much attention. This study is to determine the relationship between specific proteins in the blood and brain injury in patients less than 18-year-old undergoing heart surgery.",[23,24,25],"Cardiac Surgery Requiring Cardiopulmonary Bypass","Brain Injury","Congenital Heart Defect","NOT_YET_RECRUITING","2026-03-16",{"date":29,"type":30},"2026-03-17","ACTUAL",{"date":32,"type":19},"2026-05-01",{"date":34,"type":19},"2027-12-31",{"name":36,"class":37},"Boston Children's Hospital","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":43,"acronym":4,"eligibilityCriteria":44,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":45,"targetDuration":46,"studyType":20,"phases":4,"briefSummary":47,"conditions":48,"keywords":52,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":38},"100570331","a-comparison-of-renal-vs-limb-nirs-for-predicting-cardiac-surgery-associated-acute-kidney-injury-100570331","NCT06705855","A Comparison of Renal vs Limb NIRS for Predicting Cardiac Surgery Associated Acute Kidney Injury","Inclusion Criteria:\n\n* We will enroll a convenience sample of adult cardiac surgery patients undergoing procedures that require cardiopulmonary bypass (CPB) and who are at risk for AKI.\n\nExclusion Criteria:\n\n* Exclusion criteria will include less than age 18 years old, preoperative end-stage kidney disease requiring dialysis, emergency surgery, or patient refusal.",{"count":18,"type":19},"30 Days","Acute kidney injury (AKI) is a complication of cardiac surgery that can affect outcome. Near Infrared Spectroscopy (NIRS) is a technology that uses light to determine how well oxygenated tissues are. This technology is routinely used in cardiac surgery to measure the oxygen level in the brain by placing a sensor sticker on the forehead. The purpose of the study is to determine whether NIRS sensor stickers placed on the skin over the kidney can predict AKI better than when sensors are placed on the skin over the participant's limbs. This study is being conducted by investigators from the department of anesthesiology at the University of Utah.",[49,50,23,51],"NIRS","Cardiac Surgery Associated - Acute Kidney Injury","AKI - Acute Kidney Injury",[53],"Cardiovascular","RECRUITING","2025-08-12",{"date":57,"type":30},"2025-08-17",{"date":59,"type":30},"2025-05-29",{"date":61,"type":19},"2026-08-30",{"name":63,"class":37},"University of Utah",{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":72,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":74,"conditions":75,"keywords":76,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":38},"100587596","oxygen-consumption-hypoperfusion-and-organ-injury-after-cardio-pulmonary-bypass-100587596","NCT06930443","Oxygen Consumption, Hypoperfusion and Organ Injury After Cardio-pulmonary Bypass","Oxygen Consumption, Early Postoperative Hypoperfusion and Organ Injury After Cardio-pulmonary Bypass: a Prospective Observational Study","VO2-EPOC","Inclusion Criteria:\n\n* Elective cardiac surgery requiring cardiopulmonary bypass\n\nExclusion Criteria:\n\n* Combined, redo or annuloplasty procedures\n* Surgical procedures involving other vascular cannulation than standard direct, such as bicaval or femoral cannulation\n* Preoperative hyperlactatemia (\\>2mmol\u002FL) or anaemia (Hb \\\u003C90 g\u002FdL)\n* Preoperative need for supplementary oxygen or ICU care\n* Consent not obtainable.",{"count":73,"type":19},65,"The goal of this observational study is to understand how oxygen consumption after heart surgery relates to blood flow problems and organ injury. The study focuses on patients over 18 years old who are having planned heart surgery with a heart-lung machine (cardiopulmonary bypass).\n\nThe main questions the study aims to answer are:\n\n1. How does oxygen consumption in the early hours after surgery relate to lactate levels (a sign of low oxygen supply to the tissues)?\n2. How is oxygen consumption linked to signs of poor blood flow and organ injury (such as heart, kidney, liver, brain, and gut damage)?\n\nResearchers will measure oxygen consumption after surgery using a technique called indirect calorimetry. They will also track blood flow and oxygen use during surgery and check for signs of organ injury the day after the procedure. The study will include 65 participants. People with certain health conditions, like severe anemia, high lactate levels before surgery, or needing intensive care or extra oxygen supply before surgery, will not be included. By understanding how oxygen consumption relates to blood flow and organ injury, this research may help to better manage patients after heart surgery and reduce complications.",[23],[77,78,79],"cardiac surgery","cardiopulmonary bypass","postoperative care","2025-05-06",{"date":82,"type":30},"2025-05-11",{"date":84,"type":30},"2025-05-05",{"date":86,"type":19},"2026-02",{"name":88,"class":37},"Uppsala University Hospital",{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":93,"acronym":4,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":95,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":97,"conditions":98,"keywords":99,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":4},"100583932","relationship-of-point-of-care-coagulation-assays-with-clinical-outcomes-in-cardiac-surgery-a-retrospective-cohort-study-100583932","NCT06882759","Relationship of Point-of-care Coagulation Assays with Clinical Outcomes in Cardiac Surgery: a Retrospective Cohort Study","Inclusion Criteria:\n\n* Adult patients ≥ 18 years old\n* Underwent a cardiac surgical procedure with cardiopulmonary bypass\n\nExclusion Criteria:\n\n\\- Did not undergo viscoelastic testing during surgery",{"count":96,"type":19},15000,"The goal of this observational study is to determine the relationship of ROTEM point-of-care coagulation assay parameters with excessive bleeding and clinical outcomes in patients undergoing cardiac surgery at Toronto General Hospital. The main questions it aims to answer are: i) How well does viscoelastic testing (VET) predict the clinical outcome of excessive bleeding in cardiac surgery? ii) Which VET parameters have the greatest accuracy for identification of patients who will have excessive bleeding? iii) 3) What is the prognostic value of abnormal VET parameters with other clinical outcomes after cardiac surgery?",[23],[77,100,101,102,78,103],"viscoelastic testing","point-of-care","ROTEM","bleeding","2025-03-14",{"date":106,"type":30},"2025-03-19",{"date":108,"type":19},"2025-03-15",{"date":110,"type":19},"2026-03-15",{"name":112,"class":37},"University Health Network, Toronto"]