[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiac-surgery-subjects\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiac-surgery-subjects":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,45,73,106,146,174],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100643750","ionized-calcium-and-bleeding-in-cardiac-surgery-100643750",false,"NCT07634042","Ionized Calcium and Bleeding in Cardiac Surgery","Plasma Ionized Calcium and Perioperative Bleeding in Cardiac Surgery.","Inclusion Criteria:\n\n* age 18-100 years\n* open-heart surgery with cardiopulmonary bypass (surgery with a main procedure code in the NCSP classification F category, \"Heart and Great Vessels of the Thorax\", performed on extracorporeal perfusion, procedure code FXA00)\n* between January 2021 and March 2026\n\nExclusion Criteria:\n\n* organ transplants (procedure code FQ)\n* hemophilia, von Willebrand disease, or platelet function disorders (ICD-10 codes D65-D69)\n* essential thrombocythemia (ICD-10 code D75.2)","ALL","18 Years","100 Years",{"count":20,"type":21},4300,"ESTIMATED","OBSERVATIONAL","This retrospective study investigates the association between perioperative plasma ionized calcium concentration and perioperative bleeding in open-heart surgery. Excluding patients who meet exclusion criteria, the study will include all applicable adult patients who underwent cardiac surgery at Helsinki University Hospital between January 2021 and March 2026. As clinical routine, during both cardiac surgery and the subsequent intensive care period, multiple blood gas analyses were performed, including measurements of plasma ionized calcium concentration. Time-weighted averages of all measurements will be calculated across different phases of surgery (pre-CPB, on -CPB, post-CPB) and the first 24 hours of ICU stay (0-6 h, 6-12 h, 12-24 h). Perioperative bleeding will be assessed using the Universal Definition of Perioperative Bleeding (UDPB) classification validated for cardiac surgery. In addition to chest drain output, this classification accounts for blood products administered to treat bleeding (red blood cells, platelets, and fresh frozen plasma), pharmacological coagulation factor concentrates (fibrinogen\u002Fcryoprecipitate, PCC, aFVIIa) and surgical interventions (open sternum, resternotomy). The association between plasma ionized calcium and UDPB class will be assessed with regression models. The primary analysis will be the association between time-weighted mean plasma ionized calcium level during the post-CPB phase as a continuous variable and dichotomous UDPB (UDPB 3-4 vs. UDPB 0-2) in patients who did not receive blood products during the post-CPB phase. One secondary and two sensitivity analyses will be performed",[25],"Cardiac Surgery Subjects",[27,28,29,30,31],"cardiac surgery","cardiopulmonary bypass","plasma ionized calcium","bleeding","perioperative bleeding","NOT_YET_RECRUITING","2026-06-03",{"date":35,"type":36},"2026-06-08","ACTUAL",{"date":38,"type":21},"2026-06-01",{"date":40,"type":21},"2029-12-31",{"name":42,"class":43},"Helsinki University Central Hospital","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":59,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":44},"100632460","objective-measurement-of-the-mechanical-pain-threshold-with-an-algometer-for-predicting-intraoperative-opioid-consumption-in-patients-who-will-be-operate-by-thoracotomy-and-sternotomy-in-cardiac-surgery-100632460","NCT07513974","Objective Measurement of the Mechanical Pain Threshold With an Algometer for Predicting Intraoperative Opioid Consumption in Patients Who Will be Operate by Thoracotomy and Sternotomy in Cardiac Surgery","The Usefulness of Preoperative Measurement of the Mechanical Pain Threshold for Predicting Intraoperative Opioid Consumption","Inclusion Criteria:\n\n* ASA 3 patients with scheduled cardiac surgery by thoracotomy or sternotomy\n\nExclusion Criteria:\n\n* Patient refusal,\n* A body mass index (BMI) \\> 30 kg\u002Fm²,\n* Allergies to any medication used in typical cardiac anesthesia,\n* Chronic pain or regular use of analgesics,\n* Severe ventricular dysfunction, pulmonary hypertension, poorly controlled arhythmia,\n* Non-elective surgery.\n* Patients enrolled in another study protocol within the previous 3 months,\n* Pregnant or breastfeeding patients,\n* Patients with severe renal or hepatic impairment.\n* Patients for whom the study will be stopped in the event of blood loss greater than or equal to one liter, or for any other severe perioperative surgical complication.",{"count":53,"type":21},100,"INTERVENTIONAL",[56],"NA","The study aims to test the relationship between the preoperative pain threshold and the intraoperative need for opioids.\n\nThe objective of the study is to try to predict a patient's analgesic needs based on their objectively determined preoperative pain threshold.\n\nThe investigators will include patients scheduled for elective cardiovascular surgery.\n\nThe investigators will investigate the correlation between the preoperative pain threshold and intraoperative\u002Fpostoperative opioid consumption in a highly standardized anesthesia setting.",[25],[60,61,62],"pain threshold","intra operative opioid consumption","algometer","RECRUITING","2026-04-04",{"date":66,"type":36},"2026-04-07",{"date":68,"type":36},"2026-01-24",{"date":70,"type":21},"2026-12-15",{"name":72,"class":43},"Université Libre de Bruxelles",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":54,"phases":84,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":44},"100601933","multisensory-and-cognitive-interventions-in-the-icu-effects-on-health-and-recovery-100601933","NCT07116941","Multisensory and Cognitive Interventions in the ICU: Effects on Health and Recovery","Effects of Multisensory and Cognitive Interventions Applied in the Intensive Care Unit on Physiological, Psychological and Functional Outcomes","MICU-CARE","Inclusion Criteria:\n\n* Age between 18 and 80 years\n* Underwent coronary artery bypass grafting (CABG) or other open-heart surgery\n* Admitted to the ICU postoperatively and eligible for early mobilization\n* Hemodynamically stable (within normal blood pressure and heart rate ranges, without inotropic support)\n* Alert and able to communicate\n\nExclusion Criteria:\n\n* Diagnosis of ICU delirium or altered mental status\n* Severe hemodynamic instability\n* Presence of neurological disease or significant cognitive impairment\n* Significant sensory deficits (e.g., severe hearing or vision loss)\n* Known allergy or psychological sensitivity to auditory or olfactory stimuli (e.g., aromatherapy or music)","80 Years",{"count":83,"type":21},125,[56],"The goal of this clinical trial is to examine the effects of sensory and cognitive stimulation on physiological, psychological, and functional recovery in adult patients after cardiac surgery who are treated in the intensive care unit (ICU). The main questions it aims to answer are:\n\n* Does sensory and\u002For cognitive stimulation reduce anxiety and improve hemodynamic stability in ICU patients?\n* Does it enhance physical function and independence during early rehabilitation in the ICU?\n\nResearchers will compare four groups:\n\n1. Standard care (control),\n2. Cognitive stimulation,\n3. Auditory stimulation (music),\n4. Multisensory stimulation (touch + smell)\n\nto assess which intervention is most effective in improving recovery parameters.\n\nParticipants will:\n\n* Be randomly assigned to one of four groups during early mobilization in the ICU\n* Receive a 30-minute intervention session depending on group assignment\n* Be evaluated for heart rate, blood pressure, oxygen saturation, anxiety (VAS), physical function (PFIT, FIM), and satisfaction before and after the session",[87,25,88],"Coronary Artery Bypass Graft (CABG)","Postoperative Care",[90,91,92,93,94,95,96],"Early Mobilization","Intensive Care Unit","Cardiac Surgery","Multisensory Intervention","Anxiety","Non-pharmacological Intervention","Rehabilitation in ICU","2026-02-10",{"date":99,"type":36},"2026-02-12",{"date":101,"type":36},"2025-08-01",{"date":103,"type":21},"2026-06-30",{"name":105,"class":43},"Abant Izzet Baysal University",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":16,"minAge":114,"maxAge":4,"enrollmentInfo":115,"targetDuration":4,"studyType":54,"phases":117,"briefSummary":119,"conditions":120,"keywords":126,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":44},"100565938","phase-2-lemborexant-to-prevent-post-operative-delirium-in-cardiac-surgery-patients-100565938","NCT06648681","Lemborexant to Prevent Post-operative Delirium in Cardiac Surgery Patients","A Randomized Trial of Lemborexant for the Prevention of Delirium After Cardiac Surgery (PROTEX): A Pilot Study","PROTEX","Inclusion Criteria:\n\n* Admitted to hospital following open cardiac surgery through midline sternotomy\n\nExclusion Criteria:\n\n* ● Known severe obstructive sleep apnea diagnosed by polysomnography or STOPBANG score \\> 5\n\n  * Periodic limb movement disorder or restless legs syndrome\n  * Narcolepsy\n  * Somnolence (Pasero Opioid Sedation Scale (POSS) \\>2)\n  * Current alcohol or substance use disorder as defined by the DSM-V\n  * Patient already taking moderate or strong CYP3A inhibitors\n  * Frequent use of medications for insomnia defined as \\>4 days per week.\n  * Liver failure (Child-Pugh score B or C)\n  * Renal failure (eGFR\\\u003C30 ml\u002Fmin\u002F1.73 m2)\n  * Pre-existing delirium (ICDSC score \\>3 or CAM\u002FCAM-ICU positive) at time of consent\n  * BMI\\>40 kg\u002Fm2\n  * Known allergy or hypersensitivity to study drug\n  * Inability to communicate in English","61 Years",{"count":116,"type":21},60,[118],"PHASE2","Post-operative delirium is a common complication following cardiac surgery and is associated with increased 1 year mortality. Currently there are no drug therapies to prevent delirium. Orexin is a neuromodulator thought to play an important role in disordered sleep, one of the instigators of delirium. Lembrorexant is an orexin antagonist, originally approved for sleep, that may also reduce the incidence of delirium. The Investigators propose a pilot study to determine the feasibility of a randomized controlled trial comparing Lembrorexant to placebo in patients following cardiac surgery in reducing the incidence of delirium, and improving sleep.",[121,92,25,122,123,124,125],"Delirium - Postoperative","Orexin Antagonist","Feasibility Studies","Sleep","In-hospital Mortality",[127,128,129,130,131,27,132,133,134,135,136],"lemborexant","Postoperative Delirium","sleep medication","ICDSC","CAM","sleep aid","open heart surgery","delirium","sleep quality","Richards-Campbell Sleep Questionnaire","2025-04-18",{"date":139,"type":36},"2025-04-23",{"date":141,"type":21},"2025-05-01",{"date":143,"type":21},"2027-04-30",{"name":145,"class":43},"University of British Columbia",{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":152,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":154,"enrollmentInfo":155,"targetDuration":4,"studyType":54,"phases":157,"briefSummary":158,"conditions":159,"keywords":160,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":4},"100584196","puo2-in-renalguard-pilot-study-100584196","NCT06886191","PuO2 in RenalGuard Pilot Study","Effects on Urine Oxygenation of Forced Diuresis with Neutral Fluid Balance During Cardiac Surgery, a Randomized Controlled Trial","PURE","Inclusion Criteria:\n\n* Patients ≥18 years of age\n* scheduled for cardiac surgery with normothermic CPB\n* Estimated glomerular filtration rate ≥50 ml\u002Fmin as assessed by the CKD-EPI formula\n\nExclusion Criteria:\n\n* Patient receiving furosemide at a dose\\>100 mg\u002Fday orally (or the equivalent dose of an alternative loop diuretic) in the last week\n* Patient who cannot be urethrally catheterized for any reason\n* Patient already dialysis dependent\n* Known or suspected AKI (KDIGO criteria) at the time of screening\n* Any condition which, in the judgement of the investigator, might increase the risk to the patient","85 Years",{"count":156,"type":21},30,[56],"The PuO2 in RenalGuard (PURE) study is planned as a single center, randomized controlled pilot study comparing renal oxygenation during cardiac surgery with cardiopulmonary bypass (CPB) with or without balanced forced diuresis using the RenalGuard (RG) system.\n\nRenal oxygenation will be assessed by urine oxygen tension, continuously measured by optodes placed through the urine catheter. Measurements will start after induction of anesthesia and continue for 24 hours.\n\nIn total, 30 patients will be randomized 1:1 to RG or standard of care (SOC) during cardiac surgery with CPB. In the RG group, the forced diuresis with neutral fluid balance will be maintained from before the start of surgery until 3 hours after weaning from CPB.\n\nThe primary endpoint is the group difference (RG vs SOC) in delta PuO2, defined as the change in mean PuO2 from baseline to the last 5-minute period at 45 minutes after start of CPB.\n\nThe secondary endpoints include\n\n1. Group difference in mean PuO2 before, during and after CPB\n2. Group difference in time weighted area under the curve for PuO2\n3. Group differences in renal near infrared spectroscopy (NIRS) before, during and after CPB\n4. Group difference in urine and blood biochemistry including renal biomarkers\n5. Group difference in urine output and fluid balance during surgery and first postoperative day\n6. Group differences in postoperative AKI according to the KDIGO criteria\n7. Time (minutes) with puO2 ≤ 15 and ≤ 10 mmHg during and after CPB\n8. Dynamics of PuO2 during the early postoperative phase\n\nPatients ≥18 years scheduled for cardiac surgery with CPB with estimated glomerular filtration rate ≥50 ml\u002Fmin are eligible for inclusion. Exclusion criteria include patients on higher doses of furosemide, patients with AKI or under renal replacement therapy.\n\nPatients will be analyzed according to study group. In patients where hemofiltration has been used during CPB, control group patients who has received furosemide and patients in the RG group who do not reach target urine flow will be excluded from the main analysis but will be included in a separate analysis.",[25],[161,162,163,164],"renal oxygenation","urine oxygen tension","furosemide","balanced diuresis","2025-03-14",{"date":167,"type":36},"2025-03-20",{"date":169,"type":21},"2025-03-17",{"date":171,"type":21},"2026-12-31",{"name":173,"class":43},"Sahlgrenska University Hospital",{"id":175,"slug":176,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":179,"acronym":180,"eligibilityCriteria":181,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":182,"targetDuration":4,"studyType":54,"phases":183,"briefSummary":184,"conditions":185,"keywords":189,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":44},"100576821","polyurethane-foam-pink-pad-rct-use-in-or-100576821","NCT06790277","Polyurethane Foam-Pink Pad (RCT) Use in OR","Effectiveness of Polyurethane Foam (Pink Pad) Compared With Mepilex Dressing for Pressure Ulcer Prevention in Operating Room: A Randomized Control Clinical Trial","pink-pad","Inclusion Criteria:\n\n* Subjects ≥ 18.\n* Willing to participate.\n* Patients undergoing cardiac surgery.\n* Patient who is at risk for PU development as measured with Braden scale.\n* Patient who has skin intact and having a life expectancy greater than 72 hours as per clinical judgement.\n\nExclusion Criteria:\n\n* Subjects under 17\n* Not consenting to participate\n* Patients with suspected hypersensitivity reactions to any of the dressing formulation's ingredients.\n* Patients who are unable to continue the study because of death or change in the care setting.",{"count":53,"type":21},[56],"King Abdullah medical city has a cardiac center, and a lot of open-heart surgeries are performed there, and both polyurethane foam (pink Pad) and Mepilex dressing are applied to those patients. Therefore, the present study was designed to compare the effects of polyurethane foam (pink Pad) versus Mepilex dressing for prevention of pressure ulcer in operating room.",[25,186,187,188],"Pressure Ulcer Prevention","Pressure Ulcer of Skin","Pressure Ulcer",[190,191,192,193,194],"five layers sacral foam dressing","PINK PAD","pressure ulcers","Patients undergoing cardiac surgery","Mepilex dressing","2025-01-21",{"date":197,"type":36},"2025-01-24",{"date":199,"type":36},"2023-10-10",{"date":201,"type":21},"2025-10-10",{"name":203,"class":204},"King Abdullah Medical City","OTHER_GOV"]