[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiac-surgery-with-sternotomy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiac-surgery-with-sternotomy":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,54],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100638373","effect-of-positioning-and-acbt-on-pulmonary-complications-after-cardiac-surgery-100638373",false,"NCT07612033","Effect of Positioning and ACBT on Pulmonary Complications After Cardiac Surgery","Effect of Positioning Combined With Active Cycle of Breathing Techniques on Pulmonary Complications After Cardiac Surgeries","P-ACBT","Inclusion Criteria:\n\n* Adult patients (aged from 20 years to 65 years old).\n* Undergoing elective cardiac surgery (Coronary Artery bypass Grafting (CABG) or valves surgeries) via median sternotomy.\n* Hemodynamically stable postoperatively (no high-dose vasopressor support).\n* Fully conscious and capable of following complex verbal instructions.\n\nExclusion Criteria:\n\n* • Patients undergoing emergency cardiac surgery.\n\n  * History of chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), bronchial asthma, or bronchiectasis\n  * Pre-existing pulmonary complications (e.g., pneumonia, atelectasis, pleural effusion) prior to surgery\n  * Neuromuscular disorders affecting respiratory muscles\n  * Severe obesity (e.g., BMI ≥35 kg\u002Fm²)\n  * Cognitive impairment or inability to follow instructions\n  * Any contraindication to physiotherapy techniques (e.g., unstable sternum, severe pain not controlled)","ALL","20 Years","65 Years",{"count":21,"type":22},124,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this quasi-experimental clinical trial is to learn if position management combined with the Active Cycle of Breathing Techniques (ACBT) works to reduce postoperative pulmonary complications in adult patients undergoing elective cardiac surgery. It will also evaluate the individual effects of each technique compared to routine care.\n\nThe main questions it aims to answer are:\n\nDoes the combination of positioning and ACBT significantly lower the incidence and severity of postoperative pulmonary complications (like atelectasis, pneumonia, and respiratory failure) within the first 7 days after surgery? Does the combination of these techniques reduce the length of hospital stay compared to using each technique alone or routine care? Does the application of ACBT alone lower the rate of respiratory infections? Does position management alone improve oxygenation parameters (such as SpO\\_{2} and PaO\\_{2})?\n\nResearchers will compare four groups of patients to determine the most effective nursing approach:\n\nGroup 1 (Control Group): Participants will receive routine postoperative hospital care only.\n\nGroup 2 (ACBT Group): Participants will perform the Active Cycle of Breathing Techniques (breathing control, thoracic expansion, and huffing) three times daily for 10-15 minutes over 5 postoperative days.\n\nGroup 3 (Positioning Group): Participants will receive structured position management exclusively, shifting from head elevation (30-45) early after surgery to a semi-recumbent position (approx60) during waking hours, alongside other positions like lateral or forward-leaning as tolerated.\n\nGroup 4 (Combined Group): Participants will receive both structured position management and perform the ACBT sessions according to the same schedules.\n\nAll participants will undergo daily respiratory assessments using a standardized scoring system for 7 days post-surgery or until hospital discharge.",[28,29,30,31],"Postoperative Pulmonary Complications (PPCs)","Cardiac Surgery With Sternotomy","Atelectasis","Postoperative Pneumonia",[33,34,35,36,37,38,39,40],"Position management","Active Cycle of Breathing Techniques ACBT","Postoperative pulmonary complications (PPCs)","Cardiac surgery (Open heart surgery)","Median sternotomy","Respiratory rehabilitation","Atelectasis prevention","Nursing-driven intervention","NOT_YET_RECRUITING","2026-05-21",{"date":44,"type":45},"2026-05-28","ACTUAL",{"date":47,"type":22},"2026-06-15",{"date":49,"type":22},"2027-01-01",{"name":51,"class":52},"Assiut University","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":23,"phases":65,"briefSummary":67,"conditions":68,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":53},"100634433","phase-3-suzetrigine-enhanced-multimodal-opioid-sparing-therapy-in-cardiac-and-bariatric-surgery-100634433","NCT07539623","Suzetrigine-enhanced MultimOdal Opioid-sparing THerapy in Cardiac and Bariatric SURGery","SMOOTH-SURG","Inclusion Criteria:\n\nTo be eligible to participate in this study, an individual must meet all of the following criteria:\n\n* Adults 18-85 years old\n* Scheduled to undergo cardiac procedures via sternotomy or bariatric surgery (laparoscopic or open)\n* All genders\n\nExclusion Criteria:\n\nAny individual who meets any of the following criteria will be excluded from participation in this study:\n\n* ASA Class V\n* Urgent or emergent surgery\n* Contraindications to administration of Suzetrigine (e.g. concomitant use of strong CYP3A inhibitors)\n* History of substance use disorder or chronic opioid use\n* Reoperation\n* Patient refusal or inability to consent\n* Patients who take moderate-to-severe CYP3A inhibitors (such as Ritonavir, Voriconazole, and\n* Clarithromycin)\n* Patients who take moderate-to-severe CYP3A inducers (such as Phenytoin, Carbamazapine, and Rifabutin)","18 Years","85 Years",{"count":64,"type":22},235,[66],"PHASE3","This is prospective, randomized study. The purpose of this study is to evaluate whether the addition of Suzetrigine to well established multimodal pain regimen for participants undergoing bariatric patients undergoing weight-loss surgery and cardiac patients undergoing sternotomy will reduce post-operative opioid consumption and pain scores.",[69,29,70],"Bariatric Surgery","Post-operative Pain","RECRUITING","2026-05-11",{"date":74,"type":45},"2026-05-14",{"date":76,"type":45},"2026-05-01",{"date":78,"type":22},"2026-12-22",{"name":80,"class":52},"Icahn School of Medicine at Mount Sinai"]