[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiac-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiac-surgery":30},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,101,0,25,[9,49,77,105,132,162,183,208,241,262,286,311,333,353,381,404,436,456,483,515,534,559,583,608,632],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100054134","appropriateness-of-hemostatic-agent-use-in-cardiovascular-surgery-haemovax-100054134",false,"NCT07699016","Appropriateness of Hemostatic Agent Use in Cardiovascular Surgery (HAEMOVAX)","Evaluation of Appropriateness in the Use of Hemostatic Agents in Cardiovascular Surgery: A Mixed-Methods Single-Center Observational Study","HAEMOVAX","Inclusion Criteria:\n\n* Physicians with a surgical role in the Departments of Cardiac Surgery or Vascular Surgery at IRCCS Galeazzi-Sant'Ambrogio, Milan Including attending surgeons, consultant surgeons, and surgical residents\n* Active participation in cardiovascular operative procedures during the study period (or within the preceding 12 months)\n* Employment at the study institution at the time of survey administration Willingness to participate and complete the anonymous structured questionnaire\n\nExclusion Criteria:\n\n* Non-surgical healthcare personnel (e.g., nurses, anesthesiologists, administrative staff, or allied health professionals)\n* Surgeons not involved in operative cardiovascular practice during the study period\n* External collaborators or visiting surgeons without regular clinical activity at the institution\n* Individuals who do not provide informed consent for participation in the anonymous survey\n* Questionnaires with missing or incomplete vignette responses preventing calculation of the KPA-Score",true,"ALL","18 Years",{"count":22,"type":23},15,"ESTIMATED","OBSERVATIONAL","Hemostatic agents are widely used in cardiac and vascular surgery to support intraoperative bleeding control. Despite their clinical relevance and substantial economic impact, little is known about real-world patterns of use, adherence to evidence-based recommendations, and the alignment between clinicians' perceived knowledge and actual decision-making.\n\nHAEMOVAX is a single-center mixed-methods observational study conducted at IRCCS Galeazzi-Sant'Ambrogio Hospital, Milan, Italy. The study combines an anonymous survey of cardiovascular surgeons with a retrospective audit of institutional hemostatic agent consumption. The primary objective is to evaluate the appropriateness of hemostatic agent selection using a Knowledge-Practice Alignment Score (KPA-Score) derived from standardized clinical vignettes based on current EACTS and ESA recommendations. Secondary objectives include assessment of usage patterns, barriers to appropriate use, concordance between declared practice and real-world consumption, and opportunities for evidence-based standardization.",[27,28,29,30,31],"Hemostasis","Perioperative Bleeding","Cardiovascular Surgery","Cardiac Surgery","Vascular Surgery",[33,34,35,28],"Hemostatic Agents","Surgical Hemostasis","Topical Hemostatic Agents","RECRUITING","2026-07-07",{"date":39,"type":40},"2026-07-13","ACTUAL",{"date":42,"type":23},"2026-07-01",{"date":44,"type":23},"2026-08-15",{"name":46,"class":47},"University of Milan","OTHER",1,{"id":50,"slug":51,"hasResults":12,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":48},"100605604","serratus-posterior-superior-plane-block-for-postoperative-pain-in-cardiac-surgery-100605604","NCT07164677","Serratus Posterior Superior Plane Block for Postoperative Pain in Cardiac Surgery","Efficacy of the Serratus Posterior Superior Intercostal Plane Block for Postoperative Acute Pain Management in Open-Heart Surgery","Inclusion Criteria:\n\n* Patients aged 18-80 undergoing elective on-pump open-heart surgery via median sternotomy.\n* American Society of Anesthesiologists (ASA) classification II-III patients.\n* Patients who can use PCA.\n* Patients who will sign the informed consent form.\n\nExclusion Criteria:\n\n* History of opioid use for more than four weeks\n* Chronic pain syndromes\n* Patients with a history of local anesthetic or opioid allergy, hypersensitivity\n* Alcohol and drug addiction\n* Conditions where regional anesthesia is contraindicated\n* Failure in the dermatomal examination performed after the block\n* Emergency surgeries and redo surgeries.\n* Individuals with obstructive sleep apnea.\n* Left ventricular ejection fraction less than 30%.\n* Patients with severe psychiatric illnesses (such as psychosis, dementia) that limit cooperation with verbal numerical pain scales.\n* Pregnant and breastfeeding patients.\n* Hematological disorders.\n* Significant impairment in the function of a major organ (e.g., severe hepatic or renal disease). • Patients who cannot be extubated within the first 6 hours postoperatively.","80 Years",{"count":58,"type":23},50,"INTERVENTIONAL",[61],"NA","The aim of this study is to investigate the efficacy of bilateral serratus posterior superior intercostal plane (SPSIP) block on postoperative acute pain and opioid consumption in patients undergoing on-pump open-heart surgery. Postoperative outcomes including pain scores, cumulative morphine use, quality of recovery, and opioid-related side effects will be evaluated within the first 24 hours after surgery.",[30,64],"Post Operative Pain, Acute",[66,67],"Cardiac surgery","Serratus Posterior Superior Plane Block","2026-06-30",{"date":70,"type":40},"2026-07-02",{"date":72,"type":40},"2025-09-13",{"date":74,"type":23},"2027-02-01",{"name":76,"class":47},"Ondokuz Mayıs University",{"id":78,"slug":79,"hasResults":12,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":12,"sex":19,"minAge":84,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":59,"phases":87,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":48},"100644894","sage-heart--senior-assessment-fragility-and-post-operative-qalys-1-year-after-emergency-heart-surgery-for-patients-aged-75-and-older-100644894","NCT07677319","SAGE-Heart : Senior Assessment fraGility and Post-opErative QALYs 1 Year After Emergency HEART Surgery for Patients Aged 75 and Older","SAGE-Heart","Inclusion Criteria:\n\n* Patients aged ≥ 75 years who are affiliated with or beneficiaries of a social security scheme and undergoing emergency cardiac surgery under cardiopulmonary bypass, either immediate or urgent (relative) :\n\n  * Immediate emergency surgery: intervention performed before the start of the next working day following the decision to operate,\n  * Urgent (relative) emergency surgery: patients not admitted electively for surgery but requiring an intervention during the current hospital stay for medical reasons, and who cannot be discharged without undergoing a definitive procedure\n\nExclusion Criteria:\n\n* Patients requiring preoperative cardiopulmonary resuscitation\n* Scheduled (elective) surgery\n* Lack of informed consent\n* Impaired consciousness at the time of inclusion (defined by a Glasgow Coma Scale score \\\u003C 15)\n* Individuals under legal guardianship or judicial protection\n* Individuals participating in another interventional research protocol","75 Years",{"count":86,"type":23},265,[61],"The hypothesis is that the preoperative Clinical Frailty Score (CFS) is a predictive factor for a loss in quality-adjusted life years (QALYs) one year after emergency cardiac surgery under cardiopulmonary bypass (CPB) in patients aged 75 years and older.",[90,30,91],"Frailty","QALYs",[90,93,30,94,91,95,96],"Elderly","Cardio-pulmonary Bypass","Clinical Frailty Scale","EuroQol, postoperative","2026-06-29",{"date":68,"type":40},{"date":100,"type":40},"2025-12-03",{"date":102,"type":23},"2028-12-03",{"name":104,"class":47},"University Hospital, Bordeaux",{"id":106,"slug":107,"hasResults":12,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":111,"eligibilityCriteria":112,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":56,"enrollmentInfo":113,"targetDuration":4,"studyType":59,"phases":115,"briefSummary":116,"conditions":117,"keywords":120,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":127,"completionDateStruct":128,"leadSponsor":130,"locationsCount":48},"100644856","anti-bloating-patch-for-postoperative-gastric-distension-after-cardiac-surgery-100644856","NCT07677423","Anti-Bloating Patch for Postoperative Gastric Distension After Cardiac Surgery","Efficacy of an Anti-Bloating Patch for Postoperative Gastric Distension After Cardiac Surgery: A Randomized Controlled Trial Using Quantitative Gastric Bubble Imaging Analysis","ABP-CS","Inclusion Criteria:\n\n* Age ≥18 years\n* Undergoing elective cardiac surgery\n* Postoperative chest radiographs available for gastric bubble area assessment\n* Able to provide written informed consent or have consent provided by a legally authorized representative\n* Expected postoperative intensive care unit admission\n\nExclusion Criteria:\n\n* Previous major gastrointestinal surgery affecting gastric anatomy or motility\n* Known gastrointestinal obstruction, perforation, or severe gastrointestinal disease\n* Severe hepatic or renal dysfunction judged unsuitable by the investigators\n* Known allergy or hypersensitivity to components of the anti-bloating patch\n* Participation in another interventional clinical trial within the previous 30 days\n* Pregnancy or lactation\n* Inability to complete study assessments or follow study procedures",{"count":114,"type":23},150,[61],"Postoperative gastric distension is a common gastrointestinal complication after cardiac surgery and may delay recovery, prolong intensive care unit (ICU) stay, and reduce patient comfort. Anti-bloating patches are widely used in clinical practice to promote gastrointestinal function recovery; however, high-quality evidence regarding their effectiveness in cardiac surgical patients remains limited.\n\nThis randomized controlled trial aims to evaluate the efficacy and safety of an anti-bloating patch in reducing postoperative gastric distension after cardiac surgery. Adult patients undergoing cardiac surgery will be randomly assigned to receive either standard perioperative care alone or standard perioperative care plus anti-bloating patch therapy. Gastric bubble area will be quantitatively measured using chest radiographs and image analysis software.\n\nThe primary outcome is the change in gastric bubble area on postoperative day 1 compared with baseline. Secondary outcomes include gastric bubble area on postoperative day 1, percentage change in gastric bubble area, abdominal distension score, time to first flatus, time to first bowel movement, gastric drainage volume, time to oral feeding, ICU length of stay, postoperative hospital length of stay, and patch-related adverse events.\n\nThe results of this study may provide evidence for the use of anti-bloating patches as an adjunctive intervention to enhance postoperative gastrointestinal recovery in patients undergoing cardiac surgery.",[118,119,30],"Postoperative Gastric Distension","Postoperative Gastrointestinal Dysfunction",[121,118,122,30,123],"Anti-Bloating Patch","Gastric Bubble Area","Gastrointestinal Dysfunction","NOT_YET_RECRUITING","2026-06-27",{"date":68,"type":40},{"date":42,"type":23},{"date":129,"type":23},"2027-07-01",{"name":131,"class":47},"Southeast University, China",{"id":133,"slug":134,"hasResults":12,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":138,"eligibilityCriteria":139,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":140,"targetDuration":4,"studyType":59,"phases":142,"briefSummary":143,"conditions":144,"keywords":148,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":48},"100644603","personalized-blood-transfusion-protocol-for-cardiac-patients-100644603","NCT07671469","Personalized Blood Transfusion Protocol for Cardiac Patients","Personalized (Demand-Informed) Blood Transfusion Protocol for Cardiac Patients","PerP","Inclusion Criteria:\n\n* Adults 18 years or older scheduled for cardiac surgery using the heart-lung machine (cardiopulmonary bypass), such as bypass, valve, or combined procedures\n* Moderate-to-high surgical risk (e.g., EuroSCORE II ≥ 3% or equivalent)\n* Allogeneic red blood cell transfusion is considered likely\n* Able to provide informed consent and understand randomization to different transfusion thresholds\n* Willing to receive blood products and follow study transfusion thresholds from anesthesia induction until hospital discharge or day 28, whichever comes first\n\nExclusion Criteria:\n\n* Refusal of or contraindication to allogeneic blood (e.g., Jehovah's Witness or formal directive against transfusion), or enrollment in a preoperative autologous donation program\n* Emergency or salvage procedures where protocol triggers are impractical (e.g., active arrest, aortic dissection with collapse)\n* Heart transplantation, durable ventricular assist device implantation, or surgery solely for VAD insertion\n* Off-pump bypass or other procedures not using cardiopulmonary bypass\n* Severe preoperative anemia (e.g., hemoglobin \\\u003C 8 g\u002FdL) or chronic transfusion-dependent anemia\n* Conditions preventing protocol adherence (e.g., anticipated massive hemorrhage, known bleeding disorder, very low platelets, uninterruptible dual antiplatelet\u002Fanticoagulant therapy)\n* Chronic dialysis dependence or established end-stage renal disease (eGFR \\\u003C 15 mL\u002Fmin\u002F1.73m² or on maintenance renal replacement therapy) prior to surgery.\n* Pregnancy or lactation\n* Enrollment in another interventional trial affecting transfusion practice or hemoglobin thresholds\n* Unable to provide informed consent (e.g., severe cognitive impairment without a legally authorized representative)",{"count":141,"type":23},900,[61],"This study compares two accepted ways of deciding when adults recovering from open-heart surgery should receive a blood transfusion in the intensive care unit. One approach gives a transfusion when the blood count (hemoglobin) falls below a fixed level that is the same for everyone. The other approach adds each patient's own physiology - such as oxygen levels and lactate - to help decide whether a transfusion is truly needed, within a safe range. The investigators want to learn whether the personalized approach is as safe as the standard approach for major outcomes after heart surgery, while reducing the amount of blood transfused. Participants may also choose to give blood and stool samples to a research biobank for future studies on recovery after cardiac surgery.",[30,145,146,147],"Blood Transfusion","Anemia","Cardiopulmonary Bypass",[149,150,151,152,153],"restrictive transfusion","hemoglobin trhreshold","oxygen delivery","cardiac surgery","ICU","2026-06-26",{"date":68,"type":40},{"date":157,"type":23},"2026-09-14",{"date":159,"type":23},"2030-03-15",{"name":161,"class":47},"Yan Mia Min",{"id":163,"slug":164,"hasResults":12,"nctId":165,"briefTitle":166,"officialTitle":166,"acronym":4,"eligibilityCriteria":167,"healthyVolunteers":12,"sex":19,"minAge":168,"maxAge":169,"enrollmentInfo":170,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":171,"conditions":172,"keywords":174,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":176,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":48},"100430068","assessing-the-burden-of-perioperative-atrial-fibrillation-in-patients-undergoing-cardiac-surgery-100430068","NCT04880265","Assessing the Burden of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery","Inclusion Criteria:\n\n* Elective open heart surgery\n* Age \\> 20 years\n\nExclusion Criteria:\n\n* Refusal to participate (patient or health care proxy)\n* Participation in other pharmacological trials\n* Lack of data or poor data quality which cannot be analyzed for any heart rhythm in 80% of the postoperative study period.","20 Years","90 Years",{"count":114,"type":23},"Background and Significance:\n\nIn the United States approximately 220,000 patients undergo cardiac surgery per annum. Among potential complications, the incidence of atrial fibrillation (AF) is estimated at 30 - 60 %, and therefore presents the most common adverse event after cardiac surgery. Multiple complications may be associated with AF: Patients are usually subject to an increased length-of-stay in the intensive care unit and in the hospital. Furthermore, the risk for stroke and development of long-term AF is elevated, while further anticoagulation is required putting the patient at risk for bleeding. On average, an additional $10,000 - $20,000 is spent for each patient with AF. However, the exact burden of postoperative AF still remains unknown.\n\nSpecific Aims of Research Project:\n\n1. To collect data from an electrocardiogram (EKG) monitoring patch, we aim to accurately determine the prevalence of atrial fibrillation in patients undergoing cardiac surgery at our center.\n2. To collect data on epidemiological characteristics to investigate risk factors for developing perioperative atrial fibrillation in patients undergoing cardiac surgery. This will allow us to create robust risk prediction models.",[173,30],"Atrial Fibrillation",[175],"Wearable Device",{"date":68,"type":40},{"date":178,"type":40},"2021-09-14",{"date":180,"type":23},"2030-05",{"name":182,"class":47},"Brigham and Women's Hospital",{"id":184,"slug":185,"hasResults":12,"nctId":186,"briefTitle":187,"officialTitle":187,"acronym":188,"eligibilityCriteria":189,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":190,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":192,"conditions":193,"keywords":195,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":48},"100580671","impact-of-variation-of-oxydo-reduction-potential-in-cardiac-surgery-on-post-operative-outcome-100580671","NCT06840327","Impact of VARIation of OXYdo-reduction Potential in Cardiac Surgery on Post-operative Outcome","VARIOXY","Inclusion Criteria:\n\nPatients over 18 years of age Scheduled cardiac surgery patients undergoing bypass surgery with saphenous vein harvesting.\n\nPatients able to understand the protocol; Patients able to express non-opposition to participating in the study Patients affiliated to a social security system or equivalent.\n\nExclusion Criteria:\n\nEmergency surgery patients. Pregnant or breast-feeding women. Patients deprived of their freedom or under legal protective measures.",{"count":191,"type":23},120,"Observational, prospective, monocentric study conducted in the cardiac surgery department about biological markers to predict the short-term outcome of heart surgery patients.",[30,194],"Extracorporeal Circulation",[196,152,197,198,199],"extracorporeal circulation","biological markers","Redox balance","post-operative outcome","2026-06-24",{"date":97,"type":40},{"date":203,"type":40},"2025-10-07",{"date":205,"type":23},"2027-10",{"name":207,"class":47},"University Hospital, Toulouse",{"id":209,"slug":210,"hasResults":12,"nctId":211,"briefTitle":212,"officialTitle":212,"acronym":213,"eligibilityCriteria":214,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":215,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":217,"conditions":218,"keywords":232,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":237,"completionDateStruct":238,"leadSponsor":239,"locationsCount":48},"100642312","risk-factors-of-atrial-fibrillation-after-cardiac-surgery-100642312","NCT07625033","Risk Factors of Atrial Fibrillation After Cardiac Surgery","PFAS","Inclusion Criteria:\n\n* age \\>18\n* having undergone a scheduled cardiac surgery in the study center\n* having agreed to the reuse of their hospital care data\n\nExclusion Criteria:\n\n* Atrial fibrillation at the admission in hospital.",{"count":216,"type":23},918,"Supraventricular arrhythmias complicate more than 40% of cardiac surgeries and are associated with an increased risk of bleeding, stroke, heart failure, and death. Preventing the occurrence of these arrhythmias is a major challenge. This study aims to investigate risk factors and protective factors regarding atrial fibrillation and other iatrogenic cardiac arrhythmias after cardiac surgery, particularly innovative anesthetic strategies such as stellar ganglion blockade which have been recently implemented in our center.",[30,219,220,147,221,222,223,224,225,226,227,228,229,230,231],"Peri Operative Medicine","Thoracic Surgery","Coronary Artery Bypass","Heart Valve Prosthesis Implantation","Aortic Valve Replacement","Perioperative Medicine","Preoperative Care","Intraoperative Care","Postoperative Care","Enhanced Recovery After Surgery","Anesthesia","Cardiac Anesthesia","Intensive Care Unit",[233],"Stellar Ganglion Blockade, SGB, cardiac surgery","2026-06-23",{"date":236,"type":40},"2026-06-25",{"date":42,"type":23},{"date":42,"type":23},{"name":240,"class":47},"Centre Hospitalier Régional Metz-Thionville",{"id":242,"slug":243,"hasResults":12,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":4,"eligibilityCriteria":247,"healthyVolunteers":12,"sex":19,"minAge":248,"maxAge":4,"enrollmentInfo":249,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":251,"conditions":252,"keywords":253,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":255,"startDateStruct":256,"completionDateStruct":258,"leadSponsor":260,"locationsCount":48},"100622557","perioperative-continuous-glucose-monitoring-accuracy-in-cardiac-surgery-100622557","NCT07385170","Perioperative Continuous Glucose Monitoring Accuracy in Cardiac Surgery","Evaluation of Perioperative Continuous Glucose Monitoring Accuracy in Patients Undergoing Cardiac Surgery","Inclusion Criteria:\n\n* Patients aged 19 years or older scheduled for cardiac surgery\n\nExclusion Criteria:\n\n* Skin disease at the sensor application site (proximal arm)","19 Years",{"count":250,"type":23},100,"The goal of this clinical trial is to evaluate accuracy of continuous glucose monitoring device called 'Dexcom G7' in patients undergoing cardiac surgery.",[30],[254],"continuous glucose monitoring",{"date":154,"type":40},{"date":257,"type":40},"2026-05-27",{"date":259,"type":23},"2028-05-31",{"name":261,"class":47},"Seoul National University Hospital",{"id":263,"slug":264,"hasResults":12,"nctId":265,"briefTitle":266,"officialTitle":267,"acronym":268,"eligibilityCriteria":269,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":270,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":272,"conditions":273,"keywords":275,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":279,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":48},"100616940","isolation-of-pulmonary-veins-using-the-box-technique-in-patients-undergoing-sternotomy-100616940","NCT07312149","Isolation of Pulmonary Veins Using the Box Technique in Patients Undergoing Sternotomy","BoxTer : Isolation of Pulmonary Veins Using the Box Technique in Patients Undergoing Sternotomy","BoxTer","Inclusion criteria:\n\n* Patients undergoing cardiac surgery via sternotomy\n* Concomitant use of the PWI box with GeminiS during surgery\n* Adult patients\n* Patients with the following characteristics: Preoperative paroxysmal\u002Fpersistent\u002Fpermanent AF; Duration of less than 5 years; And left atrium volume \\\u003C60 ml\u002Fm2\n* Informed patient who did not object to the collection of their data for the study\n\nExclusion criteria:\n\n* Unplanned surgery (emergency)\n* History of cardiac surgery (reoperation)\n* Pregnant or breastfeeding women\n* Adults under guardianship, curatorship or judicial protection\n* Patients with a life expectancy of less than three years\n* Patients currently taking medication or using an experimental device that clinically interferes with the study's evaluation criteria and results.\n* Inability to comply with the monitoring schedule.\n* Contraindication to long-term anticoagulants",{"count":271,"type":23},200,"Atrial Fibrillation (AF) is the most common cardiac arrhythmia worldwide, affecting approximately 2.8% of the population, with prevalence increasing with age. AF is associated with significant morbidity and mortality, accounting for about 25% of ischemic strokes, 10% of cryptogenic strokes, and a 10-40% annual increase in hospital admissions due to heart failure or anticoagulant-related events.\n\nAbout 10% of patients undergoing cardiac surgery have preoperative AF. In 1986, Dr. Cox introduced the MAZE procedure, a surgical technique to isolate AF triggers. Initially involving atrial incisions, it evolved to use radiofrequency lines, significantly reducing morbidity and mortality. The MAZE procedure is now strongly recommended (Class Ia evidence) for concomitant cardiac surgery. However, nearly 85% of eligible patients-especially those undergoing closed-chest cardiac surgery-do not receive this treatment due to technical challenges and limited reproducibility of the Cox-Maze IV technique.\n\nPulmonary Vein Isolation (PVI) with posterior wall isolation (PWI-Box) has emerged as an effective alternative, offering similar outcomes to Cox-Maze IV with fewer adverse effects. Innovative devices like the GeminiS (Medtronic) enable minimally invasive, thoracoscopic PVI-PWI-Box procedures without opening the heart, even off-pump. This approach could expand the use of AF ablation during combined sternotomy surgeries, aligning with clinical guidelines.\n\nPrimary Objective: Assess the efficacy of PWI-Box using GeminiS combined with other cardiac surgeries via sternotomy.\n\nPrimary Endpoint: Recurrence rate of paroxysmal or persistent AF (per ESC definition) at 1 year postoperatively, confirmed by 24-hour Holter monitoring.",[274,30],"Atrial Fibrillation (AF)",[276,30,277,278],"Atrial firbrillation","PWI-Box","GeminiS",{"date":200,"type":40},{"date":281,"type":23},"2026-10-05",{"date":283,"type":23},"2032-10-05",{"name":285,"class":47},"Nantes University Hospital",{"id":287,"slug":288,"hasResults":12,"nctId":289,"briefTitle":290,"officialTitle":291,"acronym":292,"eligibilityCriteria":293,"healthyVolunteers":12,"sex":19,"minAge":294,"maxAge":4,"enrollmentInfo":295,"targetDuration":4,"studyType":59,"phases":297,"briefSummary":298,"conditions":299,"keywords":301,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":305,"completionDateStruct":307,"leadSponsor":309,"locationsCount":4},"100644541","cerebral-autoregulation-and-delirium-study-100644541","NCT07671404","Cerebral Autoregulation and Delirium Study","Reducing Delirium After Cardiac Surgery: Personalized Targeted Blood Pressure Management Strategy Using Cerebral Autoregulation Monitoring: A Pilot Study","AUTO-POD","Inclusion Criteria:\n\n• Consenting patients aged ≥ 60 years undergoing elective complex cardiac surgery (coronary artery bypass grafting plus valve surgery, double-valve surgery, triple-valve surgery, redo operations, or aortic arch surgery), or patients aged ≥ 70 years undergoing isolated coronary artery bypass grafting or single-valve repair\u002Freplacement surgery.\n\nExclusion Criteria:\n\n* Patients with symptomatic cerebrovascular disease.\n* History of delirium.\n* Major neurocognitive impairment (e.g., dementia or Mini-Mental State Examination score \\\u003C 10).\n* Schizophrenia.","60 Years",{"count":296,"type":23},60,[61],"Approximately one in four elderly patients develops postoperative delirium (POD) after cardiac surgery. POD is associated with prolonged hospitalization, increased mortality, and higher health care costs. While patient-related risk factors are often difficult to modify, surgery- and anesthesia-related factors may be optimized to reduce the incidence of POD. One potentially modifiable factor is intraoperative blood pressure management. Current practice commonly relies on standardized blood pressure targets during cardiac surgery; however, this \"one-size-fits-all\" approach may not account for individual variability in cerebral perfusion requirements. This study proposes a personalized blood pressure management strategy based on real-time monitoring of cerebral autoregulation, with the goal of maintaining optimal cerebral perfusion and protecting the brain from both hypo- and hyper-perfusion",[300,30],"Delirium - Postoperative",[302],"Cerebral Autoregulation Monitoring","2026-06-22",{"date":154,"type":40},{"date":306,"type":23},"2026-06-01",{"date":308,"type":23},"2028-06-30",{"name":310,"class":47},"University Health Network, Toronto",{"id":312,"slug":313,"hasResults":12,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":4,"eligibilityCriteria":317,"healthyVolunteers":12,"sex":19,"minAge":248,"maxAge":4,"enrollmentInfo":318,"targetDuration":4,"studyType":59,"phases":320,"briefSummary":322,"conditions":323,"keywords":324,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":326,"lastUpdatePostDateStruct":327,"startDateStruct":328,"completionDateStruct":329,"leadSponsor":331,"locationsCount":332},"100624542","phase-4-hydroxyethyl-starch-versus-crystalloid-and-postoperative-major-adverse-kidney-complications-100624542","NCT07410988","Hydroxyethyl Starch Versus Crystalloid and Postoperative Major Adverse Kidney Complications","Effect of 130\u002F0.4 Hydroxyethyl Starch vs. Balanced Crystalloid for Intraoperative Fluid Therapy on Major Composite Renal Outcomes After Cardiac Surgery: a Multicenter, Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 19 years or older scheduled for coronary artery bypass grafting (CABG), heart valve surgery, and\u002For thoracic aortic surgery\n\nExclusion Criteria:\n\n1. Emergency surgery;\n2. Planned implantation of a durable left ventricular assist device;\n3. History of starch allergy or hypersensitivity;\n4. History of kidney transplantation;\n5. Preoperative end-stage renal disease (ESRD) or requirement for renal replacement therapy (RRT);\n6. Preoperative glomerular filtration rate \\\u003C 30 mL\u002Fmin\u002F1.73 m2;\n7. Planned intraoperative and postoperative RRT;\n8. Preoperative use of mechanical circulatory support devices (e.g., intra-aortic balloon pump, extracorporeal membrane oxygenation, etc.);\n9. Significant clinical coagulopathy (e.g., active bleeding disorder or thrombocytopenia with a platelet count \\\u003C100,000\u002FµL);\n10. Active infective endocarditis.",{"count":319,"type":23},1292,[321],"PHASE4","This trial aims to compare two intraoperative fluids, namely hydroxyethyl starch (HES) and balanced crystalloids in terms of major adverse kidney events after cardiac surgery. Indications for the study fluids administarion include preload augmentation and intravascular volume replacement during cardiac surgery.",[30],[325],"hydroxyethyl starch","2026-06-21",{"date":200,"type":40},{"date":303,"type":40},{"date":330,"type":23},"2029-07-31",{"name":261,"class":47},4,{"id":334,"slug":335,"hasResults":12,"nctId":336,"briefTitle":337,"officialTitle":338,"acronym":4,"eligibilityCriteria":339,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":84,"enrollmentInfo":340,"targetDuration":4,"studyType":59,"phases":342,"briefSummary":343,"conditions":344,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":345,"lastUpdatePostDateStruct":346,"startDateStruct":347,"completionDateStruct":349,"leadSponsor":351,"locationsCount":48},"100507272","efficacy-of-ultrasound-guided-pifb-versus-lidocaine-infusion-on-postoperative-pain-after-sternotomy-100507272","NCT05885230","Efficacy of Ultrasound Guided PIFB Versus Lidocaine Infusion on Postoperative Pain After Sternotomy","The Efficacy of Ultrasound-guided Pecto-Intercostal Fascial Plain Block Versus Lidocaine Infusion on Acute and Chronic Post-sternotomy Pain; A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n1. age between 18 and 75 years.\n2. patient scheduled to undergo elective on-pump cardiac surgery with sternotomy.\n3. American Society of Anesthesiologists classification of physical status \\\u003C IV.\n\nExclusion Criteria:\n\n1. emergency surgery.\n2. off-pump surgery.\n3. redo surgery.\n4. ejection fraction less than 35%.\n5. refusal of the patient.\n6. known hypersensitivity to LA.\n7. chronic opioid use or chronic pain patient.\n8. psychiatric problems or communication difficulties.\n9. liver insufficiency (defined as a serum bilirubin ≥ 34 μmol\u002Fl, albumin ≤ 35 g\u002Fdl, INR ≥ 1.7).\n10. renal insufficiency (defined as a glomerular filtration rate \\\u003C 44 ml\u002Fmin).\n11. obstructive sleep apnea syndrom.\n12. coexisting hematologic disorders.\n13. pregnancy or breastfeeding.",{"count":341,"type":23},138,[61],"Chronic pain is a common complication after cardiothoracic surgery. The prevalence of post-sternoyomy pain syndrome (PSPS) ranges from 33% to 91%. Exact pathogenetic mechanisms for developing chronic pain after sternotomy are unknown. Apart from intraoperative nerve damage and subsequent postoperative neuropathic pain, operation techniques, age, sex, pre-existing pain, genetic and psychosocial factors, severe postoperative pain, and analgesic management are suspected to have an impact on the development of PSPS .",[30],"2026-06-18",{"date":234,"type":40},{"date":348,"type":40},"2023-05-01",{"date":350,"type":23},"2027-05",{"name":352,"class":47},"Beni-Suef University",{"id":354,"slug":355,"hasResults":12,"nctId":356,"briefTitle":357,"officialTitle":358,"acronym":359,"eligibilityCriteria":360,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":361,"enrollmentInfo":362,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":364,"conditions":365,"keywords":368,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":372,"lastUpdatePostDateStruct":373,"startDateStruct":375,"completionDateStruct":377,"leadSponsor":379,"locationsCount":48},"100641782","cerebral-near-infrared-spectroscopy-in-patients-undergoing-open-cardiovascular-surgery-using-artificial-intelligence-programs-a-methodological-study-100641782","NCT07654244","Cerebral Near-infrared Spectroscopy in Patients Undergoing Open Cardiovascular Surgery Using Artificial Intelligence Programs: A Methodological Study","INTERPRETATION AND EVALUATION OF THE PROXIMITY TO CLINICAL EXPERIENCE OF CEREBRAL NEAR-INFRARED SPECTROSCOPY (NIRS) IN PATIENTS UNDERGOING OPEN CARDIOVASCULAR SURGERY USING ARTIFICIAL INTELLIGENCE PROGRAMS: A METHODOLOGICAL STUDY","NIRS for AI","Inclusion Criteria:\n\n* open cardiac surgery\n* elective open heart surgery\n* aged 18-65\n* ASA score I-III\n* BMI \\\u003C30 kg\u002Fm2\n\nExclusion Criteria:\n\n* past ischemic event\n* carotid arter stenosis\n* BMI \\>30 kg\u002Fm2\n* serious liver or kidney disease\n* ASA 4 ve more\n* anatomical abnormality at probe site\n* history of mental or neurological disease,\n* history of previous intracranial aneurysm or intracranial tumor surgery\n* history of moderate or severe pulmonary disease,\n* emergency surgery","65 Years",{"count":363,"type":23},63,"The aim of the present study is to test the accuracy and reliability of AI tools in this regard by interpreting NIRS, which we routinely use for monitoring cerebral perfusion in cardiovascular surgery, with AI tools and comparing this interpretation with the interpretations of two clinicians.",[366,367,30],"Clinical Suitability of Artificial Intelligence Programs","Near Infrared Spectroscopy",[369,370,371],"artificial intelligence","near infrared spectroscopy (NIRS)","open cardiac surgery","2026-06-12",{"date":374,"type":40},"2026-06-17",{"date":376,"type":23},"2026-06-10",{"date":378,"type":23},"2026-12-10",{"name":380,"class":47},"Antalya Health Sciences University",{"id":382,"slug":383,"hasResults":12,"nctId":384,"briefTitle":385,"officialTitle":386,"acronym":4,"eligibilityCriteria":387,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":388,"targetDuration":4,"studyType":59,"phases":390,"briefSummary":392,"conditions":393,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":376,"lastUpdatePostDateStruct":395,"startDateStruct":396,"completionDateStruct":398,"leadSponsor":400,"locationsCount":403},"100506826","phase-2-lsalt-peptide-for-prevention-or-attenuation-of-acute-kidney-injury-aki-in-patients-undergoing-on-pump-cardiac-surgery-100506826","NCT05879432","LSALT Peptide for Prevention or Attenuation of Acute Kidney Injury (AKI) in Patients Undergoing On-Pump Cardiac Surgery","Phase 2 Global, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of LSALT Peptide for the Prevention or Attenuation of Acute Kidney Injury (AKI) in Patients Undergoing On-Pump Cardiac Surgery","Inclusion Criteria:\n\n1. Male and female ≥ 18 years of age.\n2. Scheduled for a non-emergent coronary and\u002For valve surgery procedure requiring on-pump cardiopulmonary bypass including but not limited to:\n\n   * Coronary artery bypass graft (CABG) alone\n   * CABG with aortic, mitral, tricuspid, or pulmonic valve replacement or repair\n   * Aortic valve replacement or repair alone, with or without aortic root repair\n   * Mitral, tricuspid, or pulmonic valve replacement or repair alone\n   * Simultaneous replacement of several cardiac valves.\n3. Have the following AKI risk factors:\n\n   * CKD Stage 3 (CKD-EPI eGFR ≥ 30 and \\\u003C 60 mL\u002Fmin\u002F1.73 m2) and ONE or more of the following additional risk factors OR\n   * CKD Stage 2 (CKD-EPI eGFR ≥ 60 and \\\u003C 90 mL\u002Fmin\u002F1.73 m2) and ONE or more of the following additional risk factors:\n\n     * Age ≥ 75 years;\n     * Combined valve \\& coronary artery surgery;\n     * Left ventricular ejection fraction (LVEF) ≤ 35% by invasive or noninvasive techniques;\n     * Urinary (TIMP-2 x IGFBP7) \\> 0.3\n     * Diabetes mellitus\n     * Hypertension\n     * Hyperlipidemia\n4. Sexually active women of child-bearing potential (WCBP) must be using a medically acceptable method of birth control throughout the study and for at least 1 day following the end of study and have a negative urine pregnancy test at the Screening visit. A WCBP is defined as a female who is biologically capable of becoming pregnant. A medically acceptable method of birth control includes intrauterine devices in place for at least 3 months, surgical sterilization, or the implant. In patients who are not sexually active, abstinence is an acceptable form of birth control and urine will be tested per protocol. Women who are of nonchild-bearing potential, i.e., post-menopause, must have this condition captured in their medical history. Pregnant women and nursing mothers are excluded from this study.\n5. Patient or Legally Authorized Representative (LAR) is available and willing to give written informed consent, after being properly informed of the nature and risks of the study and prior to engaging in any study-related procedures.\n\nExclusion Criteria:\n\n1. The presence of AKI (KDIGO criteria) at the time of randomization\n2. Off-pump cardiac surgery\n3. Surgery to be performed under conditions of circulatory arrest or hypothermia with rectal temperature \\\u003C 28°C (82.4° F)\n4. Severe chronic kidney disease: CKD-eGFR \\\u003C 30 mL\u002Fmin\u002F1.73 m2) OR requiring dialysis\n5. Imminent or recent surgery for aortic dissection\n6. Surgery to correct a major congenital heart defect (e.g., Tetralogy of Fallot, transposition of the great vessels, single ventricle, or Ebstein's anomaly. Bicuspid aortic valve is not considered a congenital heart defect)\n7. Known history of active cancer which may interfere with interpretation of the results of this study\n8. Known or suspected sepsis at time of screening\n9. Pregnancy or lactation\n10. Known hypersensitivity to the study drug or any of its excipients\n11. Treatment with an investigational drug or participation in an interventional trial within 30 days prior to the first dose of study drug and throughout the study\n12. Any disease processes or confounding variables that would inappropriately alter the outcome of the study in the opinion of the investigator\n13. Inability to comply with the requirements of the study protocol.",{"count":389,"type":23},240,[391],"PHASE2","To evaluate the percentage of subjects with AKI within 7 days following on-pump cardiac surgery defined by the KDIGO (Kidney Disease: Improving Global Outcomes) criteria:\n\n1. Increase in baseline (pre-surgery) serum creatinine (SCr) by ≥26.5 μmol\u002FL (≥0.3 mg\u002FdL) within 7 days; OR\n2. Increase in baseline SCr to ≥1.5 times baseline, which is known or presumed to have occurred within the first 7 days following surgery; OR\n3. Urine output \\\u003C 0.5 mL\u002Fkg\u002Fh for \\>6 hours.",[394,30],"Acute Kidney Injury",{"date":372,"type":40},{"date":397,"type":40},"2024-03-08",{"date":399,"type":23},"2027-08",{"name":401,"class":402},"Arch Biopartners Inc.","INDUSTRY",9,{"id":405,"slug":406,"hasResults":12,"nctId":407,"briefTitle":408,"officialTitle":409,"acronym":410,"eligibilityCriteria":411,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":412,"targetDuration":414,"studyType":24,"phases":4,"briefSummary":415,"conditions":416,"keywords":420,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":428,"lastUpdatePostDateStruct":429,"startDateStruct":430,"completionDateStruct":432,"leadSponsor":434,"locationsCount":4},"100643230","flow-based-platelet-function-assessment-using-total-thrombus-formation-analysis-system-t-tas-and-early-bleeding-after-cardiac-surgery-with-cardiopulmonary-bypass-cpb-100643230","NCT07619261","Flow-Based Platelet Function Assessment Using Total Thrombus-Formation Analysis System (T-TAS) and Early Bleeding After Cardiac Surgery With Cardiopulmonary Bypass (CPB)","Prospective Observational Study of Flow-Based Platelet Function Using T-TAS and Early Bleeding After Cardiopulmonary Bypass in Adult Cardiac Surgery","TTAS-CPB","Inclusion Criteria:\n\n1. Adults aged 18 years or older\n2. Undergoing elective or urgent cardiac surgery requiring cardiopulmonary bypass\n3. Ability to provide written informed consent\n\nExclusion Criteria:\n\n1. Cardiac surgery performed without cardiopulmonary bypass\n2. Emergency cardiac surgery\n3. Preoperative anticoagulation not reversed at the time of surgery\n4. Refusal or withdrawal of informed consent\n5. Known pregnancy",{"count":413,"type":23},30,"2 Days","The goal of this observational study is to learn how flow-based platelet function measured with the Total Thrombus-formation Analysis System (T-TAS) relates to early postoperative bleeding in adults undergoing cardiac surgery with cardiopulmonary bypass. The study will also evaluate how T-TAS changes during the perioperative period and how it compares with standard coagulation and platelet function tests.\n\nThe main questions it aims to answer are:\n\nIs lower post-cardiopulmonary bypass T-TAS Platelet-chip (PL-chip) thrombus formation associated with increased postoperative chest tube drainage during the first 12 hours after surgery? How do T-TAS parameters change before surgery, immediately after cardiopulmonary bypass, and 24 hours after surgery? Are abnormal T-TAS results associated with blood transfusion requirements, major bleeding, re-exploration for bleeding, and length of stay in the intensive care unit and hospital? Does T-TAS provide complementary information compared with standard coagulation tests, von Willebrand factor (vWF) measurements, platelet aggregometry, and viscoelastic testing?\n\nParticipants will:\n\nUndergo blood sampling at three predefined perioperative time points:\n\nbefore anesthesia induction, immediately after cardiopulmonary bypass and heparin reversal with protamine, and 24 hours after surgery Have T-TAS testing, standard laboratory coagulation tests, vWF testing, platelet aggregometry, and viscoelastic testing performed on collected samples Have clinical, surgical, transfusion, and postoperative bleeding data collected during their hospital stay\n\nThe study is observational and does not require changes to routine clinical care or perioperative management.",[28,417,418,30,419],"Coagulopathy During Cardiac Surgery","Platelet Dysfunction","Acquired Von Willebrand Disease",[30,421,422,423,27,145,424,425,426,427],"Total Thrombus formation Analysis System (T-TAS)","Platelet Function","Postoperative Bleeding","ROTEM","Thrombus Formation","Cardiopulmonary Bypass (CPB)","von Willebrand Factor (vWF)","2026-06-08",{"date":376,"type":40},{"date":431,"type":23},"2026-09-15",{"date":433,"type":23},"2027-02-15",{"name":435,"class":47},"Hospital de la Santa creu i Sant Pau - Barcelona",{"id":437,"slug":438,"hasResults":12,"nctId":439,"briefTitle":440,"officialTitle":440,"acronym":441,"eligibilityCriteria":442,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":443,"targetDuration":445,"studyType":24,"phases":4,"briefSummary":446,"conditions":447,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":449,"lastUpdatePostDateStruct":450,"startDateStruct":452,"completionDateStruct":453,"leadSponsor":454,"locationsCount":48},"100643504","cardiac-surgery-the-incidence-and-impact-of-chronic-postoperative-pain-a-survey-100643504","NCT07640646","Cardiac Surgery, the Incidence and Impact of Chronic postOperative Pain: a Survey","Cardiac COPS","Inclusion Criteria:\n\n1. Adults, aged ≥ 18 years of age, who underwent cardiac surgery (valvular, coronary bypass, other intracardiac or aortic surgery) during the 1 year recruitment period\n2. Able to provide informed consent\n3. Able to respond by telephone\n\nExclusion Criteria:\n\n1. Deceased\n2. Refusal\n3. Chronic pain in the surgical region",{"count":444,"type":23},1000,"1 Year","This survey study aims to investigate the incidence of Chronic post surgical pain (CPSP) in cardiac surgery patients treated at UZ Leuven. The primary hypothesis is that the incidence of CPSP at 3 months postoperatively is lower than 33%, which is the rate commonly reported in the literature. Secondary objectives include comparing CPSP incidence based on the type of surgical incision, as well as comparing incidences between type of surgery. Finally, the study will assess pain intensity, interference with daily activities, and quality of life of 3 months and when required also at 1 years postoperatively.",[448,30],"Chronic Postoperative Pain","2026-06-05",{"date":451,"type":40},"2026-06-11",{"date":306,"type":40},{"date":259,"type":23},{"name":455,"class":47},"Universitaire Ziekenhuizen KU Leuven",{"id":457,"slug":458,"hasResults":12,"nctId":459,"briefTitle":460,"officialTitle":461,"acronym":462,"eligibilityCriteria":463,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":464,"targetDuration":4,"studyType":59,"phases":466,"briefSummary":467,"conditions":468,"keywords":471,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":475,"lastUpdatePostDateStruct":476,"startDateStruct":477,"completionDateStruct":479,"leadSponsor":481,"locationsCount":4},"100639174","crops-study-chronification-of-post-surgical-pain-and-risk-assessment-100639174","NCT07629453","CROPS Study: Chronification of Post-Surgical Pain and Risk Assessment","Chronification of Post-Surgical Pain and Validation of a Novel Risk Assessment Tool: A Prospective Multicenter Randomized Controlled Trial","CROPS","Inclusion Criteria:\n\n* Age ≥18 years\n* Elective cardiac surgery requiring median sternotomy, including:\n* coronary artery bypass grafting (CABG)\n* aortic valve replacement or repair\n* mitral valve replacement or repair\n* ascending aorta surgery\n* Ability to understand study information\n* Ability to provide written informed consent\n* Expected postoperative hospital stay longer than 3 days\n* Availability for follow-up at 1 week and 3 months after surgery\n\nExclusion Criteria:\n\n* Emergency surgery\n* Cognitive impairment preventing study participation\n* Serious psychiatric illness interfering with study participation\n* Language barrier preventing questionnaire completion\n* Participation in another interventional study affecting pain outcomes\n* Reoperation for postoperative bleeding\n* Severe chronic renal failure\n* Allergy or contraindication to study medication or regional anesthesia techniques\n* Pregnancy or breastfeeding\n* Chronic opioid therapy exceeding 60 mg morphine equivalents daily\n* Extensive emergency aortic surgery (e.g., Thoraflex implantation for acute aortic dissection)",{"count":465,"type":23},180,[61],"Chronic post-surgical pain (CPSP) represents a major clinical problem associated with impaired functional recovery, reduced quality of life, prolonged opioid use, and increased healthcare utilization. The mechanisms underlying pain chronification are multifactorial and involve complex interactions among surgical trauma, inflammatory responses, central sensitization, neuroimmune activation, and psychosocial risk factors.\n\nThe CROPS study (Chronification of Post-Surgical Pain and Risk Assessment) is a prospective multicenter randomized controlled trial designed to evaluate the impact of perioperative analgesic strategies on the development of chronic post-surgical pain and to validate a novel questionnaire-based pain chronification risk assessment tool in adult patients undergoing cardiac surgery.\n\nParticipants will be randomized to receive either standard multimodal opioid-based perioperative analgesia or regional anesthesia-based perioperative analgesia incorporating chest wall plane block techniques, including erector spinae plane block, paravertebral block, or PECS block, according to institutional practice.\n\nThe study will compare postoperative pain intensity, opioid consumption, postoperative recovery, postoperative complications, health-related quality of life, and the incidence of chronic post-surgical pain at 3 months after surgery. In parallel, the predictive performance of the pain chronification risk assessment questionnaire will be evaluated using discrimination and calibration analyses.\n\nThe study is conducted as an investigator-initiated academic collaboration between the East Slovakia Institute of Cardiovascular Diseases, Košice, Slovakia, and Uppsala University Hospital, Uppsala, Sweden.",[469,470,30],"Chronic Post-surgical Pain","Acute Postoperative Pain",[472,152,473,474],"chronic post-surgical pain","regional anesthesia","postoperative analgesia","2026-06-04",{"date":449,"type":40},{"date":478,"type":23},"2026-09-01",{"date":480,"type":23},"2029-06-01",{"name":482,"class":47},"Kočan Ladislav",{"id":484,"slug":485,"hasResults":12,"nctId":486,"briefTitle":487,"officialTitle":488,"acronym":489,"eligibilityCriteria":490,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":491,"targetDuration":4,"studyType":59,"phases":493,"briefSummary":494,"conditions":495,"keywords":4,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":507,"lastUpdatePostDateStruct":508,"startDateStruct":509,"completionDateStruct":511,"leadSponsor":513,"locationsCount":48},"100643703","bedside-assessment-of-right-ventricular-output-lying-in-prone-or-supine-position-100643703","NCT07632027","Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine Position","The BAROLO Study Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine Position. Hemodynamic Changes Due to Prone Position in Patients After Cardiac Surgery - a Prospective Randomized Controlled Trial Evaluating the Effect of Prone Position on Right Heart Function","BAROLO","Inclusion Criteria:\n\n* Scheduled for cardiac surgery using cardiopulmonary bypass\n\nExclusion Criteria:\n\n* BMI \\>40\n* Emergency surgery\n* In need of secondary surgery\n* Advanced grown up congenital heart disease\n* Pulmonary disease\n* Hemodynamic instability with Norepinephrine \\>0.4mcg\u002Fkg\u002Fmin\n* Any condition which, in the judgement of the investigator, might increase the risk to the patient",{"count":492,"type":23},80,[61],"Right ventricular failure (RVF) is a common complication to cardiac surgery, which is associated to mortality, kidney failure, stroke, prolonged mechanical ventilation and ICU stay. The right ventricle is particularly vulnerable to an increased afterload. By increasing pulmonary vascular resistance (PVR), atelectasis might mitigate a negative effect on the right ventricle.\n\nRecruitment maneuvers have been shown to resolve atelectasis and improve hemodynamics by increasing cardiac output and lowering PVR. However these maneuvers transiently raise airway pressures, which in turn increases right ventricular afterload, a situation often poorly tolerated by patients with RVF.\n\nProne position is used in patients with respiratory failure and has been shown to decrease mortality in patients with ARDS. Prone position decreases atelectasis and moves ventilation dorsally. In ARDS it also seems to mediate beneficial hemodynamic effects such as an increase in cardiac output and a decrease in PVR.\n\nThe investigators hypothesis is that prone position early after cardiac surgery will increase cardiac output by recruitment of atelectasis and thereby decrease PVR.",[496,497,498,499,500,501,502,503,504,505,30,506,147],"Right Ventricular Function","Prone Position","Atelectasis","Atelectases, Postoperative Pulmonary","Cardiac Output","Vasoconstriction","Heart Failure","Recruitment Maneuver","Respiratory Mechanics","Pulmonary Arterial Pressure","Cardiac Surgery Recovery","2026-06-03",{"date":428,"type":40},{"date":510,"type":23},"2026-09",{"date":512,"type":23},"2028-10",{"name":514,"class":47},"Sahlgrenska University Hospital",{"id":516,"slug":517,"hasResults":12,"nctId":518,"briefTitle":519,"officialTitle":520,"acronym":521,"eligibilityCriteria":522,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":523,"targetDuration":525,"studyType":24,"phases":4,"briefSummary":526,"conditions":527,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":507,"lastUpdatePostDateStruct":528,"startDateStruct":529,"completionDateStruct":530,"leadSponsor":532,"locationsCount":48},"100638902","care-qualitative-study-100638902","NCT07611045","CARE Qualitative Study","Cardiac Surgery Aftercare and Recovery Evaluation (CARE) - Understanding Patients' and Carers' Views About the Care Received After Leaving Hospital Following Cardiac Surgery: a Qualitative Study","CARE","Inclusion Criteria:\n\n* Patients who have had elective or urgent cardiac surgery such as coronary artery bypass graft (CABG) surgery, heart valve surgery, aortic surgery (thoracic aorta) within the last 12 months\n* Family members\u002Fcarers of patients who have had cardiac surgery in the last 12 months.\n* Patients who are no longer undergoing inpatient or outpatient follow-up by their cardiac surgeon\n\nExclusion Criteria:\n\n* Patients who have had cardiac transplantation\n* Patients who are still undergoing follow-up by their cardiac surgery team\n* People who are unable to provide informed consent\n* Prisoners",{"count":524,"type":23},24,"1 Day","Over 30,000 people have heart surgery in the UK every year. Heart surgery is safe, but around 1 in 5 people having heart surgery will be readmitted to hospital in the year after their operation. There is no research that explains why they come back into hospital. It may be because they have a complication from the heart surgery, such as an irregular heart rhythm. Or it may be because they have other health problems which the heart surgery has made worse. Researchers want to find out what care is provided to people after heart surgery and what participants and healthcare staff think should be offered to prevent people coming back to hospital. The overall aim of this Programme Development Grant is to undertake preparatory work that will allow researchers to identify the best approach to improve care after hospital discharge for people having heart surgery.",[30],{"date":449,"type":40},{"date":257,"type":40},{"date":531,"type":23},"2027-03-31",{"name":533,"class":47},"University Hospitals Bristol and Weston NHS Foundation Trust",{"id":535,"slug":536,"hasResults":12,"nctId":537,"briefTitle":538,"officialTitle":538,"acronym":539,"eligibilityCriteria":540,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":541,"targetDuration":4,"studyType":59,"phases":542,"briefSummary":543,"conditions":544,"keywords":546,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":551,"lastUpdatePostDateStruct":552,"startDateStruct":553,"completionDateStruct":555,"leadSponsor":557,"locationsCount":48},"100640436","change-in-platelet-lipid-metabolism-and-procoagulant-phenotype-induced-by-cardiopulmonary-bypass-impact-on-postoperative-inflammatory-response-and-bleeding-complications-during-cardiac-surgery-100640436","NCT07630987","Change in Platelet Lipid Metabolism and Procoagulant Phenotype Induced by Cardiopulmonary Bypass. Impact on Postoperative Inflammatory Response and Bleeding Complications During Cardiac Surgery.","PLACARD","Inclusion Criteria:\n\n* Adult patients (≥ 18 years old) suffering from coronary disease and\u002For severe valvular dysfunction (mitral or aortic) undergoing elective coronary angiography or cardiac surgery with cardiopulmonary bypass.\n\nExclusion Criteria:\n\n* Uninterrupted preoperative dual antiplatelet therapy\n* Active chronic inflammatory disease\n* Recent chemotherapy or immunotherapy (\\\u003C 3 months)\n* Active solid malignancy\n* History of hematologic malignancy\n* Hemophilia or other coagulopathy\n* History of thrombocytopenia (\\\u003C 100,000 platelets\u002Fmm³)\n* Recent administration of thrombopoietin receptor agonist or immunoglobulins\n* History of thrombopathy, thrombocytosis, or myeloproliferative syndrome\n* History of heparin-induced thrombocytopenia (HIT)\n* Cirrhosis or hepatic fibrosis (with or without hypersplenism)\n* History of splenectomy, regardless of initial indication\n* History of systemic autoimmune disease (e.g., systemic lupus erythematosus, scleroderma, antiphospholipid syndrome, systemic vasculitis)\n* Recent major surgery (\\\u003C 3 months)\n* Severe renal insufficiency (eGFR ≤ 30 mL\u002Fmin\u002Fm²) with or without dialysis\n* Recent or chronic corticosteroid therapy\n* Recent acute coronary syndrome, STEMI type (\\\u003C 3 months)\n* Urgent surgery or procedure\n* Preoperative hemodynamic instability",{"count":250,"type":23},[61],"The PLACARD research project aims to investigate the impact of CPB-induced platelet modifications during cardiac surgery on the post-operative inflammatory response and bleeding complications. Our objectives are to study the impact of CPB on the formation of procoagulant platelets, to assess changes in platelet lipid profile and bioenergetics before, during and after cardiac surgery, and to connect the ex-vivo observations to post-operative clinical and biological parameters of these patients during their stay in cardiovascular intensive care unit.",[30,147,545],"Platelet Activation",[547,548,549,550],"Procoagulant platelets","Platelet lipidomics","Postoperative inflammation","Postoperative bleeding","2026-06-02",{"date":449,"type":40},{"date":554,"type":23},"2026-05-15",{"date":556,"type":23},"2030-01",{"name":558,"class":47},"Université Catholique de Louvain",{"id":560,"slug":561,"hasResults":12,"nctId":562,"briefTitle":563,"officialTitle":564,"acronym":4,"eligibilityCriteria":565,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":56,"enrollmentInfo":566,"targetDuration":4,"studyType":59,"phases":567,"briefSummary":568,"conditions":569,"keywords":572,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":306,"lastUpdatePostDateStruct":576,"startDateStruct":577,"completionDateStruct":578,"leadSponsor":580,"locationsCount":48},"100637429","individualized-peep-and-pulmonary-complications-in-on-pump-cabg-100637429","NCT07623109","Individualized PEEP and Pulmonary Complications in On-Pump CABG","Effect of Individualized PEEP Guided by Driving Pressure and Mechanical Power on Postoperative Pulmonary Complications in On-Pump CABG: A Randomized Controlled Trial","Patients with ASA physical status II-III who are scheduled to undergo elective open-heart surgery via on-pump median sternotomy will be included in the study.\n\nPatients scheduled for emergency surgery, those planned to undergo off-pump cardiac surgery, patients with a history of myocardial infarction within the last 3 months, patients with advanced COPD, patients with an ARISCAT score of 44 or higher, patients with a BMI of 35 kg\u002Fm² or higher, patients with NYHA class IV status, patients receiving preoperative immunotherapy, and patients with severe hepatic or renal failure will be excluded from the study.",{"count":492,"type":23},[61],"Postoperative pulmonary complications (PPCs) are an important cause of morbidity and mortality after major surgery and are frequently observed in cardiac surgery patients undergoing cardiopulmonary bypass (CPB). These complications are associated with prolonged mechanical ventilation, longer intensive care unit and hospital stays, increased healthcare costs, and higher mortality (1,2).\n\nIntraoperative lung-protective ventilation strategies have traditionally focused on individual parameters such as low tidal volume, positive end-expiratory pressure (PEEP), plateau pressure, and driving pressure. However, the effects of these parameters on postoperative pulmonary outcomes in cardiac surgery patients remain unclear. In particular, PEEP- and driving pressure-guided approaches are controversial in terms of feasibility and safety in patients undergoing CPB, who may be hemodynamically vulnerable.\n\nMechanical power is a comprehensive parameter that reflects the total energy delivered to the respiratory system per unit of time by integrating ventilatory variables such as tidal volume, airway pressures, respiratory rate, and flow. Therefore, mechanical power may provide a more comprehensive assessment of the mechanical load applied to the lungs compared with individual ventilatory parameters. Previous studies have reported that higher mechanical power values may be associated with lung injury, postoperative pulmonary complications, and mortality (3).\n\nThe aim of this study is to evaluate the effect of monitoring mechanical power during perioperative mechanical ventilation on postoperative pulmonary complications in patients undergoing cardiac surgery with cardiopulmonary bypass. The study hypothesis is that a mechanical power-based ventilation approach may reduce the incidence of PPCs compared with strategies based on conventional ventilation parameters.",[30,570,571],"Mechanical Power","Postoperative Pulmonary Complications (PPCs)",[573,574,575],"cardica surgery","mechanical power","postoperative pulmonary complications",{"date":507,"type":40},{"date":554,"type":23},{"date":579,"type":23},"2026-07-15",{"name":581,"class":582},"Bursa City Hospital","OTHER_GOV",{"id":584,"slug":585,"hasResults":12,"nctId":586,"briefTitle":587,"officialTitle":588,"acronym":589,"eligibilityCriteria":590,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":591,"targetDuration":4,"studyType":59,"phases":593,"briefSummary":594,"conditions":595,"keywords":596,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":600,"lastUpdatePostDateStruct":601,"startDateStruct":602,"completionDateStruct":604,"leadSponsor":606,"locationsCount":48},"100637403","upper-extremity-exercises-with-and-without-deep-breathing-after-cardiac-surgery-100637403","NCT07627009","Upper Extremity Exercises With and Without Deep Breathing After Cardiac Surgery","Evaluation of the Effects of Upper Extremity Range of Motion Exercises Performed With and Without Deep Breathing on Respiratory Parameters After Cardiac Surgery: A Randomized Trials","ROM-DB","Inclusion Criteria:\n\n* underwent elective open-heart surgery,\n* stayed in the cardiovascular ICU for at least 2 nights post-operatively,\n* had FiO2 below 40% (Spo2 will be kept above 92),\n* were conscious,\n* could speak Turkish,\n* were willing to participate in the study.\n\nExclusion Criteria:\n\nunderwent another thoracic surgery or repeat surgery simultaneously,\n\n* had any limb loss,\n* underwent prolonged immobilization and intubation,\n* developed serious complications such as infection or respiratory failure after surgery,\n* had problems such as paresthesia, plegia, etc. after stroke, or had diseases such as Parkinson's that affect the level of relaxa",{"count":592,"type":23},90,[61],"This randomized 2×2 crossover trial aims to evaluate the effects of upper extremity range of motion exercises performed with and without deep breathing on respiratory parameters in patients after open cardiac surgery. The study will include adult patients who underwent elective open cardiac surgery and are receiving postoperative care in the cardiovascular surgery intensive care unit. Each participant will perform both exercise protocols: upper extremity range of motion exercises alone and upper extremity range of motion exercises combined with deep breathing. The order of the two interventions will be randomized. Respiratory and clinical outcomes, including oxygen saturation, tidal volume, respiratory rate, heart rate, pain, perceived exertion, and dyspnea, will be assessed before and after each intervention.",[30],[66,597,598,599],"Range of motion exercise","Deep breathing exercise","Postoperative respiratory function","2026-05-30",{"date":475,"type":40},{"date":603,"type":40},"2025-09-01",{"date":605,"type":23},"2026-09-30",{"name":607,"class":47},"Kocaeli University",{"id":609,"slug":610,"hasResults":12,"nctId":611,"briefTitle":612,"officialTitle":613,"acronym":614,"eligibilityCriteria":615,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":616,"targetDuration":4,"studyType":59,"phases":618,"briefSummary":619,"conditions":620,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":624,"lastUpdatePostDateStruct":625,"startDateStruct":626,"completionDateStruct":628,"leadSponsor":630,"locationsCount":48},"100517070","the-effect-of-combined-iron-protocols-on-perioperative-allogeneic-transfusion-100517070","NCT06012760","The Effect of Combined Iron Protocols on Perioperative Allogeneic Transfusion","Effect of Iron Sucrose Combined With Human Erythropoietin and Vitamin C on Perioperative Allogeneic Red Blood Cell Infusion in Major Cardiac Surgery","CIPAT","Inclusion Criteria:\n\n1. Participants must be at least 18 years of age.\n2. Major cardiac surgery should encompass procedures such as coronary artery bypass grafting (CABG), valve surgery, or a combination of both.\n3. Iron deficiency anemia is defined as having a ferritin level below 100 μg\u002FL or a ferritin level below 300 μg\u002FL accompanied by a transferrin saturation below 25%. Additionally, hemoglobin levels should range between 90 and 130 g\u002FL for men or between 90 and 120 g\u002FL for women.\n4. The American Society of Anesthesiologists (ASA) classification should fall within Grade 1-3.\n5. Prior to participation, the patient or their legal representative must provide informed consent.\n\nExclusion Criteria:\n\n1. Contraindications for the administration of iron sucrose, ascorbic acid, or rHuEPO.\n2. Presence of a temperature exceeding 37.5 °C or the utilization of non-prophylactic antibiotics.\n3. Individuals with a weight equal to or less than 50kg.\n4. Individuals with a family history of haemochromatosis or thalassaemia, or those with a transferrin saturation level exceeding 50% or a documented history of iron overload.\n5. Presence of other known haematological disorders such as folic acid or vitamin B12 deficiency, haemolytic anaemia, haemoglobinopathies, iron granulocytic anaemia, G6PD deficiency, etc.\n6. Requirement for emergency surgical intervention.\n7. Severe hepatic or renal impairment, ALT \\>3 times the upper limit of normal value or AST \\>3 times the upper limit of normal value, creatinine \\>1.5 times the upper limit of normal value\n8. Pregnant or lactating women\n9. history of blood transfusion, intravenous iron or ascorbic acid use within 12 weeks prior to surgery\n10. Acute blood loss, gastrointestinal bleeding, etc. in the preoperative period.",{"count":617,"type":23},400,[61],"The goal of this clinical trial is to learn if a combined iron supplementation regimen can reduce the need for blood transfusions in adults with iron-deficiency anemia undergoing major elective cardiac surgery. The trial will also look at whether this regimen is safe and well tolerated. The main questions it aims to answer are:\n\nDoes the combined regimen lower the amount of allogeneic red blood cell transfusion needed during and after surgery?\n\nAre there any side effects or safety concerns associated with the regimen?\n\nResearchers will compare the combined iron supplementation (sucrose iron, erythropoietin, and vitamin C) to standard care to see if it helps reduce blood transfusions.\n\nParticipants will:\n\nReceive either the combined regimen or standard care before surgery\n\nUndergo major elective cardiac surgery under general anesthesia\n\nBe monitored for blood transfusion needs and recovery up to 90 days after surgery",[146,621,622,623,30],"Iron Deficiency Anemia","Perioperative","Transfusion","2026-05-29",{"date":551,"type":40},{"date":627,"type":40},"2025-01-04",{"date":629,"type":23},"2028-03-31",{"name":631,"class":47},"Second Affiliated Hospital, School of Medicine, Zhejiang University",{"id":633,"slug":634,"hasResults":12,"nctId":635,"briefTitle":636,"officialTitle":636,"acronym":637,"eligibilityCriteria":638,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":639,"targetDuration":4,"studyType":59,"phases":640,"briefSummary":641,"conditions":642,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":645,"lastUpdatePostDateStruct":646,"startDateStruct":647,"completionDateStruct":649,"leadSponsor":651,"locationsCount":48},"100598754","non-interventional-study-exploring-the-composition-of-the-valvular-microbiota-of-patients-undergoing-cardiac-surgery-100598754","NCT07075601","Non-interventional Study Exploring the Composition of the Valvular Microbiota of Patients Undergoing Cardiac Surgery","BIOVALV","Inclusion Criteria:\n\n* Male or female patient.\n* Present an indication for cardiac surgery that requires explantation of the aortic valve.\n* Be able to receive information about the study process and understand the study participation information form.\n* State their non-opposition to participating in the study.\n\nExclusion Criteria:\n\n* Patients infected with HIV\n* Age under 18\n* Under court supervision, guardianship, or curatorship\n* Patients with a history of infective endocarditis.",{"count":271,"type":23},[61],"The prevalence of aortic valve disease is increasing, with these valvulopathies present in half of individuals over the age of 65.\n\nOberbach A. et al (1) demonstrated the presence of microbiota in 52% of cases of explanted aortic valves. One current hypothesis is the role of this microbiota in the pathophysiology of these degenerative valve diseases. This microbiota is probably not completely eradicated after resection of the native valve and implantation of a conventional prosthesis; it is even left in place during percutaneous aortic valve implantation, during which the prosthesis is deployed within the native valve. It could therefore also play a role in the occurrence of postoperative complications and the degeneration or thrombosis of a bioprosthesis.\n\nFurthermore, recent clinical and epidemiological studies have shown a link between oral infections and cardiovascular diseases. As recommended by the HAS, these patients require multidisciplinary care, involving cardiologists, cardiac surgeons and general practitioners, as well as careful oral and dental care and monitoring provided by specialists in oral pathologies and oral care. The accumulation of bacterial plaque on the surface of the tooth and certain oral bacteria causes the development of periodontal pockets which are characteristic of periodontitis. Bacteria, microbial products and inflammatory mediators produced locally can then enter the bloodstream and affect distant organs such as the cardiovascular system. The recommendations of the European Society of Cardiology are therefore to carry out regular oral and dental consultations to prevent the risk of infection. Therefore, within the Toulouse University Hospital, a care network has been set up for patients with cardiovascular pathologies, in order to improve their access to dental care, screening and management of oral diseases. For the past year, patients hospitalized in the cardiology departments have been seen in consultation in the dental department of the Toulouse University Hospital.",[643,30,644],"Valvulopathy","Microbiota","2026-05-28",{"date":306,"type":40},{"date":648,"type":40},"2025-11-19",{"date":650,"type":23},"2029-08-31",{"name":207,"class":47}]