[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiac-transplant-rejection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiac-transplant-rejection":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,39,63],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100529820","a-study-of-ai-in-cardiac-transplant-in-echocardiographic-analysis-oracle-100529820",false,"NCT06178744","A Study of AI in Cardiac Transplant in Echocardiographic Analysis (ORACLE)","Outcome Reflection for Immune Mediated Rejection by Utilizing Artificial Intelligence in Cardiac Transplant Patients Through Early and Late Echocardiographic Analysis (ORACLE)","ORACLE","Inclusion Criteria:\n\n* Patients undergoing post-cardiac transplant endomyocardial biopsy, and the ability to provide informed consent and a consent for the study.\n\nExclusion Criteria:\n\n* Refusal of study participation","ALL","18 Years",{"count":20,"type":21},500,"ESTIMATED","OBSERVATIONAL","The purpose of this research is to detect episodes of rejection versus non-rejection after cardiac transplant and the diagnostic accuracy of an Artificial Intelligence (AI) algorithm using the data from an ECG (electrocardiogram) and Cardiac Ultrasound (Echocardiogram and\u002For point of care ultrasound).",[25],"Cardiac Transplant Rejection","RECRUITING","2026-06-19",{"date":29,"type":30},"2026-06-24","ACTUAL",{"date":32,"type":30},"2024-04-04",{"date":34,"type":21},"2028-06",{"name":36,"class":37},"Mayo Clinic","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":46,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":49,"conditions":50,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":38},"100190666","magnetic-resonance-elastography-as-a-method-to-estimate-stiffness-of-soft-tissues-100190666","NCT01757730","Magnetic Resonance Elastography as a Method to Estimate Stiffness of Soft Tissues","MRE","Inclusion Criteria:\n\nAny participant 18 years or older and are MR safe.\n\nExclusion Criteria:\n\nThat study participants will be excluded if they have any unapproved metal in their bodies, or if the volunteers are pregnant or possible of becoming pregnant. Also if the participants are claustrophobic.",true,{"count":48,"type":21},1000,"Magnetic resonance elastography is a novel non-invasive MRI technique to obtain stiffness of soft tissues such as liver, heart, kidneys, etc. In this imaging technique a person is laid in an MR scanner and a paddle (plastic drum) is put on the area of interest to send sound vibration via a speaker placed outside the scan room which is connecting plastic drum via a plastic tube. These vibrations are scanned using MRI to estimate the stiffness of soft tissues such as liver, heart, kidneys, breast etc.",[51,52,25,53],"Heart Failure","Liver Fibrosis","Aortic Aneurysms","2025-04-04",{"date":56,"type":30},"2025-04-06",{"date":58,"type":4},"2012-03",{"date":60,"type":21},"2028-03-01",{"name":62,"class":37},"Arunark Kolipaka",{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":4,"eligibilityCriteria":69,"healthyVolunteers":46,"sex":17,"minAge":18,"maxAge":70,"enrollmentInfo":71,"targetDuration":4,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":4,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":4},"100555988","a-pilot-study-evaluating-the-potential-of-18f-fluorodeoxyglucose-pet-ct-imaging-in-diagnosing-cardiac-rejection-100555988","NCT06519240","A Pilot Study Evaluating the Potential of 18F Fluorodeoxyglucose PET-CT Imaging in Diagnosing Cardiac Rejection.","A Prospective Blinded Pilot Study Evaluating the Sensitivity and Specificity of 18F Fluorodeoxyglucose PET CT Imaging (a Non-invasive Imaging Tool) for the Diagnosis of Rejection in Heart Transplant Recipients.","Inclusion Criteria:\n\n* All heart transplant recipients with definite cardiac rejection or definite no rejection with evidence of no significant coronary disease within the last 12 months (e.g with any of the following tests (1)angiogram (2) CTCA (3) MPS (4) CMR (5) other coronary ischaemia test)\n\nExclusion Criteria:\n\n* Unable to have a PET CT scan or comply with the dietary protocol\n* Age less than 18 years old\n* Unable to consent\n* Presence of significant coronary disease or coronary ischaemia\n* Insulin dependent diabetics\n* Pregnant or breast feeding individuals","99 Years",{"count":72,"type":21},20,"INTERVENTIONAL",[75],"NA","This pilot study aims to assess whether 18F-FDG PET CT imaging has the potential in diagnosing cardiac rejection. The investigators aim to recruit 20 heart transplant subjects within two groups of 10 subjects each. One group will have participants with definite rejection and the other group will have participants with definite no rejection. Subjects will be placed into study groups based on their heart muscle biopsy, echocardiogram, clinical symptoms, ECG, and presence or absence of donor specific antibodies. Each group will then undertake a 18F-FDG PET CT scan to identify whether this imaging modality has a role in identifying cardiac rejection. The study subjects and the research team will be blinded to the results of the PET CT until the end of the study.",[25],"NOT_YET_RECRUITING","2024-07-22",{"date":81,"type":30},"2024-07-25",{"date":83,"type":21},"2024-09-30",{"date":85,"type":21},"2026-10-02",{"name":87,"class":37},"Royal Brompton & Harefield NHS Foundation Trust"]