[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardio-facio-cutaneous-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardio-facio-cutaneous-syndrome":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100497751","solid-tumors-in-rasopathies-100497751",false,"NCT05761314","Solid Tumors in RASopathies","Incidence and Molecular Pathogenesis of Solid Tumors in RASopathies","4218","Inclusion Criteria:\n\n* Clinical and molecularly confirmed diagnosis of a RASopathy\n\nExclusion Criteria:\n\n* Clinical diagnosis of RASopathy without molecular characterization",true,"ALL",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","RASopathies are a group of syndromes, caused by variants of genes involved in the regulation of the Ras\u002FMAP\u002FERK pathway. This intracellular transduction pathway profoundly affects embryogenic development, organogenesis, synaptic plasticity and neuronal growth.\n\nRASopathies are characterized by multi-organ involvement, growth delay, premature aging and haemato-oncological manifestations.\n\nBased on evidences provided by literature, cancer screening protocols are applied in some individuals affected by RASopathies, even though detailed information about prevalence and molecular pathogenesis of such tumors is still not clearly elucidate.",[27,28,29,30],"RASopathy","Costello Syndrome","Cardio-Facio-Cutaneous Syndrome","Noonan Syndrome","RECRUITING","2024-04-03",{"date":34,"type":35},"2024-04-04","ACTUAL",{"date":37,"type":35},"2021-10-12",{"date":39,"type":21},"2026-10-12",{"name":41,"class":42},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER"]