[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiometabolic-conditions\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiometabolic-conditions":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100624453","incretin-based-therapies-nutrition-and-physical-activity-100624453",false,"NCT07409831","Incretin-based Therapies, Nutrition, and Physical Activity","Holistic Approach to Cardiometabolic Health and Obesity: Incretin-based Therapies, Nutrition, and Active Lifestyle","HARMONY","Inclusion Criteria:\n\n* Adults aged 18 to 70 years\n* Prescribed, but not yet initiated, incretin-based pharmacotherapy \\[e.g., GLP-1 receptor agonist or dual GIP\u002FGLP1 agonist\\] living with obesity, defined as:\n\n  * BMI \\>30 kg\u002Fm2, or\n  * BMI \\>27 kg\u002Fm2 with presence of comorbidities (e.g., type II diabetes, hypertension, hypercholesterolemia)\n\nExclusion Criteria:\n\n* Medical contraindications to physical activity practice (e.g., unstable cardiovascular disease, severe orthopedic limitation)\n* Prior or ongoing incretin-based therapy or history of bariatric surgery\n* Pregnancy, current breastfeeding or planned pregnancy during the study period\n* Implemented medical devices (e.g. pacemaker, defibrillator)\n* Chronic conditions affecting protein metabolism or nutrition (e.g., advanced kidney disease, active cancer)","ALL","18 Years","70 Years",{"count":21,"type":22},120,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to evaluate whether combining a six-month structured lifestyle intervention (physical activity and nutrition) with incretin-based weight-loss medication improves preservation of muscle mass and physical function in adults living with obesity, compared with medication alone, and to assess the feasibility of a collaborative hospital-community care model.\n\nThis one-year pilot study will recruit 120 adults aged 18-70 years with obesity (BMI ≥30 kg\u002Fm² or ≥27 kg\u002Fm² with at least one comorbidity) receiving routine obesity care at the Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval. All participants will initiate physician-prescribed incretin-based therapy as part of standard care. The intervention group will receive medication plus a six-month structured lifestyle program delivered in collaboration with an exercise facility, including supervised strength-focused exercise and bi-monthly nutrition counseling, followed by a six-month consolidation phase. The control group will receive medication alone. Outcomes will be assessed at baseline and at 3, 6, and 12 months.\n\nParticipants will be randomly assigned in a 1:1 ratio to either the medication-only group or the combined medication and lifestyle intervention group. Participants randomized in the medication only group will receive a personalized consult with both a registered dietician and kinesiologist at the end of the study.",[28,29],"Obesity & Overweight","Cardiometabolic Conditions",[31,32,33,34,35],"Obesity","Incretin-Based Therapies","Physical Activity","Eating Behaviour","Lifestyle Intervention","NOT_YET_RECRUITING","2026-02-06",{"date":39,"type":40},"2026-02-13","ACTUAL",{"date":42,"type":22},"2026-03",{"date":44,"type":22},"2028-03",{"name":46,"class":47},"Laval University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":17,"minAge":18,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":48},"100583635","trauma-and-cardiometabolic-health-in-an-american-indian-community-100583635","NCT06878885","Trauma and Cardiometabolic Health in an American Indian Community","IHPIPO'TO'TSP","Inclusion Criteria:\n\n* 18-40 years\n* Identifying as American Indian\n* Living on or near Blackfeet reservation\n\nExclusion Criteria:\n\n* Uncontrolled hypertension",true,"40 Years",{"count":59,"type":22},400,[25],"Volunteers for the study are asked to participate in two laboratory sessions. In the first laboratory session, volunteers are asked to provide a blood sample which will be used to measure factors related to health. Participants also complete questionnaires related to demographic and health-related information and undergo evaluations of their body composition. In the second laboratory visit, participants are asked to have cardiovascular, neuroendocrine, and inflammatory activity measured during a brief period of rest and during a short challenging psychological task. Participants will also complete questionnaires. The study is designed to examine the associations between experiences such as trauma and resiliency with changes in bodily systems during a challenge and current health.",[63,29,64],"Psychological Stress","Mental Health","RECRUITING","2025-03-10",{"date":68,"type":40},"2025-03-17",{"date":70,"type":40},"2024-05-10",{"date":72,"type":22},"2027-06-30",{"name":74,"class":47},"Montana State University",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":56,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":89,"conditions":90,"keywords":93,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":48},"100579564","asian-mediterranean-diet-and-womens-health-100579564","NCT06825936","Asian-Mediterranean Diet and Women's Health","Asian-Mediterranean Diet and Women's Health: A Randomized Controlled Trial (A+ MEAL Study)","A+ MEAL","Inclusion Criteria:\n\nSubjects must meet all of the inclusion criteria for participation:\n\n1. Females aged 21-50 years\n2. Chinese ethnicity\n3. Singapore citizens, permanent residents, or long-term pass holders\n4. Is able to complete questionnaires in English\n5. BMI ≥ 23.0 kg\u002Fm2 but \\\u003C 37.5 kg\u002Fm2\n6. Not planning to conceive in the next 12 months from enrolment (you will be asked to withdraw once you conceive during the study period)\n7. Not planning to leave Singapore for more than 2 consecutive calendar weeks (10 working days) in the next six months from enrolment\n8. Not currently pregnant or breastfeeding\n9. Not currently smoking\n10. Without history of major chronic diseases (e.g., cancer, diabetes, cardiovascular diseases, chronic kidney disease), major infectious diseases (e.g. hepatitis B, HIV), severe gastrointestinal disorders (e.g. colitis or inflammation of the bowel, celiac disease, chronic gastritis) and major medical procedures\u002Fsurgeries related to these conditions\n11. Without major mental health condition\n12. Without known food allergies, especially to nuts and seafood.\n13. Not on any special diets or having dietary restrictions (e.g. vegetarians, vegans, ketogenic, Kosher diet)\n14. Not currently and will not be enrolled in another interventional study or studies that may affect weight, cardiometabolic health, gut, or brain health in the next six months from enrolment\n\nExclusion Criteria:\n\nSubjects not meeting any of the above inclusion criteria will be excluded from participation.\n\nAdditional Exclusion Criteria for MRI procedure only:\n\ni. Shoulder width ≥60cm ii. Has any medical implants or foreign bodies, particularly related to heart, brain, or eye implants, including but not limited to pacemakers, artificial heart valves, implantable cardioverter defibrillators, ventricular assist devices, brain stimulation devices, intrauterine devices, and breast biopsies (if any implant or tissue marker has been placed) iii. History of head injury or trauma with loss of consciousness iv. Metallic dental braces or dental implants v. Having claustrophobia vi. Drinks more than 30 units of alcohol per week (1 unit = 25mL 40% spirit, 1 can of beer = 2 units, 1 standard glass of wine = 2 units)","FEMALE","21 Years","50 Years",{"count":87,"type":22},300,[25],"Given the escalating high burdens of overeight and obesity, and related commobidies in Asia, Asian women with overweight\u002Fobesity is an important group for targeted intervention in promoting health and wellbeing. A study focused on Asian women at reproductive or early post-menopausal age can inform effective strategies for promoting healthy diet and lifetyle and for optimizing health not only among these women but also for their children and partners.\n\nThe Mediterranean diet has beneficial effects on cardiometabolic and reproductive health. So far, evidence on the Mediterranean diet and its health benefits mostly come from Western populations. Studies evaluating health effects of Mediterranean diet in Asian population are scant.\n\nThis study aims to investigate the beneficial effects of a healthy, Mediterranean-inspired localized diet (i.e., Asian-Mediterranean diet) on women's health, such as cardiometabolic health with potential mechanisms through modulating gut and brain health.",[91,29,92],"Cardiometabolic Risk Factors","Women Health",[94,95,96,97],"Cardiometabolic health","Mediterranean diet","Women health","Cardiometabolic risk factors",{"date":99,"type":40},"2025-03-12",{"date":101,"type":40},"2025-02-10",{"date":103,"type":22},"2026-10",{"name":105,"class":47},"Global Centre for Asian Women's Health"]