[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiopulmonary-arrest\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiopulmonary-arrest":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,52,78,107,142,171,198,225],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100550030","simulation-trial-of-telemedical-support-for-paramedics-100550030",false,"NCT06441760","Simulation Trial of Telemedical Support for Paramedics","Efficacy of Teleconsultation to Improve Prehospital Patient Safety for Critically Ill Infants and Children - A Multicenter, Simulation-based Randomized Control Trial","R01","Inclusion Criteria:\n\n* Certified Emergency Medical Technicians (EMTs), Advanced EMTs (AEMTs), and Paramedics (EMT-Ps) who provide direct scene response.\n* Board-certified Pediatric Emergency Medicine (PEM) and Emergency Medicine (EM) physicians whose practice includes online medical support for EMS are eligible.\n* The control arm will include physicians who provide radio\u002Ftelephone support in usual care at each site. In the intervention arm, experts will be PEM with\u002Fwithout EMS board-certification as they have relevant pediatric training and experience.\n\nExclusion Criteria:\n\n* EMS personnel providing interfacility transport and\u002For pediatric specialty transport\n* Resident physicians-in-training\n* Non-physician providers","ALL","21 Years",{"count":20,"type":21},420,"ESTIMATED","INTERVENTIONAL",[24],"NA","In the United States, the current standard of prehospital (i.e. outside of hospitals) emergency care for children with life-threatening illnesses in the community includes remote physician support for paramedics providing life-saving therapy while transporting the child to the hospital. Most prehospital emergency medical services (EMS) agencies use radio-based (audio only) communication between paramedics and physicians to augment this care. However, this communication strategy is inherently limited as the remote physician cannot visualize the patient for accurate assessment and to direct treatment.\n\nThe purpose of this pilot randomized controlled trial (RCT) is to evaluate whether use of a 2-way audiovisual connection with a pediatric emergency medicine expert (intervention = \"telemedical support\") will improve the quality of care provided by paramedics to infant simulator mannequins with life threatening illness (respiratory failure). Paramedics receiving real-time telemedical support by a pediatric expert may provide better care due to decreased cognitive burden, critical action checking, protocol verification, and error correction. Because real pediatric life-threatening illnesses are rare, high stakes events and involve a vulnerable population (children), this RCT will test the effect of the intervention on paramedic performance in simulated cases of pediatric medical emergencies.\n\nThe two specific aims for this research are:\n\n* Aim 1: To test the intervention efficacy by determining if there is a measurable difference in the frequency of serious safety events between study groups\n* Aim 2: To compare two safety event detection methods, medical record review, and video review",[27,28,29,30],"Emergencies","Cardiopulmonary Arrest","Acute Respiratory Failure","Status Epilepticus",[32,33,34,35,36,37,38],"Prehospital emergency care","Emergency medical services (EMS)","Paramedics","Infant simulator mannequins","Telemedical support","Critically ill infants and children","Pediatric emergencies","RECRUITING","2026-06-29",{"date":42,"type":43},"2026-06-30","ACTUAL",{"date":45,"type":43},"2025-07-10",{"date":47,"type":21},"2028-12",{"name":49,"class":50},"Boston Medical Center","OTHER",9,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":22,"phases":63,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":77},"100577033","a-randomized-controlled-study-of-the-neurescue-device-as-an-adjunct-to-advanced-cardiac-life-support-100577033","NCT06793033","A Randomized Controlled Study of the NEURESCUE Device as an Adjunct to Advanced Cardiac Life Support","ARISE RCT","Inclusion Criteria:\n\n* Age ≥18 and ≤80 years\n* Witnessed arrest\n* CPR initiated within 7 min of arrest\n* CPR time less than 40 min at enrollment\n* Non-shockable rhythm\n\nExclusion Criteria:\n\n* Traumatic cardiac arrest\n* Known pregnancy\n* Known terminal disease\n* Known do-not-attempt-CPR order\n* Known opposition to study participation","18 Years","80 Years",{"count":62,"type":21},84,[24],"The NEURESCUE device is the first intelligent balloon catheter for aortic balloon occlusion (ABO), an emergency technique that supercharges blood flow to the heart and brain within one minute from deployment.\n\nThe catheter-based device is delivered via the femoral artery, temporarily inflating a soft balloon in the descending to redirect blood flow towards the upper body.\n\nThe purpose of this study is to compare the clinical safety and performance of Advanced Cardiovascular Life Support (ACLS) versus ACLS in combination with Aortic Balloon Occlusion (ABO) using the NEURESCUE device in subjects with cardiac arrest.",[66,28],"Cardiac Arrest (CA)","2025-11-13",{"date":69,"type":43},"2025-11-17",{"date":71,"type":43},"2025-07-07",{"date":73,"type":21},"2027-03",{"name":75,"class":76},"neurescue","INDUSTRY",2,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":17,"minAge":86,"maxAge":59,"enrollmentInfo":87,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":106},"100263395","quality-of-pediatric-resuscitation-in-a-multicenter-collaborative-100263395","NCT02708134","Quality of Pediatric Resuscitation in a Multicenter Collaborative","Quality of Pediatric Resuscitation in a Multicenter Collaborative: An Observational Study","pediRES-Q","Inclusion Criteria:\n\n* Patient received chest compressions for at least 1 minute\n* Patient between gestational age ≥37 weeks and 18 years of age\n\nExclusion Criteria:\n\n* Patient on veno-arterial extracorporeal membrane oxygenation (ECMO) therapy at beginning of CPR event","0 Years",{"count":88,"type":21},7000,"OBSERVATIONAL","This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests.\n\nThe purpose of the study is to determine the association between chest compression mechanics (rate, depth, flow fraction, compression release) and patient outcomes. In addition, the investigators will determine the association of post cardiac arrest care with patient outcomes.",[92,28],"Cardiac Arrest",[94,95,96],"Chest compressions","Cardiopulmonary Resuscitation","Pediatric","2025-09-29",{"date":99,"type":43},"2025-10-02",{"date":101,"type":43},"2016-05-02",{"date":103,"type":21},"2030-01",{"name":105,"class":50},"Children's Hospital of Philadelphia",61,{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":115,"sex":17,"minAge":59,"maxAge":116,"enrollmentInfo":117,"targetDuration":4,"studyType":22,"phases":119,"briefSummary":120,"conditions":121,"keywords":124,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":141},"100398167","impact-of-a-mhealth-supportive-tool-on-cardiopulmonary-resuscitation-situational-awareness-100398167","NCT04464603","Impact of a mHealth Supportive Tool on Cardiopulmonary Resuscitation' Situational Awareness","Impact of a Shared Decision-making mHealth Tool on Caregivers' Team Situational Awareness, Communication Effectiveness, and Performance During Pediatric Cardiopulmonary Resuscitation: a Randomized Controlled Trial","InterFACE","Inclusion Criteria:\n\n* Any physician performing a fellowship in the pediatric emergency department.\n* Any postgraduate residents pursuing a \\\u003C5 years residency in pediatrics.\n* To be registered nurses from the PED.\n* To have previously completed a standardized 15-min introductory course on the use of the InterFACE tool dispensed by the study investigators.\n* Participation agreement\n\nExclusion Criteria:\n\n* To have not undergone the standardized 15-min introductory course on the use of the InterFACE tool dispensed by the study investigators.\n* Participation to a simulation in the past month is an exclusion criterion to avoid a recent training effect.",true,"65 Years",{"count":118,"type":21},36,[24],"This study will be a prospective, single-center, randomized controlled trial in a tertiary pediatric emergency department with two parallel groups of voluntary pediatric physicians and nurses. The impact of a mHealth supportive tool will be compared with conventional communication methods on situational awareness, leadership, team communication effectiveness and performance during standardized, simulation-based, pediatric in-hospital cardiac arrest scenario using a high-fidelity manikin. Thirty-six participants will be randomized (1:1). The primary endpoint is the situational awareness score measured with the situation awareness global assessment technique (SAGAT) instrument.",[28,122,123],"Pediatric ALL","Resuscitation",[125,126,127,128,129,130],"Information technologies","Situation Awareness","Teamwork","Leadership","Mobile applications","Biomedical Technology","NOT_YET_RECRUITING","2025-08-17",{"date":134,"type":43},"2025-08-19",{"date":136,"type":21},"2025-11-01",{"date":138,"type":21},"2026-01-31",{"name":140,"class":50},"Pediatric Clinical Research Platform",1,{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":148,"eligibilityCriteria":149,"healthyVolunteers":115,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":150,"targetDuration":4,"studyType":22,"phases":152,"briefSummary":153,"conditions":154,"keywords":155,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":4},"100547696","evaluation-of-the-interface-ar-system-for-cardiopulmonary-arrest-100547696","NCT06411327","Evaluation of the InterFACE-AR System for Cardiopulmonary Arrest","Design, Development and Evaluation of an Augmented Reality and Screen-based Decision Support System for Cardiopulmonary Arrest: a Multicenter, Randomized Controlled Trial","InterFACE-AR","Inclusion criteria for the team leader include:\n\n\\- attending physician, fellow, or senior resident in pediatric emergency medicine, adult emergency medicine, pediatric intensive care, pediatric anesthesia or general pediatrics.\n\nInclusion criteria for the medication and charting nurse roles include:\n\n\\- nurse in pediatric emergency medicine, pediatric intensive care, pediatric anesthesia, pediatric surgery or general pediatrics.\n\nInclusion criteria for all other team members include:\n\n\\- pediatric attending physician, resident, fellow, nurse or respiratory therapist. All participants must have prior basic life support training.\n\nExclusion Criteria:\n\n* Decline to provide informed consent\n* previously enrolled\n* unable to perform tasks required of the role.",{"count":151,"type":21},400,[24],"Cognitive aids are decision support tools that present prompts to encourage recall of information, thus freeing up mental resources to increase the likelihood of desired behaviors. Cognitive aids have been trialed in different forms for use during resuscitation, including pocket reference cards and digital apps. Simulation-based studies of cognitive aid used during cardiac arrest events have shown improved adherence to guidelines, improved time to completing critical tasks, and reduced rate of critical errors. Unfortunately, existing pocket reference cards and mobile apps have significant flaws - they all require providers to search through content to identify relevant information.\n\nIn the proposed study, the investigators will evaluate the impact of an enhanced system, InterFACE-AR, which provides role-specific decision support to the team leader and medication nurse through AR devices, while concurrently optimizing team situational awareness by displaying a roadmap for patient care on the LCD screen. Clinical data will be collected from the mobile app on a tablet used by the charting nurse. The trial aims to assess the individual and combined effectiveness of InterFACE-AR components (i.e. AR devices and LCD screen) on adherence to AHA resuscitation guidelines during simulated cardiac arrest by conducting a randomized controlled trial with a factorial design.",[28,92],[156,157,158,159,160],"Cardiopulmonary arrest","Cardiac arrest","Cognitive aid","Decision support","Simulation","2025-03-25",{"date":163,"type":43},"2025-03-28",{"date":165,"type":21},"2025-09-01",{"date":167,"type":21},"2028-06-30",{"name":169,"class":170},"KidSIM Simulation Program","NETWORK",{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":177,"eligibilityCriteria":178,"healthyVolunteers":11,"sex":17,"minAge":179,"maxAge":60,"enrollmentInfo":180,"targetDuration":4,"studyType":22,"phases":182,"briefSummary":183,"conditions":184,"keywords":185,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":141},"100518521","reboa-in-nontraumatic-ohca-100518521","NCT06031623","REBOA in Nontraumatic OHCA","Effect Of Resuscitative Endovascular Balloon Occlusion of the Aorta in Non-Traumatic Out-of-Hospital Cardiac Arrest (REBOA); A Multinational, Multicenter Randomized Controlled Trial","REBOA","Inclusion Criteria:\n\n* Adult nontraumatic OHCA\n* Witnessed arrest\n* Arrival at ER from 9AM to 5PM (in South Korea) and 8AM to 8PM (in Taiwan)\n\nExclusion Criteria:\n\n1. age below 20 years old or over 80 years old,\n2. traumatic cardiac arrest,\n3. those with unwitnessed cardiac arrest,\n4. pregnant patients,\n5. patients who have already achieved ROSC upon arrival at the emergency department\n6. pre-cardiac arrest cerebral performance category of 3-4\n7. those showing evidence of cardiac arrest due to bleeding (such as gastrointestinal bleeding)\n8. those suspected of having aortic disease, such as dissection, intramural hematoma, or aneurysm, by bedside ultrasound performed immediately after ED arrival or have a previous history of aortic disease\n9. whose legal representative has requested termination of resuscitation efforts before study enrollment\n10. declared dead at scene before randomization\n11. Patients who meet the criteria for extracorporeal cardiopulmonary resuscitation (ECPR), and therefore the decision is made to perform ECPR, will not be enrolled. The ECPR criteria applies when all of the following criteria are met: pre-cardiac arrest CPC of 1-2, witnessed cardiac arrest with bystander CPR, ages between 20-70, initial shockable rhythm, ECMO pump-on available within 60 minutes of onset of cardiac arrest, and patients without end-stage diseases such as cancer, liver cirrhosis, or end-stage renal failure.","20 Years",{"count":181,"type":21},234,[24],"The investigators propose a multicenter randomized controlled trial in South Korea and Taiwan to observe the clinical effects of REBOA on nontraumatic out-of-hospital-cardiac-arrest (OHCA) patients. While REBOA has been traditionally used in trauma for hemorrhage control, it has also shown promising results in nontraumatic cardiac arrests by rerouting circulation to increase perfusion in the coronary and brain.",[28],[186,187,188],"Advanced cardiopulmonary resuscitation (ACLS)","Cardiopulmonary resuscitation (CPR)","Resuscitative endovascular balloon occlusion of the aorta (REBOA)","2025-01-24",{"date":191,"type":43},"2025-01-28",{"date":193,"type":43},"2023-10-17",{"date":195,"type":21},"2026-10-01",{"name":197,"class":50},"Seoul National University Hospital",{"id":199,"slug":200,"hasResults":11,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":204,"eligibilityCriteria":205,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":206,"targetDuration":4,"studyType":22,"phases":208,"briefSummary":209,"conditions":210,"keywords":213,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":223,"locationsCount":141},"100557390","synergy-of-elevation-of-the-head-and-thorax-and-reboa-during-out-of-hospital-cardiac-arrest-100557390","NCT06537492","Synergy of Elevation of the Head and Thorax and REBOA During Out-of-Hospital Cardiac Arrest","Synergy of Elevation of the Head and Thorax and Resuscitative Endovascular Balloon Occlusion of the Aorta During Out-of-Hospital Cardiac Arrest: a Pilot Study","GRAVITY2","Inclusion Criteria:\n\n* Patient with age over or equal to 18 years old\n* Patient with a witnessed medical cardiac arrest and with a no-flow duration under 10 min\n* Patient with EtCO2 greater than 20 mmHg at REBOA team arrival\n* Patient located in the Grenoble Metropolitan area\n* Patient affiliated to French social security\n\nExclusion Criteria:\n\n* Patient with ROSC before REBOA placement.\n* Patient eligible to extracorporeal life support (according to local guidelines).\n* CA of traumatic origin (including drowning or hanging).\n* Patients whose size is not adapted to the LUCAS device: height of the sternum from 170 to 303 mm or maximum chest width of 449 mm. The use of the LUCAS device is not subject to a patient weight condition.\n* Cardiac arrest for which resuscitation seems unjustified (inevitable death, terminally ill irreversible condition, too long duration of cardiac arrest, advance personal directives of no-resuscitation).\n* Obvious pregnancy at inclusion.\n* Subject in a period of exclusion from another clinical investigation.\n* Patients with a femoral arterial access site that cannot accommodate an 8 Fr (minimum) introduces sheath",{"count":207,"type":21},35,[24],"Long-term neurological outcome after successful resuscitation of cardiac arrest remains poor, mainly due to cerebral hypoperfusion and severe hypoxic-ischemic brain injuries. Automated head and chest elevation during cardiopulmonary resuscitation (AHUP-CPR) improves cerebral perfusion by decreasing the intracranial pressure and increasing cerebral perfusion in experimental pig studies. The addition of an impedance threshold device (ITD) and active chest compression-decompression device (ACD) improved hemodynamics and cerebral perfusion. In addition, early implementation of AHUP-CPR in patients with out-of-hospital cardiac arrest (OHCA) was associated with improved survival to hospital discharge, in a multicenter observational study. A 2-year prospective clinical trial in Grenoble evaluating this combination was just completed. This study showed for the first time that the value of end-tidal CO2 (EtCO2), a surrogate for cardiopulmonary resuscitation (CPR) quality and cardiac output, measured with this combination therapy, was significantly higher than with standard CPR.\n\nResuscitative endovascular balloon occlusion of the aorta (REBOA) has recently been proposed during CPR. This technique temporarily diverts blood flow to the coronary and cerebral circulation. Its beneficial effect on hemodynamics, cerebral blood flow and survival has been experimentally validated. In several feasibility studies, encouraging results were observed by slightly optimizing cerebral perfusion and coronary pressure when REBOA was used in combination with standard CPR.\n\nIn a porcine model of cardiac arrest, the addition of REBOA to AHUP CPR was associated with a marked improvement in coronary perfusion pressure and near-normalization of cerebral perfusion pressure. These two interventions act synergistically. REBOA directs flow and pressure to the heart and brain, while AHUP CPR improves preload on the right side of the heart and reduces intracranial pressure.\n\nThe aims of this clinical investigation are to assess the feasibility of placing a REBOA catheter combined with automated CPR with head and chest elevation, and to quantify the associated changes in clinical parameters for OHCA.",[211,212,28,95],"Heart Arrest","Cardiac Arrest, Out-Of-Hospital",[214,215],"Resuscitative endovascular balloon","Head-up cardiopulmonary resuscitation","2024-07-31",{"date":218,"type":43},"2024-08-05",{"date":220,"type":21},"2024-10",{"date":222,"type":21},"2026-01",{"name":224,"class":50},"University Hospital, Grenoble",{"id":226,"slug":227,"hasResults":11,"nctId":228,"briefTitle":229,"officialTitle":229,"acronym":4,"eligibilityCriteria":230,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":231,"targetDuration":233,"studyType":89,"phases":4,"briefSummary":234,"conditions":235,"keywords":237,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":141},"100555687","effects-of-corticosteroid-use-on-restoration-of-spontaneous-circulation-in-cardiac-arrest-patients-100555687","NCT06515327","Effects of Corticosteroid Use on Restoration of Spontaneous Circulation in Cardiac Arrest Patients","Inclusion Criteria:\n\nAge 18 and above Witnessed cardiac arrest\n\nExclusion Criteria:\n\nTraumatic cardiac arrest Forensic cases Cardiac arrest secondary to ST-elevation myocardial infarction Patients in whom spontaneous circulation could not be achieved despite cardiopulmonary resuscitation lasting more than 20 minutes Patients with inaccessible past medical records or unknown medication history Patients without identification Unwitnessed cardiac arrest Pregnant patients",{"count":232,"type":21},46,"1 Month","We aim to investigate the effects of pre-arrest corticosteroid use for any reason on the time of return of spontaneous circulation in patients experiencing witnessed cardiac arrest, either in-hospital or out-of-hospital. Additionally, we plan to study the effects of corticosteroid use on post-ROSC administration of vasoactive agents, required dosage of vasoactive agents and number of vasoactive agents needed in order to reach targeted blood pressure levels.",[28,236],"Corticosteroids Adverse Reaction",[238],"Cardiac Arrest, Corticosteroids Use,","2024-07-17",{"date":241,"type":43},"2024-07-23",{"date":243,"type":21},"2024-08-01",{"date":245,"type":21},"2025-08-01",{"name":247,"class":50},"Saglik Bilimleri Universitesi"]