[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiopulmonary-diseases\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiopulmonary-diseases":34},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100604810","community-exercise-treating-effect-on-cardiopulmonary-disease-patients-100604810",false,"NCT07154355","Community Exercise Treating Effect on Cardiopulmonary Disease Patients","Clinical Study Protocol on the Impact of Community-Based Exercise Training on the Exercise Capacity of Patients With Reduced Cardiovascular and Pulmonary Function","Inclusion Criteria:\n\n1. Patients aged 18 to 85 with abnormal pulmonary or cardiovascular function.\n2. Individuals who have completed a medical screening form to confirm they are free from illnesses and prescription medications that could impair their ability to complete the required testing and fitness training.\n3. Participants who did not engage in structured, systematic moderate-to-intense strength or endurance training during the study period (specifically, not within the previous year).\n4. At the onset of the trial, participants were physically active but had never participated in formal exercise more than twice a week.\n\nExclusion Criteria:\n\n1. Patients with neuromuscular or skeletal disorders, or systemic diseases such as diabetes, cancer, or heart disease.\n2. Individuals using medications known to affect health or the interpretation of study results.\n3. Participants who have engaged in organized, systematic endurance or strength training of moderate to high intensity within the past year.\n4. Patients who decline to participate in the study.\n5. Other medical conditions or states that render exercise training inappropriate.","ALL","18 Years","85 Years",{"count":20,"type":21},200,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn if community-based exercise training can benefit patients aged 18 to 85 with diminished cardiovascular and pulmonary function. The main aim of this study is:\n\n• Establish a community or home-based fitness training program for patients with cardiopulmonary insufficiency to improve adherence, safety, and efficacy while alleviating the burden on both patients and society.\n\nResearchers will compare community-based exercise training to non-exercise training to see if community-based exercise training works to improve cardiovascular and pulmonary function.\n\nParticipants will:\n\n* Engage in community or home exercise training for 40-60 minutes, five times weekly, during a duration of eight weeks. Exercise modalities are primarily determined by the patients' individual preferences and habits, such as brisk walking, running, swimming, cycling, and hiking.\n* Adjust the exercise intensity according to their cardiopulmonary exercise test and the person's perceived exertion level.\n* Utilize fitness bracelets or watches to document statistics during workouts and submit them to the experimenter weekly, covering the five days of exercise within that week.\n* refrain from making any dietary modifications throughout the trial.",[27,28,29,30,31,32,33,34],"Coronary Heart Disease (CHD)","Heart Failure","Cardiomyopathy","COPD","Bronchial Asthma","Respiratory Failure","Thoracic Tumors","Cardiopulmonary Diseases","RECRUITING","2025-08-26",{"date":38,"type":39},"2025-09-04","ACTUAL",{"date":41,"type":39},"2025-01-30",{"date":43,"type":21},"2030-12",{"name":45,"class":46},"Guangdong Provincial People's Hospital","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":47},"100545270","cardiopulmonary-changes-following-spinal-cord-stimulation-in-individuals-with-spinal-cord-injury-100545270","NCT06379711","Cardiopulmonary Changes Following Spinal Cord Stimulation in Individuals With Spinal Cord Injury","INCLUSION \\& EXCLUSION CRITERIA:\n\nINCLUSION CRITERIA:\n\nA participant must meet all of the following criteria in order to be eligible for inclusion:\n\n1. Resident of British Columbia, Canada with active provincial medical services plan\n2. Male or female, 19-65 years of age\n3. Chronic SCI at or above the T10 spinal cord segment\n4. \\>1-year post injury or diagnosis, at least 6 months from any spinal surgery.\n5. American Spinal Injury Association Impairment Scale (AIS) A, B, C and D for SCI\n6. Stable management of spinal cord related clinical issues (e.g., spasticity management)\n7. Women of childbearing potential must not be intending to become pregnant, currently pregnant, or lactating. The following conditions apply:\n\n   7.1 Women of childbearing potential must have a confirmed negative pregnancy test prior to the baseline visit.\n\n   7.2 Women of childbearing potential must agree to use adequate contraception during the period of the trial and for at least 28 days after completion of treatment. Effective contraception includes abstinence.\n8. Sexually active males with female partners of childbearing potential must agree to use effective contraception during the period of the trial and for at least 28 days after completion of treatment.\n9. Must provide informed consent.\n10. Able to understand and complete study-related questionnaires (must be able to understand and speak English or have access to an appropriate interpreter as judged by the investigator).\n11. Willing and able to comply with all clinic visits and study-related procedures.\n\nEXCLUSION CRITERIA:\n\nA participant who meets any of the following criteria will not be eligible to participate:\n\n1. Ventilator dependent.\n2. Painful musculoskeletal dysfunction, unhealed fracture, pressure sore, or active infection that may interfere with testing\n3. Clinically significant, unmanaged, depression (PHQ-9 above 15) or ongoing drug abuse.\n4. Use of any medication or treatment that in the opinion of the investigator indicates that it is not in the best interest of the participant to participate in this study.\n5. Intrathecal baclofen pump.\n6. Cardiovascular, respiratory, bladder, or renal disease unrelated to SCI or presence of hydronephrosis or presence of obstructive renal stones.\n7. Presence of severe acute medical issue(s) that in the investigator's judgement would adversely affect the participant's participation in the study (e.g., pressure sore, urinary tract infection, etc.).\n8. Any implanted metal (other than dental implants) in the skull or presence of pacemakers, stimulators, or medication pumps in the trunk.\n9. Severe anemia (Hgb\\\u003C8 g\u002Fdl) or hypovolemia as measured by hematocrit via blood test in the last six months.\n10. Participant has undergone electrode implantation surgery.\n11. Participant is a member of the investigational team or his\u002Fher immediate family.","19 Years","65 Years",{"count":57,"type":21},22,[24],"The aim of this study is to examine the mechanisms of transcutaneous spinal cord stimulation (tSCS) for improving cardiovascular and pulmonary function in individuals with chronic motor-complete spinal cord injury (SCI) by measuring vascular related endothelial biomarkers, plasma catecholamines, and respiratory parameters.",[61,62,34],"Spinal Cord Injuries","Cardiovascular Diseases",[64,65,66,67,68,69,70,71,72],"Spinal Cord Stimulation","Transcutaneous Spinal Cord Stimulation","Cardiovascular dysfunction","Cardiopulmonary dysfunction","Cardiovascular Biomarkers","Endothelial cell-derived Microvesicles","Plasma Catecholamines","Autonomic Dysreflexia","Orthostatic Hypotension","NOT_YET_RECRUITING","2024-04-17",{"date":76,"type":39},"2024-04-23",{"date":78,"type":21},"2024-08-01",{"date":80,"type":21},"2028-08-01",{"name":82,"class":46},"University of British Columbia"]