[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiopulmonary-exercise-test\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiopulmonary-exercise-test":37},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,57,83],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":41,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100640479","reaction-vad-trial-remote-exercise-training-via-telemedicine-in-patients-with-long-term-ventricular-assist-devices-100640479",false,"NCT07611188","REACTION-VAD Trial: Remote Exercise Training Via Telemedicine in Patients With Long-Term Ventricular Assist Devices","Efficacy and Safety of a Remote Conditioning Program in Patients Supported With a Ventricular Assist Device: THE RE-ACTION-VAD TRIAL.","REACTION-VAD","Inclusion Criteria (must meet all):\n\n* Recent LVAD Implantation (\\\u003C6 months)\n* Clinical stability (defined as meeting all of the following criteria): discharge from the LVAD implantation hospitalization, absence of inotropic medication, hemoglobin \\>9 g\u002FdL, and no active infection.\n* Inability to participate in a supervised rehabilitation program (due to lack of availability, or inability because geographical reasons).\n\nExclusion Criteria (any):\n\n* Functional Inability to Perform Cardiopulmonary Exercise Testing\n* Prior Participation in a Supervised Rehabilitation Program (after the LVAD implantation)","ALL","18 Years",{"count":20,"type":21},78,"ESTIMATED","INTERVENTIONAL",[24],"NA","Current international guidelines recommend that patients with a heart pump (left ventricular assist device, LVAD) participate in supervised exercise cardiac rehabilitation programs. However, not all patients with a heart pump are able to attend to a supervised program on a daily basis.\n\nThe goal of this clinical trial is to determine whether a home-based exercise program helps patients with a heart pump improve their exercise capacity and quality of life, guided by telemedicine tools including a mobile app, smartwatch, and remote medical checkups. The study will also provide information about the safety of this program by monitoring for any issues or symptoms during home activity.\n\nThe trial aims to answer the following questions:\n\n* Does a 12-week remote exercise program improve patients' exercise capacity? This will be measured using the 6-minute walk test and a cardiopulmonary exercise test.\n* Is it safe for patients to follow this exercise plan at home while being monitored through a mobile app and smartwatch?\n* Does the program improve quality of life and reduce feelings of anxiety or depression? This will be assessed using widely validated questionnaires, such as the Kansas City Cardiomyopathy Questionnaire.\n\nResearchers will compare the remote exercise program to standard care, which usually does not include exercise for patients who are unable to attend the hospital daily.\n\nParticipants will:\n\n* Join the study voluntarily after signing a consent form.\n* Be randomly assigned, with a 50% chance of being in either the exercise group (following a structured plan with a mobile app) or the usual care group (receiving general written advice), to see which approach works best for recovery.\n* Follow a 12-week home-based routine if in the exercise group, including warm-up routine, walking or cycling, respiratory exercises, and light strength training, all supported by the mobile app, smartwatch, and professional monitoring.\n* Visit the hospital three times over six months for medical checkups, including walking and exercise tests, blood analyses, and questionnaires about physical and emotional health.",[27,28,29,30,31,32,33,34,35,36,37,38,39,40],"Heart Failure","Advanced Heart Failure","Left Ventricular Assist Device","LVAD","Cardiac Rehabilitation","Telemedicine","Remote Exercise","Ventricular Assist Device","Exercise Training","Conditioning Therapy","Cardiopulmonary Exercise Test","Six Minute Walk Test","Quality of Life","Telerehabilitation",[29,28,27,31,42,32,43,39,37,40],"Remote rehabilitation","6 minute walking test","NOT_YET_RECRUITING","2026-05-20",{"date":47,"type":48},"2026-05-28","ACTUAL",{"date":50,"type":21},"2026-05",{"date":52,"type":21},"2030-12",{"name":54,"class":55},"Puerta de Hierro University Hospital","OTHER",10,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":65,"targetDuration":4,"studyType":67,"phases":4,"briefSummary":68,"conditions":69,"keywords":70,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100634030","automated-cpet-interpretation-international-validation-study-100634030","NCT07534384","Automated CPET Interpretation: International Validation Study","International Validation Study of Automated Interpretation for Cardiopulmonary Exercise Testing","Patients referred for a cardiopulmonary exercise test (CPET):\n\nInclusion Criteria:\n\n* Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures\n* At least 18 years of age at the time of signing the Informed Consent Form\n* Patients referred for a CPET during their standard clinical care\n\nExclusion Criteria:\n\n\\- If the participant has a disorder making it unable to perform a CPET, they must not proceed to be enrolled in the study and will be documented as a screen failure via applicable log forms in the Investigator Site File.",true,{"count":66,"type":21},600,"OBSERVATIONAL","The goal of this observational experimental study is to validate a rule-based algorithm to automate CPET interpretation.\n\nThe endpoints of this study are the following:\n\n* The change in agreement between key opinion leaders (KOLs) and the algorithm-generated CPET interpretation reports, comparing baseline to the end of the 6 month study period.\n* Baseline agreement between KOLs and the algorithm\n* Agreement at 6 months between KOLs and the algorithm\n* Change in self-reported confidence scores before and after using the automated report\n* Feedback on automated protocols generated via the platform during the 6-month implementation period\n* Descriptive evaluation of center-level CPET interpretation reports practices at three timepoints\n\nPatients referred for a CPET will be included to collect observational data without interference within clinical routine. KOLs will be recruited from participating centres to fill out a survey for CPET interpretations.",[37],[71,72],"CPET","automated interpretation","2026-04-15",{"date":75,"type":48},"2026-04-16",{"date":77,"type":21},"2026-03-30",{"date":79,"type":21},"2026-11-30",{"name":81,"class":55},"KU Leuven",2,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":91,"targetDuration":93,"studyType":67,"phases":4,"briefSummary":94,"conditions":95,"keywords":99,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":5},"100627382","ted-rogers-understanding-of-exacerbations-in-heart-failure-2-monitor-100627382","NCT07447908","Ted Rogers Understanding of Exacerbations in Heart Failure 2: Monitor","Ted Rogers Understanding of Exacerbations in Heart Failure 2 (TRUE-HF2): Observational Study","TRUE-HF 2","Inclusion Criteria:\n\n* broad age range (\\> 18 years of age)\n* NT-proBNP \\> 400 or 1000 if in AF\n* Within 3 months post discharge from HF hospitalization\u002F HF ED visit\u002F HF rapid clinic visit with intensification of diuretic therapy\n* NYHA functional class I-IV, heart failure with reduced and preserved ejection fraction\n* Literacy in English\n* Patient provided informed consent\n\nExclusion Criteria:\n\n* Unable to perform a CPET based on the standard protocol\n* End stage renal disease requiring dialysis\n* Living with LVAD\n* MRP deems patient unfit for the study\n* Post heart transplant",{"count":92,"type":21},360,"1 Year","Heart Failure (HF) is a complex disease associated with the highest burden of cost to the healthcare system. The cardiopulmonary exercise test (CPET) is instrumental in determining the prognosis of patients with HF. This multicentre study will validate whether aggregate biometric data from the Apple Watch combined with demographic, cardiac, and biomarker testing can improve our ability to predict heart failure outcomes among a diverse outpatient HF population.",[27,96,97,37,98],"Heart Failure - NYHA II - IV","Heart Failure Patients","Apple Watch",[98,71,27,100,101,102,103],"Artificial Intelligence","Wearable Technology","Wearable","Remote monitoring","2026-02-25",{"date":106,"type":48},"2026-03-04",{"date":108,"type":21},"2026-03-16",{"date":110,"type":21},"2029-09",{"name":112,"class":55},"University Health Network, Toronto"]