[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiopulmonary-function\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiopulmonary-function":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,67],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100593342","effects-of-lpg-and-ventilation-interventions-on-reducing-hap-and-improving-cardiopulmonary-health-100593342",false,"NCT07005193","Effects of LPG and Ventilation Interventions on Reducing HAP and Improving Cardiopulmonary Health","Effects of Liquefied Petroleum Gas and Ventilation Interventions on Reducing Household Air Pollution From Solid Fuel Use and Improving Cardiopulmonary Health: A Multi-center, 2×2 Factorial Randomized Controlled Trial","1. Inclusion Criteria Primary Participants：\n\n   * Aged 18-75 years;\n   * Local permanent residents with no plans for long-term travel or relocation within one year;\n   * Kitchen suitable for installation of ventilation facilities;\n   * Responsible for daily household cooking, cooking ≥5 times per week;\n   * To control for community penetration of pollution, households will be preferentially recruited in naturally ventilated, open villages, avoiding valleys or basins that hinder pollutant dispersion; preference for detached houses with ≥10 m distance from neighboring kitchens and well-sealed doors and windows.\n\n   Secondary Participants:\n   * Elderly individuals aged 65-75 living with the primary participant;\n   * Children aged 3-6 living in the same household.\n2. Exclusion Criteria:\n\n   * Clinical diagnosis of major chronic diseases such as severe respiratory diseases, cardiovascular diseases, malignant tumors, or end-stage renal disease;\n   * Pregnant or breastfeeding women;\n   * Current smokers or individuals with self-reported exposure to productive dust or other occupational hazards;\n   * Individuals who are unable to fully understand the study process or clearly express their own complaints, such as those with psychiatric disorders or severe neuroses, or who cannot cooperate with the study for other reasons.",true,"ALL","18 Years","75 Years",{"count":21,"type":22},1200,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to evaluate the independent and synergistic effects of liquefied petroleum gas (LPG) substitution and improved ventilation on household air pollution (HAP) reduction and cardiopulmonary health. The main questions it aims to answer are:\n\n1. Does LPG substitution or improved ventilation reduce HAP and improve cardiopulmonary health?\n2. Would the combined intervention of LPG substitution and improved ventilation outperform single interventions?\n3. What is the cost-effectiveness of such interventions, and are they sustainable?\n4. Does the intervention reduce the incidence of cardiopulmonary clinical events?\n\nParticipants will be randomized in 4 groups:\n\nA: Solid fuel + no ventilation facilities group (300 households): Continued use of solid fuels without installation of ventilation facilities and receipt of standardized health education. No LPG stoves or ventilation equipment will be provided during the intervention period. However, after the primary endpoint assessment at 12 months, all households in Group A will be provided with LPG stoves and ventilation facilities of equivalent specifications free of charge, along with health guidance. Phased cash compensation will be provided during the intervention period.\n\nB: Liquefied petroleum gas (LPG) + no ventilation facilities group (300 households): Provided with LPG stoves and instructed to use them during cooking, with regular LPG supply throughout the intervention period. Participants will also receive standardized health education.\n\nC: Solid fuel + ventilation facilities group (300 households): Continued use of solid fuels while being provided with ventilation facilities and instructed to use them during cooking. Electricity costs will be compensated during the intervention period. Participants will also receive standardized health education.\n\nD: LPG + ventilation facilities group (300 households): Provided with both LPG stoves and ventilation facilities and instructed to use both during cooking. Regular LPG supply and electricity cost compensation will be provided throughout the intervention period. Participants will also receive standardized health education.",[28,29],"Cardiopulmonary Function","Environmental Exposures","RECRUITING","2026-03-15",{"date":33,"type":34},"2026-03-17","ACTUAL",{"date":36,"type":34},"2025-07-01",{"date":38,"type":22},"2029-06-30",{"name":40,"class":41},"Huazhong University of Science and Technology","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":66},"100590850","xiangya-cardiopulmonary-health-and-disease-cohort-100590850","NCT06972784","Xiangya Cardiopulmonary Health and Disease Cohort","XY-CPHDC","I1 Inclusion and exclusion criteria for retrospective cohorts 1) Inclusion criteria:\n\n1. Patients were either treated or hospitalized in the physical examination center, outpatient and emergency clinic in the Xiangya Hospital of Central South University from January 2010 to April 2025.\n2. Completion of cardiac function (e.g., echocardiography) and pulmonary function (e.g., pulmonary function test) assessment, with an interval of no more than 1 year between the two.\n3. Those who had complete clinical diagnostic and therapeutic information (e.g., medical history, medication records, laboratory test results, imaging reports) except for the cardiopulmonary function test report.\n\n2)Exclusion criteria\n\n1. Patients with complete loss of cardiopulmonary function test reports or key data (e.g., VO2peak, FEV1\u002FFVC, LVEF).\n2. Patients with loss of key clinical diagnostic and treatment data (e.g., medical history, medication records, laboratory test results).\n\n2.1.2 Inclusion and exclusion criteria for prospective cohort\n\n1）Inclusion criteria\n\n1. Patients who have been included in the retrospective cohort.\n2. Voluntarily signed informed consent form to participate in long-term follow-up for ≥3 years.\n3. Able to complete the baseline assessment of the prospective cohort (including cardiopulmonary function retesting, questionnaires, etc.).\n4. Stable conditions for follow-up (e.g., living in the local area, available valid contact information, no plans to move in the short term or go out for a long period of time).\n\n2\\) Exclusion Criteria.\n\n1. Patients who have been excluded from the retrospective cohort or for whom key data are missing.\n2. With severe cognitive impairment, psychiatric disease or verbal communication disorder, unable to cooperate with follow-up and data collection.\n3. Expected survival time \\\u003C3 years (e.g., advanced malignancy, end-stage cardiopulmonary failure, etc.).\n4. Incomplete cardiopulmonary function or other clinical data during the baseline assessment.\n5. Those who plan to participate in other interventional clinical trials that may interfere with the assessment of cardiopulmonary function.",{"count":50,"type":22},30000,"OBSERVATIONAL","Xiangya Cardiopulmonary Health and Disease Cohort (XY-CPHDC) is a non-intervention study grounded in real-world data. It is designed as a bidrectional clinical cohort combined retrospective and prospective design, in order to evaluate cardiopulmonary function systematically and holistically, integrate physiology and medical theory, and explore the changing pattern of the cardiopulmonary under different health states. Cardiovascular System and Respiratory System are closely linked and interdependent physiological systems, and they play a vital role in maintaining normal life activities in the human body. Patients with cardiopulmonary disease often have conspicuous comorbidity characteristics, however, current measurements of cardiopulmonary function indicators are mostly limited to the assessments of single organ. This pattern of subspecialty care leads to deficiencies in the recognition of cardiopulmonary synergy dysfunction, and there is an urgent need for a more comprehensive and systematic approach to assessment. This study plans to construct a cardiopulmonary holistic assessment cohort, aiming at comprehensively and systematically reveal the intrinsic connection between the cardiopulmonary function in different scenarios, such as resting, exercise, and sleep, to deeply explore the core indicators of cardiopulmonary holistic function, to construct a joint stratification system of cardiopulmonary function, and to map cardiopulmonary comorbidity spectrum, so that they can accurately guide the diagnosis of the disease, the prognostic prediction and the intervention strategies.",[54,28],"Respiratory Function Tests，Heart Function Tests",[56],"Respiratory function tests，Heart Function Tests，Cardiopulmonary function","2025-06-30",{"date":59,"type":34},"2025-07-02",{"date":61,"type":34},"2025-06-01",{"date":63,"type":22},"2035-12-01",{"name":65,"class":41},"Xiangya Hospital of Central South University",1,{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":16,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":23,"phases":80,"briefSummary":81,"conditions":82,"keywords":86,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":66},"100483093","12--bangladesh-center-for-global-environmental-and-occupational-health--bangladesh-100483093","NCT05570552","1\u002F2- Bangladesh Center for Global Environmental and Occupational Health- Bangladesh","Long Term Effects of Household Air Pollution (HAP) Reduction on Cardio-pulmonary and Immune Function Outcomes - a Household Level Randomized mHealth Intervention Trial","GEOHealth-II","Inclusion Criteria:\n\n* Participants in the previous GEOHEALTH round-I study\n* Aged between 25 and 70 years\n* Live in biomass-using home with traditional stoves\n* Non-smoker and live with non-smokers\n* Exposed to \\\u003C10 µg\u002FL of water arsenic\n\nExclusion Criteria:\n\n* Known to have immune related illness or taking any prescription medication (particularly those that suppress or enhance immune function)\n* Known to have any clinical events of CVD or lung disease, including stroke or coronary heart disease.","FEMALE","25 Years","70 Years",{"count":79,"type":22},1000,[25],"Almost 3 billion people worldwide, including 89% people in Bangladesh, are exposed to harmful household air pollutants (HAP) emitted from combustion of biomass (wood, agricultural residue, cow dung, etc.) fuel use for cooking. While health risks associated with air-pollution have been reasonably well-studied in developed countries, there is little evidence on health benefits achievable by HAP reduction through clean fuel use, especially in low- and middle-income countries (LMICs). Earlier the investigators showed that Liquid Petroleum Gas (LPG) for 24 months, reduced personal PM2.5 exposure by 58.17 percent which induced novel changes in immune and inflammatory responses in the participants; however cardiopulmonary markers remained relatively stable in post-intervention assessment.\n\nIn this study, the investigators aim to evaluate the effects of mobile phone based (mHealth) Behavioural Change Communication (BCC) intervention on adoption and exclusive use of LPG. The investigators also aimed to observe whether long-term effects of HAP reduction can impact the subclinical measures of cardio-vascular and pulmonary dysfunction and regulate innate and inflammatory immune function among women and children in semi-rural settings in Bangladesh. The investigators will also investigate the influence of exposure to HAP on antibody response to vaccines (adaptive immunity). The BCC intervention will be provided by conducting a large household level randomized controlled trial by educational intervention using mHealth based technology. In addition, the investigators will continue following the cohort and will conduct rigorous and repeated personalized (24 hours) and area (over 5 days) assessments of PM2.5 and black carbon (BC) exposure to examine the long-term effects of HAP reduction on subclinical measures of cardio-pulmonary and immune dysfunction including effect of HAP exposure on antibody response to vaccine.",[83,84,28,85],"Air Pollution","mHealth Intervention","Immune Function",[87,88,89,90,91],"Mobile based Behavioral Change Communication intervention","Household air pollution reduction","Cardiopulmonary function","Immune function","Clean fuel LPG","2024-03-20",{"date":94,"type":34},"2024-03-22",{"date":96,"type":34},"2023-06-20",{"date":98,"type":22},"2027-06",{"name":100,"class":41},"International Centre for Diarrhoeal Disease Research, Bangladesh"]