[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiopulmonary-resuscitation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiopulmonary-resuscitation":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,46,75,107,140,163,192],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100361050","compression-only-cpr-versus-standard-cpr-in-out-of-hospital-cardiac-arrest---a-randomized-survival-study-100361050",false,"NCT03981107","Compression Only CPR Versus Standard CPR in Out-Of-Hospital Cardiac Arrest - A Randomized Survival Study","A Randomized Trial Comparing Survival After of a Simplified Form of Cardiopulmonary Resuscitation (CPR) Consisting of Compressions Only Compared to CPR With Compressions and Rescue Breaths","TANGO2","Inclusion Criteria:\n\n* Unconsciousness with no, abnormal or agonal breathing (suspected OHCA)\n* The suspected OHCA is witnessed (seen or heard)\n* Any Bystander at the scene has previous training in CPR\n\nExclusion Criteria:\n\n* Age below 18 years\n* Collapse is not witnessed\n* Bystander has no prior CPR training\n* Obvious asphyxia (i.e. hanging, foreign body, suffocation, strangulation)\n* Obvious drug overdose \u002F intoxication\n* Pregnancy\n* Trauma (penetrating, blunt, burn injury)\n\nPost randomisation exclusion Criteria from data analysis:\n\n* Not EMS-verified cardiac arrest\n* Previous do not resuscitate (DNR) decision","ALL","18 Years",{"count":20,"type":21},3260,"ESTIMATED","INTERVENTIONAL",[24],"NA","Out-of-hospital cardiac arrest (OHCA) is one of the leading causes of mortality in the industrialized world. Bystander CPR before arrival of the Emergency Medical Service (EMS) is associated with an increased chance of survival.\n\nDuring the last decade, the best form of bystander CPR has been debated. Chest Compression Only CPR (CO-CPR) has been advocated as a preferable method in situations where the bystander has no previous knowledge in CPR, both because its believed to be equally efficient but also a simplified form of CPR that could lead to a higher incidence of bystander-CPR.\n\nIn an initiative to increase CPR rates the American Heart Association has launched public campaigns such as the \"hands-only CPR\" promoting CO-CPR as an option to S-CPR for adult non-asphyxic cardiac arrest. In the 2015 updates of the European resuscitation council guidelines it states that the confidence in the equivalence between the two methods is not sufficient to change current practice.\n\nWhether CO-CPR leads to a survival rate no worse than, or even superior to standard CPR in situations where the bystander has previous CPR training remains unclear. This clinical question remains unanswered while millions of people are trained in CPR worldwide each year.\n\nTo investigate whether CO-CPR is non-inferior to standard CPR (S-CPR) when performed by a bystander with previous CPR training in witnessed, non-asphyxic cases of OHCA. Superiority testing will also be performed for the purpose of demonstrating a possible increase in survival with CO-CPR.",[27,28,29],"Out-Of-Hospital Cardiac Arrest","Cardiac Arrest","Cardiopulmonary Resuscitation",[29,31,32,28],"Chest compressions only CPR","Dispatcher assisted CPR","RECRUITING","2026-05-04",{"date":36,"type":37},"2026-05-08","ACTUAL",{"date":39,"type":37},"2017-01-01",{"date":41,"type":21},"2028-12-31",{"name":43,"class":44},"Karolinska Institutet","OTHER",2,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100625380","pre-hospital-cooling-to-improve-cardiac-arrest-neurological-outcomes-precedence-100625380","NCT07421882","PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE)","PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE): a Pilot Feasibility Study","PRECEDENCE","Inclusion Criteria:\n\n1. Out-of-hospital cardiac arrest (OHCA) of any rhythm attended by Singapore Civil Defence Force (SCDF) paramedics.\n2. Return of spontaneous circulation (ROSC) achieved in the pre-hospital setting.\n3. Age ≥16 years and ≤80 years.\n4. Patient remains comatose after ROSC, with Glasgow Coma Scale (GCS) ≤8.\n\nExclusion Criteria:\n\n1. Age \\>80 years.\n2. Traumatic cause of cardiac arrest.\n3. Tympanic temperature \\\u003C34°C at time of assessment.\n4. Pregnant females.\n5. Termination of resuscitation in the Emergency Department.\n6. Withdrawal of life support within 24 hours of Coronary Care Unit (CCU) admission.","16 Years","80 Years",{"count":57,"type":21},50,[24],"The PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE) study is a pilot feasibility trial evaluating the implementation of pre-hospital targeted temperature management (TTM) using a wearable surface cooling device (CarbonCool® vest) in adult out-of-hospital cardiac arrest (OHCA) patients with return of spontaneous circulation (ROSC). The study aims to assess feasibility, fidelity, acceptability, and safety of initiating cooling in the field by emergency medical services (EMS) prior to hospital arrival. Results will inform the design of a larger definitive trial to determine the clinical effectiveness of early pre-hospital TTM in improving neurological outcomes.",[27,29,61,62],"Death, Sudden, Cardiac","Therapeutic Hypothermia",[64],"Return of Spontaneous Circulation","2026-04-23",{"date":67,"type":37},"2026-04-29",{"date":69,"type":37},"2026-02-01",{"date":71,"type":21},"2027-03",{"name":73,"class":44},"Singapore General Hospital",1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":5},"100463958","predictive-outcome-in-comatose-patients-100463958","NCT05321459","Predictive Outcome in Comatose Patients","New Predictive Tool of Awakening in Comatose Patients in the Intensive Care Unit","PRECOM","Inclusion Criteria:\n\n* Age above18 years old\n* Patient affiliated to a French Heath Care Insurance\n* Admitted in the intensive care unit (ICU) for coma post extra- or intra-hospital cardiac arrest (CA) with shockable or non-shockable rhythm\n* Persistent coma on day 3 after post CA, defined by the inability to respond to a verbal command in an appropriate manner (motor Glasgow components ≤ 3) and at the time of neurophysiological recordings (D3-D7 ± week -end).\n\nExclusion Criteria:\n\n* Decision to limit resuscitation therapies taken by the resuscitation team\n* Inability to perform the auditory evoked potentials (AEP) (deafness, skin lesion or any condition preventing to record AEP).\n* Opposition by the trusted person or by the patient once he\u002Fshe wakes up",{"count":84,"type":21},100,"OBSERVATIONAL","Evaluating the prognosis of comatose patients after cardiac arrest (CA) in the intensive care unit (ICU) remains challenging. It requires a multimodal approach combining standardized clinical examination, serum biomarkers, imaging and classically electrophysiological examinations, (among them auditive evoked potentials or AEP) but none has a sufficient sensitivity\u002Fspecificity. In a preliminary study, the investigators developed an algorithm from the signal collected with AEP, and generated a probability map to visually classify the participants after the algorithm processing. Participants could be classified either with a good neurological prognosis or with bad neurological prognosis or death.\n\nThe investigators hypothesize that the \"PRECOM\" tool, applied blindly to a large prospective multicenter cohort of patients admitted to intensive care for coma in the aftermath of CA will predict neurological prognosis at 3 months with high sensitivity and specificity.",[88,89,29],"Coma","Heart Arrest",[91,92,93,94,95,96,97],"Post cardiac arrest for comatose patients","Electroencephalography","Somatosensory evoked potentials","Auditory evoked potentials","Prognosis","Algorithms","Classification","2025-12-16",{"date":100,"type":37},"2025-12-23",{"date":102,"type":37},"2023-11-15",{"date":104,"type":21},"2028-05-29",{"name":106,"class":44},"Assistance Publique - Hôpitaux de Paris",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":22,"phases":117,"briefSummary":119,"conditions":120,"keywords":126,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":74},"100452609","phase-4-rehabilitation-for-survivors-of-out-of-hospital-cardiac-arrest-100452609","NCT05173740","Rehabilitation for Survivors of Out-of-hospital Cardiac Arrest","The ROCK Trial. A Multidisciplinary Rehabilitation Intervention Targeted Return-to-work in Sudden Out-of-hospital Cardiac Arrest Survivors A Pragmatic Randomised Controlled Trial","Inclusion criteria:\n\n* All adult survivors with first time out-of-hospital cardiac arrest\n* Discharged from the Hospitals will be assessed eligible for inclusion\n\nExclusion criteria:\n\n* Survivors who prior to the cardiac arrest were not part of the labour force with at least two years until they are qualified to receive retirement state pensions\n* Patients that cannot understand and fulfil the study surveys (in Danish)\n* Patients with short witnessed cardiac arrests with return of spontaneous circulation estimated less than 4 minutes and immediate awakening without ICU treatment","65 Years",{"count":116,"type":21},214,[118],"PHASE4","This study is a parallel group multicentre investigator-initiated clinical randomised controlled superiority trial that will include a total of 214 survivors of OHCA.\n\nParticipants will to be randomized with a 1:1 allocation ratio to either a intervention consisting of a comprehensive initiated tailored rehabilitation intervention focusing on supporting RTW plus usual care compared to usual care alone.",[28,89,29,121,122,123,124,125],"Return to Work","Return-to-work","Rehabilitation","Recovery of Function","Cardiac Rehabilitation",[127,128,89,29,129,122,130,123,124,125],"Labour marked","Cardiac arrest","Return to work","Back to Work","2025-12-01",{"date":133,"type":37},"2025-12-08",{"date":135,"type":37},"2022-02-01",{"date":137,"type":21},"2028-07-31",{"name":139,"class":44},"Rigshospitalet, Denmark",{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":147,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":148,"targetDuration":4,"studyType":22,"phases":150,"briefSummary":151,"conditions":152,"keywords":153,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":74},"100558529","evaluating-length-and-depth-estimation-accuracy-of-laypersons-and-health-care-providers-100558529","NCT06552299","Evaluating Length and Depth Estimation Accuracy of Laypersons and Health-Care Providers","Evaluating Length and Depth Estimation Accuracy","Inclusion criteria:\n\n* Laypersons: adult laypersons without cardiopulmonary resuscitation training within 2 years\n* Health-care providers: adult health-care providers (doctors, nurses and emergency medical technicians)\n\nExclusion criteria:\n\n* Laypersons: laypersons with cardiopulmonary resuscitation training within 2 years.\n* Health-care providers: health-care providers who are inactive (not currently working at medical facilities)",true,{"count":149,"type":21},200,[24],"The objective of the study is to measure accurateness of length and depth estimation of laypersons and health-care providers.",[29],[29,28],"2025-01-15",{"date":156,"type":37},"2025-01-17",{"date":158,"type":37},"2024-08-27",{"date":160,"type":21},"2025-02-25",{"name":162,"class":44},"Seoul National University Hospital",{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":169,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":171,"enrollmentInfo":172,"targetDuration":4,"studyType":22,"phases":174,"briefSummary":175,"conditions":176,"keywords":178,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":74},"100509767","cardiac-arrest-bundle-of-care-trial-100509767","NCT05917717","Cardiac Arrest Bundle of cARE Trial","Cardiac Arrest Bundle of Care Trial","CABARET","Inclusion Criteria:\n\n1. Adult patients (\\>18 year of age) who have suffered a cardiac arrest\n2. Body habitus is compatible with the bundle devices.\n3. Witnessed event\n4. Time of collapse was known with reasonable certainty to have been to be within 20 minutes.\n\nExclusion Criteria:\n\n1. Visibly pregnant women\n2. Prisoners\n3. Traumatic cardiac arrest\n4. Drowning\n5. Hanging\n6. DNACPR\n7. Have been in witnessed cardiac arrest for an estimated time of 21 minutes or more","120 Years",{"count":173,"type":21},32,[24],"An out-of-hospital cardiac arrest is a sudden event where the heart stops beating and a person becomes unresponsive. During this event, vital organs in the body receive no blood flow, causing them to shut down. Without intervention to restart the heart, a person effectively dies. In the UK, around 60,000 people experience cardiac arrests each year, with most occurring at home. Despite prompt emergency service response, survival rates are typically low.\n\nThere is technology available that has the potential to improve survival rates for out-of-hospital cardiac arrests. The intervention involves three devices used together: head-up position CPR (Elegard), active compression-decompression mechanical CPR (Lucas-3), and the Impedance Threshold device (Resqpod-16). When combined, these devices can enhance blood flow during resuscitation, potentially leading to improved initial resuscitation rates and higher rates of survival with normal brain function after a cardiac arrest.\n\nA pilot study is planned to test the feasibility of using these devices. The results will inform the design of a larger study to determine if this technology can indeed improve survival rates in out-of-hospital cardiac arrests.",[29,28,177],"Out of Hospital Cardiac Arrest",[28,179,29,180,181,182],"Mechanical CPR","Impedance threshold device","Active compression decompression CPR","Head up cardiopulmonary resuscitation (HUP-CPR)","2024-11-27",{"date":185,"type":37},"2024-12-02",{"date":187,"type":37},"2024-05-24",{"date":189,"type":21},"2025-08-30",{"name":191,"class":44},"University Hospital Southampton NHS Foundation Trust",{"id":193,"slug":194,"hasResults":11,"nctId":195,"briefTitle":196,"officialTitle":197,"acronym":198,"eligibilityCriteria":199,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":200,"targetDuration":4,"studyType":22,"phases":202,"briefSummary":203,"conditions":204,"keywords":207,"overallStatus":210,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":218,"locationsCount":74},"100557390","synergy-of-elevation-of-the-head-and-thorax-and-reboa-during-out-of-hospital-cardiac-arrest-100557390","NCT06537492","Synergy of Elevation of the Head and Thorax and REBOA During Out-of-Hospital Cardiac Arrest","Synergy of Elevation of the Head and Thorax and Resuscitative Endovascular Balloon Occlusion of the Aorta During Out-of-Hospital Cardiac Arrest: a Pilot Study","GRAVITY2","Inclusion Criteria:\n\n* Patient with age over or equal to 18 years old\n* Patient with a witnessed medical cardiac arrest and with a no-flow duration under 10 min\n* Patient with EtCO2 greater than 20 mmHg at REBOA team arrival\n* Patient located in the Grenoble Metropolitan area\n* Patient affiliated to French social security\n\nExclusion Criteria:\n\n* Patient with ROSC before REBOA placement.\n* Patient eligible to extracorporeal life support (according to local guidelines).\n* CA of traumatic origin (including drowning or hanging).\n* Patients whose size is not adapted to the LUCAS device: height of the sternum from 170 to 303 mm or maximum chest width of 449 mm. The use of the LUCAS device is not subject to a patient weight condition.\n* Cardiac arrest for which resuscitation seems unjustified (inevitable death, terminally ill irreversible condition, too long duration of cardiac arrest, advance personal directives of no-resuscitation).\n* Obvious pregnancy at inclusion.\n* Subject in a period of exclusion from another clinical investigation.\n* Patients with a femoral arterial access site that cannot accommodate an 8 Fr (minimum) introduces sheath",{"count":201,"type":21},35,[24],"Long-term neurological outcome after successful resuscitation of cardiac arrest remains poor, mainly due to cerebral hypoperfusion and severe hypoxic-ischemic brain injuries. Automated head and chest elevation during cardiopulmonary resuscitation (AHUP-CPR) improves cerebral perfusion by decreasing the intracranial pressure and increasing cerebral perfusion in experimental pig studies. The addition of an impedance threshold device (ITD) and active chest compression-decompression device (ACD) improved hemodynamics and cerebral perfusion. In addition, early implementation of AHUP-CPR in patients with out-of-hospital cardiac arrest (OHCA) was associated with improved survival to hospital discharge, in a multicenter observational study. A 2-year prospective clinical trial in Grenoble evaluating this combination was just completed. This study showed for the first time that the value of end-tidal CO2 (EtCO2), a surrogate for cardiopulmonary resuscitation (CPR) quality and cardiac output, measured with this combination therapy, was significantly higher than with standard CPR.\n\nResuscitative endovascular balloon occlusion of the aorta (REBOA) has recently been proposed during CPR. This technique temporarily diverts blood flow to the coronary and cerebral circulation. Its beneficial effect on hemodynamics, cerebral blood flow and survival has been experimentally validated. In several feasibility studies, encouraging results were observed by slightly optimizing cerebral perfusion and coronary pressure when REBOA was used in combination with standard CPR.\n\nIn a porcine model of cardiac arrest, the addition of REBOA to AHUP CPR was associated with a marked improvement in coronary perfusion pressure and near-normalization of cerebral perfusion pressure. These two interventions act synergistically. REBOA directs flow and pressure to the heart and brain, while AHUP CPR improves preload on the right side of the heart and reduces intracranial pressure.\n\nThe aims of this clinical investigation are to assess the feasibility of placing a REBOA catheter combined with automated CPR with head and chest elevation, and to quantify the associated changes in clinical parameters for OHCA.",[89,205,206,29],"Cardiac Arrest, Out-Of-Hospital","Cardiopulmonary Arrest",[208,209],"Resuscitative endovascular balloon","Head-up cardiopulmonary resuscitation","NOT_YET_RECRUITING","2024-07-31",{"date":213,"type":37},"2024-08-05",{"date":215,"type":21},"2024-10",{"date":217,"type":21},"2026-01",{"name":219,"class":44},"University Hospital, Grenoble"]