[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiopulmonary\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiopulmonary":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,58,93,116,137],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":33,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":52,"leadSponsor":54,"locationsCount":57},"100641181","compare-vent-feasibility-pilot-study-100641181",false,"NCT07656259","COMPARE-VENT Feasibility Pilot Study","COMPARE-VENT Feasibility Pilot Study: A Pragmatic Cluster Randomized Crossover Trial for Ventilation Strategies and Hemodynamic Impact in Critically Ill Patients With Cardiovascular Disease","Inclusion Criteria:\n\nEligible adults ≥ 18 years of age admitted to the cardiac ICU with need for invasive mechanical ventilation of expected duration \\>12 hours.\n\nPre-Specified Subgroups for exploratory outcomes:\n\n1. SCAI Stages C-E Cardiogenic Shock\n2. Mechanical circulatory support use, including intra-aortic balloon pumps and microaxial flow pumps, including Impella CP, RP Impella Flex, and Impella 5.5 devices\n3. Heart failure with reduced ejection fraction: LVEF \\\u003C40% or;\n4. Moderate to severe RV systolic dysfunction or;\n5. Moderate to severe Pulmonary hypertension, as defined by ACC\u002FAHA\u002FESC guidelines\n\nExclusion Criteria:\n\n1. Expected duration of intubation \\\u003C12 hours.\n2. Severe COPD, bronchopleural fistulas, or severe ARDS (Berlin criteria P\u002FF \\\u003C100, in the absence of pulmonary edema)\n3. Home ventilator or chronic tracheostomy.\n4. Pregnant, incarcerated, patients or those receiving extracorporeal membrane oxygenation","ALL","18 Years",{"count":19,"type":20},75,"ESTIMATED","INTERVENTIONAL",[23],"NA","Cardiac disease complicated by respiratory insufficiency comprises the most frequent indication for cardiac intensive care unit (CICU) admission, with nearly one-third patients requiring advanced respiratory support and over 20% patients requiring invasive mechanical ventilation (IMV). IMV among patients with impaired cardiovascular reserve is further compounded by the adverse impact of positive pressure ventilation (PPV) and systemic sedation on intracardiac hemodynamics, pulmonary vascular mechanics and consequently end-organ perfusion. Despite widespread use, evidence guiding optimal ventilatory practices and mode selection in cardiovascular intensive care unit patients remains limited. Pressure-controlled and volume-controlled ventilation may differ in their effects on patient-ventilator synchrony, sedation requirements, and hemodynamic impact, but comparative data among patients with critical cardiac disease remains inconclusive. This pilot study will evaluate the feasibility of implementing a pragmatic cluster-randomized crossover trial comparing ventilatory modes in a contemporary cardiovascular intensive care unit.",[26,27,28,29,30,31,32],"Respiration Failure","Cardio Vascular Disease","Cardiogenic Pulmonary Oedema","Critical Illness","Mechanical Ventilation","Cardiogenic Shock","Cardiopulmonary",[34,35,36,37,38,39,40,41,42,43,44],"Cardiovascular disease","Cardiac arrest","Cardiogenic shock","Respiratory failure","Cardiopulmonary interactions","Critical illness","Intensive care unit","Critical care therapies","Outcomes","Mechanical ventilation","Positive pressure ventilation","NOT_YET_RECRUITING","2026-06-14",{"date":48,"type":49},"2026-06-18","ACTUAL",{"date":51,"type":20},"2026-07-01",{"date":53,"type":20},"2027-06-30",{"name":55,"class":56},"Mayo Clinic","OTHER",1,{"id":59,"slug":60,"hasResults":11,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":4,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":16,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":4,"studyType":70,"phases":4,"briefSummary":71,"conditions":72,"keywords":76,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":57},"100642947","lung-and-heart-function-across-decades-of-life-in-health-100642947","NCT07641413","Lung and Heart Function Across Decades of Life in Health","Lung and Heart Function Across Decades of Life in Healthy Population","Inclusion Criteria:\n\n* Age 24-68\n* No respiratory complaints (defined as modified Medical Research Council score = 0)\n* No use of respiratory medications\n\nExclusion Criteria:\n\n* Non-English speaking\n* Pregnancy\n* BMI\\>35 Kg\u002Fm2\n* Tobacco smoking within prior year\n* Lifetime tobacco smoking of \\>5 pack-years\n* Current inhaled cannabis use (any modality) \\>2x weekly\n* Prior inhaled cannabis uses exceeding 2x weekly within the prior year\n* Illicit drug use (other than cannabis)\n* No prior or current major organ disease, including but not limited to:\n\n  * Neuromuscular weakness\n  * History of malignancy (other than non-melanoma skin cancer)-- HIV\u002FAIDS\n  * Autoimmune disease\n  * Solid-organ or hematopoietic stem cell transplant\n  * Cardiovascular disease (other than mild HTN; \\\u003C 140\u002F90; controlled on 2 or less medications)\n\n    * Poorly-controlled HTN (SBP\\>140 or DBP\\>90 or use of more than 2 anti-hypertensive medications)\n    * Any history of congestive heart failure (CHF, either HFpEF or HFrEF)\n    * Any history of arrythmia (including atrial fibrillation)",true,"24 Years","68 Years",{"count":69,"type":20},200,"OBSERVATIONAL","The main objective of this study is to develop baseline \"normal\" reference values of both lung and heart function for healthy adults within the age range relevant to the United States Veteran population who served in the Southwest Asia theater of military operations.\n\nThis study will involve performing key components of the Department of Veterans Affairs the Airborne Hazards and Open Burn Pit Center of Excellence (AHOBPCE) and a VA network of Post-Deployment Cardiopulmonary Evaluation Network (PDCEN) Core Clinical Evaluation in asymptomatic unexposed healthy controls without known lung or heart disease to serve as a \"normal\" control comparator group for veterans evaluated by PDCEN.",[73,74,75,32],"Pollution Related Respiratory Disorder","Pollution; Exposure","Dyspnea",[77,78,79,80,81,82],"Cardiopulmonary function","Pulmonary function testing","Forced oscillometry testing","Echocardiography","Cardiopulmonary exercise testing","Computed tomography imaging","RECRUITING","2026-06-08",{"date":86,"type":49},"2026-06-11",{"date":88,"type":49},"2024-08-01",{"date":90,"type":20},"2030-12-31",{"name":92,"class":56},"University of California, San Francisco",{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":4,"eligibilityCriteria":99,"healthyVolunteers":65,"sex":16,"minAge":100,"maxAge":101,"enrollmentInfo":102,"targetDuration":4,"studyType":70,"phases":4,"briefSummary":104,"conditions":105,"keywords":4,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":57},"100611968","triple-eit-electrical-impedance-tomography-100611968","NCT07247474","Triple EIT (Electrical Impedance Tomography)","Characterizing the Evolution of Neonatal Lung Disease Throughout Infancy and Childhood Using Electrical Impedance Tomography: A Pilot Study","Inclusion Criteria:\n\n* 2 weeks to 25 years of age\n* evidence of cardiopulmonary disease including, but not limited to:\n\n  1. Post-prematurity respiratory disease\n  2. Congenital diaphragmatic hernia\n  3. Pulmonary Hypertension\n  4. Congenital heart disease\n  5. Respiratory failure\n  6. Neuromuscular Disease\n  7. Developmental or congenital lung disease\n\nOR matched healthy controls (born at term gestation (\\>36 weeks gestational age) with no cardiopulmonary disease)\n\nExclusion Criteria:\n\n* \\\u003C2 weeks of age\n* Anything that interferes with lead placement on the chest wall (such as, dermatologic conditions, multiple chest tubes, anatomic abnormality, or large dressings that cannot be moved)\n* No informed consent\n* Pregnant or lactating\n* Pacemaker or other metal intrathoracic surgical implant (causes noise in the data)","2 Weeks","25 Years",{"count":103,"type":20},140,"This study plans to learn more about ways to look at participant's lungs using new machines called Electrical Impedance Tomography (EIT). The EIT does not use harmful radiation like CT or x-ray. It is read through electrodes like using EKG reading heartbeats.\n\nThe investigators want to compare the results of patients who have chronic respiratory disease to patients without chronic respiratory disease to learn more about lung structure and composition.",[106,32],"Neonates and Preterm Infants","2026-02-19",{"date":109,"type":49},"2026-02-23",{"date":111,"type":49},"2026-01-30",{"date":113,"type":20},"2028-12",{"name":115,"class":56},"University of Colorado, Denver",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":65,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":122,"targetDuration":4,"studyType":70,"phases":4,"briefSummary":124,"conditions":125,"keywords":4,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":136},"100491392","observational-non-interventional-study-supporting-validation-of-vo2max-estimation-methods-using-results-in-patients-receiving-standard-of-care-cardiopulmonary-exercise-tests-cpet-100491392","NCT05678530","Observational, Non-Interventional Study Supporting Validation of VO2Max Estimation Methods Using Results in Patients Receiving Standard of Care Cardiopulmonary Exercise Tests (CPET)","Inclusion Criteria:\n\n1. Willing and able to comply with protocol procedures and available for the duration of the study.\n2. Willing to sign and date informed consent document for study participation.\n3. Participant is undergoing the Cardiopulmonary Exercise Test (CPET) as Standard of Care\n\nExclusion Criteria:\n\n1. Participant is pregnant, lactating or ≤30 days post-partum.\n2. Participant has limited or no intrinsic sinus node function (i.e. chronic atrial pacing).\n\n   • If participant has an indwelling cardiac device and programming cannot be sufficiently ascertained to assure sinus node competence and lack of atrial pacing, the patient should be excluded.\n3. Barostim (™) or similar noncardiac electrical pulse generating device in situ.\n4. Complex congenital heart disease (even repaired or palliated) with the following exception:\n\n   • Biventricular physiology without severe valvar dysfunction (e.g. free pulmonary insufficiency) at the discretion of the investigator.\n5. Any history of allergy to adhesive\n6. Any cognitive or physical limitations that, in the opinion of the investigator, limits the participant's ability to fully follow study procedures and\u002For reach a respiratory exchange ratio of 1.0.",{"count":123,"type":20},1000,"In this study, the hypothesis being explored is that VO2Max and other CPET parameters can be accurately estimated from biosignals (namely, motion from accelerometers and cardiopulmonary variables from EKG) collected during activities of daily living using wearable biosensors worn by study participants. This study will aim to collect development and validation data for a machine learning algorithm and to evaluate the performance of the algorithm. A total of 1000 participants will be enrolled including: (Normal) 100 participants, self-reported healthy male and female participants aged 18 to 80 and (Standard of Care) 900 participants.",[32],"2025-12-22",{"date":128,"type":49},"2025-12-30",{"date":130,"type":49},"2019-06-06",{"date":132,"type":20},"2027-03-31",{"name":134,"class":135},"Prolaio","INDUSTRY",16,{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":65,"sex":16,"minAge":144,"maxAge":145,"enrollmentInfo":146,"targetDuration":4,"studyType":21,"phases":148,"briefSummary":149,"conditions":150,"keywords":151,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":57},"100612137","effects-of-rope-skipping-in-cardiopulmonary-fitness-in-children-100612137","NCT07249671","Effects of Rope Skipping in Cardiopulmonary Fitness in Children","Effects of Rope Skipping in Cardiopulmonary Fitness in School Going Children","Inclusion Criteria:\n\n* School going children age 6 to 12 years\n* Children with no pre existing regular rope skipping training\n* No student athletes\n* Children with no physical and psychological disabilities\n\nExclusion Criteria:\n\n* Children with pre existing injuries\n* Children with chronic medical conditions\n* Children with cardiovascular issues\n* Children with disability","6 Years","12 Years",{"count":147,"type":20},178,[23],"The study will be conducted in a school setting, involving a randomized control trial (RCT) of 178 children aged 6 to 12. The participants will be divided into two groups: a control group engaging in regular physical education (PE) classes and an experimental group practicing rope skipping for 50 minutes, three times a week, over a period of 8 weeks. Cardiopulmonary fitness will be assessed before and after the intervention using the borg rating scale and talk test of perceived exertion.. Data will be analyzed to determine changes in endurance, heart rate recovery, and lung function between the groups. The expected outcome is a significant improvement in cardiopulmonary parameters among the rope-skipping group, highlighting the exercise's effectiveness in promoting heart and lung health in children.",[32],[152],"Cardiopulmonary, rope skipping, Borg scale.","2025-11-18",{"date":155,"type":49},"2025-11-25",{"date":157,"type":49},"2025-10-31",{"date":159,"type":20},"2026-01-16",{"name":161,"class":56},"Riphah International University"]