[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiorespiratory-fitness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiorespiratory-fitness":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,45,71,105,131,171,200,230,261,284,312,339,367],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100642200","calibre-vs-cosmed-100642200",false,"NCT07596108","Calibre vs. COSMED","Correlation of Cardiopulmonary Exercise Testing (CPET) VO2 Max Parameters Between the Calibre Device and COSMED Metabolic Cart","Inclusion Criteria:\n\n* Age 18-55\n* Able to speak English\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Acute myocardial infarction\n* Unstable angina\n* Syncope\n* Uncontrolled asthma\n* Arterial desaturation at rest on room air \\\u003C85%\n* Severe untreated arterial hypertension at rest (\\>200 mm Hg systolic, \\>120 mm Hg diastolic)\n* Significant pulmonary hypertension\n* Active thrombosis of the lower extremity, unless treated for at least 2 weeks prior to participation.\n* Within 2 weeks of acute symptomatic pulmonary embolus\n* Considered inappropriate to participate by Principal Investigator\n* Previously experienced a heart attack\n* Pregnancy",true,"ALL","18 Years","55 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study evaluates agreement between the Calibre device and the COSMED Quark CPET system for measurement of cardiorespiratory fitness parameters during maximal exercise testing in adults aged 18-55 years.",[28],"Cardiorespiratory Fitness",[30,31,32],"Cardiopulmonary Exercise Testing","VO2 Max","Exercise Physiology","NOT_YET_RECRUITING","2026-06-16",{"date":36,"type":37},"2026-06-17","ACTUAL",{"date":39,"type":22},"2026-09",{"date":41,"type":22},"2027-07",{"name":43,"class":44},"Duke University","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":70},"100456016","remotely-monitored-mobile-health-supported-multidomain-rehabilitation-program-with-high-intensity-interval-training-for-covid-19-100456016","NCT05218083","REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19","REMM-HIIT-CoV","Inclusion Criteria:\n\n* Primary diagnosis of COVID-19 requiring hospital admission\n* Discharged or expected to be discharged directly home from the hospital (not to a skilled nursing facility, inpatient rehabilitation center, or long-term acute care hospital)\n* Able to ambulate with or without a gait aid prior to hospital discharge\n* Age ≥ 18 years\n\nExclusion Criteria:\n\n* Hospital discharge \\> 60 days unless readmitted to hospital in first 30 days, then 60 day window restarts and new exclusion is last hospital discharge \\> 60 days\n* Not ambulating independently prior to COVID-19 illness (use of a gait aid permitted)\n* Functional impairment resulting in inability to exercise at baseline\n* Inability or unwillingness to comply with the study requirements or unable or unwilling to follow coaching via mobile-health iPhone interaction\n* Any absolute contraindications to exercise, including but not limited to:\n\n  * Recent (\\\u003C 5 days) acute primary cardiac event\n  * Unstable Angina\n  * Uncontrolled dysrhythmias causing symptoms or hemodynamic compromise\n  * Uncontrolled hypertension over 255 mmHg Systolic or 155 diastolic blood pressure\n  * Symptomatic aortic stenosis\n  * Uncontrolled symptomatic heart failure\n  * Acute myocarditis or pericarditis\n  * Suspected or known dissecting aneurysm\n* Any adverse changes during GXT (i.e., persistent oxygen saturation drop below 88% while on prescribed oxygen therapy or significant hypotension such as mean arterial blood pressure \\\u003C 60 mmHg on 2 consecutive readings within 1 minute)\n* High risk for non-adherence as determined by screening evaluation\n* Any condition, including cognitive impairment, that, in the judgment of the investigator, precludes participation because it could affect subject safety or ability of subject to complete the study\n* Pregnant",{"count":53,"type":22},120,[25],"Multicenter, prospective, randomized controlled trial providing mobile health supported physical rehabilitation to 120 patients who have been critically ill with COVID-19 and who complete at least one exercise session.",[57,58,59,60,28],"COVID-19","Critical Illness","ICU Acquired Weakness","PICS","RECRUITING","2026-05-27",{"date":64,"type":37},"2026-05-28",{"date":66,"type":37},"2023-02-23",{"date":68,"type":22},"2027-04-01",{"name":43,"class":44},5,{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":4},"100638741","retrospective-analysis-of-cpet-and-cognitive-tests-of-healthy-individuals-treated-with-60-treatment-of-hbot-100638741","NCT07596641","Retrospective Analysis of CPET and Cognitive Tests of Healthy Individuals, Treated With 60 Treatment of HBOT","Retrospective Analysis of Cardiopulmonary Exercise Tests and Cognitive Tests of Healthy Individuals Age 18+ Years, Treated at the Sagol Center for Hyperbaric Medicine and Research With 60 Hyperbaric Oxygen Therapy Treatments.","HBOT","Inclusion Criteria:\n\n* Adults aged 18-65 years\n* Completed a full treatment series of 60 hyperbaric oxygen therapy (HBOT) sessions at the Sagol Center\n* Availability of pre- and post-treatment cardiopulmonary exercise testing (CPET) data\n* Availability of pre- and post-treatment cognitive assessment data\n\nExclusion Criteria:\n\n* Inability to complete a maximal CPET test, pre and post HBOT or Missing pre- or post-treatment CPET data.\n* Incomplete HBOT treatment series\n* Missing cognitive assessment data","65 Years",{"count":81,"type":22},1000,"OBSERVATIONAL","This retrospective observational study evaluates physiological and cognitive changes following a series of 60 hyperbaric oxygen therapy (HBOT) sessions in healthy individuals. Participants underwent treatment five days per week, each session included 90 minutes exposure to 100% oxygen at 2ATA with a five-minute air break every 20 minutes. Pre- and post-treatment data include cardiopulmonary exercise testing (CPET) and standardized cognitive assessments. The study aims to characterize associations between changes in cardiorespiratory fitness and cognitive performance following repeated HBOT exposure in a real-world clinical cohort",[85,28,86],"Hyperbaric Oxygenation","Cognition",[77,88,89,90,91,92,93,94],"VO2MAX","VO2 PEAK","cognitive function","CPET","cardiopulmonary exercise testing","hyperbaric oxygen therapy","HEALTH","2026-05-17",{"date":97,"type":37},"2026-05-19",{"date":99,"type":22},"2026-12-01",{"date":101,"type":22},"2028-03-30",{"name":103,"class":104},"Assaf-Harofeh Medical Center","OTHER_GOV",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":23,"phases":114,"briefSummary":115,"conditions":116,"keywords":117,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":130},"100446337","development--validation-of-preoperative-objective-physiological-evaluation-100446337","NCT05092126","Development & Validation of Preoperative Objective Physiological Evaluation","POPE","Inclusion Criteria:\n\n* Age 18 and older\n* Able to speak English\n* Ambulatory \\[assistive devices ok\\]\n* Preoperative Anesthesia and Surgical Screening (PASS) clinic patient with DASI score \\\u003C34\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Acute myocardial infarction (3-5 days)\n* Unstable angina\n* Severe untreated arterial hypertension at rest (\\>200 mm Hg systolic, \\>120 mm Hg diastolic)\n* Resting heart rate \\> 120 bpm\n* Room air desaturation at rest on room air \\\u003C85%\n* Inmate of correctional facility (i.e. prisoner)\n* Diagnosed history of dementia\n* Inability to ambulate independently\n* Considered inappropriate to participate by Principal Investigator",{"count":113,"type":22},100,[25],"This study will compare the measured oxygen consumption (VO2) obtained during sub-maximal exercise testing with the estimated VO2 derived from a non-exercise questionnaire.",[28],[118,92,119,120,121],"areobic power","exercise capacity","functional capacity","physical activity","2026-04-22",{"date":124,"type":37},"2026-04-27",{"date":126,"type":37},"2021-11-23",{"date":128,"type":22},"2027-03-01",{"name":43,"class":44},1,{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":137,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":17,"minAge":139,"maxAge":140,"enrollmentInfo":141,"targetDuration":4,"studyType":23,"phases":143,"briefSummary":144,"conditions":145,"keywords":151,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":170},"100576667","aerobic-exercise-induced-effect-on-endothelial-function-in-patients-with-ischaemic-heart-disease-100576667","NCT06788275","Aerobic Exercise-induced Effect on Endothelial Function in Patients With Ischaemic Heart Disease","Effect of Different Aerobic Exercise Methods in Cardiac Rehabilitation on Endothelial Function in Patients With Ischaemic Heart Disease and Study of the Associated Physiological Mechanisms (ENDO-R)","ENDO-R","Inclusion Criteria:\n\n* Men and women aged between 45 and 75 years.\n* Diagnosed with acute myocardial infarction, unstable or stable angina.\n* Treated with percutaneous coronary intervention, coronary artery bypass grafting, or conservative treatment.\n* Event or intervention within 3 to 12 months prior to participation in the study.\n* Fluency in speaking and reading Spanish.\n* Residing in Elche or surrounding areas and able to attend evaluations and the exercise programme (not planning to be absent for more than one week during the programme).\n* Functional Class I-II according to the New York Heart Association (NYHA) classification.\n* No physical limitations for exercise.\n* Stable optimal medical treatment.\n* Physically inactive, defined as 1) not meeting the World Health Organization recommendations for both aerobic and strength exercise, and 2) not participating in a structured exercise programme at least 3 days per week for more than 3 months. Both conditions must be met for inclusion. Note: Casual walking is not considered grounds for exclusion.\n\nExclusion Criteria:\n\n* Use of walking assistive devices.\n* Treatment with chemotherapy for any type of cancer in the past 2 years.\n* Hospitalisation in an intensive care unit in the past 6 months for reasons other than the ischaemic event.\n* Acute myocardial infarction group IV Killip-Kimball.\n* Obesity grade III (≥40.0 kg\u002Fm²).\n* Medical contraindication for inclusion in an exercise programme.\n* Diabetes with uncontrolled blood glucose levels.\n* Poorly controlled hypertension: resting blood pressure \\> 180\u002F110 mmHg.\n* Chest pain with exertion or ST-segment changes suggestive of residual ischemia during ergometry. Residual ischemia.\n* Severely reduced functional capacity on initial ergometry (\\<5 metabolic equivalent of task).\n* Left ventricular ejection fraction less than 50%.\n* Severe stenosis of the left main coronary artery (\\>50% significant disease).\n* Severe aortic stenosis, left ventricular outflow tract obstruction (e.g., obstructive hypertrophic cardiomyopathy) or aortic dissection.\n* Severe valvulopathy.\n* Acute pulmonary embolism or deep vein thrombosis.\n* Severe pulmonary hypertension.\n* Acute heart failure.\n* Acute endocarditis, myocarditis, or pericarditis.\n* Acute or chronic renal insufficiency (estimated glomerular filtration rate \\<30 ml\u002Fmin).\n* Pulmonary fibrosis or interstitial disease (severe respiratory insufficiency or confirmed chronic obstructive pulmonary disease).\n* Uncontrolled cardiac arrhythmias\u002Fhemodynamically unstable.\n* Permanent or persistent\u002Fparoxysmal atrial fibrillation with episodes in the past 6 months.\n* High-grade cardiac block.\n* Presence of implantable devices: cardiac resynchronization therapy pacemaker, implantable cardioverter defibrillators, or pacemaker.\n* Presence of ischaemic symptoms during the incremental exercise test performed before the intervention.\n* Severe autonomic or peripheral neuropathy.\n* Use of nitrates in pharmacological treatment.\n* Any planned surgical or medical intervention during the study period.\n* Plans to participate in or current participation in other studies that may interfere with this study.\n* Current pregnancy or intention to become pregnant during the study period.","45 Years","75 Years",{"count":142,"type":22},132,[25],"Endothelial dysfunction is one of the aetiological factors in ischaemic heart disease (IHD). Aerobic exercise is effective in improving endothelial function, as measured by flow-mediated dilation (FMD), in patients with IHD. Within the aerobic exercise methods, there is evidence showing that high-intensity interval training (HIIT) increases FMD to a greater extent than moderate-intensity training (MIT) in these patients. Notably, in a recent review, our research group found that only studies performing long bouts of HIIT (long HIIT: higher than 1 min) found a greater effect on FMD, while no differences were found in those studies using short bouts of HIIT (short HIIT: ≤ 1 min) and MIT. However, no experimental studies comparing the effect of long HIIT, short HIIT, and MIT on endothelial function, as well as other predictors of mortality, such as cardiorespiratory fitness, brain-derived neurotrophic factor (BDNF) levels or parasympathetic branch activity, have been performed. Therefore, the main objective of this project will be to compare the effect of the three aerobic exercise methods on endothelial function, as measured by FMD, in patients with IHD. Complementarily, the effect of aerobic exercise, depending on the exercise method, on different mortality predictors will be compared. For this purpose, a multicentre randomised study will be carried out (2 hospitals in Elche and one in Alicante). Assessors will be blinded to the patients allocation. Participants will be aware about their allocation in the experimental groups due to the nature of the study. A total of 132 men and women with IHD (66 per sex), diagnosed between three and 12 months before the start of the intervention, aged between 45 and 75 years, and without limitations for the practice of exercise training, will be recruited. All patients will train 3 days a week for 12 weeks. Participants will be assessed before the intervention (i.e., pre), at 6 weeks of training (i.e., mid) and after the intervention (i.e., post). Physiological and psychological variables will be registered in the assessment periods. Training intensity will be individually prescribed based on the cardiopulmonary exercise test (CPET). Intensity exercise will be adapted after the first part of the intervention. Analysis of covariance will be used to compare the values of the three groups after the intervention for the continuous variables, including the pre-intervention value as a covariate, while a logistic regression model will be used for the categorical variables.",[146,147,148,149,28,150],"Percutaneous Coronary Intervention (PCI)","Acute Myocardial Infarction","Angina (Stable)","Unstable Angina Pectoris","Ischaemic Heart Diseases",[152,153,154,155,156,157,158,159],"Aerobic exercise","High-intensity interval training","Cardiac rehabilitation","Multicenter study","Coronary artery disease","Flow-mediated dilation","Nitroglycerin-mediated dilation","Mortality predictors","2026-02-25",{"date":162,"type":37},"2026-02-27",{"date":164,"type":37},"2024-11-01",{"date":166,"type":22},"2027-11",{"name":168,"class":169},"Instituto de Investigación Sanitaria y Biomédica de Alicante","NETWORK",2,{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":11,"sex":17,"minAge":178,"maxAge":179,"enrollmentInfo":180,"targetDuration":4,"studyType":23,"phases":182,"briefSummary":183,"conditions":184,"keywords":186,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":170},"100575313","effect-of-tele-exercise-on-cardiorespiratory-fitness-in-paediatrics-100575313","NCT06770660","Effect of Tele-exercise on Cardiorespiratory Fitness in Paediatrics","Evaluating the Effectiveness of Telemedicine-based Exercise Programme in Improving Cardiorespiratory Fitness in Asian Paediatric Population: a Randomised Controlled Trial","Inclusion Criteria:\n\n* 12 to 17 years (secondary school students)\n* able to participate in school physical education lessons\n\nExclusion Criteria:\n\n* less than 12 years or older than 17 years (non-secondary school students)\n* has medical or musculoskeletal condition(s) preventing participation in school physical education lessons or exercise","12 Years","17 Years",{"count":181,"type":22},122,[25],"The goal of this clinical trial is to learn if telemedicine exercise programme can improve the cardiorespiratory fitness (how well your body delivers oxygen to muscles and organs) and insulin resistance in Asian children with low cardiorespiratory fitness levels. The main questions it aims to answers are:\n\n* Does telemedicine exercise programme improve the number of 20-metre laps the participant is able to run?\n* Does telemedicine exercise programme improve the insulin sensitivity using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) formula?\n\nResearchers will compare the telemedicine exercise programme to current active lifestyle programme (e.g., daily step count monitoring) to see if telemedicine exercise programme is more effective in improving cardiorespiratory fitness.\n\nParticipants will:\n\n* participate in weekly telemedicine exercise programme or adhere to current active lifestyle recommendations through daily step count reporting for 10 weeks\n* visit the clinic for pre- and post-programme cardiorespiratory fitness assessments and blood taking",[28,185],"Insulin Resistance",[187,188,189,190],"paediatric","cardiorespiratory fitness","telemedicine","insulin resistance","2025-08-27",{"date":193,"type":37},"2025-09-04",{"date":195,"type":37},"2025-05-02",{"date":197,"type":22},"2027-01",{"name":199,"class":104},"KK Women's and Children's Hospital",{"id":201,"slug":202,"hasResults":11,"nctId":203,"briefTitle":204,"officialTitle":205,"acronym":206,"eligibilityCriteria":207,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":79,"enrollmentInfo":208,"targetDuration":210,"studyType":82,"phases":4,"briefSummary":211,"conditions":212,"keywords":214,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":220,"lastUpdatePostDateStruct":221,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":229},"100601269","a-study-on-cardiopulmonary-exercise-tolerance-standards-for-healthy-chinese-population-100601269","NCT07108296","A Study on Cardiopulmonary Exercise Tolerance Standards for Healthy Chinese Population","Multi-center Clinical Cohort Study on Cardiopulmonary Exercise Tolerance Standards in Chinese Healthy Population","MCCS-CCPETS","Inclusion Criteria:\n\n* Detailed medical history taken, with no symptoms of discomfort reported\n* Good physical condition, with no history of severe chronic diseases\n* No history of long - term medication use\n* Willing to undergo cardiopulmonary exercise testing, with no ST - T segment changes observed during the test\n* Age: 18 - 65 years old\n* BMI: 18.5 - 28kg\u002Fm²\n* No smoking history or quit smoking for ≥5 years\n* Physical examination reports within 2 years show no significant abnormalities.\n\nExclusion Criteria:\n\n* Pre - test resting blood pressure ≥160\u002F100 mmHg (1 mmHg=0.133 kPa)\n* Chronic cardiovascular diseases, such as heart failure, coronary atherosclerotic heart disease, hypertension, congenital heart disease, cardiomyopathy, and severe arrhythmias\n* Respiratory diseases, such as chronic obstructive pulmonary disease, asthma, pulmonary artery hypertension, bronchiectasis, and respiratory failure\n* Digestive system diseases, such as peptic ulcer, gastrointestinal bleeding, hepatitis, liver cirrhosis, ulcerative colitis, Crohn's disease, chronic pancreatitis, and chronic cholecystitis\n* Endocrine system diseases, such as hyperthyroidism, hypothyroidism, diabetes, and other diseases with clear hormone abnormalities\n* Acute or chronic kidney diseases, blood system diseases, malignant tumors, and bone and joint diseases that affect activity\n* No history of acute infection within 2 weeks\n* Unable to cooperate with the examination\n* Contraindications to cardiopulmonary exercise testing: acute myocardial infarction",{"count":209,"type":22},4620,"1 Day","This project intends to conduct a large-sample, prospective, multicenter clinical cohort study in healthy populations. By utilizing a digital cardiopulmonary rehabilitation clinical data research platform, The investigators aim to achieve automated, standardized, and uniform collection, analysis, and AI modeling of large-scale cardiopulmonary exercise testing (CPET) data. The ultimate goals are:\n\nTo establish reference standards for cardiopulmonary exercise capacity in the Chinese healthy population.\n\nTo develop machine learning-based predictive models for key CPET variables (e.g., peak VO₂) tailored to Chinese demographics.\n\nTo compare performance differences between domestically produced and imported CPET devices.",[213,28],"Oxygen Consumption",[215,216,217,218,219],"Peak Oxygen Uptake","VO2@AT","Cardiopulmonary Exercise Tolerance","Prediction Model","Healthy Population","2025-08-06",{"date":222,"type":37},"2025-08-11",{"date":224,"type":22},"2025-09-01",{"date":226,"type":22},"2027-03-30",{"name":228,"class":44},"Affiliated Hospital of Changchun University of Chinese Medicine",15,{"id":231,"slug":232,"hasResults":11,"nctId":233,"briefTitle":234,"officialTitle":235,"acronym":236,"eligibilityCriteria":237,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":238,"enrollmentInfo":239,"targetDuration":4,"studyType":23,"phases":241,"briefSummary":242,"conditions":243,"keywords":245,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":260},"100589379","remotely-monitored-mobile-health-supported-high-intensity-interval-training-before-hematopoietic-stem-cell-transplant-100589379","NCT06953648","Remotely Monitored, Mobile Health-supported, High Intensity Interval Training Before Hematopoietic Stem Cell Transplant","Remotely Monitored, Mobile Health-supported, High Intensity Interval Training Before Hematopoietic Stem Cell Transplantation (REMM-HIIT-HCT)","REMM-HIIT","Inclusion Criteria:\n\n* Plan to undergo allogeneic hematopoietic stem cell transplant in 4-12 weeks after enrollment on this study.\n* Age 18-80 years\n* Able to read\u002Fwrite English (as many participant-reported outcome measures lack validated translations in other languages)\n\nExclusion Criteria:\n\n* Unable or unwilling to follow coaching\n* Functional impairment resulting in inability to exercise\n* Any absolute contraindications to exercise:\n\n  1. recent (\\\u003C6 months) acute cardiac event;\n  2. unstable angina;\n  3. uncontrolled dysrhythmias causing symptoms;\n  4. symptomatic aortic stenosis;\n  5. uncontrolled symptomatic heart failure;\n  6. acute pulmonary embolus;\n  7. acute myocarditis or pericarditis;\n  8. suspected or known dissecting aneurysm","80 Years",{"count":240,"type":22},126,[25],"The goal of this clinical trial is to learn how a remotely monitored high-intensity interval training (REMM-HIIT) affects the cardiorespiratory fitness and physical function for patients planning to undergo stem cell transplantation. The main questions it aims to answer are:\n\nIs there a change in the participant's cardiorespiratory fitness level? Is there a change in the participant's physical function?\n\nResearchers will compare the REMM-HIIT program to a control group of participants who do not take part in the training program to see if REMM-HIIT helps improve stem cell transplantation outcomes.\n\nParticipants will:\n\n* Complete cardiopulmonary exercise testing (CPET) 4 times during the study\n* Do basic tests to measure physical function 6 times during the study\n* Answer questions about their life and how they are feeling 6 times during the study\n* Wear a device to keep track of step counts and heart rate daily\n* Keep a log of every time they exercise throughout the study\n* Optionally, provide blood and stool samples 6 times during the study",[244,28],"Hematopoietic Stem Cell Transplantation",[246,247,244,248,249,250,28],"High Intensity Interval Training","HIIT","Remote Monitoring","Mobile Health","Exercise","2025-04-23",{"date":253,"type":37},"2025-05-01",{"date":255,"type":22},"2025-05",{"date":257,"type":22},"2030-03",{"name":259,"class":44},"University of Kansas Medical Center",3,{"id":262,"slug":263,"hasResults":11,"nctId":264,"briefTitle":265,"officialTitle":266,"acronym":267,"eligibilityCriteria":268,"healthyVolunteers":16,"sex":17,"minAge":269,"maxAge":79,"enrollmentInfo":270,"targetDuration":4,"studyType":23,"phases":272,"briefSummary":273,"conditions":274,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":278,"completionDateStruct":280,"leadSponsor":282,"locationsCount":130},"100477421","response-variability-to-exercise-100477421","NCT05496751","Response Variability to Exercise","Response Variability to Exercise in Adults","REVISE","Inclusion Criteria:\n\n* Sedentary lifestyle (planned physical activity for one day per week or less).\n* Weight stable (± 2 kg) for 6 months prior to the beginning of the study.\n* BMI between 20 and 40 kg\u002Fm2.\n\nExclusion Criteria:\n\n* Physical impairment which would make the intervention very difficult or unsafe according to doctor's advice.\n* Diabetes, current smokers.\n* Plan to move from the area in next 8 months.","25 Years",{"count":271,"type":22},200,[25],"In this proposal, the investigators challenge the assumption that following the physical activity guidelines implies benefit for ALL adults, and that if benefit is not achieved in response to first line therapy, it will be by simply exercising more. Thus, for improving cardiorespiratory fitness and cardiometabolic risk factors, unanswered questions include: 1) To what extent, regardless of increasing exercise intensity or amount, is exercise not associated with benefit? Demonstration of a resistance to benefit through exercise in a substantial number of adults would be a novel and important finding, would counter the assumptions of many if not most health care practitioners, and could have immediate and direct application in all health care settings. 2) To what extent will non-responders to first line therapy (150 min\u002Fwk) be required to increase exercise intensity or amount to achieve benefit? 3) To what extent will failure to improve CRF segregate (be associate with) with cardiometabolic risk factors? The investigators propose that adults who remain exercise resistant for improvement in CRF and cardiometabolic risk despite increasing amount or intensity are at high risk of metabolic disease and consequently, are candidates for alternative treatment strategies.",[250,28],"2025-03-17",{"date":277,"type":37},"2025-03-20",{"date":279,"type":37},"2022-09-30",{"date":281,"type":22},"2025-09-30",{"name":283,"class":44},"Robert Ross, PhD",{"id":285,"slug":286,"hasResults":11,"nctId":287,"briefTitle":288,"officialTitle":289,"acronym":290,"eligibilityCriteria":291,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":140,"enrollmentInfo":292,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":294,"conditions":295,"keywords":298,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":306,"completionDateStruct":308,"leadSponsor":310,"locationsCount":130},"100582912","insomnias-impact-on-dna-stability-cardio-metabolic-health-and-lifestyle-behaviors-100582912","NCT06869486","Insomnia´s Impact on DNA Stability, Cardio-metabolic Health and Lifestyle Behaviors","Insomnia´s Impact on DNA Stability, Cardio-metabolic Health and Lifestyle Behaviors: A Case-control Study","INSIGHTS","Inclusion Criteria:\n\nEach population group will meet the following inclusion criteria:\n\n* Healthy Individuals (18-35 years old, men and women)\n\n  * Waist circumference: \\\u003C90 cm (men), \\\u003C80 cm (women)\n  * Fasting glucose: 70-110 mg\u002FdL\n  * Blood pressure: \\\u003C120\u002F80 mmHg\n  * Triglycerides: \\\u003C150 mg\u002FdL\n  * HDL-C: \\>40 mg\u002FdL (men), \\>50 mg\u002FdL (women)\n  * Physical activity level: 600-1500 MET-min\u002Fweek\n* Athletes (18-35 years old, men and women)\n\n  \\*Engaged in structured sports training with a physical activity level \\>1500 MET-min\u002Fweek\n* Older Adults (65-75 years old, men and women)\n\n  \\*Free of cognitive or mental health disorders. No specific cardiometabolic or body composition criteria due to the study's exploratory nature.\n* University Students (18-35 years old, men and women)\n\n  \\*No specific cardiometabolic or body composition criteria due to the study's exploratory nature.\n* Individuals with Metabolic Syndrome (18-35 years old, men and women)\n\n  * Waist circumference: \\>90 cm (men), \\>80 cm (women)\n  * Fasting glucose: \\>110 mg\u002FdL\n  * Blood pressure: \\>130\u002F80 mmHg\n  * Triglycerides: \\>150 mg\u002FdL\n  * HDL-C: \\\u003C40 mg\u002FdL (men), \\\u003C50 mg\u002FdL (women)\n  * Physical activity level: \\\u003C600 MET-min\u002Fweek\n\nExclusion Criteria:\n\n* Individuals with respiratory diseases or musculoskeletal injuries that prevent exercise, as determined by a clinical history review, a physical activity readiness questionnaire (PART-Q+), and pulmonary function tests (spirometry).\n\nIndividuals with rotating or night-shift work schedules (e.g., emergency personnel, security guards), as circadian rhythm disruptions significantly impact sleep quality\n\n* Women diagnosed with polycystic ovary syndrome (PCOS) or showing high testosterone levels with a history of oligomenorrhea, as these conditions may influence metabolic and hormonal markers. However, women with menstrual irregularities related to premenstrual syndrome (PMS) or dysmenorrhea will not be excluded, given the established link between sleep disorders and menstrual cycle variations\n* This study does not involve chronic dietary or exercise interventions, nor does it require long-term participant follow-up, so no additional exclusion criteria apply",{"count":293,"type":22},300,"Insomnia is a highly prevalent sleep disorder worldwide, with an increasing incidence in athletes, older adults, university students, and individuals with metabolic syndrome. This disorder has been associated with metabolic dysfunction, cardiovascular diseases, and genetic instability. Recent evidence suggests that insomnia negatively impacts cardiorespiratory fitness, insulin sensitivity, and overall health through mechanisms involving neuroendocrine dysregulation, oxidative stress, and alterations in energy metabolism. However, the specific biological and environmental factors that contribute to its prevalence and health consequences remain poorly understood, particularly across different populations. Understanding these associations is crucial for developing effective prevention and intervention strategies to mitigate the long-term impact of insomnia. Therefore, this study aims to analyze the impact of insomnia on body composition, cardiorespiratory fitness, metabolic flexibility, and DNA integrity, across populations with high prevalence of insomnia, including athletes, older adults, university students, and individuals with metabolic syndrome. This study will also investigate which biological and lifestyle behaviors contribute to insomnia and its health consequences. By doing so, this work will provide critical insights into the physiological and molecular mechanisms that link insomnia with metabolic and cardiovascular dysfunction, contributing to the development of targeted interventions for at-risk populations",[296,28,297],"Insomnia","Metabolic Disease",[299,300,301,302],"Physical Activity","Physical Fitness","DNA integrity","Endocrinology and Metabolism","2025-03-04",{"date":305,"type":37},"2025-03-11",{"date":307,"type":37},"2024-10-01",{"date":309,"type":22},"2026-12-31",{"name":311,"class":44},"Universidad Autonoma de Baja California",{"id":313,"slug":314,"hasResults":11,"nctId":315,"briefTitle":316,"officialTitle":317,"acronym":4,"eligibilityCriteria":318,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":319,"enrollmentInfo":320,"targetDuration":4,"studyType":23,"phases":322,"briefSummary":323,"conditions":324,"keywords":326,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":331,"startDateStruct":333,"completionDateStruct":335,"leadSponsor":337,"locationsCount":130},"100581372","effects-of-exercise-snacks-and-sprint-interval-training-in-overweight-adults-100581372","NCT06849453","Effects of Exercise Snacks and Sprint Interval Training in Overweight Adults","Effects of Exercise Snacks and Sprint Interval Training on Cardiovascular Function in Overweight Adults: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Men and women aged between 18 and 35 years;\n* Overweight but not obese (BMI ≥24 and ≤ 28 kg\u002Fm2);\n* Physically inactive (3 or less bouts of purposeful exercise per week);\n* Ability to understand the research details and voluntarily sign the informed consent form;\n* Non-smoker (for \\>5 years);\n* Body weight has been stable over the past six months, with no recent weight gain or loss behaviors;\n* Healthy (see exclusion criteria).\n\nExclusion Criteria:\n\n* Any chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, peripheral arterial disease, insulin- or non-insulin dependent diabetes or other metabolic disorders - all ascertained through preliminary screening;\n* Individuals with a history of bone, joint or neuromuscular problems or a current musculoskeletal injury ascertained through preliminary screening;\n* Abnormal electrocardiogram (ECG) results;\n* Currently taking medication that may affect physiological testing;\n* Contraindications to exercise.","35 Years",{"count":321,"type":22},45,[25],"Exploring the efficacy and acceptability of exercise snacks (ES) and sprint interval training (SIT) could provide time-efficient, low-barrier alternatives for individuals, especially those who, due to 'lack of time, environment, and equipment,' struggle to meet traditional physical activity recommendations. This research aims to investigate the effects of ES and SIT, of equal exercise volume, on overweight adults.",[325,28],"Cardiovascular Function",[327,328,329,325],"Exercise Snacks","Sprint Interval Training","Overweight Adults","2025-02-25",{"date":332,"type":37},"2025-02-27",{"date":334,"type":22},"2025-02-24",{"date":336,"type":22},"2025-10-31",{"name":338,"class":44},"Beijing Sport University",{"id":340,"slug":341,"hasResults":11,"nctId":342,"briefTitle":343,"officialTitle":344,"acronym":4,"eligibilityCriteria":345,"healthyVolunteers":16,"sex":17,"minAge":269,"maxAge":346,"enrollmentInfo":347,"targetDuration":4,"studyType":23,"phases":349,"briefSummary":350,"conditions":351,"keywords":353,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":359,"lastUpdatePostDateStruct":360,"startDateStruct":361,"completionDateStruct":363,"leadSponsor":365,"locationsCount":130},"100573406","effects-of-aerobic-and-diaphragmatic-exercises-on-choir-singers-100573406","NCT06745869","Effects of Aerobic and Diaphragmatic Exercises on Choir Singers","Effects of Aerobic and Diaphragmatic Breathing Exercises on Respiratory Functions and Voice Performance of Choir Singers","Inclusion Criteria:\n\n* Being a chorist in an active choir that rehearses at least once a week for an average of 2 hours\n* Having an inactive or minimally active physical activity level according to the International Physical Activity Questionnaire-Short Form\n* Being between the ages of 25-60\n* Being willing to participate in the study\n\nExclusion Criteria:\n\n* Having a neurological or orthopedic disease\n* Having a condition related to the cardiopulmonary system that would prevent exercise according to the Physical Activity Readiness Questionnaire (PAR-Q)","60 Years",{"count":348,"type":22},42,[25],"The goal of this randomized-controlled study is to compare the effects of diaphragmatic breathing exercise training provided by a physiotherapist and aerobic exercise training applied in addition to diaphragmatic breathing exercise training provided by a physiotherapist on respiratory functions and voice performance in choir singers.\n\nThe main questions this study aims to answer are:\n\n* Is diaphragmatic breathing exercise training provided by a physiotherapist effective in improving the respiratory functions of choir singers?\n* Is diaphragmatic breathing exercise training provided by a physiotherapist effective in improving the vocal performance of choir singers?\n* Does aerobic exercise training applied in addition to diaphragmatic breathing exercise training provided by a physiotherapist have a greater effect on improving the respiratory functions of choir singers compared to diaphragmatic breathing exercise training applied alone?\n* Does aerobic exercise training applied in addition to diaphragmatic breathing exercise training provided by a physiotherapist have a greater effect on improving the vocal performance of choir singers compared to diaphragmatic breathing exercise training applied alone?\n\nThe research data are going to be collected by Sociodemographic Information Form, International Physical Activity Questionnaire-Short Form, Self-Performance Evaluation Questionnaire, Vocal Fatigue Index, Singing Voice Handicap Index, measurement of maximum phonation time, pulmonary function test, maximal inspiratory and expiratory pressure measurement, and 6-minute walk test.",[352,28],"Respiratory Muscles",[354,355,356,357,358],"Singing","Respiratory Function Tests","Voice","Diaphragm","Exercise, aerobic","2025-02-20",{"date":334,"type":37},{"date":362,"type":37},"2024-12-23",{"date":364,"type":22},"2025-07-01",{"name":366,"class":44},"Medipol University",{"id":368,"slug":369,"hasResults":11,"nctId":370,"briefTitle":371,"officialTitle":372,"acronym":4,"eligibilityCriteria":373,"healthyVolunteers":16,"sex":17,"minAge":374,"maxAge":375,"enrollmentInfo":376,"targetDuration":4,"studyType":23,"phases":378,"briefSummary":379,"conditions":380,"keywords":381,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":385,"startDateStruct":387,"completionDateStruct":389,"leadSponsor":391,"locationsCount":130},"100479323","combating-physical-inactivity-pandemic-in-kindergartens-100479323","NCT05521490","Combating Physical Inactivity Pandemic in Kindergartens","Combating Physical Inactivity Pandemic by Promoting Physical Fitness Education and Physical Activity-Embedded Curriculum in Kindergartens","Inclusion Criteria\n\n1. Children aged 5-6 years (limited number of children may be between 4-5 and 6-7 years)\n2. Able to communicate in Chinese\n3. Able to participate in physical activity in a standard kindergarten setting\n\nExclusion Criteria:\n\n1. Inherent or serious disease limiting participation in physical activity (e.g., congenital heart disease, pediatric cancer, Down syndrome).\n2. Diagnosed mental illness impairing daily behavior and performance (e.g., anxiety disorder, depression, attention deficit hyperactivity disorder, psychotic disorders, autism spectrum disorder).\n3. Physical disability (e.g., physical handicap, assistive device to walk).\n4. Visual or hearing impairment.\n5. Cognitive deficit or intellectual disability that requires special care and educational needs (e.g., handicapped children with learning difficulties).","5 Years","6 Years",{"count":377,"type":22},3300,[25],"The aim of this study is to examine the effects of a kindergarten-based, parent-involved intervention during the upper kindergarten year (K3) on physical activity and physical fitness in preschool children.",[299,28],[382,383],"Childhood Physical Inactivity","Childhood Obesity","2022-08-25",{"date":386,"type":37},"2022-08-30",{"date":388,"type":22},"2022-08",{"date":390,"type":22},"2026-12",{"name":392,"class":44},"The University of Hong Kong"]