[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiovascular-disease-risk-factors\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiovascular-disease-risk-factors":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100612934","determining-the-benefits-of-exercise-on-cardiovascular-risk-in-ptsd-100612934",false,"NCT07260032","Determining the Benefits of Exercise on Cardiovascular Risk in PTSD","Using Advanced Imaging to Determine the Benefits of Exercise on Cardiovascular Risk in PTSD","Inclusion Criteria:\n\n* Age 18-65 years\n* Trauma exposure\n* PTSD symptoms\n* Subclinical atherosclerotic CVD (e.g., coronary, cerebrovascular, or peripheral arterial plaque or calcifications on imaging), clinical atherosclerotic CVD (e.g., myocardial infarction or revascularization), or increased risk for atherosclerotic CVD (i.e., \\>2 of hypertension, diabetes mellitus, hyperlipidemia, and active smoking)\n* Ability to understand and sign informed consent\n\nExclusion Criteria:\n\n* History of stroke, brain surgery, or seizure\n* Use of certain CVD medications (e.g., beta-blockers, high-intensity statins \\[e.g., rosuvastatin 20\u002F40 mg and atorvastatin 40\u002F80 mg\\], PCSK-9 inhibitors)\n* Psychiatric or cardiovascular medication change within 4 weeks (i.e., stable regimen is allowed)\n* Unstable blood pressure or cardiac arrhythmia\n* Currently in a supervised or graduated exercise program\n* Neurological or systemic inflammatory disease\u002Fcurrent systemic anti-inflammatory therapy\n* Moderate\u002Fsevere alcohol\u002Fsubstance use disorder\n* Current mania\u002Fpsychosis\n* Weight \\>300 lbs.\n* Claustrophobia\n* Pregnancy\n* Metal implants\n* Uncontrolled hyperglycemia (HgbA1c\\>7.5%)\n* Subjects who have had significant radiation exposure as part of research (\\>2 nuclear tests, computed tomography images, or fluoroscopic procedures) during the preceding 12-months","ALL","18 Years","65 Years",{"count":20,"type":21},10,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this study is to use a non-invasive imaging technique called positron emission tomography\u002Fmagnetic resonance imaging (PET\u002FMRI) to investigate the effects of exercise on brain activity and arterial (blood vessel) inflammation in people with PTSD symptoms and evidence of or elevated risk for artery disease.",[27,28,29],"PTSD","Cardiovascular Disease","Cardiovascular Disease Risk Factors","RECRUITING","2025-11-20",{"date":33,"type":34},"2025-12-02","ACTUAL",{"date":36,"type":34},"2025-02-01",{"date":38,"type":21},"2027-01-31",{"name":40,"class":41},"Massachusetts General Hospital","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":68,"leadSponsor":70,"locationsCount":42},"100595061","remote-exercise-to-improve-physical-activity-levels-and-markers-of-heart-health-in-cystic-fibrosis-rhh-cf-100595061","NCT07027553","Remote Exercise to Improve Physical Activity Levels and Markers of Heart Health in Cystic Fibrosis (RHH-CF)","A Research Study to Understand Whether Remote Exercise Can Improve Physical Activity Levels and Markers of Heart Health in Cystic Fibrosis","RHH-CF","Inclusion Criteria:\n\n* Past diagnosis of Cystic Fibrosis confirmed via two copies of a faulty CFTR gene, or; previous sweat chloride test with a result \\>60mmol\u002FL chloride, or; prescribed modulator therapy (Orkambi, Symkevi, Kaftrio);\n\nExclusion Criteria:\n\n* Any reported condition, behaviour or reported use of substances which may pose undue personal risk to the participant or introduce bias into the study, except for any which are ubiquitous in society and so would be equally distributed between groups and\u002For therefore relevant to generalisation (e.g. caffeine)\n* Medications which increase risk of harm to a participant exercising remotely such as fluoroquinolone antibiotics, beta blockers, or blood pressure medication\n* Individuals with unstable or poorly controlled diabetes\n* Individuals on statins\n* Females who are pregnant or lactating\n* Individuals with a previous self-reported history of an eating disorder\n* Individuals unable to provide informed consent e.g. inability to read or speak English\n* Individuals who are not weight stable (i.e. \\>3kg change in body mass in the past 3 months)\n* Individuals awaiting a solid organ transplant, have a diagnosis of pulmonary hypertension or require long term oxygen therapy to exercise at home\n* Individuals with chest pain, dizziness or loss of consciousness during exercise, who have been instructed by a doctor to only do certain types\u002Fquantity of physical activity\n* Individuals on any current ongoing medication or treatment for injuries or illness which impact on their ability to do physical tasks or exercises\n* Individuals who are PAR-Q positive response during screening",{"count":52,"type":21},30,[24],"With advances in genetic therapies, many people with Cystic Fibrosis (CF) are living longer. With the improvement in life expectancy has emerged an increased risk of cardiovascular disease (CVD). Factors such as insulin resistance, reduced physical activity, rising blood pressure from newer medications, and changes in body mass index have made cardiovascular health a growing concern in CF care.\n\nThis study aims to assess whether a remotely delivered, monitored exercise programme can increase physical activity levels in adults with CF. Secondary outcomes will explore whether the intervention improves key CVD risk factors. Participants will be randomly assigned to either a control group or an intervention group, which will complete an 8-week home-based aerobic and resistance exercise programme. Exercise intensity will be tailored using the Rate of Perceived Exertion scale.\n\nKey outcomes include weekly physical activity levels, body mass index, waist circumference, lung function (spirometry) and blood biomarkers. Home-based capillary blood tests, analysed pre- and post-intervention, will measure cholesterol, lipid profiles, inflammation and other relevant hormones.",[56,29],"Cystic Fibrosis (CF)",[58,59,60,61,62],"Exercise","Physical activity","Cystic Fibrosis","Cardiovascular disease risk","Mobile health interventions","NOT_YET_RECRUITING","2025-06-19",{"date":66,"type":34},"2025-06-25",{"date":64,"type":21},{"date":69,"type":21},"2026-09-19",{"name":71,"class":41},"University of Bath"]