[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cardiovascular-outcome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cardiovascular-outcome":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100584222","pact-involvement-in-cardiology-patients-100584222",false,"NCT06886529","PACT Involvement in Cardiology Patients","Early PACT Involvement in Cardiology Patients Using Machine Learning","Inclusion Criteria:\n\n* Pediatric inpatients admitted to cardiology\n\nExclusion Criteria:\n\n* Expected to be discharged prior to midnight on the day of admission","ALL","18 Years",{"count":19,"type":20},1000,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this trial is to determine the effectiveness of a machine-learning (ML) model predicting a serious cardiac event within the next three months, when compared pre- versus post-deployment, in pediatric cardiac inpatients. The main questions it aims to answer are whether deployment of the ML model:\n\n1. Increases PACT consultation within the next three months among admissions without PACT involvement in the previous 100 days\n2. Increases PACT consultation or visit within the next three months among those who experience a serious cardiac event during this period\n3. Decreases time to PACT consultation or visit among those seen by PACT during this period\n4. Decreases the incidence of death in the intensive care unit (ICU)\n5. Increases documentation of goals of care\n\nHigh-risk cardiology patients will be identified by an ML model each morning. If the patient has been seen by the PACT team within the past year, the update will go to the PACT team members. If the patient hasn't been seen by the PACT team, the email will be sent to the cardiology physician in charge of the patient. This physician will decide whether a PACT consultation is necessary based on their clinical judgment. If so, a referral will be made using the usual process. Outcomes of the identified patients will be compared pre- and post-deployment.",[26,27,28,29],"Machine Learning","Cardiovascular Outcome","Pediatric Palliative Care","Pediatric Cardiology",[31,32,33,34,35],"quality of life","cardiovascular outcomes","machine learning","prediction models","pediatric","RECRUITING","2026-04-22",{"date":39,"type":40},"2026-04-23","ACTUAL",{"date":42,"type":40},"2025-10-16",{"date":44,"type":20},"2027-10-16",{"name":46,"class":47},"The Hospital for Sick Children","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":21,"phases":63,"briefSummary":64,"conditions":65,"keywords":69,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":48},"100591106","impact-of-lean-pork-on-endothelial-function-in-perimenopause-100591106","NCT06976112","Impact of Lean Pork on Endothelial Function in Perimenopause","Effects of Lean Pork Intake on Endothelial Function and Vasomotor Symptoms in Perimenopausal Women","LEAP","Inclusion Criteria:\n\n* Are female\n* Are between 40 and 55 years of age\n* Have a BMI (a number calculated from participant height and weight) between 28 and45 kg\u002Fm2\n* Are experiencing irregular menstrual cycles but have not gone longer than 12 consecutive months without a period\n* Are experiencing severe vasomotor (menopause) symptoms\n* Are doing less than 3 hours per week of structured exercise\n* Have systolic blood pressure between 120 and 140 mmHg and\u002For diastolic blood pressure between 80 and 90 mmHg\n* Have \"sugary\" hemoglobin called hemoglobin A1c less than or equal to 6.5%\n* Are willing and able to refrain from using oral mouth wash for the duration of the study because the alcohol in mouth wash inhibits nitrate synthesis\n* Are willing and able to comply with both the study diets\n* Are willing to collect blood for future research\n* Can read, speak, and understand English\n\nExclusion Criteria:\n\n* Hysterectomy (partial or full) or oophorectomy\n* Using hormone replacement therapy use and\u002For hormonal contraception use 6 months prior to study start\n* Has systolic blood pressure ≥140 mmHg and\u002For diastolic blood pressure ≥ 90 mmHg)\n* Triglycerides ≥350 mg\u002FdL, low-density lipoprotein cholesterol (LDL-C) ≥190 mg\u002FdL, and\u002For taking a lipid-lowering medication -Diagnosed cardiovascular disease, diabetes (type 1 or 2), or endocrine- related disease (e.g. thyroid, PCOS), unstable gastrointestinal disease, kidney, liver, and\u002For pancreatic disease\n* Diagnosed cancer (except skin cancer) in the last 5 years\n* Taking \\>1 blood pressure medication and\u002For taking 1 blood pressure medication for \\\u003C3 months\n* Taking phosphodiesterase-5 inhibitors, anti-coagulants, corticosteroids, metformin, or insulin.\n* Weight change ≥6.6 pounds in the past 3 months, actively trying to lose weight, or unwilling to remain weight stable throughout the study\n* Current smoking or vaping, Binge and\u002For heavy drinker\n* Food allergies or other reasons preventing consumption of study foods with both study diets",true,"FEMALE","40 Years","55 Years",{"count":62,"type":20},30,[23],"The goal of this study is to examine the impact of a diet high in fresh lean pork, compared to a plant-based diet, on cardiovascular function and vasomotor symptoms in perimenopausal women with overweight and obesity. The main questions it aims to answer are:\n\n1. How does a diet high in pork, compared to a plant-based diet, affects blood lipids, endothelial function, and blood pressure?\n2. How does a diet high in pork, compared to a plant-based diet, affects blood nitrate, cardiometabolic biomarkers, inflammatory biomarkers, and vasomotor symptoms?\n\nResearchers will compare the diet high in pork to a plant-based diet to see if pork helps improve cardiovascular and mesopause symptoms.\n\nParticipants will:\n\n* Consume both of the diets, each for 4 weeks, with a washout period between 2 and 6 weeks in between the diets trials\n* Visit the clinic 5 times with weekly meal pick ups during the diet trials\n* Undergo testing procedures including: weight and body composition, blood pressure and pulse, endothelial function using ultrasound of upper arm, microvascular blood flow, blood draws, physical activity measurements, and questionnaires.",[27,66,67,68],"Overweight and Obese Women","Perimenopausal Women","Vasomotor Symptoms (VMS)",[70,71,72,73,74,75,76,77,78],"Perimenopause","Perimenopausal","Vasomotor Symptoms","VMS","Menopause","Cardiovascular Health","Blood pressure","Pork","Vegetarian","2025-11-26",{"date":81,"type":40},"2025-11-28",{"date":83,"type":40},"2025-08-01",{"date":85,"type":20},"2027-05",{"name":87,"class":47},"Pennington Biomedical Research Center"]