[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"caregiver-burden\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:caregiver-burden":34},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,61,0,25,[9,52,76,102,127,154,181,213,252,280,308,336,366,396,417,449,484,509,538,560,587,623,648,682,710],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":35,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100638259","brief-intervention-addressing-stigma-among-parents-of-children-with-mental-health-problems-100638259",false,"NCT07594730","Brief Intervention Addressing Stigma Among Parents of Children With Mental Health Problems","RCT of Brief Intervention Addressing Stigma Among Parents of Children With Mental Health Problems","Inclusion Criteria:\n\n* Self-identify as English Speaking\n* Live in the US\n* Ages 25-50\n* Have a child 6-18 years old with either depression, ADHD, or a substance use problem\n\nExclusion Criteria:\n\n* Do not speak English\n* Do not live in the US\n* \\\u003C25 or \\>50\n* Do not have a child between ages 6-18 with depression, ADHD, or a substance use problem",true,"ALL","25 Years","50 Years",{"count":22,"type":23},1600,"ESTIMATED","INTERVENTIONAL",[26],"NA","The goal of this study is to test the efficacy of brief video interventions parental internalized stigma and stigma-related outcomes (e.g., treatment intentions, caregiver burden, secrecy) among parents (ages 25-50) of children ages 6-18 with depression, ADHD, or substance use problems.\n\nTimely identification and treatment of mental health problems in youth is a public health priority. However, many youth do not receive treatment, and stigma has been identified as the primary barrier to help-seeking. Parents experience stigma related to their children having mental health problems, which has been associated with reduced help-seeking and increased parental distress. Prior experiments have found brief video-based interventions (BVIs), 1-2 minute videos similar to those viewed by youth on social media platforms, based on the principle of \"social contact\" with individuals affected by a stigmatized condition, effective in reducing mental health stigma and increasing help-seeking.\n\nIn this 4-arm RCT, the investigators will recruit parents aged 25-50 using an online crowdsourcing platform, to test the efficacy of BVIs featuring a personal parent narrative of their experience with their child's a) depression, b) ADHD, or c) substance use, or d) a control condition that provides general written psychoeducational information without social contact.",[29,30,31,32,33,34],"Depression Disorders","ADHD","Substance Abuse","Social Stigma","Help-Seeking Behavior","Caregiver Burden",[36,37,38],"social stigma","help-seeking behavior","caregiver burden","NOT_YET_RECRUITING","2026-06-26",{"date":42,"type":43},"2026-06-30","ACTUAL",{"date":45,"type":23},"2026-07-06",{"date":47,"type":23},"2026-09-06",{"name":49,"class":50},"New York State Psychiatric Institute","OTHER",1,{"id":53,"slug":54,"hasResults":12,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":24,"phases":63,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100644580","care-burden-and-qualty-of-lfe-100644580","NCT07672340","Care Burden And Qualıty of Lıfe","Effect Of Multıdımensıonal Traınıng Applıed to Caregıvers of Home Health Servıce Recıpıents Aged 65 And Over on Care Burden And Qualıty of Lıfe","Care Burden","Inclusion Criteria:\n\nBe willing to participate in the study\n\n* Be literate\n* Have registered with a home health care unit\n* Have been responsible for the care of a relative aged 65 or older for at least one month\n* Score at least 21 on the Zarit Caregiver Burden Scale\n\nExclusion Criteria:\n\n* • Having severe reading comprehension difficulties\n\n  * Having severe hearing difficulties\n  * Having been diagnosed with a psychiatric disorder (schizophrenia, bipolar disorder, or anxiety disorder)\n  * Failing to complete the data collection instruments used in the study\n  * Failing to attend at least two training sessions","18 Years",{"count":62,"type":23},78,[26],"This randomized controlled trial will be conducted to examine the effect of a multidimensional training program, to be implemented by a public health nurse, on the care burden and quality of life of primary caregivers of patients aged 65 and older.",[34,66,67],"Quality of Life","Public Health","2026-06-24",{"date":40,"type":43},{"date":71,"type":23},"2026-07",{"date":73,"type":23},"2026-08",{"name":75,"class":50},"Aydin Adnan Menderes University",{"id":77,"slug":78,"hasResults":12,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":17,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":86,"conditions":87,"keywords":91,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":4},"100644131","burden-of-care-and-health-literacy-of-caregivers-in-the-emergency-department-100644131","NCT07666373","Burden of Care and Health Literacy of Caregivers in the Emergency Department","The Relationship Between Caregiver Burden and Health Literacy Among Caregivers of Patients With Chronic Diseases Presenting to the Emergency Department","The patient having visited the Yalova Training and Research Hospital Emergency Department.\n\nBeing at least 18 years of age. Being cognitively capable of answering the data collection tools (scales\u002Fquestionnaires).\n\nVolunteering to participate in the study and providing informed consent.\n\nExclusion Criteria:\n\nRefusal to participate in the research voluntarily. Not being the primary caregiver for the patient. Inability to communicate or complete the scales due to cognitive or language barriers.\n\n\\-",{"count":84,"type":23},350,"OBSERVATIONAL","This study aims to investigate the relationship between caregiver burden and health literacy among primary caregivers of patients with chronic diseases presenting to the emergency department. The study will be conducted in the Emergency Department of Yalova Training and Research Hospital and will include at least 300 caregivers. Data will be collected using a sociodemographic questionnaire, the Turkish Health Literacy Scale-32 (THLS-32), and the Zarit Burden Interview (ZBI). The findings are expected to contribute to a better understanding of caregivers' needs and to clarify the role of health literacy in caregiver burden among those providing care for individuals with chronic illnesses.",[34,88,89,90],"Health Literacy","Chronic Disease","Emergency Service Utilization",[34,88,92,93],"Family Caregivers","Emergency Service","2026-06-18",{"date":68,"type":43},{"date":97,"type":23},"2026-07-01",{"date":99,"type":23},"2027-05-31",{"name":101,"class":50},"University of Yalova",{"id":103,"slug":104,"hasResults":12,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":12,"sex":18,"minAge":110,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":24,"phases":113,"briefSummary":114,"conditions":115,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":123,"leadSponsor":125,"locationsCount":51},"100628402","penn-state-emergency-medicine-cares-care-partner-evaluation-and-sourcing-in-the-emergency-department-100628402","NCT07461168","Penn State Emergency Medicine CarES: Care-partner Evaluation and Sourcing in the Emergency Department","Penn State Emergency Medicine CarES: Care-partner Evaluation and Sourcing in the ED","CarES","Inclusion Criteria:\n\n* Person completed the CarES Observational Study.\n* Person is a care partner and:\n* Lives with the person living with dementia or\n* Checks on them at least once per week in person or by phone\n* Person is willing and able to participate in study assessments\n\nExclusion Criteria:\n\n* Person is no longer a care partner for a person living with dementia\n* Person declines participation","60 Years",{"count":112,"type":23},20,[26],"Care partners of people living with dementia often experience ongoing stress and unmet support needs. This study evaluates the feasibility of a low-intensity, supportive education and resource intervention for care partners who previously participated in an observational study.\n\nParticipants complete a baseline phone interview and a short stress journaling activity, followed by a six-week series of automated educational and supportive messages delivered by text message or email. Participants may also take part in an optional peer support focus group. The study examines caregiver stress, resilience, engagement with resources, and participant feedback to inform future caregiver support interventions.",[116,117,34,118],"Dementia","Caregiver Stress","Caregiver Burden of People With Dementia","2026-06-12",{"date":121,"type":43},"2026-06-15",{"date":97,"type":23},{"date":124,"type":23},"2026-12-30",{"name":126,"class":50},"Milton S. Hershey Medical Center",{"id":128,"slug":129,"hasResults":12,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":133,"eligibilityCriteria":134,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":135,"targetDuration":4,"studyType":24,"phases":137,"briefSummary":138,"conditions":139,"keywords":143,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":51},"100501644","the-snap-tool-for-head-and-neck-cancer-survivor-caregiver-dyads-100501644","NCT05811936","The SNAP Tool for Head and Neck Cancer Survivor-Caregiver Dyads","A Randomized Controlled Trial to Evaluate the Survivorship Needs Assessment Planning (SNAP) Tool for Head and Neck Cancer Survivor-Caregiver Dyads","SNAP","Patient Inclusion Criteria:\n\n1. Age \\>18\n2. Stage I-IV non-metastatic HNC (i.e., lip\u002Foral cavity, nasopharynx, salivary gland, oropharynx, hypopharynx, paranasal sinus, larynx and cutaneous cancers)\n3. Currently receiving radiation treatment (with\u002Fwithout surgery and\u002For concurrent chemotherapy) with curative intent\n4. Able to nominate caregiver, the primary support person, also interested in participating\n\nCaregiver Inclusion Criteria:\n\n1. Age \\>18\n2. Provide care for a loved one with stage I-IV HNC\n3. Agrees to participate after being nominated\n\nPatient Exclusion Criteria:\n\n1. Patients who do not read\u002Funderstand English\n2. Patients who are cognitively impaired and cannot complete interviews as judged by the referring health care provider\n3. Patients concurrently diagnosed with and\u002For receiving treatment for a second \"significant\" primary cancer, except the following:\n\n   * Excised and cured non-melanoma skin cancer\n   * Carcinoma in situ of breast or cervix\n   * Superficial bladder cancer\n   * Stage 1 differentiated thyroid cancer that is resected or observed\n   * pT1a\u002FpT1b prostate cancer comprising \\\u003C5% of resected tissue with normal prostate specific antigen (PSA) since resection\n   * cT1a\u002FcT1b prostate cancer treated with brachytherapy\n\nCaregiver Exclusion Criteria:\n\n1. Inability to read or understand English\n2. Cognitively impaired and cannot complete interviews, as judged by the referring health care provider",{"count":136,"type":23},352,[26],"In this randomized behavioral intervention, head and neck cancer (HNC) survivors and their caregivers (N=176 HNC survivor-caregiver dyads) will be randomized to either Survivorship Needs Assessment Planning (SNAP) or Usual Care (UC) groups to examine the effects of SNAP on outcomes. SNAP includes two sessions with a needs assessment and tailored care plan and a supportive mobile app after completion of radiation to promote uptake of recommended medical and supportive care. The study aims to evaluate the effects of SNAP on symptom severity in patients and caregiver burden in caregivers. Secondary outcomes include psychological distress (anxiety and depression), healthcare utilization (receipt of recommended care) and unmet needs and self-efficacy in HNC survivor-caregiver dyads. Participants will complete surveys at baseline, 6 months, and 9 months post randomization with validated PROMs, and receive intervention modules at the end of radiation and month 3. Participants in the SNAP group will also receive mobile app support.",[140,141,34,142],"Head and Neck Cancer","Survivorship","Head and Neck Neoplasms",[140,141],"RECRUITING","2026-06-09",{"date":147,"type":43},"2026-06-11",{"date":149,"type":43},"2023-08-23",{"date":151,"type":23},"2027-12-31",{"name":153,"class":50},"Medical University of South Carolina",{"id":155,"slug":156,"hasResults":12,"nctId":157,"briefTitle":158,"officialTitle":159,"acronym":160,"eligibilityCriteria":161,"healthyVolunteers":17,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":162,"targetDuration":4,"studyType":24,"phases":164,"briefSummary":165,"conditions":166,"keywords":170,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":175,"completionDateStruct":176,"leadSponsor":178,"locationsCount":180},"100596131","psychoeducation-program-for-family-caregivers-coordinated-by-an-aprn-100596131","NCT07041463","Psychoeducation Program for Family Caregivers Coordinated by an APRN","Impact of a New Psychoeducation Program Coordinated by an Advanced Practce Nurse on the Burden of Family Caregivers of Patients With a First Pyschotic Episode.","APIPEP","Inclusion Criteria:\n\n* Caregiver relative of a patient under the care of the FEP team and meeting the criteria of international recommendations of FEP diagnosis made by the specialized team of less than 6 months, between 18 and 35 years of age.\n* Caregiver having received information about the study and having giveń consent.\n* Caregiver covered by a health insurance plan\n\nExclusion Criteria:\n\n* Caregiver under curatorship, guardianship, safeguard of justice, family habilitation or future protection mandate\n* Caregiver participating in another study that may interact with this one\n* Caregiver not fluent in French (comprehension\u002Freading)\n* Caregiver who has already received psycho-education on FEP\n* Patient's opposition to caregiver's participation in research",{"count":163,"type":23},180,[26],"The aim of this study is to assess the impact of implementing a specific family program coordinated by APRNs, covering the 5 levels of the family care pyramid through a consultation, an individual psychoeducation program and a group psychoeducation program, on improving caregiver burden and thus contributing to the recovery of users suffering from FEP.\n\nDetailed Description: Psychotic disorders are among the most disabling chronic pathologies in psychiatry. These disorders modify the individual's perceptions, thoughts, moods, behaviours and day-to-day functioning (Implementing interventions as early as possible in the first psychotic episode (FEP) would be likely to decrease the severity and consequences of the illness and improve prospects for recovery. Evidence supports the establishment of multidisciplinary teams to detect early and treat early those experiencing FEP and those at increased risk of psychosis. Recommended interventions include cognitive-behavioral therapies, family interventions, employment and educational support, and above all, at the heart of the system, case management. These specialized teams need to be multidisciplinary, bringing together psychiatrists, psychologists and social workers in addition to case managers. More recently in France, Advanced practice nurse (APRN) have joined these teams. But getting young people to accept both disorders and care is a difficult necessity, and remains a major challenge. Poor compliance with treatment is said to be one of the primary causes of relapse after FEP. Factors that increase the risk of relapse include initially more severe symptoms, persistent substance abuse, poor adherence to treatment and inadequate support from family and friends. Nowadays, support from a close caregiver for a person living with a psychic disorder is recognized as a very favorable factor for long-term prognosis. But the occurrence of a FEP often has the effect of a tidal wave for loved ones, who present high levels of psychological distress and feelings of burden. Unfortunately, it is still difficult for families to gain access to family caregiver support services, which are still insufficiently available and often unknown to them. A number of barriers stand in the way of systematically proposing family interventions, such as health professionals' lack of awareness of the effectiveness of interventions aimed at family carers, their difficulty in establishing a double therapeutic alliance with the young person and his or her family, or the misperception that family interventions are in contradiction with professional secrecy.\n\nThe pyramid of family care in early intervention presents the family support that should be available to families of young people with FEP. The levels of intervention are designed to meet the support needs of family caregivers and can be used flexibly depending on specific needs or the phase of the psychotic episode. Also, APRNs could contribute to the success of these caregiver support programs thanks to their skills in prevention, assessment and coordination of complex pathways. This study therefore aims to determine the extent to which a specific program coordinated by APRNs can influence the burden of a family caregiver of a young person suffering from FEP.",[167,34,168,169],"First Episode Psychosis (FEP)","Nurse Practitioners","IMPACT OF A NEW PSYCHOEDUCATION PROGRAM COORDINATED BY AN ADVANCED PRACTICE NURSE ON THE BURDEN OF FAMILY CAREGIVERS OF PATIENTS WITH A FIRST PSYCHOTIC EPISODE",[167,171,172],"Caregiver burden","Advanced Practice Nurse","2026-06-05",{"date":145,"type":43},{"date":173,"type":43},{"date":177,"type":23},"2030-11-04",{"name":179,"class":50},"Hôpital le Vinatier",5,{"id":182,"slug":183,"hasResults":12,"nctId":184,"briefTitle":185,"officialTitle":186,"acronym":187,"eligibilityCriteria":188,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":189,"targetDuration":4,"studyType":24,"phases":191,"briefSummary":192,"conditions":193,"keywords":196,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":51},"100643619","nurse-led-caregiver-support-program-in-home-palliative-care-100643619","NCT07593729","Nurse-Led Caregiver Support Program in Home Palliative Care","Effect of a Nurse-Led Caregiver Support Program on Caregiver Competency and Healthcare Utilization Among Family Caregivers in Home Palliative Care: A Randomized Controlled Trial","CARE-PAL","Inclusion Criteria:\n\n* Adult family caregivers of patients receiving home palliative care services\n* Age 18 years or older\n* Being the primary caregiver responsible for the patient's daily care\n* Ability to communicate in Turkish\n* Willingness to participate in the study\n\nExclusion Criteria:\n\n* Professional or paid caregivers\n* Caregivers with severe cognitive impairment or severe psychiatric disorders\n* Inability to participate in follow-up assessments",{"count":190,"type":23},150,[26],"This randomized controlled trial aims to evaluate the effect of a nurse-led caregiver support program on caregiver competency and healthcare utilization among family caregivers of patients receiving home palliative care. Family caregivers in the intervention group will receive a structured 6-week nurse-led support program including face-to-face education, weekly telephone coaching, caregiver guidance materials, and decision support for symptom management and healthcare utilization. The control group will continue to receive routine home palliative care services. Primary outcome is caregiver competency. Secondary outcomes include caregiver burden, self-efficacy, patient symptom burden, emergency department visits, and hospitalizations.",[194,34,195],"Palliative Care","Home Care",[197,198,199,200,201,202,203],"Nurse-led intervention","Family caregiver","Caregiver competency","Home care","Randomized controlled trial","Palliative care","Healthcare utilization","2026-06-04",{"date":206,"type":43},"2026-06-08",{"date":208,"type":23},"2026-05-12",{"date":210,"type":23},"2026-09-30",{"name":212,"class":50},"Kutahya Health Sciences University",{"id":214,"slug":215,"hasResults":12,"nctId":216,"briefTitle":217,"officialTitle":218,"acronym":219,"eligibilityCriteria":220,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":221,"targetDuration":4,"studyType":24,"phases":223,"briefSummary":224,"conditions":225,"keywords":229,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":246,"completionDateStruct":248,"leadSponsor":250,"locationsCount":51},"100643231","vocale-lbd-online-peer-support-for-caregivers-of-people-with-lewy-body-dementia-100643231","NCT07637097","VOCALE LBD: Online Peer Support for Caregivers of People With Lewy Body Dementia","Reducing Depression in Family Caregivers of Persons Living With Lewy Body Dementia Through Tailored Asynchronous Online Intervention.","VOCALE LBD","Inclusion Criteria:\n\n* Current family member or informal (unpaid) caregiver of a person with a confirmed diagnosis of Lewy Body Dementia (LBD) or LBD mixed pathology\n* Experiences depressive symptoms as defined by a score of 5 or higher on the Patient Health Questionnaire-9 (PHQ-9)\n* Able to read, write, and speak English\n* Has access to a device (computer, tablet, or smartphone) that can connect to the internet and be used for videoconferencing or phone calls, OR is interested in using a loaner device\n\nExclusion Criteria:\n\n* Active suicidal ideation as indicated by endorsement of PHQ-9 Item 9 (thoughts that you would be better off dead, or thoughts of hurting yourself)\n* Paid or professional caregiver (must be unpaid family\u002Finformal caregiver)\n* Unable to read, write, or speak English",{"count":222,"type":23},220,[26],"This study tests whether a tailored, fully asynchronous online group intervention (VOCALE LBD) reduces depression in family caregivers of people with Lewy Body Dementia (LBD), compared to standard educational materials. LBD is the second most common form of degenerative dementia and causes distinct challenges, including visual hallucinations, REM sleep disorder, and severe motor symptoms, that are not addressed by generic caregiver interventions. Depression rates in LBD caregivers reach 40-50%, double the rate seen in Alzheimer's disease caregivers, yet no rigorous digital interventions exist specifically for this population. VOCALE LBD is a text-based, low-bandwidth platform (Discourse) that brings groups of 10-15 caregivers together in an 8-week moderated online community. Weekly topics address LBD-specific challenges (sleep problems, hallucinations, self-care) and problem-solving skills using the ADAPT method. A pilot study (n=54) showed strong effects on depressive symptoms (Cohen's d=0.54 at 1-month follow-up), near-perfect engagement, and high participant satisfaction. This RCT (N=220) will test efficacy, examine mechanisms of action (self-efficacy and problem-solving), and explore analytics approaches for pragmatic monitoring, laying groundwork for future implementation in clinics and community organizations.",[226,227,34,228],"Lewy Bodies Disease","Depression Disorder","Caregivers",[230,231,232,233,234,235,236,237,238,239,240,241,242,243],"Lewy body disease","LBD","Family caregivers","Caregiver Depression","Online Intervention","Asynchronous","Digital Health","Peer Support","Problem-solving therapy","VOCALE","Telehealth","Dementia caregiver","ADAPT method","Discourse Platform","2026-06-03",{"date":145,"type":43},{"date":247,"type":23},"2026-12-01",{"date":249,"type":23},"2030-11-30",{"name":251,"class":50},"University of Washington",{"id":253,"slug":254,"hasResults":12,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":258,"eligibilityCriteria":259,"healthyVolunteers":17,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":260,"targetDuration":4,"studyType":24,"phases":262,"briefSummary":263,"conditions":264,"keywords":267,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":274,"completionDateStruct":276,"leadSponsor":278,"locationsCount":51},"100640320","tiva-mobile-health-intervention-for-family-caregivers-100640320","NCT07616284","TIVA Mobile Health Intervention for Family Caregivers","A Mobile Health Intervention for the Promotion of Mental Health in Family Caregivers: Protocol for a Pilot Study","TIVA-Pilot","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Unpaid family caregivers of a person with chronic illness, disability, or dependency.\n* Providing regular caregiving assistance for at least 4 months.\n* Living in Portugal.\n* Ability to read and understand Portuguese.\n* Ownership and use of a smartphone with internet access compatible with the TIVA mobile application.\n* Willingness to install and use the TIVA app for 4 weeks.\n* Ability to provide informed consent.\n\nExclusion Criteria:\n\n* Severe cognitive impairment.\n* difficulties preventing independent use of the application or completion of study assessments.\n* Severe psychiatric disorder or acute mental health crisis interfering with participation.\n* Participation in another structured caregiver support or psychological intervention during the study period.\n* Inability to use a smartphone independently.",{"count":261,"type":23},80,[26],"This pilot study aims to evaluate the feasibility, usability, and preliminary effects of the TIVA mobile health intervention in promoting positive mental health among family caregivers of older adults. TIVA is a culturally adapted mobile application based on Lluch's Positive Mental Health model and designed to support caregivers through daily activities, motivational messages, relaxation strategies, and psychoeducational content over a four-week intervention period.\n\nA pilot randomized controlled study with parallel allocation will be conducted involving family caregivers recruited in community and primary healthcare settings in Portugal. Participants will be allocated either to the TIVA intervention group or to a usual care control group. Outcomes will include positive mental health, caregiver burden, usability, satisfaction, adherence, and acceptability. Data will be collected at baseline, post-intervention, and follow-up.\n\nThis study intends to contribute to the development of accessible digital mental health strategies to support family caregivers and promote healthy ageing.",[265,92,266,34],"Positive Mental Health","Mental Health Promotion",[268,92,265,269,266,270,34],"TIVA mHealth","Older Adults","Mobile Application","2026-05-29",{"date":273,"type":43},"2026-06-01",{"date":275,"type":23},"2026-09",{"date":277,"type":23},"2027-04",{"name":279,"class":50},"Universidade do Porto",{"id":281,"slug":282,"hasResults":12,"nctId":283,"briefTitle":284,"officialTitle":285,"acronym":4,"eligibilityCriteria":286,"healthyVolunteers":17,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":287,"targetDuration":4,"studyType":24,"phases":289,"briefSummary":290,"conditions":291,"keywords":294,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":305,"locationsCount":307},"100539722","a-study-of-meaning-centered-psychotherapy-for-caregivers-to-people-with-cancer-100539722","NCT06307535","A Study of Meaning-Centered Psychotherapy for Caregivers to People With Cancer","Meaning-Centered Psychotherapy to Meet Palliative Care Needs of Cancer Caregivers","Inclusion Criteria:\n\n* Age 18 or over;\n* As per self-report, a current caregiver to a patient with Stage III or IV solid tumor cancer currently receiving medical care of any kind (e.g., curative, palliative);\n* Experiences distress as evidenced by a score of 4 or greater on the Distress Thermometer (DT) and an indication that this distress is associated with caregiving;\n* As per self-report, can read and understand English;\n* As per self-report, residing in New York, New Jersey, Connecticut, or Florida, or have the ability to complete sessions while complying with current telehealth regulations.\n\nExclusion Criteria:\n\n* Participant does not have a reasonable understanding of the study activities by the judgment of the consenting professional;\n* Engagement in regular individual psychotherapeutic support that the participant is unable or unwilling to put on hold for the course of treatment.",{"count":288,"type":23},200,[26],"Participants will complete 1 set of questionnaires about 2 weeks before beginning their Meaning-Centered Psychotherapy for Caregivers\u002FMCP-C or standard Supportive Psychotherapy for Caregivers\u002FSP-C sessions. These questionnaires will ask about participants' sense of meaning and purpose in life, spiritual well-being, depression and\u002For anxiety, and social support. Participants will then be assigned to receive either MCP-C or SP-C for 7 sessions. Participants will complete additional sets of questionnaires about 2 weeks, 6 months, and 12 months after their last session of MCP-C or SP-C. It will take between 35 and 50 minutes to complete each set of questionnaires.\n\nAfter participants complete the MCP-C or SP-C sessions and all 4 sets of questionnaires, their participation in this study will end. If participants decide not to complete all 7 sessions, they may still choose to complete the questionnaires.\n\nParticipants may remain in the study and continue to receive all 7 sessions of MCP-C or SP-C even if their loved one passes away.",[34,292,293],"Caregiver Burnout","Caregiver Stress Syndrome",[295,293,34,292,296,297],"Caregiver","Meaning-Centered Psychotherapy","23-376","2026-05-21",{"date":300,"type":43},"2026-05-26",{"date":302,"type":43},"2024-03-13",{"date":304,"type":23},"2029-03-01",{"name":306,"class":50},"Icahn School of Medicine at Mount Sinai",8,{"id":309,"slug":310,"hasResults":12,"nctId":311,"briefTitle":312,"officialTitle":312,"acronym":313,"eligibilityCriteria":314,"healthyVolunteers":17,"sex":18,"minAge":315,"maxAge":4,"enrollmentInfo":316,"targetDuration":4,"studyType":24,"phases":318,"briefSummary":319,"conditions":320,"keywords":322,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":327,"lastUpdatePostDateStruct":328,"startDateStruct":330,"completionDateStruct":332,"leadSponsor":334,"locationsCount":51},"100456159","caregiver-stress-and-sleep-study-100456159","NCT05219955","Caregiver Stress and Sleep Study","CARES","Inclusion Criteria:\n\n* Age 55 years or older.\n* Provide at least 15 hours\u002Fweek of unpaid care to a patient with a dementia diagnosis.\n* Reporting stress or strain delivering care\n* No or stable pharmacotherapy for depression\n* Meets screening definition for having morning activation difficulty or a definite morning type per the Composite Morningness Questionnaire (CMQ)\n\nExclusion Criteria:\n\n* Unsafe or unable to undergo MRI\n* Active Cognitive Behavioral Therapy for mood or insomnia\n* Probable dementia diagnosis\n* Deadly illness or plans to leave the study area\n* Current active substance use disorder","55 Years",{"count":317,"type":23},120,[26],"The purpose of this research study is to better understand how stress, sleep and activity might impact caregivers' mood and brain health. This study includes a randomized experimental component where therapists will systematically deliver one of two evidence-based talk-therapy treatments. The aim is to evaluate effects on meaningful health-relevant measures including morning activation levels, depression symptoms, rumination, and aspects brain connectivity previously linked with depression. Participants will complete surveys about their caregiving experiences, health, and mood, undergo an MRI, and wear an actigraphy watch that measures activity levels throughout the day and when sleeping.",[321,34],"Depressive Symptoms",[323,324,325,326],"Depression","Caregiving","Late-Life","Morningness","2026-05-15",{"date":329,"type":43},"2026-05-19",{"date":331,"type":43},"2022-07-15",{"date":333,"type":23},"2027-06-30",{"name":335,"class":50},"University of Pittsburgh",{"id":337,"slug":338,"hasResults":12,"nctId":339,"briefTitle":340,"officialTitle":341,"acronym":342,"eligibilityCriteria":343,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":344,"enrollmentInfo":345,"targetDuration":4,"studyType":24,"phases":347,"briefSummary":348,"conditions":349,"keywords":352,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":358,"lastUpdatePostDateStruct":359,"startDateStruct":361,"completionDateStruct":362,"leadSponsor":364,"locationsCount":4},"100609916","improving-self-care-of-caregivers-of-adults-in-homecare-with-heart-failure-and-cognitive-impairment-100609916","NCT07220798","Improving Self-Care of Caregivers of Adults in Homecare With Heart Failure and Cognitive Impairment","Improving Self-Care of Caregivers of Adults in Homecare With Heart Failure and Cognitive Impairment (iCare4Me Homecare)","iCare4Me HC","Inclusion Criteria:\n\n* Patient Inclusion Criteria\n\n  1. Older adults (=\\>50 years of age)\n  2. Enrolled in Home Health Care\n  3. Documented to have HF\n  4. Mild to moderate CI on the BIMS or OASIS items\n  5. Able to provide informed consent\n  6. Able to provide self-report data\n* Caregiver Inclusion Criteria\n\n  1. Adults (=\\>18 years of age)\n  2. Spouse\u002Fpartner or child living with or in close proximity to the patient\n  3. Caregiver of a home care patient who is currently receiving or recently received services and who has mild to severe cognitive impairment\n  4. Reporting poor self-care on screening (Health Self-Care Neglect scale score =\\>2)\n  5. Reporting poor mental health on screening (screened with the PROMIS Global Mental Health 4a score \\\u003C12)\n  6. Caregiving or supporting the patient at least 8 hours\u002Fweek\n  7. Able to complete the protocol, e.g., adequate vision and hearing, English speaking.\n  8. Able to provide informed consent\n  9. Able to use technology\n\nExclusion Criteria:\n\n* Patient Exclusion Criteria\n\n  1. Dementia (ICD-10 code for dementia)\n  2. Enrolled in hospice\n  3. Non-English speaking\n* Caregiver Exclusion Criteria 1. Non-English speaking","101 Years",{"count":346,"type":23},316,[26],"This RCT design will enroll 256 informal caregivers (spouse\u002Fpartner or child) of HHC patients with HF\u002FCI and 60 patients with HF and mild to moderate CI (60 dyads). After collecting baseline data, we will block randomize the caregivers 1:1 to the ViCCY intervention or comparator group, stratifying randomization by caregiver sex (male\u002Ffemale), relationship (spouse\u002Fpartner or child), and race (white\u002Fother)- factors known to influence caregiving burden, perceived stress, and receptivity to the intervention. We will encourage caregivers to use their own devices but provide tablet devices with wireless network access if needed. The intervention group will receive 10 sessions of ViCCY over 6 months.",[350,351,34],"Heart Failure","Cognitive Impairment",[353,354,38,355,356,357],"heart failure","cognitive impairment","caregiver stress","self-care","dyads","2026-05-06",{"date":360,"type":43},"2026-05-08",{"date":121,"type":23},{"date":363,"type":23},"2029-09-15",{"name":365,"class":50},"Visiting Nurse Service of New York",{"id":367,"slug":368,"hasResults":12,"nctId":369,"briefTitle":370,"officialTitle":371,"acronym":4,"eligibilityCriteria":372,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":373,"targetDuration":4,"studyType":24,"phases":375,"briefSummary":376,"conditions":377,"keywords":384,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":358,"lastUpdatePostDateStruct":388,"startDateStruct":390,"completionDateStruct":392,"leadSponsor":394,"locationsCount":51},"100605888","ai-based-personalized-health-and-self-care-100605888","NCT07168382","AI-Based Personalized Health and Self-Care","AI-Based Personalized Health and Self-Care: Investigating A Mobile Virtual Assistant to Address Health-Related Social Needs","Inclusion Criteria (Caregivers):\n\n* Must be a caregiver of a child seen within the NCH primary care network who self-identifies with at least one unmet social need\n* Must be 18 years of age or older\n* Must be English-speaking\n* Must have a device that connects to the internet\n\nInclusion Criteria (Primary Care Providers and Support Team Members):\n\n* Must be 18 years or older\n* Must be employed at Nationwide Children's Hospital\n\nExclusion Criteria:\n\n\\- Due to the intervention only being translated into English, non-English Speakers will be excluded from this study.",{"count":374,"type":23},70,[26],"The goal of this clinical trial is to learn if the DAPHNE chatbot can improve caregiver engagement, usability, and integration of social care support tools into clinical workflows in caregivers of pediatric patients receiving care at the Nationwide Children's Hospital Primary Care Center (NCH PCC). This is a pilot randomized clinical trial.\n\nThe main questions it aims to answer are:\n\n* Is the DAPHNE chatbot usable, acceptable, and minimally burdensome for caregivers over a 6-month period?\n* Can the DAPHNE chatbot be effectively integrated into primary care provider workflows?\n\nResearchers will compare the DAPHNE chatbot intervention arm to the standard of care control arm to see if the intervention improves caregiver-reported outcomes and provider workflow integration.\n\nParticipants that are patients will be randomly assigned to either the DAPHNE chatbot group or the standard of care group. Complete surveys assessing usability, acceptability, and burden and participate in brief qualitative interviews to share feedback on their experience.\n\nParticipants that are Primary Care providers will discuss integration of DAPHNE into clinical workflows and complete workflow integration assessments.",[378,379,380,381,34,382,383],"Social Needs Status","Unmet Health-Related Social Needs and Access to Community Resources","Primary Health Care and Access to Primary Care","Technology Use to Support Caregivers","Health Status, Child and Infant Care","Preventative Care Services",[385,386,387],"Social Needs","Chatbot","Community Resources",{"date":389,"type":43},"2026-05-11",{"date":391,"type":43},"2026-04-24",{"date":393,"type":23},"2028-08",{"name":395,"class":50},"Emre Sezgin",{"id":397,"slug":398,"hasResults":12,"nctId":399,"briefTitle":400,"officialTitle":401,"acronym":4,"eligibilityCriteria":402,"healthyVolunteers":17,"sex":18,"minAge":110,"maxAge":4,"enrollmentInfo":403,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":405,"conditions":406,"keywords":4,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":358,"lastUpdatePostDateStruct":410,"startDateStruct":411,"completionDateStruct":413,"leadSponsor":415,"locationsCount":51},"100568198","swallowing-impairments-in-adults-with-and-without-alzheimers-disease-100568198","NCT06678100","Swallowing Impairments in Adults With and Without Alzheimer's Disease","Prevalence and Care Partner Burden of Individuals With Alzheimer's Disease","Inclusion criteria for AD cohort:\n\n1. adult ≥60 years old\n2. diagnosis of AD by a neurologist (confirmed with imaging, spinal tap, behavioral testing)\n3. no prior history of other neurological diseases (aside from stroke which has resolved with no current symptoms)\n4. no prior history of respiratory diseases\n5. no prior history of head and neck surgery\u002Fhead and neck cancer\u002Fradiation to head and neck region\n6. consuming some form of oral intake\n7. able to follow basic directions\n8. able\u002Fwilling to provide consent\u002Fassent.\n\nExclusion Criteria for AD Cohort:\n\n1. individual \\\u003C60 years old\n2. Diagnosis of another type of dementia\n3. History of neurological\u002Frespiratory diseases\n4. History of head and neck surgery\u002Fhead and neck cancer\u002Fradiation to head and neck region\n5. not consuming any oral intake\n6. Unable to follow basic directions\n7. Unable to provide consent based on the University of California, San Diego Brief Assessment of Capacity to Consent (UBACC), score \\\u003C15 OR provide assent and a legal guardian\u002Fhealth care decision maker provides consent.\n\nInclusion criteria for care partners of individuals with AD will be:\n\n1. care partner of an individual with AD\n2. willing to complete questionnaires\u002Fparticipate in an interview.\n\nExclusion Criteria for Caregivers of Individuals with AD:\n\n1. not the primary caregiver of an individual with AD\n2. unwilling to complete questionnaires\u002Fsemi-structured interview\n\nInclusion criteria for community-dwelling adults will be:\n\n1. adult ≥60 years old\n2. no prior history of neurological diseases (aside from stroke which has resolved with no current symptoms)\n3. no prior history of respiratory diseases\n\n3\\) no prior history of head and neck surgery\u002Fhead and neck cancer\u002Fradiation to head and neck region 4) no prior history of swallowing difficulties based on participant report. 5) Score ≥25th percentile based on sex\u002Fage\u002Feducation\u002Frace on the Montreal Cognitive Assessment (MOCA)\n\nExclusion Criteria for Healthy Cohort:\n\n1. individual \\\u003C60 years old\n2. history of neurological disease\n3. history of respiratory disease\n4. history of head and neck surgery\u002Fhead and neck cancer\u002Fradiation to head and neck region\n5. history of swallowing difficulties\n6. Score \\\u003C25th percentile based on sex\u002Fage\u002Feducation\u002Frace on the Montreal Cognitive Assessment (MOCA)",{"count":404,"type":23},240,"This research study is investigating whether people with Alzheimer's disease (AD) experience more changes to swallowing than their healthy age-matched peers. The prevalence of swallowing impairments in moderate-severe AD is high (85-93%), yet little is known about how swallow function evolves throughout the disease course in people with AD. The overall objective of this study is to evaluate swallowing function in adults with and without Alzheimer's disease. The investigator will also be involving the primary caregivers of individuals with Alzheimer's that are enrolled in the study to better understand the impact of swallowing impairments on the primary caregivers of those with Alzheimer's Disease.\n\nHealthy adults and individuals with Alzheimer's disease will:\n\n* undergo tests of cough and swallow function\n* undergo tests of grip and tongue strength\n* complete questionnaires\n\nCaregivers of individuals with Alzheimer's disease will also complete questionnaires.",[407,34,408,409],"Alzheimer Disease","Healthy Aging","Dysphagia",{"date":360,"type":43},{"date":412,"type":43},"2025-04-21",{"date":414,"type":23},"2028-02",{"name":416,"class":50},"Vanderbilt University Medical Center",{"id":418,"slug":419,"hasResults":12,"nctId":420,"briefTitle":421,"officialTitle":422,"acronym":4,"eligibilityCriteria":423,"healthyVolunteers":17,"sex":18,"minAge":424,"maxAge":4,"enrollmentInfo":425,"targetDuration":4,"studyType":24,"phases":427,"briefSummary":428,"conditions":429,"keywords":4,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":440,"lastUpdatePostDateStruct":441,"startDateStruct":443,"completionDateStruct":445,"leadSponsor":447,"locationsCount":51},"100633559","act-group-for-family-caregivers-of-stroke-survivors-100633559","NCT07528261","ACT Group for Family Caregivers of Stroke Survivors","Effects of Acceptance and Commitment Therapy (ACT) Group for Family Caregivers of Stroke Survivors","Inclusion Criteria:\n\n* Age 40 or above.\n* Taking the primary responsibility for the care of a family member suffering from stroke (i.e. spending at least 70% of the time on performing caregiving tasks).\n* The stroke patient has been discharged from hospital and is currently living with the caregiver.\n* Having cared for the stroke patient for at least six months, including at least two months after discharge.\n* CSAQ score (as determied during pre-group screening meeting) indicates a high level of distress, as evidenced by one of the following: a) participant answered \"Yes\" to either or both questions 4 and 11; b) total \"Yes\" scores = 10 or more; c) score on question 17 is 6 or higher; d) score on question 18 is 6 or higher.\n* Able to use a computer and has internet access.\n* Able to provide informed consent to participate.\n\nExclusion Criteria:\n\n* is below 40 years old.\n* has any comorbid mental disorder or disability that may impede group participation (e.g., personality disorder, learning disability).\n* does not understand English (read, write, listen, and speak).\n* has current active suicidal\u002Fhomicidal ideation.\n* is currently receiving psychological intervention (individual or group).","40 Years",{"count":426,"type":23},30,[26],"The goal of this study is to evaluate the efficacy of group-based ACT intervention in improving the levels of psychological distress in caregivers of stroke survivors. The main questions it aims to answer are:\n\n1. Does group-based ACT intervention improve the levels of psychological distress and QoL in family caregivers of stroke survivors?\n2. Do the levels of psychological flexibility and experiential avoidance in family caregivers of stroke survivors mediate the outcome of the ACT Group?\n\nThe researcher will compare the experimental group (i.e., participants who received group-based ACT intervention) with the control group (i.e., participants who did not receive group-based ACT intervention) to assess whether the group-based ACT intervention is effective in mitigating caregiver stress and improving caregivers' QoL.\n\nParticipants in the experimental group will:\n\n1. Receive a 5-weekly, 1.5-hour group intervention based on the ACT Model;\n2. Complete study measures at pre-treatment, immediate post-treatment, and 2-month follow-up.\n\nParticipants in the control group will not receive the group intervention but will complete the same study measures.",[117,293,292,430,431,432,433,434,34,435,436,437,438,439],"Caregiver Distress","Caregiver Exhaustion","Caregiver Health Related QOL","Caregiver Burden for Those Who Care for Adults With Impaired Functional Status","Caregiver Quality of Life","Caregiver Mental Health","Caregiver Resilience and Stress","Caregiver Sense of Control Over Life","Caregiver Awareness","Caregiver Stress in Chronic Mental Illness","2026-04-29",{"date":442,"type":43},"2026-05-01",{"date":444,"type":43},"2025-09-01",{"date":446,"type":23},"2028-05-31",{"name":448,"class":50},"The Wright Institute",{"id":450,"slug":451,"hasResults":12,"nctId":452,"briefTitle":453,"officialTitle":454,"acronym":455,"eligibilityCriteria":456,"healthyVolunteers":17,"sex":18,"minAge":457,"maxAge":4,"enrollmentInfo":458,"targetDuration":4,"studyType":24,"phases":460,"briefSummary":461,"conditions":462,"keywords":466,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":475,"lastUpdatePostDateStruct":476,"startDateStruct":477,"completionDateStruct":479,"leadSponsor":481,"locationsCount":483},"100571599","palliative-care-education-in-assisted-living-for-dementia-care-providers-pceal-dcp-100571599","NCT06722352","Palliative Care Education in Assisted Living for Dementia Care Providers (PCEAL-DCP)","Preparing Assisted Living Staff to Provider Palliative Care to Residents With Dementia: Palliative Care Education in Assisted Living for Dementia Care Providers (PCEAL-DCP)","PCEAL-DCP","Inclusion Criteria:\n\nThe AL community eligibility criteria include a minimum of 40+ beds and provide memory care services to at least 35% of their residents, and access to hospice services from Lifepath or Suncoast Hospice. The AL size of 40+ beds is selected so we will be able to recruit a minimum of 14 residents per site, based on the power analysis for the sample size of 450 for the primary study outcome of documentation of ACP discussions.\n\nResidents are eligible if 1) they have a dementia diagnosis confirmed by the resident's physician (physician's signature required by University of South Florida (USF) Institutional Reiew Board (IRB) in prior clinical trial) regardless of dementia severity (mild, moderate, or severe), 2) if they have been admitted to the AL in the last month, and 3) if they have a legally responsible representative who understands English.\n\nStaff are eligible if they are currently employed with the participating study AL as a registered\u002Flicensed practical nurse, administrator, or dementia care coordinator of a memory care unit and English speaking and 21 years of age or older.\n\nFamily members are eligible if 1) they are listed as the legally responsible party in the chart records for the resident with ADRD, 2) they understand English, and 3) are at least 21 years of age or older. This could include someone related to the person, a close friend or a legal guardian who oversees the person's care and is responsible for decisions about their care.\n\nExclusion Criteria:\n\nAL sites will be ineligible if 1) the are not a licensed Florida assisted living facility; 2) they have previously participated in a PCEAL-DCP clinical trial (2018-2021) to avoid possible experimental contamination effects, and 3) if no staff employed at the AL are willing to participate in the study.\n\nResidents are ineligible if they: 1) are currently receiving hospice services because residents who receive hospice are already engaged in ACP discussions upon admission; 2) if they are discharged from assisted living to another setting (nursing home or hospital) or are admitted to hospice or have died before baseline data is collected.\n\nStaff will be ineligible if they are not licensed nurses, administrators or dementia care coordinators of a dementia care unit or terminated\u002Fresign before baseline data is collected.\n\nFamily are ineligible if: 1) they are under 21 years of age and do not understand spoken or written English and if there is already a legal authorized representative for a resident participating in the study (one family member per resident).\n\n\\-","21 Years",{"count":459,"type":23},792,[26],"The palliative care education in assisted living for dementia care providers (PCEAL-DCP) is a 4-week intervention (once a week for 1.5 hours, a total of 6 hours) for licensed nurses, administrators and dementia care coordinators to improve quality of dementia care outcomes",[407,463,34,292,464,465],"End of Life","Patient Participation","Self Efficacy",[467,468,469,470,471,472,473,474],"end of life","palliative care","education","staff training","assisted living","dementia","dementia care","Alzheimer's","2026-04-27",{"date":440,"type":43},{"date":478,"type":43},"2025-01-28",{"date":480,"type":23},"2029-08-01",{"name":482,"class":50},"University of South Florida",2,{"id":485,"slug":486,"hasResults":12,"nctId":487,"briefTitle":488,"officialTitle":488,"acronym":489,"eligibilityCriteria":490,"healthyVolunteers":17,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":491,"targetDuration":4,"studyType":24,"phases":492,"briefSummary":493,"conditions":494,"keywords":496,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":501,"lastUpdatePostDateStruct":502,"startDateStruct":503,"completionDateStruct":505,"leadSponsor":507,"locationsCount":51},"100566455","efficacy-and-sustainability-of-a-carepartner-integrated-telerehabilitation-program-for-persons-with-stroke-100566455","NCT06655402","Efficacy and Sustainability of a Carepartner-Integrated Telerehabilitation Program for Persons With Stroke","CARE-CITE","CarePartners (CP):\n\nInclusion Criteria:\n\n* Must be at least18 years old,\n* Able to read and write English,\n* Mini-mental test score greater than 24\n* Individuals who are a spouse\u002Fpartner or family member dwelling in the same household and self-identify as the primary caregiver of the SS.\n\nStroke Survivors (SS):\n\nInclusion Criteria:\n\n* Must be at least18 years old\n* More than 3 months and less than 2yrs post-ischemic or hemorrhagic event\n* Discharged home from the hospital with minimal to moderate UE deficits (can actively initiate 20 degrees of wrist and 10 degrees of finger extension)\n* Mini-mental test greater than 24\n* No physician determined medical problems that would limit participation,\n* Must have CP living in the home\n\nExclusion Criteria for CP and SS:\n\n* Significant cognitive deficits",{"count":222,"type":23},[26],"Stroke is a leading cause of long-term disability. Research has placed little emphasis on integrating care partners (CP) (family members) into the rehabilitation process without increasing negative care partner outcomes. The research team has developed and implemented a novel, web-based care partner-focused intervention (CARE-CITE) designed to foster problem-solving and skill building while facilitating care partner engagement during stroke survivor (SS) upper extremity practice of daily activities in the home setting. By providing a family-focused approach to rehabilitation interventions, this project will help develop more effective treatments that improve CP and outcomes after stroke.",[495,34],"Stroke",[497,498,228,499,240,500],"Stroke Survivors","Carepartners","Post-Stroke Recovery","Rehabilitation","2026-04-23",{"date":440,"type":43},{"date":504,"type":43},"2025-03-25",{"date":506,"type":23},"2029-03",{"name":508,"class":50},"Emory University",{"id":510,"slug":511,"hasResults":12,"nctId":512,"briefTitle":513,"officialTitle":514,"acronym":515,"eligibilityCriteria":516,"healthyVolunteers":12,"sex":18,"minAge":517,"maxAge":4,"enrollmentInfo":518,"targetDuration":4,"studyType":24,"phases":520,"briefSummary":522,"conditions":523,"keywords":4,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":501,"lastUpdatePostDateStruct":530,"startDateStruct":531,"completionDateStruct":533,"leadSponsor":535,"locationsCount":537},"100507142","phase-2-lysergic-acid-diethylamide-lsd-in-palliative-care-100507142","NCT05883540","Lysergic Acid Diethylamide (LSD) in Palliative Care","Lysergic Acid Diethylamide (LSD) in Palliative Care: a Randomised, Double-blind, Active-placebo Controlled Phase II Study (LPC-Study)","LPC","Inclusion Criteria:\n\n* Age ≥ 22 years.\n* Advanced or End-stage fatal disease of any cause with a life expectancy ≥ 12 weeks and ≤ 2 years\n* Sufficient understanding of the study procedures and risks associated with the study.\n* Participants must be willing to adhere to the study procedures and sign the consent form.\n* Participants must be willing not to drive a traffic vehicle or to operate machines within 24 h after LSD administration.\n* Participants must complete an actual \"Emergency Medical Directive\"\n* Participants with central nervous system (CNS) involvement of cancer are eligible if the following apply:\n\n  * treated and stable CNS lesion(s) OR untreated but asymptomatic\u002Fstable lesions, defined as clinically and\u002For radiologically stable for ≥ 4 weeks before screening\n  * no seizures within ≥ 4 weeks; if on antiepileptic medication: stable dose ≥ 4 weeks and no relevant drug-drug interactions expected\n  * no requirement for high-dose corticosteroids, defined as ≤10 mg prednisone equivalent per day on a stable or decreasing dose\n  * no leptomeningeal metastases\n  * no concomitant therapeutic anticoagulation\n\nExclusion Criteria:\n\n* Life expectancy \\< 12 weeks\n* Known hypersensitivity to LSD\n* Requiring ongoing concomitant therapy with a psychoactive prescription drug which might interfere with the study drug, and unable or unwilling to comply with the washout period.\n* Current use of a potent drug CYP2D6 inhibitor\n* Women who are pregnant or nursing or intend to become pregnant during the course of the study.\n* Somatic disorders including CNS involvement of cancer, untreated epilepsy with a history of generalized grand-mal seizures, history of delirium, end-stage heart failure (NYHA IV), untreated hypertension or insufficiently treated hypertension, angina pectoris, severe liver disease or severely impaired renal function, or other that in the judgement of the investigators pose too great potential for side effects.\n* Inability to follow the procedures of the study, e.g., due to language problems, psychological disorders, dementia, etc. of the participant.\n* Participation in another study with an investigational drug within the 30 days preceding and during the present study\n* concomitant diagnosis of past or present psychotic disorder, first-degree relative with psychotic disorders\n* concomitant diagnosis of past or present bipolar disorder\n* current delirium\n* substance use disorder (within the last 2 months, except nicotine, opioids used for analgesia, and benzodiazepine treatment for anxiety).\n* Weight \\< 45 kg\n* Suicidal ideation with active intent or plan to act on suicidal thoughts as assessed by the treating investigator.\n* CNS involvement of cancer if\n\n  * CNS disease is unstable or high-risk, including clinically and\u002For radiologically progressive lesions, signs of raised intracranial pressure, radiologically uncontrolled edema, need for escalating corticosteroid doses, or any neurological condition judged to pose too excessive risk.\n  * CNS-directed therapy (surgery and\u002For radiation) within ≤ 4 weeks","22 Years",{"count":519,"type":23},60,[521],"PHASE2","Background: Terminally ill patients often experience significant psychosocial distress having depressed mood, death anxiety, pain, and an overall poor quality of life. Recent evidence from pilot studies suggests that serotonergic hallucinogens including lysergic acid diethylamide (LSD) and psilocybin produce significant and sustained reductions of depressive symptoms and anxiety, along with increases in quality of life, and life meaning in patients suffering from life-threatening diseases. Additionally, serotonergic hallucinogens may produce antinociceptive effects.\n\nObjective and Design: The study aims to evaluate effects of LSD on psychosocial distress in 60 patients suffering from an advanced or end-stage fatal disease with a life expectancy ≥12wks and ≤2yrs in an active placebo-controlled double-blind parallel study. Patients will be allocated in a 2:1 ratio to one of the two intervention arms receiving either two moderate to high doses of LSD (100 µg and 100 µg or 100 µg and 200 µg) as intervention and two low doses of LSD (25 µg and 25 µg) as active-placebo control.",[194,524,525,323,526,527,66,34,528,529],"Pain","Anxiety","Demoralization","Psychological Distress","Fear of Death","Existential Distress",{"date":440,"type":43},{"date":532,"type":43},"2024-06-09",{"date":534,"type":23},"2028-05",{"name":536,"class":50},"University Hospital, Basel, Switzerland",4,{"id":539,"slug":540,"hasResults":12,"nctId":541,"briefTitle":542,"officialTitle":543,"acronym":544,"eligibilityCriteria":545,"healthyVolunteers":12,"sex":18,"minAge":457,"maxAge":546,"enrollmentInfo":547,"targetDuration":4,"studyType":24,"phases":549,"briefSummary":550,"conditions":551,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":552,"lastUpdatePostDateStruct":553,"startDateStruct":555,"completionDateStruct":556,"leadSponsor":558,"locationsCount":4},"100634412","wellness-enhancement-for-caregivers-100634412","NCT07539350","Wellness Enhancement for Caregivers","WECARE: A Personalized Intervention for Underserved Chinese American Dementia Caregivers","WECARE","Inclusion Criteria:\n\n1. currently residing in the United States,\n2. self-identify as Chinese or Chinese American and are able to read in Chinese,\n3. are 21 years of age or older,\n4. own a cellphone and use WeChat, and\n5. provide at least 8 hours of care per week to a family member or loved one with ADRD.\n\nExclusion Criteria:\n\n(1) evidence of severe cognitive impairment or mental disorders, or (2) the care recipient was receiving hospice care or had a life expectancy of fewer than six months.","100 Years",{"count":548,"type":23},160,[26],"The purpose of this study is to test WECARE, a seven-week multimedia intervention designed to reduce psychosocial distress and provide education and support for caregivers. This study will include Chinese American family caregivers of persons living with Alzheimer's disease and related dementias. Participants will engage with digital learning materials and supportive resources over the course of the program. The goal is to determine whether this approach improves caregiver well-being and reduces stress related to caregiving.",[34],"2026-04-13",{"date":554,"type":43},"2026-04-20",{"date":275,"type":23},{"date":557,"type":23},"2030-10",{"name":559,"class":50},"George Mason University",{"id":561,"slug":562,"hasResults":12,"nctId":563,"briefTitle":564,"officialTitle":565,"acronym":4,"eligibilityCriteria":566,"healthyVolunteers":12,"sex":18,"minAge":567,"maxAge":4,"enrollmentInfo":568,"targetDuration":4,"studyType":24,"phases":570,"briefSummary":571,"conditions":572,"keywords":573,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":579,"lastUpdatePostDateStruct":580,"startDateStruct":581,"completionDateStruct":583,"leadSponsor":585,"locationsCount":51},"100531353","effects-of-jing-si-herbal-tea-on-quality-of-life-and-sleep-in-dementia-and-their-caregivers-100531353","NCT06198699","Effects of Jing Si Herbal Tea on Quality of Life and Sleep in Dementia and Their Caregivers","Effects of Jing Si Herbal Tea on Quality of Life and Sleep Among Patients With Dementia and Their Caregivers: A Randomized Controlled Trial","For people with dementia:\n\nInclusion Criteria:\n\n* diagnosis of dementia\n* 50 years or older\n* with sufficient cognition to complete the questionnaires\n* can communicate using Mandarin or Taiwanese\n\nExclusion Criteria:\n\n* with renal function problems\n* not suitable for Jing Si Herbal Tea after evaluation from a psychiatrist\u002Fphysician\n* with the condition of change the commencement of guardianship (or commencement of assistance)\n\nFor caregivers:\n\nInclusion Criteria:\n\n* caregivers of people with dementia for more than half years\n* 20 years or older\n* with sufficient cognition to complete the questionnaires\n* can communicate using Mandarin or Taiwanese\n\nExclusion Criteria:\n\n* with renal function problems\n* not suitable for Jing Si Herbal Tea after evaluation from a psychiatrist\u002Fphysician\n* with the condition of change the commencement of guardianship (or commencement of assistance)","20 Years",{"count":569,"type":23},400,[26],"Jing Si Herbal Tea has been found to be effective in improving health for the conditions of cancers, aging, depression, and sleep. Such evidence has been shown in animal models and clinical research with publications in the international journals. However, empirical evidence regarding the effectiveness of Jing Si Herbal Tea for patients with dementia and their caregivers on their quality of life and psychosocial health remains unclear. Therefore, the present project aims to investigate the feasibility of taking Jing Si Herbal Tea among patients with dementia; then, to investigate if Jing Si Herbal Tea could improve quality of life and psychosocial health for patients with dementia and their caregivers. The project will be three years. The first year will examine the feasibility for the patients with dementia. A total of 100 patients with dementia will be recruited and they will be informed to take the Jing Si Herbal Tea two times per day (one time in the morning and another time in the afternoon). All the participants will be measured for their quality of life and psychosocial health at baseline, three months after baseline, and six months after baseline, to have initial evidence of the improvements in quality of life and psychosocial health without having a control group. The second year will recruit 200 patients with dementia and randomly assign them into a treatment group (taking Jing Si Herbal Tea) and a control group (taking placebo). All the participants will be measured for their quality of life and psychosocial health at baseline, three months after baseline, and six months after baseline, to investigate the strong evidence of Jing Si Herbal Tea on quality of life and psychosocial health. The third year will recruit 200 caregivers of patient with dementia and randomly assign them into a treatment group (taking Jing Si Herbal Tea) and a control group (taking placebo). All the participants will be measured for their quality of life and psychosocial health at baseline, three months after baseline, and six months after baseline, to investigate the strong evidence of Jing Si Herbal Tea on quality of life and psychosocial health.",[116,34,66],[472,574,575,576,577,578],"caregiver","quality of life","Jing Si Herbal Tea","psychosocial health","randomized controlled trial","2026-04-07",{"date":552,"type":43},{"date":582,"type":43},"2025-01-17",{"date":584,"type":23},"2026-12",{"name":586,"class":50},"National Cheng Kung University",{"id":588,"slug":589,"hasResults":12,"nctId":590,"briefTitle":591,"officialTitle":592,"acronym":593,"eligibilityCriteria":594,"healthyVolunteers":17,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":595,"targetDuration":4,"studyType":24,"phases":597,"briefSummary":598,"conditions":599,"keywords":610,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":616,"lastUpdatePostDateStruct":617,"startDateStruct":618,"completionDateStruct":619,"leadSponsor":621,"locationsCount":4},"100619558","communityrx-dementia--peer-navigation-crxdpeer-100619558","NCT07346183","CommunityRx-Dementia + Peer Navigation (CRxDpeer)","CommunityRx-Dementia + Peer Navigation (CRxDpeer): A Real-World Implementation and Effectiveness Study of an IT-Based Social Care Intervention","CRxDpeer","Inclusion Criteria:\n\n* Self-identifies as a caregiver of a home-dwelling person with Alzheimer's disease or related dementias (ADRD)\n* Resides in the target geographic region of the study\n* Has access to a cell phone and agrees to receive text messages from the study\n* Has an email address that they can receive emails from\n* Individuals under the age of 18 who are emancipated minors in the state of Illinois and a caregiver of a person with dementia\n\nExclusion Criteria:\n\n* Minors who are not emancipated in the state of Illinois.\n* Previously participated in the intervention arm of the CommunityRx-Dementia clinical trial",{"count":596,"type":23},330,[26],"The CRxDpeer intervention, delivered by a trained peer navigator, in practice called a \"peer mentor\", includes three evidence-based components: (a) focused education about common social (e.g., food and housing insecurity) and caregiving (e.g., respite and end of life care) needs, (b) activation of personalized community resource information for social and caregiving needs through delivery of a resource list (HealtheRx) at the baseline encounter and coaching on how to communicate with service providers, coordinate services and manage social support (e.g., connect with their peer navigator, reach out to friends or relatives for support, identify support groups, etc.) and (c) ongoing navigation-focused support meant to boost the baseline intervention, including a series of proactive text messages over 12 months. During this time, the subject can respond to and communicate with the peer navigator for ongoing support.",[600,116,295,601,602,603,604,605,34,525,606,323,607,237,608,609],"Alzheimer s Disease","Loneliness","Health-Related Social Needs","Social Care","Healthcare Utilization","End of Life Care","Stress","Self-Efficacy","Implementation Science","Advance Care Planning",[611,612,613,614,615],"resource navigation","peer navigator","peer mentor","social care","dementia caregiver","2026-04-06",{"date":579,"type":43},{"date":273,"type":23},{"date":620,"type":23},"2029-02-28",{"name":622,"class":50},"University of Chicago",{"id":624,"slug":625,"hasResults":12,"nctId":626,"briefTitle":627,"officialTitle":628,"acronym":629,"eligibilityCriteria":630,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":631,"targetDuration":4,"studyType":24,"phases":633,"briefSummary":634,"conditions":635,"keywords":638,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":640,"lastUpdatePostDateStruct":641,"startDateStruct":642,"completionDateStruct":644,"leadSponsor":646,"locationsCount":51},"100560973","buddy-up-dyadic-physical-activity-program-for-persons-with-dementia-and-family-caregivers-100560973","NCT06584110","Buddy-Up Dyadic Physical Activity Program for Persons With Dementia and Family Caregivers","Effects of Buddy-Up Dyadic Physical Activity Program on Health Outcomes and Social Dynamic of Persons With Dementia and Family Caregivers: A Mixed Method Randomized Controlled Trial","BUDPA","Eligibility for person with dementia (PwD) includes i) a confirmed diagnosis of dementia and ii) an HK-MoCA score of 8-19 to indicate mild to early moderate dementia.\n\nThe caregivers will have to i) live with the participant with dementia ii) self-identify as the primary family caregiver iii) providing care for ≥ 4 hours\u002Fday iv) has a smartphone for FaceTime\n\nThe exclusion criteria are i) engaging in ≥60 min\u002Fweek of moderate or vigorous exercise in the past six months ii) having acute muscular-skeletal problems, cerebro-cardio-respiratory disease or condition contradictory to exercise training",{"count":632,"type":23},236,[26],"The global cost of dementia is over 818 billion, and a further rise is expected in the next decade. While family caregiving is the backbone of the formal care service, promoting \"living well with dementia\" needs to extend to a dyadic perspective to address the needs of persons with dementia (PwD) and their caregivers. Unique to dementia caregiving, imbalanced exchange in the assistance, interaction, relationship and autonomy between the partners in a care dyad always challenges their social interaction and relationships. Such eroding dyadic dynamics not only worsens the mental health of caregivers, but also compromises the quality of caregiving, fosters more dementia deterioration, and eventually complicates the caregiving process. Nevertheless, least attention is directed to dyadic dynamics in promoting living well with dementia. Partner exercise is designed in a way which requires collaboration of two members to enable the workout of each other. In addition to the benefits of exercise on dementia symptom control and caregiver's stress management, partner exercise provides a meaningful encounter to encourage reciprocity, collaboration and relationship closeness within the care dyad.\n\nThis is a sequential mixed-method study including a multicenter RCT to evaluate the effects of the 16-week enhanced BUDPA and a descriptive qualitative study to explore the care dyad's overall engagement experience and perceptions. The study will be conducted in 8 elderly community centres operated by four NGOs.\n\nThe primary aim of the study investigates the effects of a 16-week enhanced BUDPA program on the health and dyadic dynamic of the persons with dementia and their family caregivers (Objective 1-3). The secondary aim explores dyads' overall experience in program engagement, particularly in terms of perceived benefits, challenges, and experience in self-directed practice (Objective 4). The primary outcomes include PwD's cognitive function and caregivers' mood status.\n\nWe hypothesize that the 16-week enhanced BUDPA program will be more effective than usual care immediately post-test (T1: week 16) and 3 months (T2: week 29) and 6 months thereafter (T3: week 42) in:\n\n1. improving cognitive function, NPS and HRQL of persons with mild to early-moderate dementia.\n2. improving the affect, positive aspects of caregiving, and HRQL of family caregivers.\n3. improving the dyadic dynamic between the person with dementia and family caregiver in a dyad.",[636,637,116,34],"Cognitive Impairment, Mild","Dementia, Mild",[472,639,354,574],"dyads exercise","2026-03-31",{"date":616,"type":43},{"date":643,"type":43},"2024-10-01",{"date":645,"type":23},"2027-03-30",{"name":647,"class":50},"The University of Hong Kong",{"id":649,"slug":650,"hasResults":12,"nctId":651,"briefTitle":652,"officialTitle":653,"acronym":654,"eligibilityCriteria":655,"healthyVolunteers":12,"sex":18,"minAge":656,"maxAge":4,"enrollmentInfo":657,"targetDuration":4,"studyType":24,"phases":659,"briefSummary":660,"conditions":661,"keywords":669,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":672,"lastUpdatePostDateStruct":673,"startDateStruct":675,"completionDateStruct":677,"leadSponsor":679,"locationsCount":681},"100510689","evaluating-novel-healthcare-approaches-to-nurturing-and-caring-for-hospitalized-elders-100510689","NCT05929703","Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders","Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders (ENHANCE)","ENHANCE","Inclusion Criteria:\n\n* Provision of informed consent\n* At least 70 years of age\n* Anticipated length of hospital stay at least 72 hours\n* Family member or care partner available to be on-site in the hospital\n* At least one delirium risk factor (e.g., cognitive or functional impairment, dehydration, vision or hearing impairment)\n* Evaluable cognitive function at baseline (i.e., ability to complete baseline cognitive function assessment)\n\nExclusion Criteria:\n\n* Delirium on admission\n* Unable to communicate verbally (e.g., coma, mechanical ventilation)\n* Unable to participate fully in interventions (e.g., terminal condition, advanced dementia)\n* Staff safety concerns (e.g., violent behavior)\n* Cardiac or intracranial surgery (due to competing causes of delirium)","70 Years",{"count":658,"type":23},1900,[26],"The goal of this clinical trial is to compare the Hospital Elder Life Program (HELP) with a family-augmented version of HELP (FAM-HELP), that includes family members and care partners, for the prevention of delirium in older patients during hospital admission. The main objectives of the trial are the following:\n\n1. To compare the effectiveness of FAM-HELP and HELP in reducing both the incidence of delirium and its severity.\n2. To compare the effectiveness of FAM-HELP and HELP in improving patient- and family-reported outcomes.\n3. To explore the implementation context, process, and outcomes of the FAM-HELP program in diverse hospital settings.",[662,663,664,407,665,666,667,34,608,668],"Delirium","Neurocognitive Disorders","Mild Cognitive Impairment","Aging","Family Support","Family Members","Patient Satisfaction",[662,670,671,608],"Clinical Trial","Comparative Effectiveness Research","2026-03-20",{"date":674,"type":43},"2026-03-24",{"date":676,"type":43},"2023-12-04",{"date":678,"type":23},"2027-08",{"name":680,"class":50},"University of Michigan",7,{"id":683,"slug":684,"hasResults":12,"nctId":685,"briefTitle":686,"officialTitle":687,"acronym":4,"eligibilityCriteria":688,"healthyVolunteers":12,"sex":18,"minAge":689,"maxAge":457,"enrollmentInfo":690,"targetDuration":4,"studyType":24,"phases":691,"briefSummary":692,"conditions":693,"keywords":696,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":701,"lastUpdatePostDateStruct":702,"startDateStruct":704,"completionDateStruct":706,"leadSponsor":708,"locationsCount":51},"100627920","from-kitchen-to-clinic-100627920","NCT07454902","From Kitchen to Clinic","From Kitchen to Clinic: A Family-Centered, Food-As-Medicine Approach Using Medically Tailored Meals and Caregiver Coaching in Pediatric Oncology Care","Patient Inclusion Criteria:\n\n1. Receiving cancer treatment for any cancer diagnosis\n2. Within the first 3-6 weeks of diagnosis i. Diagnosis date is defined as the date of the family meeting relaying diagnosis to the patient\u002Fcaregiver\u002Ffamily\n3. At least 5-21 years of age at the time of enrollment\n4. English-speaking\n5. Approved to participate by both their oncologist and RDN\n6. Must anticipate to live in the same household as the designated caregiver for the duration of the study\n\nPatient Exclusion Criteria:\n\n1. Experiencing swallowing or digestive diseases\u002Ffood allergies (e.g. celiacs, lactose intolerance, nut allergy), or specific food preferences that cannot be accommodated by MANNA.\n2. Receiving nutrition via nasogastric or gastric tube feedings\n3. Bone marrow transplant patient","5 Years",{"count":317,"type":23},[26],"Children receiving cancer treatment often experience nutrition-related challenges, such as changes in appetite, weight, and food intake, due to treatment side effects and the demands placed on families during care. These challenges can increase caregiver stress, reduce diet quality, and contribute to short- and long-term health risks for children. While medically tailored meals have been shown to improve nutrition and reduce burden in adults with serious illness, their use in pediatric cancer care has not been well studied. This pilot study will evaluate the feasibility and acceptability of a 12-week, family-centered food-as-medicine program for children undergoing active cancer treatment and their caregivers. The program combines weekly delivery of medically tailored meals with individualized caregiver coaching provided by registered dietitian nutritionists. During the first eight weeks, families receive full meal support and weekly coaching sessions, followed by a four-week transition period with tapered meal delivery and bi-weekly coaching to support sustainable nutrition practices. A total of 60 pediatric patients and their caregivers will be enrolled at the Children's Hospital of Philadelphia. The study will assess whether families can be successfully recruited and retained, whether they are able to participate in study activities, and whether the program is acceptable and usable during cancer treatment. The study will also explore preliminary effects on children's dietary intake, weight and growth patterns, treatment tolerance, household nutrition security, and caregiver stress and burden.",[694,695,34],"Pediatric Cancer","Malnutrition, Child",[697,698,699,700,228],"Pediatric oncology","Nutrition intervention","Medically tailored meals","Feasibility studies","2026-03-05",{"date":703,"type":43},"2026-03-09",{"date":705,"type":23},"2026-03",{"date":707,"type":23},"2028-12",{"name":709,"class":50},"Drexel University",{"id":711,"slug":712,"hasResults":12,"nctId":713,"briefTitle":714,"officialTitle":714,"acronym":715,"eligibilityCriteria":716,"healthyVolunteers":17,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":717,"targetDuration":4,"studyType":24,"phases":718,"briefSummary":719,"conditions":720,"keywords":721,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":723,"lastUpdatePostDateStruct":724,"startDateStruct":725,"completionDateStruct":727,"leadSponsor":729,"locationsCount":51},"100548282","testing--refinement-of-carepair-an-assessment-and-referral-platform-to-support-family-caregivers-of-alzheimers-disease-and-related-dementias-100548282","NCT06418971","Testing & Refinement of CarePair: An Assessment and Referral Platform to Support Family Caregivers of Alzheimer's Disease and Related Dementias.","CarePair","Inclusion:\n\n* Currently a primary caregiver of a community-dwelling PwD\n* Provides at least 10 hours of care per week\n* ≥18 years of age\n* Fluent in English\n* Both the caregiver and care-recipient reside in and\u002For can easily access one of the following cities\u002Fareas: New York City, New York (NY); Long Island, NY; Westchester County, NY; Seattle, Washington (WA); Los Angeles, California (CA)\n* Provides at least 10 hours of care per week\n* Has provided care for at least 6 months\n* Able to use the internet and has internet access\n* Owns and can operate a smartphone\n* Able and willing to provide their informed consent to participate for the six-week study duration\n* Does not self-report any cognitive impairments\n\nExclusion:\n\n* Not currently the primary caregiver of a community-dwelling person with dementia\n* Care-recipient lives in residential care (e.g., assisted living, skilled nursing facility)\n* ≤18 years of age\n* Not fluent in English\n* The caregiver and\u002For care-recipient resides outside of and\u002For cannot easily access any of the following cities: New York City (NY); Long Island (NY); Westchester County (NY); Seattle (WA); Los Angeles (CA)\n* Provides less than 10 hours of care per week\n* Has provided care for less than 6 months\n* Unable to use the internet or does not have internet access\n* Does not own and\u002For cannot operate a smartphone\n* Unable or unwilling to provide informed consent to participate for the six-week study duration\n* Self-reports having a cognitive impairment",{"count":261,"type":23},[26],"The purpose of this study is to develop and test CarePair, a mobile application-based needs assessment and service referral platform for family caregivers of persons with dementia designed to alleviate stress and promote psychosocial well being.\n\nThe main aims of this study are:\n\n* To evaluate the feasibility and acceptability of the CarePair mobile application.\n* To explore the potential for CarePair to reduce feelings of depression and burden, and improve caregivers' feelings of self-efficacy.\n\nCaregiver participants will be asked to log in and use the CarePair application and complete study activities for a six-week duration. Researchers will compare the intervention group to an attention control comparator to see if application use is associated with improved psychosocial outcomes at follow-up.",[34,292,116],[722],"Dementia family caregivers","2026-03-03",{"date":701,"type":43},{"date":726,"type":43},"2025-09-15",{"date":728,"type":23},"2026-07-31",{"name":730,"class":50},"University of Southern California"]