[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"caregivers\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:caregivers":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,22,0,[8,45,86,113,143,175,211,242,268,302,328,363,393,418,453,477,507,529,560,588,614,638],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100564837","pilot-study-of-hospital-gameplan4care-100564837",false,"NCT06634368","Pilot Study of Hospital GamePlan4Care","Pilot Study of Hospital GamePlan4Care for Family Caregivers of People With Dementia (CDA 21-143)","Inclusion Criteria:\n\n* 18 years of age or older\n* provide care for a Veteran with a diagnosis of Alzheimer's Disease or related dementias or a Veteran with a prescription for a medication for dementia listed in CPRS who is admitted to the hospital at the Michael E. DeBakey VA Medical Center\n* Veteran must be experiencing signs of dementia as verified by a score of 2 or greater on the AD-8\n* provide at least eight hours of care or supervision per week to the Veteran with dementia\n* provide care primarily due to a personal relationship, rather than a financial relationship\n* have access to a telephone\n* have access to a tablet or computer with internet access\n* report using the computer or tablet to access the internet at least three times per week\n* speak English\n\nExclusion Criteria:\n\n* unable to complete informed consent","ALL","18 Years",{"count":19,"type":20},50,"ESTIMATED","INTERVENTIONAL",[23],"NA","Hospital stays are stressful for the family and friends who care for adults with dementia. Following hospital discharge, adults with dementia often have increased care needs, which places new caregiving demands on their family and friends. Family and friends are critical to ensuring that Veterans with dementia can live safely in the community following discharge. Healthcare systems have an opportunity to support family and friends of adults with dementia by addressing dementia-specific caregiving challenges that arise during the transition from hospital to home.\n\nThe investigators are comparing two different support programs for family and friends of hospitalized adults with dementia. The two programs are Hospital GamePlan4Care and Caregiver Education. Hospital GamePlan4Care was developed with feedback from people who care for Veterans with dementia. Hospital GamePlan4Care helps caregivers build skills to care for someone with dementia recently discharged from the hospital. It includes a written handbook, online training on the Hospital GamePlan4Care website, and phone calls with a dementia care specialist. The online training is tailored to the caregiver. The Caregiver Education program provides information that helps caregivers care for someone recently hospitalized. It includes a written handbook, recommendations for high-quality online resources, and phone calls with a dementia care specialist.\n\nBoth programs will start when the adult with dementia is hospitalized. Each program lasts at least three months. To be eligible, the caregiver must care for a Veteran with dementia admitted to the Michael E. DeBakey VA Medical Center in Houston, Texas. Caregivers interested in participating and passing eligibility screening will be enrolled in the study for at least three months. Each enrolled caregiver will have a 50% chance of being enrolled in the Hospital GamePlan4Care group or the Caregiver Education group (like flipping a coin). Both groups will be asked to complete several questionnaires about their needs as a caregiver and their well-being. Questionnaires will be completed at the beginning of the study and one and three months after the Veteran is discharged from the hospital. Each questionnaire should take 30-60 minutes to complete.",[26],"Caregivers",[28,29,30,31],"Dementia","Hospitalization","Patient Discharge","Caregiver Burden","RECRUITING","2026-06-04",{"date":35,"type":36},"2026-06-08","ACTUAL",{"date":38,"type":36},"2025-02-04",{"date":40,"type":20},"2026-09-30",{"name":42,"class":43},"VA Office of Research and Development","FED",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":44},"100643231","vocale-lbd-online-peer-support-for-caregivers-of-people-with-lewy-body-dementia-100643231","NCT07637097","VOCALE LBD: Online Peer Support for Caregivers of People With Lewy Body Dementia","Reducing Depression in Family Caregivers of Persons Living With Lewy Body Dementia Through Tailored Asynchronous Online Intervention.","VOCALE LBD","Inclusion Criteria:\n\n* Current family member or informal (unpaid) caregiver of a person with a confirmed diagnosis of Lewy Body Dementia (LBD) or LBD mixed pathology\n* Experiences depressive symptoms as defined by a score of 5 or higher on the Patient Health Questionnaire-9 (PHQ-9)\n* Able to read, write, and speak English\n* Has access to a device (computer, tablet, or smartphone) that can connect to the internet and be used for videoconferencing or phone calls, OR is interested in using a loaner device\n\nExclusion Criteria:\n\n* Active suicidal ideation as indicated by endorsement of PHQ-9 Item 9 (thoughts that you would be better off dead, or thoughts of hurting yourself)\n* Paid or professional caregiver (must be unpaid family\u002Finformal caregiver)\n* Unable to read, write, or speak English",{"count":54,"type":20},220,[23],"This study tests whether a tailored, fully asynchronous online group intervention (VOCALE LBD) reduces depression in family caregivers of people with Lewy Body Dementia (LBD), compared to standard educational materials. LBD is the second most common form of degenerative dementia and causes distinct challenges, including visual hallucinations, REM sleep disorder, and severe motor symptoms, that are not addressed by generic caregiver interventions. Depression rates in LBD caregivers reach 40-50%, double the rate seen in Alzheimer's disease caregivers, yet no rigorous digital interventions exist specifically for this population. VOCALE LBD is a text-based, low-bandwidth platform (Discourse) that brings groups of 10-15 caregivers together in an 8-week moderated online community. Weekly topics address LBD-specific challenges (sleep problems, hallucinations, self-care) and problem-solving skills using the ADAPT method. A pilot study (n=54) showed strong effects on depressive symptoms (Cohen's d=0.54 at 1-month follow-up), near-perfect engagement, and high participant satisfaction. This RCT (N=220) will test efficacy, examine mechanisms of action (self-efficacy and problem-solving), and explore analytics approaches for pragmatic monitoring, laying groundwork for future implementation in clinics and community organizations.",[58,59,31,26],"Lewy Bodies Disease","Depression Disorder",[61,62,63,64,65,66,67,68,69,70,71,72,73,74],"Lewy body disease","LBD","Family caregivers","Caregiver Depression","Online Intervention","Asynchronous","Digital Health","Peer Support","Problem-solving therapy","VOCALE","Telehealth","Dementia caregiver","ADAPT method","Discourse Platform","NOT_YET_RECRUITING","2026-06-03",{"date":78,"type":36},"2026-06-09",{"date":80,"type":20},"2026-12-01",{"date":82,"type":20},"2030-11-30",{"name":84,"class":85},"University of Washington","OTHER",{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":92,"sex":16,"minAge":17,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":21,"phases":96,"briefSummary":97,"conditions":98,"keywords":101,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":112},"100577573","focus-on-us-adapting-the-focus-program-for-sexual-and-gender-minority-sgm-cancer-patients-and-caregivers-100577573","NCT06800053","FOCUS ON US: Adapting the FOCUS Program for Sexual and Gender Minority (SGM) Cancer Patients and Caregivers","Inclusion Criteria:\n\nPatients must:\n\n1. have been diagnosed or had a biochemical recurrence or progression of any invasive (e.g., Stage ≥1) cancer within the past 24 months;\n2. have at least one informal (unpaid) caregiver willing to participate in the program;\n3. identify as a sexual and\u002For gender minority (SGM) OR have a caregiver who identifies as SGM (e.g., either the patient or caregiver(s) must be SGM);\n4. be age 18 or older;\n5. be able to complete all written and oral components of the study in English;\n6. provide informed consent;\n7. live in the United States.\n\nCaregivers must:\n\n1. self-report having provided support for a cancer patient as an informal (unpaid) caregiver;\n2. have a cancer patient for whom they provided support willing to participate in the program;\n3. identify as a sexual and\u002For gender minority (SGM) OR have provided support to a patient who identifies as SGM (e.g., either the patient or caregiver(s) must be SGM);\n4. be age 18 or older;\n5. be able to complete all written and oral components of the study in English;\n6. provide informed consent;\n7. live in the United States",true,"100 Years",{"count":95,"type":20},160,[23],"Our aim for this study is to assess the feasibility and acceptability and explore potential outcomes of the adapted FOCUS On Us intervention in a two-arm pilot trial. The investigators will randomize 80 sexual and\u002For gender minority (SGM; e.g., lesbian, gay, bisexual, transgender, queer, etc.) cancer patients and their ≥80 informal caregivers (total N≥160) to either FOCUS On Us (adapted from the evidence-based FOCUS program) or a waitlist control.",[99,100,26],"Cancer Support","Oncology Patients",[102,103],"Cancer Patients and Caregivers","LGBTQ+","2026-06-02",{"date":33,"type":36},{"date":107,"type":36},"2025-09-04",{"date":109,"type":20},"2026-06-30",{"name":111,"class":85},"Charles Kamen",2,{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":4,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":21,"phases":122,"briefSummary":123,"conditions":124,"keywords":131,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":44},"100579202","dyadic-mindfulness-for-people-with-parkinsons-disease-and-their-caregivers-100579202","NCT06821230","Dyadic Mindfulness for People With Parkinson's Disease and Their Caregivers","Enhancing Psychological Wellbeing and the Patient-caregiver Relationship Through Dyadic Mindfulness: A Randomized Controlled Trial in People With Parkinson's Disease and Their Caregivers","Inclusion Criteria of PwPD:\n\n* Chinese patients with idiopathic mild-moderate PD (as indicated by the Hoehn and Yahr Scale stages I-III: those with unilateral\u002Fbilateral symptoms, with\u002Fwithout postural instability who are able to walk\u002Fstand unassisted)\n* Aged ≥18 years\n\nInclusion Criteria of caregivers of PwPD:\n\n\\- Self-identified as the primary caregivers of their patient\n\nEither patient or caregiver needs to experience at least mild negative emotions (as indicated by the 21-item Depression, Anxiety and Stress Scale \\[DASS21\\] score of Depression subscale ≥10, Anxiety subscale ≥8, or Stress subscale ≥15)\n\nBoth need to be able to communicate in Cantonese and provide written consent.\n\nExclusion Criteria:\n\n* Engage in regular supervised mind-body practices such as Tai Chi, yoga, or other forms of mindfulness training (\\>2 times per week)\n* Have a pre-existing acute psychotic disease\n* Currently participating in any other behavioral or pharmacological trial\n* Have significant cognitive impairment, as indicated by an Abbreviated Mental Test score≤ 6\n* Have other contraindications that may limit their full participation (e.g., severe hearing\u002Fvision impairment)",{"count":121,"type":20},200,[23],"The proposed two-arm randomized waitlist-controlled trial will use a mixed-methods design to investigate the effects of dyadic mindfulness on physio-psycho-spiritual outcomes in people with Parkinson's Disease (PwPD) and their family caregivers. One hundred Chinese patient-caregiver dyads will be randomized to receive eight weekly 90-minute dyadic mindfulness sessions or usual care. Outcome measures include negative emotions (primary outcome), patient-caregiver relationship, mindfulness, HRQOL, gut microbiome, PD-related symptoms, and caregiving burden. An actor-partner interdependence model will be used to explore the interactions of treatment effects within the dyads. The dyads will be assessed at baseline(T0), post-intervention(T1), and 4-months post-intervention(T2). The investigators will also invite 25 dyads to attend in-depth interviews exploring their experiences, perceived changes, and factors attributable to the effectiveness\u002Fineffectiveness of the intervention. Generalized linear mixed-effects (GLME) with intention-to-treat analysis will be used to compare the changes in outcomes over time within and between the two arms. The findings will be triangulated to provide a comprehensive evaluation of the intervention's effectiveness. This study will generate rigorous scientific evidence to inform the application of dyadic mindfulness as a public health practice preventing the progression of psychological distress in PwPD and caregivers to clinically severe levels. Its self-help nature also enriches the primary care for this clinical cohort.",[125,26,126,127,128,129,130],"Mindfulness","Movement Disorders","Neurodegenerative Disease","Dyadic Intervention","Psychosocial Health","Parkinsons Disease",[132,125,133],"Parkinsons disease","dyadic care","2026-05-28",{"date":136,"type":36},"2026-06-01",{"date":138,"type":36},"2025-02-11",{"date":140,"type":20},"2027-06-30",{"name":142,"class":85},"The University of Hong Kong",{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":4,"eligibilityCriteria":149,"healthyVolunteers":92,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":150,"targetDuration":4,"studyType":21,"phases":152,"briefSummary":153,"conditions":154,"keywords":160,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":44},"100512176","smartphone-based-cognitive-emotion-regulation-training-for-unpaid-primary-caregivers-of-persons-with-alzheimers-disease-100512176","NCT05949047","Smartphone-based Cognitive Emotion Regulation Training for Unpaid Primary Caregivers of Persons With Alzheimer's Disease","Biobehavioral Mechanisms of Smartphone-based Cognitive Emotion Regulation Training for Unpaid Primary Caregivers of Persons With Alzheimer's Disease","Inclusion Criteria:\n\nHealthy Adult Caregivers\n\n* Unpaid primary caregiver of patient with Alzheimer's Disease\u002FAlzheimer's Disease and Related Dementias (AD\u002FADRD)\n* At least 18 years of age, with no maximum age, provided that all other inclusion\u002Fexclusion criteria are met\n* Must be able to speak, read, and write in English\n* Must be free of any current or past DSM diagnosis (i.e. healthy adults), with the exception of current or past mood or anxiety disorders or past substance-related disorders (i.e., current or past mood or anxiety disorders and\u002For past substance-related disorders would not represent an exclusion factor)\n* Must have a smartphone. This represents any major iOS or Android-based smartphone. The smartphone will also be used for collection of ecological momentary assessment (EMA) data via SurveySignal.\n* Must provide significant level of caregiving to their care recipient\n* Must be at least minimally-stressed\n\nCognitively Impaired Adults\n\n* Must have diagnosed with Alzheimer's Disease\u002FAlzheimer's Disease and Related Dementias (AD\u002FADRD)\n* Must be the care recipient of the primary caregiver who is completing the study\n* Must be able to understand and willing to complete a questionnaire and the consent form\n* Must have minimum level of dementia symptoms\n\nExclusion Criteria:\n\nHealthy Adult Caregivers\n\n* Current or past psychiatric disorders (e.g., psychotic and personality disorders) with the exception of current or past mood or anxiety disorders or past substance-related disorders (i.e., current or past mood or anxiety disorders and\u002For past substance-related disorders would not represent an exclusion factor)\n* Currently receiving psychotherapy that specifically addresses caregiver burden\u002Fdistress or employs cognitive reappraisal as a major component\n* Significant visual, auditory, or cognitive impairment that compromises their ability to understand and complete the task\n* Caregiver participants who cease meeting inclusion criteria during the study will be dismissed from the study and compensated pro-rata.\n* Has formerly participated in a study from our lab involving the same or essentially same design (e.g., former participants who provided pilot\u002Fpreliminary data for this study)\n\nCognitively Impaired Adults\n\n* The care recipient does not wish to participate, and\u002For their caregiver does not want them to participate\n* Significant visual, auditory, or cognitive impairment that compromises their ability to understand and complete questionnaires, even with their caregiver's help will exclude them from the study\n* Has formerly participated in a study from our lab involving the same or essentially same design (e.g., former participants who provided pilot\u002Fpreliminary data for this study)",{"count":151,"type":20},270,[23],"Alzheimer's Disease (AD) and Alzheimer's Disease-Related Dementias (ADRD) not only exact a heavy toll on patients, they also impose an enormous emotional, physical, and financial burden on unpaid, often family, caregivers. The strain of providing care for a loved one diagnosed with AD, often across several years, is associated with elevated depression risk and poorer overall health. Emotion regulation skills represent an ideal target for psychological intervention to promote healthy coping in ADRD caregivers. The project seeks to use an experimental medicine approach to test the efficacy and biobehavioral mechanisms of a novel, relatively brief, targeted, scalable, smartphone-based cognitive emotion regulation intervention aimed at improving psychological outcomes (i.e., reducing perceived stress, caregiver burden, and depressive symptoms) in ADRD unpaid primary caregivers as well as examine potential benefits of the caregiver intervention on quality of life in care recipients. Cognitive reappraisal is the ability to modify the trajectory of an emotional response by thinking about and appraising emotional information in an alternative, more adaptive way. Reappraisal can be operationalized via two primary tactics: psychological distancing (i.e. appraising an emotional stimulus as an objective, impartial observer) and reinterpretation (i.e., imagining a better outcome than what initially seemed apparent). The project will investigate the efficacy and underlying biobehavioral mechanisms of a novel, one-week cognitive reappraisal intervention in this population, with follow-up assessments at 2 weeks, 4 weeks, and 3 months. ADRD unpaid primary caregivers will be randomly assigned to receive training in either distancing, reinterpretation, or a no regulation natural history control condition, with ecological momentary assessments of self-reported positive and negative affect, remotely- collected psychophysiological health-related biomarkers (i.e., heart rate variability data) using pre-mailed Polar H10 chest bands, and health-related questionnaire reports. Distancing training is expected to result in longitudinal reductions in self-reported negative affect, longitudinal increases in positive affect, and longitudinal increases in HRV that are larger than those attributable to reinterpretation training and no-regulation control training.",[26,155,156,157,158,159],"Emotions","Emotion Regulation","Stress","Psychological","Psychophysiology",[161,162,163,164,165],"emotion regulation","caregiving","affective science","psychophysiology","psychoneuroimmunology","2026-05-27",{"date":168,"type":36},"2026-05-29",{"date":170,"type":36},"2023-09-14",{"date":172,"type":20},"2027-05-31",{"name":174,"class":85},"Bryan Denny",{"id":176,"slug":177,"hasResults":11,"nctId":178,"briefTitle":179,"officialTitle":180,"acronym":4,"eligibilityCriteria":181,"healthyVolunteers":92,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":182,"targetDuration":4,"studyType":21,"phases":184,"briefSummary":185,"conditions":186,"keywords":187,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":204,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":209,"locationsCount":44},"100455352","cereset-research-for-caregivers-100455352","NCT05209438","Cereset Research for Caregivers","Cereset Research for Caregivers: A Randomized, Controlled Trial","Inclusion Criteria:\n\n* Participants must provide caregiving at least 10 hours per week. This includes all types of caregiving\n* participants must be willing to provide informed consent\n* participants must be able to comply with basic instructions\n* participants must be able to sit comfortably for up to 90 minutes, and attend up to three 60-minute intervention sessions each week during the 4-week intervention period\n* participants must self report experiencing symptoms of stress, anxiety, or insomnia and meet threshold scores on one or more self-report inventories of these symptoms (Insomnia Severity Index (ISI, ≥ 8), the Perceived Stress Index (PSS, ≥ 14), or the Generalized Anxiety Disorder 7-item (GAD-7, ≥ 5) scale)\n\nExclusion criteria:\n\n* participants providing less than 10 hours a week of care to a person\n* participants who are unable or unwilling to attend intervention sessions during the planned study period\n* participants who are unable or unwilling to provide consent\n* participants who are not exhibiting symptoms of stress, anxiety or insomnia\n* participants with hearing impairment severe enough that they cannot perceive tones through ear buds\n* participants with known seizure disorder, or suicidal thoughts within the last 3 months\n* participants who respond positively to a question about risk for suicide within the last 3 months will be excluded and receive a behavioral health resource list\n* participants weighing more than 400 pounds (the weight limit of the chair used during intervention)\n* participants currently enrolled in another intervention study\n* prior use (past 3 years) of the technology being tested\n* prior use of neuromodulation, neurostimulation, deep brain stimulation, neurofeedback, biofeedback, alpha stim, Eye Movement Desensitization and Reprocessing (EMDR),or electroconvulsive therapy within the last month\n* Pace makers and beta blockers that affect the assessment of heart rate variability will also be exclusionary\n* participants taking Medications that may affect the assessment of heart rate variability (beta blockers.",{"count":183,"type":20},20,[23],"Caregivers experience high levels of prolonged stress that can lead to chronic problems with health, including increased risk of cardiovascular disease that is linked to autonomic dysregulation. Heart rate variability (HRV), measures of autonomic cardiovascular regulation, is decreased (worse) in caregivers. Autonomic function is linked to lateralization in the brain, and emerging neuromodulation methods that target lateralized signals in the brain, like Cereset (CR), may be able to improve heart rate variability. Therefore, this pilot study aims to test whether CR can improve HRV in caregivers of a person living with dementia experiencing stress, anxiety, or insomnia, as well as improve self-report measures of stress, sleep and caregiver burden.",[26],[188,162,189,190,191,192,193,194,195,196,197,198,199,200,201,202,203],"caregiver","stress","anxiety","insomnia","neurotechnology","autonomic dysregulation","hyperarousal","brain electrical activity","allostasis","Alzheimer's","dementia","neuromodulation","acoustic stimulation","heart rate variability","High-resolution relational resonance-based electroencephalic mirroring HIRREM","Cereset Research",{"date":136,"type":36},{"date":206,"type":36},"2022-06-16",{"date":208,"type":20},"2027-12",{"name":210,"class":85},"Wake Forest University Health Sciences",{"id":212,"slug":213,"hasResults":11,"nctId":214,"briefTitle":215,"officialTitle":215,"acronym":4,"eligibilityCriteria":216,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":217,"targetDuration":4,"studyType":21,"phases":219,"briefSummary":220,"conditions":221,"keywords":223,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":233,"lastUpdatePostDateStruct":234,"startDateStruct":236,"completionDateStruct":238,"leadSponsor":240,"locationsCount":44},"100619280","the-weact-program-for-family-caregivers-of-people-living-with-dementia-100619280","NCT07342569","The WeACT Program for Family Caregivers of People Living With Dementia","Inclusion criteria\n\nFamily caregivers of people living with dementia will be eligible to participate if they meet all of the following criteria:\n\n1. Are community-dwelling adults aged 18 years or older who have primary caregiving responsibilities for a relative diagnosed with dementia;\n2. Present mild to moderately severe depressive symptoms, as measured by the Patient Health Questionnaire-9 (PHQ-9), with scores between 5 and 19; and\n3. Have access to a web-enabled device, such as a smartphone, tablet, laptop, or desktop computer, with internet access.\n\nExclusion criteria\n\nFamily caregivers of people living with dementia will be excluded if they meet any of the following criteria:\n\n1. Have cognitive, physical, or sensory impairments, or are unable to complete study procedures in English, that may impede study participation;\n2. Present severe depressive symptoms, defined as PHQ-9 scores of 20 or higher;\n3. Report having thoughts of harming themselves or attempting suicide within the past six months;\n4. Have previously participated in a research study involving an ACT program;\n5. Are currently participating in another caregiver intervention study; or\n6. Have experienced more than three hospitalizations of either the family caregiver or the relative with dementia within the past year.",{"count":218,"type":20},40,[23],"The goal of this clinical trial is to learn whether WeACT, a self-paced, web-based program, is feasible and helpful for adult family caregivers of a relative living with dementia. WeACT is based on acceptance and commitment therapy (ACT), which teaches skills to handle difficult thoughts and feelings and take steps toward what matters most.\n\nThe main questions this study aims to answer are:\n\n* Can caregivers complete WeACT as planned?\n* Do caregivers show improvements in mental health and coping after using WeACT?\n* What are caregivers' experiences with the program, and what suggestions do they have to improve it?\n\nParticipants will:\n\n* Complete six self-paced weekly online modules and use the daily practice section during the program.\n* Complete online questionnaires before starting and after completing the program.\n* Take part in one online interview about their experience.",[222,26,28],"Depression",[224,225,226,198,227,228,229,230,231,232],"acceptance and commitment therapy","Internet-Based Intervention","caregivers","depressive symptoms","feasibility","usability","web-based intervention","mixed methods","Pilot Study","2026-05-09",{"date":235,"type":36},"2026-05-13",{"date":237,"type":20},"2026-06",{"date":239,"type":20},"2026-12",{"name":241,"class":85},"University of South Florida",{"id":243,"slug":244,"hasResults":11,"nctId":245,"briefTitle":246,"officialTitle":247,"acronym":248,"eligibilityCriteria":249,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":250,"targetDuration":4,"studyType":21,"phases":252,"briefSummary":253,"conditions":254,"keywords":258,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":4},"100636569","virtual-reality-therapy-for-improving-caregiver-and-patient-quality-of-life-in-home-based-palliative-care-in-saudi-arabia-100636569","NCT07567391","Virtual Reality Therapy for Improving Caregiver and Patient Quality of Life in Home-Based Palliative Care in Saudi Arabia","Virtual Reality Nature Therapy for Palliative Patients and Caregivers in Saudi Arabia: A Randomized Controlled Trial to Support Quality of Life and Cultural Adaptation","VIRTIC-Hajj","Inclusion Criteria:\n\n* Adult patients (≥18 years) receiving palliative care in Saudi Arabia\n* Primary family caregivers living with and providing daily care to the patient\n* Ability to provide informed consent\n* Fluent in Arabic\n\nExclusion Criteria\n\n* Severe cognitive impairment or psychiatric conditions that prevent use of VR\n* History of epilepsy or vestibular disorders\n* Inability to understand or follow instructions for using VR equipment",{"count":251,"type":20},100,[23],"This randomized controlled trial evaluates the efficacy of a culturally adapted virtual reality (VR) nature therapy intervention aimed at improving the quality of life (QOL) and emotional well-being of palliative patients and their family caregivers in Saudi Arabia. The study involves immersive VR sessions depicting natural environments, including Saudi-specific landscapes, delivered to patient-caregiver dyads at home. Outcomes include self-reported QOL measures, psychophysiological parameters, and qualitative feedback.",[255,256,257,26],"Virtual Reality","Quality of Life","Palliative Care",[255,257,256,26],"2026-05-03",{"date":261,"type":36},"2026-05-05",{"date":263,"type":20},"2026-10-20",{"date":265,"type":20},"2027-09-01",{"name":267,"class":85},"University of Bisha",{"id":269,"slug":270,"hasResults":11,"nctId":271,"briefTitle":272,"officialTitle":272,"acronym":273,"eligibilityCriteria":274,"healthyVolunteers":92,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":275,"targetDuration":4,"studyType":21,"phases":277,"briefSummary":278,"conditions":279,"keywords":286,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":293,"lastUpdatePostDateStruct":294,"startDateStruct":296,"completionDateStruct":298,"leadSponsor":300,"locationsCount":4},"100632905","recovery-inspired-support-engagement-rise-pilot-100632905","NCT07519759","Recovery Inspired Support Engagement (RISE) Pilot","(RISE)","Inclusion Criteria:\n\n* Inclusion Criteria for Support Persons:\n\n  * Ages 18+.\n  * Having a loved one who participated in an inpatient or residential substance use disorder program in the past 30 days, as reported by loved one, support person, clinician, or chart review.\n  * Interest in supporting the loved one's recovery from substance use.\n  * At least 4 days per month virtual or in-person contact per month with the loved one.\n  * Access to a computer with internet or mobile phone with video conferencing capabilities.\n  * Ability to provide written informed consent.\n  * Speak and read English.\n* Inclusion Criteria for Loved Ones:\n\n  * Ages 18+.\n  * Participated in an inpatient or residential substance use disorder program in the past 30 days, as reported by self, support person, clinician, or chart review.\n  * At least 4 days per month virtual or in-person contact per month with the support person.\n  * Access to a computer with internet or mobile phone with video conferencing capabilities.\n  * Ability to provide written informed consent.\n  * Speak and read English.\n\nExclusion Criteria:\n\n* Exclusion Criteria for Support Persons:\n\n  * DSM-5 moderate or severe substance use disorder in the past year.\n  * History of domestic violence with the loved one that would interfere with the ability to safely follow through with the intervention plan.\n  * Psychiatric, cognitive, or medical impairments that would interfere with the ability to follow through with the intervention plan.\n  * Prior participation of a support person of the loved one in an ITC-related research study.\n  * Significant prior experience with ITC or CRAFT (e.g., having completed an ITC-related training workshop or course prior to study enrollment)\n* Exclusion Criteria for Loved Ones: N\u002FA",{"count":276,"type":20},18,[23],"The goal of this clinical trial is to learn if a 1-on-1 support program is easy to complete and acceptable for people supporting loved ones who have recently received treatment for substance use. The main questions it aims to answer are:\n\nHow many people complete the program? How satisfied are people with the program?\n\nParticipants will:\n\nComplete weekly telehealth sessions for 12 weeks Complete surveys\u002Finterviews at the beginning, in the middle (\\~week 6), at the end of the program (\\~week 12), and 12-weeks after the end of the program Complete a focus group or interview",[280,281,282,283,284,26,285],"Support Persons","Family Members","Chosen Family","Romantic Partners","Friends","Substance Use Disorders",[280,284,285,287,288,289,290,291,292,283,282,281,26],"Alcohol","Substance Use (Drugs, Alcohol)","Social Support","Recovery","Invitation to Change","ITC","2026-04-23",{"date":295,"type":36},"2026-04-28",{"date":297,"type":20},"2026-07-01",{"date":299,"type":20},"2028-02-28",{"name":301,"class":85},"Mclean Hospital",{"id":303,"slug":304,"hasResults":11,"nctId":305,"briefTitle":306,"officialTitle":306,"acronym":4,"eligibilityCriteria":307,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":308,"targetDuration":4,"studyType":21,"phases":310,"briefSummary":311,"conditions":312,"keywords":313,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":320,"lastUpdatePostDateStruct":321,"startDateStruct":323,"completionDateStruct":325,"leadSponsor":326,"locationsCount":44},"100614519","feasibility-and-acceptability-of-an-llm-based-chatbot-for-family-caregivers-evaluation-study-100614519","NCT07280650","Feasibility and Acceptability of an LLM-based Chatbot for Family Caregivers: Evaluation Study","Inclusion Criteria (care partner)\n\n* Age 18 years or older\n* Able to independently provide informed consent\n* Able to read, speak, and understand English\n* Have an Apple (iOS) smartphone, tablet, or laptop, have access to the internet and text messages, and be willing to use these resources for the study, including downloading and using the AI chatbot app (Earkick)\n* Be caring for and adult with a medically documented diagnosis of TBI, dementia or Huntington disease (HD)\n* Provide emotional, physical, and\u002For financial support\u002Fassistance to the individual with the TBI, dementia, or HD, indicating a response per protocol\n* Indicate high levels of caregiver burden, confirmed using the 12-item Zarit Burden questionnaire (scores must be ≥20)\n* Willing to complete all study assessments for the duration of their study participation\n\nInclusion Criteria (care recipient):\n\n* Age 18 years or older\n* Have a medically documented diagnosis of TBI, dementia or Huntington disease as noted per protocol\n\nExclusion Criteria (care partner)\n\n* Anyone not meeting inclusion criteria above\n* Professional, paid caregivers\n* Anyone at the discretion of the Principal investigator (PI) that would be a preclusion of safe or meaningful participation\n\nExclusion Criteria (care recipient):\n\n* Anyone not meeting inclusion criteria\n* Lives in a care facility (assisted living, nursing home) or is bedbound",{"count":309,"type":20},60,[23],"This study evaluates the feasibility and acceptability of using the artificial intelligence (AI) chatbot mobile application (an LLM-based Chatbot) to support the well-being of informal care partners of individuals with traumatic brain injury (TBI), dementia, or Huntington disease (HD). Over an 8-week intervention period, up to 60 care partners will engage with the application (app), spending four weeks focusing on physical health and four weeks focusing on mental health. Participants will complete surveys at the midpoint and end of the intervention period. Participants will also complete a semi-structured interview to discuss participants experience using an LLM-based Chatbot.\n\nThe study team hypothesizes that care partners will find the chatbot acceptable and feasible to use in daily life, and that there will be low attrition and high completion rates of the study.",[26],[314,315,316,317,318,319],"Caregivers for adults with Traumatic Brain Injury (TBI)","Caregivers for adults with dementia","Caregivers for adults with Huntington disease","Artificial intelligence (AI) mobile application","Chatbot","Surveys","2026-04-14",{"date":322,"type":36},"2026-04-20",{"date":324,"type":20},"2026-08",{"date":140,"type":20},{"name":327,"class":85},"University of Michigan",{"id":329,"slug":330,"hasResults":11,"nctId":331,"briefTitle":332,"officialTitle":333,"acronym":334,"eligibilityCriteria":335,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":336,"targetDuration":4,"studyType":21,"phases":338,"briefSummary":339,"conditions":340,"keywords":346,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":354,"startDateStruct":356,"completionDateStruct":358,"leadSponsor":360,"locationsCount":362},"100618415","the-coma-family-program-coma-f-a-resilience-program-for-caregivers-of-patients-with-severe-acute-brain-injury-100618415","NCT07331324","The Coma Family Program (COMA-F): A Resilience Program for Caregivers of Patients With Severe Acute Brain Injury","The Coma Family Program (COMA-F): A Multi-site Clinical Trial of a Resilience Program for Caregivers of Patients With Severe Acute Brain Injury","COMA-F","Inclusion Criteria:\n\n1. 18 years or older - study population\n2. English fluency and literacy - measures and intervention are in English\n3. Screens positive for emotional distress on either depression or anxiety subscales (\\>7) of the Hospital Anxiety and Depression scale - study population (caregivers must be at-risk for chronic distress via heightened acute distress)\n4. Confirmed by the clinical team as the primary caregiver of a patient who has been admitted to an intensive care unit (ICU) with a severe acute brain injury with the following characteristics:\n\n   1. 18 years or older - study population\n   2. Admitted with ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, traumatic brain injury, or hypoxic-ischemic encephalopathy - study population\n   3. Glasgow Coma Scale score below 9 (in judgement of the clinical team) while not intubated or an inability to follow meaningful commands while intubated at any point during the hospitalization for \\> 24 consecutive hours due to the brain injury itself and not a confounding factor (e.g., sedation or seizures) - study population\n   4. Still alive in ICU at the time the clinical team approaches the caregiver about possible recruitment - excludes caregivers of those that passed away as would require a different intervention (e.g., grieving intervention)\n   5. Has been committed to or has already received long-term life-sustaining treatments including tracheostomy and\u002For percutaneous endoscopic or surgical gastrostomy tube placement (trach or PEG) - study population; at time of enrollment patients can be in various early stages of cognitive\u002Ffunctional recovery from initial coma, but all were severe enough to require trach and\u002For PEG\n   6. Has a prognosis for survival of greater than 3 months and does not have a concurrent diagnosis of a terminal illness or injury as judged by the clinical team - as in \"d\"; such caregivers would require different intervention\n   7. Is still in ICU or has been transferred to a lower level of care (e.g., stepdown) for \\\u003C7 days at the time of consent - study population; we aim to begin the intervention when caregivers are acutely distressed in the context of the patient's ICU stay or shortly after the ICU stay (i.e., within 7 days of leaving)\n\nExclusion Criteria:\n\n* 1\\. Serious mental illness, substance misuse, or active suicidal intent or plan - requires higher level of care",{"count":337,"type":20},150,[23],"The purpose of this research study is to determine whether COMA-F is more efficacious at reducing emotional distress in caregivers of patients with severe acute brain injuries, compared to health education control.",[341,342,26,343,344,345],"Caregiver Distress","Emotional Distress","Resilience","Coma","Brain Injury",[226,347,348,349,350,351,352],"emotional distress","caregiver burden","resilience","coma","severe acute brain injury","mindfulness","2026-02-18",{"date":355,"type":36},"2026-02-20",{"date":357,"type":20},"2026-05",{"date":359,"type":20},"2030-12",{"name":361,"class":85},"Massachusetts General Hospital",3,{"id":364,"slug":365,"hasResults":11,"nctId":366,"briefTitle":367,"officialTitle":368,"acronym":369,"eligibilityCriteria":370,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":371,"targetDuration":4,"studyType":21,"phases":373,"briefSummary":374,"conditions":375,"keywords":379,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":385,"lastUpdatePostDateStruct":386,"startDateStruct":388,"completionDateStruct":390,"leadSponsor":392,"locationsCount":44},"100603964","mind-body-resilience-program-for-cardiac-arrest-survivors-and-their-caregivers-recovering-together-after-cardiac-arrest-100603964","NCT07143357","Mind-body Resilience Program for Cardiac Arrest Survivors and Their Caregivers: Recovering Together After Cardiac Arrest","Development of a Dyadic Mind-body Program for Cardiac Arrest Survivors and Their Caregivers: Recovering Together After Cardiac Arrest (RT-CA).","RT-CA","Inclusion Criteria:\n\n1. Out-of-hospital or in-hospital CA survivor (must have new diagnosis of \"cardiac arrest\" in electronic medical record from index hospitalization with documented loss of pulse) with an identified caregiver (identified by the survivor who is their primary source of emotional and functional support)\n2. survivor must score \\>5 on Short Form of the Mini Mental State Exam for sufficient cognitive function for meaningful participation\n3. ability and willingness to participate in a hybrid in-person\u002Flive video intervention\n4. English speaking adults (18 year or older)\n5. at least one member of the dyad endorses clinically significant emotional distress during screening (\\>7 on either of the Hospital Anxiety and Depression Scale subscales).\n\nExclusion Criteria:\n\n1. active psychosis, mania, substance dependence, or suicidal intent or plan that would require a higher level of care\n2. any other psychiatric or neurological condition that would preclude meaningful participation\n3. the caregiver must not be a cardiac arrest survivor",{"count":372,"type":20},84,[23],"The purpose of this study is to pilot two resilience interventions for cardiac arrest survivors and their informal caregivers, Recovering Together after Cardiac Arrest 1 and Recovering Together after Cardiac Arrest 2 . The data the investigators gather in this study will be used to further refine the interventions.",[342,376,377,222,26,378,343,125],"Cardiac Arrest (CA)","Anxiety","Survivorship",[347,380,381,226,349,352,382,383,190,384],"cardiac arrest","cardiac arrest survivorship","mind-body","behavioral interventions","depression","2025-10-21",{"date":387,"type":36},"2025-10-23",{"date":389,"type":36},"2025-10-17",{"date":391,"type":20},"2028-07",{"name":361,"class":85},{"id":394,"slug":395,"hasResults":11,"nctId":396,"briefTitle":397,"officialTitle":398,"acronym":4,"eligibilityCriteria":399,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":400,"targetDuration":4,"studyType":402,"phases":4,"briefSummary":403,"conditions":404,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":409,"lastUpdatePostDateStruct":410,"startDateStruct":412,"completionDateStruct":414,"leadSponsor":416,"locationsCount":44},"100549387","a-multi-center-investigation-of-family-health-100549387","NCT06433349","A Multi-center Investigation of Family Health.","A Multi-center Investigation of Family Health, Needs, Perceived Support, Self-efficacy and Quality of Life During the Cancer Trajectory: A Longitudinal Mixed Methods Study Among Danish Cancer Patients and Their Caregivers","Inclusion Criteria:\n\n* curative intended patients and their eventual appointed caregivers \\>18\n* breast-, prostate- colorectal cancer or lymphoma.\n\nExclusion Criteria:\n\n* Not able to understand or give written informed consent\n* Not able to speak Danish or complete questionnaires in Danish",{"count":401,"type":20},240,"OBSERVATIONAL","The current healthcare system is unable to identify burdened and vulnerable families affected by cancer, partly due to a lack of knowledge of how cancer affects family health during treatment and survivorship. Recent reviews have documented a general lack of cancer studies including both the patient and the family, and a particular deficiency in studies including more than the spouse.\n\nThe principal aim of this study is to investigate family health, needs and perceived support, quality of life, self-efficacy, depression, stress and resilience in both patients with cancer and their families across the cancer trajectory. Additionally, the study seeks to identify particularly burdened and vulnerable families and investigate contributing factors to their vulnerability.",[405,406,407,408,26],"Breast Cancer","Prostate Cancer","Colorectal Cancer","Hematologic Neoplasms","2025-09-30",{"date":411,"type":36},"2025-10-06",{"date":413,"type":36},"2024-05-13",{"date":415,"type":20},"2028-12-31",{"name":417,"class":85},"Odense University Hospital",{"id":419,"slug":420,"hasResults":11,"nctId":421,"briefTitle":422,"officialTitle":422,"acronym":423,"eligibilityCriteria":424,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":425,"targetDuration":4,"studyType":21,"phases":426,"briefSummary":427,"conditions":428,"keywords":430,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":445,"lastUpdatePostDateStruct":446,"startDateStruct":448,"completionDateStruct":450,"leadSponsor":451,"locationsCount":44},"100607104","effect-of-a-person-centred-care-intervention-for-families-providing-home-based-care-to-a-person-with-advanced-chronic-illness-a-pilot-randomised-controlled-trial-100607104","NCT07184216","Effect of a Person-Centred Care Intervention for Families Providing Home-Based Care to a Person With Advanced Chronic Illness: A Pilot Randomised Controlled Trial","HELP-F","Inclusion Criteria:\n\n1. Inclusion Criteria for the Person with Advanced Chronic Illness:\n\n   * Diagnosis of an advanced chronic disease, such as chronic heart failure (NYHA functional class IV), renal failure (stages 4-5), chronic obstructive pulmonary disease (COPD) (grades 4-5 on the MRC scale), or liver failure.\n   * Not currently receiving care from a specialized palliative care team.\n   * Habitual residence in their own home or that of a family member, without requiring permanent hospitalization.\n2. Inclusion Criteria for the Family Caregiving Unit:\n\n   * Actively providing care at home to an adult with advanced illness at the time of the study.\n   * A minimum of two months must have elapsed since the initiation of family caregiving for the person with advanced chronic illness at home.\n   * At least two or more adult family members of the person with advanced illness must participate in the study.\n3. Inclusion Criteria for Individual Caregivers\n\n   * Recognized as a caregiver by the person with advanced chronic illness.\n   * Aware of the advanced illness diagnosis of the care recipient.\n   * Aged 18 years or older.\n   * Able to communicate in Spanish.\n   * Having the physical and mental capacity to participate in the interview.\n   * Willing and able to provide written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Life expectancy of less than one year\n* Families experiencing an acute crisis situation (e.g., recent bereavement, severe family conflict).",{"count":19,"type":20},[23],"The goal of this clinical trial is to learn if a Person-Centred Care (PCC) intervention can improve the caregiving experience and wellbeing of families who provide home care for a loved one with advanced chronic illness. The main questions it aims to answer are:\n\n* Does the PCC intervention improve families' caregiving experience, preparedness for caregiving, and psychological wellbeing?\n* Is the PCC intervention feasible and acceptable for implementation in primary care settings?\n\nResearchers will compare families who receive the PCC intervention in addition to usual care to families who receive usual care alone.\n\nParticipants will:\n\n* Take part in an initial in-person consultation with a primary care nurse to share their family caregiving experience and co-create a personalized health plan.\n* Have monthly follow-up contacts with the same nurse over a 3-month period to update and adapt the plan.\n* Receive a copy of the updated plan after each contact to guide caregiving and support decision-making.",[429,26],"Chronic Illness",[431,432,433,434,435,436,437,438,439,440,441,442,63,443,444],"Person-centredness","RCT","Partnership","Health plan","Person-centred care","Person-centered care","Patient-centered care","Home care","In-home care","Home-based care","Community home care","Carers","Informal caregivers","Care providers","2025-09-13",{"date":447,"type":36},"2025-09-19",{"date":449,"type":20},"2025-10-01",{"date":109,"type":20},{"name":452,"class":85},"Clinica Universidad de Navarra, Universidad de Navarra",{"id":454,"slug":455,"hasResults":11,"nctId":456,"briefTitle":457,"officialTitle":457,"acronym":458,"eligibilityCriteria":459,"healthyVolunteers":92,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":460,"targetDuration":4,"studyType":21,"phases":462,"briefSummary":463,"conditions":464,"keywords":466,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":469,"lastUpdatePostDateStruct":470,"startDateStruct":472,"completionDateStruct":474,"leadSponsor":475,"locationsCount":44},"100605209","music-listening-impact-on-quality-of-life-brain-and-burnout-of-alzheimer-patients-informal-caregivers-100605209","NCT07159542","MUSic Listening Impact on QUality of Life, Brain and Burnout of ALzheimer' Patients Informal Caregivers","MUSIQUAL+","Inclusion Criteria:\n\n* Native language: French\n* Medical, neurological, neuropsychological and neuroradiological depth in accordance with the criteria for inclusion and exclusion-specific population, that is to say:\n\n  * Informal Caregivers: Being a carer for someone with neurodegenerative cognitive disorders (NCD), living at home, without memory complaints, normal performances compared to the age and the educational level for all tests of the diagnostic battery.\n  * Patients with neurodegenerative cognitive disorders: presenting neurodegenerative cognitive disorders, have an identified informal caregiver.\n\nExclusion Criteria:\n\n* A chronic neurological, psychiatric, endocrine, hepatic or infectious complaint\n* A history of major disease (an uncontrolled diabetes, a lung, heart, metabolic, hematologic, endocrine disease or a severe cancer);\n* A medication that may interfere with memory or metabolic measures",{"count":461,"type":20},90,[23],"Although life expectancy is increasing, the risk of dependence and\u002For loss of autonomy is increasing too with ageing. Alzheimer's disease affects many people and this kind of disease is constantly growing. Today, relatives of these sick people are increasingly taking on the role of carer to help them remain at home as long as possible. This situation of assistance has often a negative impact on the quality of life of the caregiver, which in some cases can lead to the caregiver burnout and increase the risk factors for developing pathological ageing. This situation can also damage the relationship and the quality of interactions between patient\u002Fcaregiver dyad. Non-pharmacological therapies and the use of digital tools appear to be promising avenues to fight psychological distress and social isolation, but also to improve the quality and duration of homecare services, by promoting the autonomy of the patient. The MUSIQUAL+ study aims to evaluate the impact of music listening offered to caregivers, alone or with their sick relative, on the quality of life and the exhaustion felt by the caregiver. Three times 20-minute sessions a week of music listening at home through the use of a tablet application, for 12 weeks, will be proposed. In addition to the collection of subjective feelings of the caregivers, a neuropsychological evaluation of the patient and the caregiver will be carried out on 90 dyads divided. Finally, in order to better understand the cerebral mechanisms involved and to provide evidence of the effect of this intervention, an EEG recording will be made before and after the musical listening. This study proposes a therapeutic and preventive alternative to drug treatments and to the currently unsatisfactory support of patients and their caregivers in distress; its benefits will be assessed too.",[465,26],"Alzheimer Dementia (AD)",[26,467,468],"Music intervention","Alzheimer","2025-09-05",{"date":471,"type":36},"2025-09-08",{"date":473,"type":20},"2025-09",{"date":208,"type":20},{"name":476,"class":85},"University Hospital, Caen",{"id":478,"slug":479,"hasResults":11,"nctId":480,"briefTitle":481,"officialTitle":482,"acronym":4,"eligibilityCriteria":483,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":484,"targetDuration":4,"studyType":402,"phases":4,"briefSummary":486,"conditions":487,"keywords":493,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":499,"startDateStruct":501,"completionDateStruct":503,"leadSponsor":505,"locationsCount":44},"100605863","young-children-and-screens-parents-perspectives-and-child-health-nurses-approaches-in-a-digital-age-100605863","NCT07168057","Young Children and Screens: Parents' Perspectives and Child Health Nurses' Approaches in a Digital Age","Young Children and Screens: A Study Protocol of Parents' Perspectives and Child Health Nurses' Approaches in a Digital Age","Inclusion Criteria:\n\n* Parents whose child\u002Fchildren is\u002Fare registered in the Swedish Child Health Care center(s) that participate in the study and that have at least one child at age 0-5 yrs.\n* Child health nurses working in the Swedish Child Health Care center(s) that participate in the study\n\nExclusion Criteria:\n\n* Parent not having children registered in the participating health care centers at age 0-5 yrs.\n* Child health nurses not working at the participating child health centers.",{"count":485,"type":20},320,"The overall aim of the research project is to investigate screen habits among children (0-5 years) and their parents including nurses' perspective, and further parents' and nurses' experiences of using web-based healthcare advisory services within Swedish child health care (CHC).\n\nThe main research questions are:\n\nWhat is the correlation between children's and their parents' screen use?\n\nHow does screen use differ among families with various socioeconomic backgrounds?\n\nHow well does the modified SCREEN-Q instrument measure screen use in Swedish conditions?\n\nHow do parents perceive their own and their children's screen use and their parental role?\n\nWhat are parents' views on available advice and recommendations regarding children's screen use?\n\nHow do parents use and experience web-based advisory services within health care and Swedish child health care (CHC)?\n\nHow do CHC nurses address screen media-related issues within CHC?\n\nWhat are CHC nurses' experiences with web-based advisory services?\n\nParticipants will:\n\n* Complete a survey on screen habits and digital health service use (N ≈ 300)\n* Contribute to validation of a modified SCREEN-Q instrument\n* Take part in interviews (parents) and focus groups (child health nurses)",[488,489,490,491,26,492],"Primary Health Care Providers","Early Childhood Behavior","Child Health Services","Parenting Practices","Nursing Practice",[494,495,496,497,498],"digital advisory services","child healthcare","nurses","parents","screen use",{"date":500,"type":36},"2025-09-11",{"date":502,"type":20},"2026-02-01",{"date":504,"type":20},"2030-12-31",{"name":506,"class":85},"Karolinska Institutet",{"id":508,"slug":509,"hasResults":11,"nctId":510,"briefTitle":511,"officialTitle":511,"acronym":4,"eligibilityCriteria":512,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":513,"targetDuration":4,"studyType":402,"phases":4,"briefSummary":514,"conditions":515,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":520,"lastUpdatePostDateStruct":521,"startDateStruct":523,"completionDateStruct":525,"leadSponsor":527,"locationsCount":44},"100602388","predictive-factors-for-initial-mmse-score-and-rapid-decline-in-alzheimers-disease-patients-100602388","NCT07122856","Predictive Factors for Initial MMSE Score and Rapid Decline in Alzheimer's Disease Patients","Inclusion Criteria:\n\n* Confirmed diagnosis of Alzheimer's disease according to NIAA 2018 or IWG 2021 criteria\n* At least two MMSE evaluations spaced 12 months apart\n* Follow-up at the Memory Clinic of CH Gonesse\n\nExclusion Criteria:\n\n* Presence of other neurodegenerative diseases (e.g., Frontotemporal Dementia, Multiple System Atrophy, Vascular Dementia, LATE)\n* Patient has moved out of the study area (outside the CH Gonesse territory)",{"count":251,"type":20},"This study looks at people with Alzheimer's disease to find out which factors are linked to their initial score on the Mini-Mental State Examination (MMSE) and which factors may predict a fast decline in their score over 12 months. Researchers will review medical records from patients seen at the Memory Clinic of Gonesse Hospital and analyze information such as age, education, medical history, nutrition, mood, and caregiver burden. The goal is to better understand what influences early cognitive performance and how quickly it changes, to help improve patient care and planning.",[516,517,518,519,26],"Alzheimer Disease","Mini-Mental State Examination","Cognitive Dysfunction","Neuropsychological Tests","2025-08-08",{"date":522,"type":36},"2025-08-14",{"date":524,"type":20},"2025-09-15",{"date":526,"type":20},"2026-03-15",{"name":528,"class":85},"Centre Hospitalier de Gonesse",{"id":530,"slug":531,"hasResults":11,"nctId":532,"briefTitle":533,"officialTitle":533,"acronym":4,"eligibilityCriteria":534,"healthyVolunteers":92,"sex":16,"minAge":535,"maxAge":4,"enrollmentInfo":536,"targetDuration":4,"studyType":402,"phases":4,"briefSummary":538,"conditions":539,"keywords":545,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":551,"lastUpdatePostDateStruct":552,"startDateStruct":554,"completionDateStruct":556,"leadSponsor":558,"locationsCount":44},"100597195","development-and-improvement-of-home-rehabilitation-scheme-for-preschool-children-with-congenital-heart-disease-after-operation-100597195","NCT07055334","Development and Improvement of Home Rehabilitation Scheme for Preschool Children With Congenital Heart Disease After Operation","Children With Congenital Heart Disease After Surgery\n\nInclusion Criteria:\n\n* Age 3 to 7 years\n* Clinical diagnosis of congenital heart disease\n* Underwent a single open-heart surgical correction under direct vision at the study site\n* Ability to communicate in Chinese\n\nExclusion Criteria:\n\n* Postoperative arrhythmia\n* Comorbid neurological, respiratory, or other systemic diseases\n* Deemed unsuitable for exercise by a physician\n* Cardiac function classified as NYHA Class IV\n* Intellectual, language, or motor impairments resulting from perioperative complications or other causes\n\nCaregivers of Children With Congenital Heart Disease After Surgery\n\nInclusion Criteria:\n\n* Primary caregiver who voluntarily provides care\n* Caregiver who spends the most time with the child\n* Ability to communicate in Chinese\n\nExclusion Criteria:\n\n* Caregivers of children who voluntarily discontinued treatment before completion\n* Paid or professional caregivers\n* Diagnosed cognitive impairment or mental illness\n* Inability to communicate effectively through spoken language\n* Presence of serious conflict or instability in the caregiver-child relationship\n* Inability to independently operate or use smart electronic devices and the internet\n\nMedical Professionals Involved in Congenital Heart Disease Care\n\nInclusion Criteria:\n\n* Licensed healthcare professionals, including physicians, nurses, dietitians, physical therapists, or psychological counselors\n* At least 5 years of professional experience in congenital heart disease care, rehabilitation, or education\n\nExclusion Criteria:\n\n* Not currently engaged in frontline clinical work\n* Not engaged in clinical work within the past year due to leave, study, or reassignment","3 Years",{"count":537,"type":20},30,"This part of the study focuses on understanding the home rehabilitation situation for preschool children with congenital heart disease after operation. Qualitative research interviews with caregivers and medical staff (including doctors, nurses, rehabilitation therapists, nutritionists, and psychologists) are conducted to explore the benefits, obstacles, and professional guidance needs of home rehabilitation. The aim is to summarize the best evidence for home rehabilitation through evidence-based nursing and qualitative research, in order to develop a more comprehensive and suitable home rehabilitation scheme for these children.",[540,541,542,543,26,544],"Heart Defects, Congenital","Rehabilitation","Preschool Child","Qualitative Research","Medical Staff, Hospital",[546,547,548,549,550],"congenital heart disease","home-based cardiac rehabilitation","Primary caregiver","qualitative research","preschool child","2025-06-27",{"date":553,"type":36},"2025-07-08",{"date":555,"type":20},"2025-07-10",{"date":557,"type":20},"2026-12-31",{"name":559,"class":85},"Wei XIA, PhD",{"id":561,"slug":562,"hasResults":11,"nctId":563,"briefTitle":564,"officialTitle":565,"acronym":566,"eligibilityCriteria":567,"healthyVolunteers":92,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":568,"targetDuration":569,"studyType":402,"phases":4,"briefSummary":570,"conditions":571,"keywords":577,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":580,"lastUpdatePostDateStruct":581,"startDateStruct":583,"completionDateStruct":585,"leadSponsor":586,"locationsCount":44},"100579972","new-rear-anti-tip-device-for-manual-wheelchairs-subjective-input-rad-si-100579972","NCT06831240","New Rear Anti-tip Device for Manual Wheelchairs: Subjective Input (RAD-SI)","New Rear Anti-tip Device for Manual Wheelchairs: Subjective Input from Wheelchair Service Providers and End-Users","RAD-SI","Inclusion Criteria:\n\nAll participants:\n\n* at least 18 years of age\n* willing to participate\n* alert\n* co-operative\n* able to see and hear the video demonstrations\n* able to communicate in English\n* have the capacity to provide informed consent\n* committed to setting a scheduled time for the study activity\n\nWheelchair service providers:\n\n* Occupational Therapists or Occupational Therapy Assistants who self-identify as being regularly involved in the wheelchair provision process wheelchair users:\n* person who has used a manual wheelchair for at least one month caregiving participant:\n* spends an average total of at least 2 hours per week with the manual wheelchair user that includes manual wheelchair mobility online survey:\n* self-identifies as being regularly involved in the wheelchair provision process\n\nExclusion Criteria:\n\n• emotional problems that might make participation unsafe or unpleasant",{"count":337,"type":20},"1 Day","The objective of this study is to obtain subjective input from wheelchair service providers and end-users about their experiences with conventional rear anti-tip devices (C-RADs) of manual wheelchairs and the potential usefulness of a new design.",[572,26,573,574,575,576],"Wheelchair Users","Wheelchair Service Providers","Amputation","Stroke","Spinal Cord Injury",[578,579],"wheelchair","rear anti-tip device","2025-02-20",{"date":582,"type":36},"2025-02-21",{"date":584,"type":20},"2025-04-15",{"date":320,"type":20},{"name":587,"class":85},"Nova Scotia Health Authority",{"id":589,"slug":590,"hasResults":11,"nctId":591,"briefTitle":592,"officialTitle":593,"acronym":4,"eligibilityCriteria":594,"healthyVolunteers":92,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":595,"targetDuration":4,"studyType":21,"phases":597,"briefSummary":598,"conditions":599,"keywords":600,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":605,"lastUpdatePostDateStruct":606,"startDateStruct":608,"completionDateStruct":610,"leadSponsor":612,"locationsCount":4},"100557923","the-impact-of-chatbot-assisted-nursing-education-on-perceived-burden-of-care-and-caregiver-stress-100557923","NCT06544421","The Impact of Chatbot-Assisted Nursing Education on Perceived Burden of Care and Caregiver Stress","The Effect of Chatbot-Assisted Nursing Education on Perceived Care Burden and Caregiver Stress","Inclusion Criteria:\n\n* To be at least a primary school graduate\n* Caregivers have the cognitive capacity to use chatbots (The chatbot application will be installed on the caregiver's android phone and the status of using it will be evaluated)\n* Willingness to participate in the study\n* To be open to communication and cooperation\n* Having a phone with Android operating system\n* Have literacy skills\n* Not having participated in stress training before\n\nExclusion Criteria:\n\n* Having received any psychiatric diagnosis.\n* Taking antipsychotic medication",{"count":596,"type":20},62,[23],"Caregivers play a key role in the provision of day-to-day care and the coordination of care services. Caregivers of stroke patients use dysfunctional coping strategies to cope with the stressors and burden of care they encounter during this long caregiving process. In this study, it will be tried to improve the stress coping skills of caregivers by using an application with chatbot support based on the COM-B model.In the study, introductory information form, stress coping styles scale, depression, anxiety, stress (DASS 21) and burden of care measurement tool will be used. The study will be conducted in a randomized controlled manner. Chatbot will be applied to the experimental group and the control group will be exposed to routine practice. The study group will consist of individuals who care for those who are discharged home from Atatürk University stroke center. Experiments and controls will be accessed by searching the hospital records. The fact that nursing education is given through a chatbot and that the chatbot is designed according to a stress training model (behavior change wheel) reflects the originality of the study. With this study, caregivers are expected to be able to manage stress effectively by teaching them how to cope with stress.",[318,377,222,157,26],[189,318,601,602,603,604],"paralysis","Caring giver","Nursing Education","Home Care","2024-08-06",{"date":607,"type":36},"2024-08-09",{"date":609,"type":20},"2024-08-10",{"date":611,"type":20},"2025-07-31",{"name":613,"class":85},"Ataturk University",{"id":615,"slug":616,"hasResults":11,"nctId":617,"briefTitle":618,"officialTitle":619,"acronym":4,"eligibilityCriteria":620,"healthyVolunteers":92,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":621,"targetDuration":4,"studyType":21,"phases":622,"briefSummary":623,"conditions":624,"keywords":626,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":630,"lastUpdatePostDateStruct":631,"startDateStruct":633,"completionDateStruct":635,"leadSponsor":637,"locationsCount":4},"100553351","the-effect-of-horticultural-therapy-on-mental-health-and-burnout-levels-of-nursing-home-workers-100553351","NCT06484959","The Effect of Horticultural Therapy on Mental Health and Burnout Levels of Nursing Home Workers","The Effect of Horticultural Therapy Applied to Nursing Home Workers on Depression, Anxiety, Stress and Burnout Levels","Inclusion Criteria:\n\n* Working in a nursing home\n* Not being allergic to flowers and plants\n* Willingness to work\n* To be open to communication and cooperation,\n* Scoring 8 points or more on the stress sub-dimension of the DASS measurement tool\n\nExclusion Criteria:\n\n* Those with musculoskeletal disorders\n* Those who use antipsychotic drugs",{"count":309,"type":20},[23],"The incidence of people with disabilities in need of care services is increasing all over the world. This situation significantly increases the need for nursing homes and caregivers. In many countries, it is seen that \"Horticultural Therapy\" programs have started to be implemented to improve mental health. In this context, our aim in the project is to determine the effect of the \"Horticultural therapy\" program applied to nursing home employees in terms of mental health and burnout in nursing home employees. It is thought that the positive effect of this practice on nursing home employees will be able to better maintain their care-oriented practices. It is envisaged that the gardens to be built within the scope of the therapy program can be planned as areas where both caregivers and caregivers can be used, and the application can be integrated into other areas within the scope of public health over time",[625,377,222,157,26],"Horticultural Therapy",[627,628,26,629],"Horticultural therapy","exhausted","Mental Health","2024-07-01",{"date":632,"type":36},"2024-07-03",{"date":634,"type":20},"2024-07-15",{"date":636,"type":20},"2024-11-30",{"name":613,"class":85},{"id":639,"slug":640,"hasResults":11,"nctId":641,"briefTitle":642,"officialTitle":643,"acronym":644,"eligibilityCriteria":645,"healthyVolunteers":92,"sex":16,"minAge":17,"maxAge":93,"enrollmentInfo":646,"targetDuration":4,"studyType":21,"phases":648,"briefSummary":649,"conditions":650,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":667,"lastUpdatePostDateStruct":668,"startDateStruct":670,"completionDateStruct":672,"leadSponsor":674,"locationsCount":44},"100462875","cancer-associated-muscle-mass---molecular-factors-and-exercise-mechanisms-100462875","NCT05307367","Cancer-associated Muscle Mass - Molecular Factors and Exercise Mechanisms","Identifying Molecular Factors Contributing to Cancer-associated Muscle Mass Loss and Providing Clinical Evidence for Exercise Mechanisms to Functionally Restore Muscle in Cancer","PANACEA","Inclusion Criteria, WP1+WP2X+WP2:\n\n* Men and women at or above the age of 18\n* Histological and radiological verified NSCLC (both squamous and adenocarcinoma) st. IIIb\u002FIV stage not eligible to concurrent chemo\u002Fradiation therapy as primary treatment\n* Referred for 1st line palliative anticancer therapy (platin based, immunotherapy, combined therapy or TKI), this goes for WP1 + WP2\n* Referred for palliative anticancer therapy (platin based, immunotherapy, combined therapy or TKI), for recurrent cancer, this goes only for WP2X.\n* Having a staging\u002Fbaseline CT within 4 weeks of initiation of treatment (PET\u002FCT are also allowed), or a baseline scan planned within the first week of treatment.\n* ECOG Performance Status 0-2\n* Having signed the informed consent form\n\nExclusion Criteria, WP1+WP2X+WP2:\n\n* Any other known malignancy requiring active treatment (prior cancer diagnosis is not some exclusion criteria if oncology-treatment is completed)\n* Local palliative radiotherapy as primary treatment\n* ECOG Performance status \\> 2\n* Physical disabilities excluding physical testing\n* Inability to understand Danish\n* Inability to understand scoring systems\u002Fpatient-reported outcome measures\n\nInclusion Criteria, WP3:\n\n* Men and women above the age of 18\n* Histological and radiological verified NSCLC (both squamous and adenocarcinoma) st. IIIb\u002FIV stage\n* ECOG Performance Status 0-2\n* Having signed the informed consent form.\n\nExclusion Criteria, WP3:\n\n* Any other known malignancy requiring active treatment (prior cancer diagnosis is not some exclusion criteria if oncology-treatment is completed)\n* ECOG Performance Status \\> 2\n* Physical disabilities excluding physical testing\n* Inability to understand Danish\n* Inability to understand scoring systems\u002Fpatient-reported outcome measures",{"count":647,"type":20},144,[23],"Muscle mass loss is a common adverse effect of cancer. Muscle mass loss occurs with or without reduction in body weight. Cancer cachexia (CC) is the involuntary loss of body weight of \\>5% within 6 months and it occurs in 50-80% of patients with metastatic cancer.\n\nIt is estimated that CC is a direct cause of up to 30% of all cancer-related deaths. No treatment currently is available to prevent CC, likely because the chemical reactions that causes of this devastating phenomenon in unknown.\n\nNo treatment currently is available to prevent muscle mass loss in patients with cancer but is urgently needed as the reduced muscle mass and function is associated with impaired physical function, reduced tolerance to anticancer therapy, poor quality of life (QoL), and reduced survival. There is evidence of an interdependence between informal caregiver (e.g. spouse) and patient QoL. Thus, identifying caregiver distress and needs can potentially benefit QoL for patients with cancer cachexia. Despite the enormous impact on disease outcomes, it is not known why the loss of muscle mass and function occurs and very few studies have investigated the underlying molecular causes in humans. In particular, there is a severe lack of studies that have obtained human skeletal muscle and adipose tissue sample material. Such reference sample materials will be invaluable to obtaining in-depth molecular information about the underlying molecular causes of the involuntary but common muscle mass and fat mass loss in cancer.\n\nAt a whole body level, cancer cachexia is associated with reduced sensitivity to the hormone insulin, high levels of lipids in the blood, and inflammation. Within the skeletal muscle, the muscle mass loss is associated with elevated protein breakdown and reduced protein build-up while emerging, yet, limited data also suggest malfunction of the power plants of the cells called mitochondrions. The role of malnutrition and how it contributes to weight loss is understood only to the extent of the observed loss of appetite and the reduced food intake because of pain, nausea, candidiasis of the mouth, and breathlessness. Evidence is increasing that the environment of the intestinal system could be implicated in cancer cachexia, yet, the possible effect of cancer and the cancer treatment on the intestinal environment is not understood. Thus, large and as yet poorly understood details of this syndrome precede a later weight loss.\n\nExercise training could help restore muscle function and how the chemical reactions works in cancer. In healthy people, and patients with diabetes, cardiovascular disease, and obesity exercise potently improves health. Exercise has been thought to slow down the unwanted effects of cancer cachexia by changing the reactions mentioned above. Thus, there is a tremendous gap in our knowledge of how and if exercise can restore the cells power plants function, muscle mass, strength, and hormone sensitivity in human cachexic skeletal muscle. Tackling that problem and examining potential mechanisms, will enable us to harness the benefits of exercise for optimizing the treatment of patients with cancer.\n\nThe data will provide novel clinical knowledge on cachexia in cancer and therefore addressing a fundamental societal problem.\n\nThree specific aims will be addressed in corresponding work packages (WPs):\n\n* investigate the involvement of hormone sensitivity of insulin and measure the chemical reactions between the cells in patients with lung cancer (NSCLC) and describe the physical performance and measure amount of e.g. muscles and adipose tissue across the 1st type of cancer treatment and understand how that is related to the disease and how patients and informal caregiver feel (WP1).\n* find changes in the chemical reactions in skeletal muscle, adipose tissue (AT), and blood samples in these patients, to understand how to predict how the disease will develop (WP2).\n* measure changes of skeletal muscle tissue in response to exercise and see if it might reverse the hormone insensitivity and improve muscle signaling and function (WP3).\n\nThe investigators believe that:\n\n* the majority of patients with advanced lung cancer, at the time of diagnosis already are in a cachectic state, where they lose appetite, and have hormonal changes, and an overall altered chemical actions between the cells affecting both muscle mass and AT. The investigators propose that all this can predict how the disease will progress, and how patient- and informal caregiver fell and how they rate their quality of life.\n* lung cancer and the treatment thereof is linked with changes in the blood, the muscle tissues, and the adipose tissues, especially in patients experiencing cachexia, that could be targeted to develop new treatment.\n* exercise can restore the muscles and improve insulin sensitivity and improve the function of the cells power plants in patients with lung cancer-associated muscle problems.",[651,652,653,654,655,656,657,256,658,26,659,660,661,662,663,664,665,666],"Cachexia","Neoplasms","Exercise","Metabolism","Body Composition","Insulin Resistance","Physical Functional Performance","Sarcopenia","Adipose Tissue","Muscle, Skeletal","Patient Reported Outcome Measures","Gastrointestinal Microbiome","Proteomics","Lipidomics","Epigenomics","Mitochondria","2022-05-09",{"date":669,"type":36},"2022-05-16",{"date":671,"type":36},"2022-04-01",{"date":673,"type":20},"2028-01-01",{"name":675,"class":85},"University of Copenhagen"]