[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"caries-arrested\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:caries-arrested":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100495628","comparison-of-mi-paste-plus-and-resin-infiltration-in-white-spot-lesions-following-orthodontic-treatment-100495628",false,"NCT05733676","Comparison of MI Paste Plus and Resin Infiltration in White Spot Lesions Following Orthodontic Treatment","Comparison of MI Paste Plus and Resin Infiltration in Improvement of White Spot Lesions Following Fixed Orthodontic Treatment: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Individuals in the age range of 12-21 years who had undergone fixed orthodontic appliance therapy for a duration of 12-36 months.\n* Should have at least one white spot lesion on the labial surface of either maxillary or mandibular anterior teeth after debonding. Lesion visible with or without drying the lesion surface.\n* Patients with mild to moderate plaque accumulation. Fair oral hygiene. With a simplified Oral Hygiene Index of no more than 1.3-3.0\n\nExclusion Criteria:\n\n* Poor oral hygiene Simplified Oral Hygiene Index of 3.1-6.0 or more\n* Patients with hypoplasia or any developmental defects on the buccal of upper or lower incisors\n* Patients with any restorations on the buccal of upper or lower incisors\n* Patients that have presented WSL on the buccal of upper or lower incisors before orthodontic treatment was initiated.\n* Patients that have received any re-mineralizing agent other than regular toothpaste during the last three months\n* Patient with allergy to milk or any of their products\n* Patient with any medical \u002F oral or mental condition\n* Patients or legal guardians that does not speak or read English",true,"ALL","12 Years","21 Years",{"count":21,"type":22},62,"ESTIMATED","INTERVENTIONAL",[25],"NA","Dental cavities are among the most frequent diseases that affect teeth, particularly in patients who are treated with braces due to the difficulty in maintaining good oral hygiene in the presence of the mouth appliances. The white spot lesion (WSL) is the first clinical sign of cavities that presents itself as a milky-white opacity when located on the front face of the tooth. The aim to manage these early lesions focuses on promoting natural remineralization and preventing further demineralization. Various materials have been introduced for management of WSLs including MI paste and MI paste combined with fluoride (MI paste plus). Recently, a new material called resin infiltration has been found to treat these lesions with high esthetic results and great performance. According to the few numbers of in-vivo studies investigating the effectiveness of remineralization products, the aim of the current study is to clinically compare the outcome of the resin-infiltration and etching + MI paste plus to stop and improve the appearance of the WSL on front teeth in patients after treatment with braces.",[28,29,30,31],"White Spot Lesions","Orthodontic Appliance Complication","Caries Arrested","Smooth Surface Caries",[33,34,35,36],"White spot lesion","caries","arrested","orthodontic","RECRUITING","2026-06-25",{"date":40,"type":41},"2026-06-30","ACTUAL",{"date":43,"type":41},"2023-05-30",{"date":45,"type":22},"2028-10-01",{"name":47,"class":48},"University of Alberta","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100582316","caries-arrest-using-silver-diamine-fluoride-versus-fissure-sealant-in-occlusal-dental-carious-lesions-randomized-controlled-trial-100582316","NCT06861725","CARIES ARREST USING SILVER DIAMINE FLUORIDE VERSUS FISSURE SEALANT in OCCLUSAL DENTAL CARIOUS LESIONS: RANDOMIZED CONTROLLED TRIAL","Inclusion Criteria:\n\n1. Patient consulting in the outpatient clinic.\n2. Patients with enamel caries in molars permanent teeth, according to ICDAS 1 and 2.\n3. Provide informed consent.\n4. Co-operative patients approving to participate in the trial.\n5. Patient age (20-45 years old).\n\nExclusion Criteria:\n\n1. Tooth mobility.\n2. Signs of pulpal infection.\n3. Severe medical conditions that would not allow management in the clinic.\n4. Hereditary developmental defects, such as amelogenesis imperfecta or dentinogenesis imperfecta.\n5. Known allergies or sensitivities to dental materials, including SDF and fissure sealant.\n6. Inability to return for recall visits.\n7. Patients with bad oral hygiene\n8. Refuse to participate in the study.","20 Years","45 Years",{"count":59,"type":22},76,[25],"The goal of this randomized clinical trial is to evaluate if Silver Diamine Fluoride (SDF) is a more conservative and effective treatment in preventing the progression of mild occlusal caries compared to fissure sealant in patients aged 20-45 years with incipient molar caries. The main question it aims to answer is:\n\nIs SDF more effective in arresting caries progression than fissure sealant? Does SDF prevent the formation of new caries compared to fissure sealant? Researchers will compare SDF treatment to fissure sealant application to see if SDF results in better caries arrest and fewer new carious lesions.\n\nParticipants will:\n\nBe randomly assigned to receive either SDF or fissure sealant. Have follow-up assessments at 1, 3, 6, and 12 months for caries progression, arrest, and new caries formation.\n\nUndergo clinical evaluations using visual and tactile examinations to assess caries arrest and progression and using DIAGNOdent laser fluorescence system .",[63,30,64,65],"Dental Caries","Silver Diamine Fluoride","Fissure Sealant","NOT_YET_RECRUITING","2025-03-01",{"date":69,"type":41},"2025-03-06",{"date":71,"type":22},"2025-04-01",{"date":73,"type":22},"2026-05-01",{"name":75,"class":48},"Cairo University"]