[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"caries-dental\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:caries-dental":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,44,78,109,135,159,184],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100598185","comparative-study-of-caries-preventive-effects-2-calcium-hypophosphite-toothpaste-vs-sodium-fluoride-toothpaste-1450ppm-f-100598185",false,"NCT07068204","Comparative Study of Caries-Preventive Effects: 2% Calcium Hypophosphite Toothpaste vs. Sodium Fluoride Toothpaste (1450ppm F)","Caries-preventing Effect of 2% Calcium Hypophosphite Toothpaste Compared to a Sodium Fluoride Toothpaste (1450ppm F) in Adults","Inclusion Criteria:\n\n* A minimum of 10 healthy molars and premolars (DMFS of these teeth = 0)\n* Willingness to use an electric (powered) toothbrush\n* Willingness to use interdental floss\n* Willingness to have bitewing radiographs taken\n* Willingness to undergo an oral examination by an intraoral camera (DIAGNOcam)\n\nExclusion Criteria:\n\n* Untreated caries \\[clinical investigation and analysis with an intraoral camera (DIAGNOcam)\\] (→ unsuitable subjects with one or two untreated caries in need of a restoration can become eligible after restorative therapy. If there are three or more untreated caries patients will be excluded)\n* Xerostomia (medication, radiation, disease induced)\n* Chemo\u002Fradiation therapy\n* Physical or mental disability which prevents proper oral health care\n* Orthodontic treatment\n* Severe periodontitis at the Baseline Visit (pocket depth on at least one tooth ≥ 5.5 mm)\n* Known hypersensitivity to one of the ingredients of the toothpastes to be tested\n* Regular medication intake interfering with salivary function or flow\n* Current pregnancy, the wish to become pregnant, the suspicion of being pregnant, or breastfeeding or in the course of the study\n* 3 or more carious lesions\u002Frestorations in last 36 months until Baseline Visit\n* Teeth missing due to caries in last 36 months until Baseline Visit",true,"ALL","18 Years","45 Years",{"count":21,"type":22},164,"ESTIMATED","INTERVENTIONAL",[25],"NA","The aim of the study is to compare the caries-preventive effect of the test and control toothpaste in order to proof the non-inferiority of the test toothpaste compared to the control.",[28,29,30],"Caries, Dental","Calcium Hypophosphite","Fluoridation","RECRUITING","2026-04-10",{"date":34,"type":35},"2026-04-13","ACTUAL",{"date":37,"type":35},"2026-01-22",{"date":39,"type":22},"2028-01",{"name":41,"class":42},"Dr. Joachim Enax","INDUSTRY",2,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":16,"sex":17,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":61,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":77},"100603238","effect-of-ai-supported-child-friendly-communication-on-dental-anxiety-in-pediatric-patients-100603238","NCT07133919","Effect of AI-Supported Child-Friendly Communication on Dental Anxiety in Pediatric Patients","Evaluation of the Effect of Traditional Behavior Management Techniques and AI-Assisted Child-Friendly Communication on Dental Anxiety in Pediatric Dental Anesthesia Applications","Inclusion Criteria:\n\n* Children volunteers and their parents\u002Flegal guardians who have read and signed the informed consent form and agreed to participate in the study\n* Systemically healthy children aged 6-12 years in the mixed dentition period\n* Children requiring restorative dental procedures (including pulpotomy, pulp capping, or composite restorations) on mandibular teeth under inferior alveolar nerve block local anesthesia\n* Children who are attending their first dental visit and demonstrate behavior rated as 2 (negative) or 3 (positive) according to the Frankl Behavior Rating Scale (Categories: 1 - definitely negative; 2 - negative; 3 - positive; 4 - definitely positive) Behaviors will be categorized as positive (+) or negative (-) based on the Frankl Behavior Rating Scale (Wright's modification)\n* Children receiving local anesthesia for the first time\n\nExclusion Criteria:\n\n* Children volunteers and their parents\u002Flegal guardians who read the informed consent form but declined to participate in the study\n* Children with systemic diseases requiring continuous medication\n* Children with mental or cognitive impairments, as well as those with visual or hearing disabilities\n* Children who, after oral prophylaxis at the first visit, exhibit \"definitely negative\" (Frankl 1) or \"definitely positive\" (Frankl 4) behavior according to the Frankl Behavior Rating Scale\n* Children with previous experience of local anesthesia","7 Years","12 Years",{"count":54,"type":22},60,[25],"This study compares the effects of traditional behavior management techniques and AI-assisted child-friendly communication on dental anxiety, physiological stress, and pain perception during local anesthesia in healthy children aged 6-12. The aim is to evaluate the effectiveness of AI-supported communication tools in reducing anxiety and improving comfort in pediatric dental treatments, potentially enhancing clinical outcomes and advancing technology use in pediatric dentistry.",[28,58,59,60],"Local Anesthesia","Inferior Alveolar Nerve Block","Dental Anxiety",[62,63,64,65,66],"dental anesthesia","dental anxiety","pediatric dentistry","pediatric patients","inferior alveolar nerve block","2025-12-22",{"date":69,"type":35},"2025-12-24",{"date":71,"type":35},"2025-10-15",{"date":73,"type":22},"2026-01",{"name":75,"class":76},"Çanakkale Onsekiz Mart University","OTHER",1,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":17,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":23,"phases":89,"briefSummary":90,"conditions":91,"keywords":94,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":77},"100599964","3d-printed-ceromer-crowns-versus-stainless-steel-in-posterior-primary-molars-100599964","NCT07091331","3D-printed Ceromer Crowns Versus Stainless Steel in Posterior Primary Molars","Clinical Evaluation of 3D-printed Ceromer Crowns Versus Stainless Steel in Posterior Primary Molars","Inclusion Criteria:\n\n* Children aged 4 to 9 years with at least 2 primary molars affected by deep occlusoproximal caries.\n* Teeth may require pulp therapy (pulpotomy or pulpectomy) and be suitable for full-coverage restoration.\n* Teeth must have an antagonist and be located in opposing hemiarches.\n* The affected primary molars must be expected to remain in the mouth for at least 12 months.\n* The child must be in general good health.\n* Parents or legal guardians must sign informed consent, and the child must provide assent.\n* Patient does not come to control appointment or does not want to continue research.\n\nExclusion Criteria:\n\n* Children with systemic diseases or medical conditions affecting oral health.\n* Uncooperative behavior (Frankl scale 3 or 4).\n* Temporomandibular joint disorders or parafunctional habits (e.g., bruxism).\n* Absence of antagonist or adjacent teeth in the selected quadrants.\n* Children on long-term medication.\n* Patient with allergy to local anesthetic, nickel or chromium.","4 Years","9 Years",{"count":88,"type":22},40,[25],"The aim of the study is to compare preformed metal crowns and 3D-printed ceromer crowns in primary molars of 4-9 years old children. The main questions it aims to answer are:\n\n* How does 3D-printed ceromer crowns compare clincally to stainless steel crowns when restoring posterior molars?\n* What is the level of satisfaction of the patient with both materials?\n* What is the level of parental satisfaction with both materials?\n\nStudy methodology:\n\nThis study is a split-mouth clinical trial where participants will receive at least one of each materials in different quadrants of the mouth.",[28,92,93],"Caries; Dentin","Dental Caries in Children",[95,96,97,98],"Printing, Three-dimensional","Pediatric Dentistry","Tooth, Deciduous","Esthetics, Dental","NOT_YET_RECRUITING","2025-07-22",{"date":102,"type":35},"2025-07-29",{"date":104,"type":22},"2025-07-30",{"date":106,"type":22},"2026-06-15",{"name":108,"class":76},"Universidad Autonoma de Baja California",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":16,"sex":17,"minAge":115,"maxAge":18,"enrollmentInfo":116,"targetDuration":118,"studyType":119,"phases":4,"briefSummary":120,"conditions":121,"keywords":124,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":4},"100579453","orthodontic-treatment-on-oral-microbiota-and-salivary-proteins-100579453","NCT06824493","Orthodontic Treatment on Oral Microbiota and Salivary Proteins","Inclusion Criteria:\n\n* No carries and White spot\n* No missing teeth\n* No history of oral treatment\n* No malocclusion\n* No systemic diseases\n\nExclusion Criteria:\n\n* Antibiotic use in the past three months\n* A history of long-term medication use\n* A history of dental fillings\n* Unable to attend regular follow-ups","6 Years",{"count":117,"type":22},150,"2 Years","OBSERVATIONAL","Study on the changes in oral microbiota during orthodontic treatment in patients aged 8-18 years. Orthodontic patients treated at Stomatology Hospital of Xi'an Jiaotong University from March 2025 to March 2027 will be recruited. Prior to orthodontic treatment, routine preoperative examinations will be conducted, informed consent forms will be signed, baseline oral conditions will be recorded, and oral and psychological-related questionnaires will be completed. Patients will be informed of the need for regular oral hygiene check-ups, caries risk assessments will be performed, and plaque, saliva, and intraoral photographs will be collected. During orthodontic treatment, plaque samples will be collected every 3 months, and saliva samples will be collected every 6 months until the treatment is completed to evaluate the changes in oral microbiota throughout the orthodontic process.",[122,123,28],"Orthodontics","White Spot Lesions [Initial Caries] on Smooth Surface of Tooth",[125],"microbiota","2025-05-28",{"date":128,"type":35},"2025-06-04",{"date":130,"type":22},"2025-07-01",{"date":132,"type":22},"2027-09-01",{"name":134,"class":76},"Xi'an Jiaotong University",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":4,"eligibilityCriteria":141,"healthyVolunteers":11,"sex":17,"minAge":142,"maxAge":143,"enrollmentInfo":144,"targetDuration":4,"studyType":23,"phases":146,"briefSummary":147,"conditions":148,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":4},"100583900","performance-of-bioactive-low-viscosity-composite-in-deep-marginal-elevation-restorations-100583900","NCT06882343","Performance of Bioactive Low Viscosity Composite in Deep Marginal Elevation Restorations","Performance of Bioactive Low Viscosity Composite in Deep Marginal Elevation Restorations: a Randomized Clinical Trial","Inclusion Criteria:\n\n* Adults patients (20-50)\n* Good oral hygiene (plaque index 0 or 1 )\n* Patient approving to participate in the study\n* Absence of parafunctional habits and\u002For bruxism\n\nExclusion Criteria:\n\n* Patients with known allergic or adverse reaction to the tested materials.\n* Systematic disease that may affect participation.\n* Xerostomic patients.\n* Bad oral hygiene (plaque index 2 or 3 )\n* Heavy smokers\n* Patients undergoing or will start orthodontic treatment\n* Patients with removable prothesis","20 Years","50 Years",{"count":145,"type":22},50,[25],"The goal of this study is to evaluate the clinical, radiographic and periodontal performance of bioactive Giomer Shofu Flow Plus X F03 compared to nanohybrid resin composite restoration in deep subgingival proximal cavities over a period of 12 months.",[149,28],"Deep Caries","2025-03-18",{"date":152,"type":35},"2025-03-21",{"date":154,"type":22},"2025-04-01",{"date":156,"type":22},"2026-04-01",{"name":158,"class":76},"Future University in Egypt",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":16,"sex":17,"minAge":142,"maxAge":166,"enrollmentInfo":167,"targetDuration":4,"studyType":119,"phases":4,"briefSummary":169,"conditions":170,"keywords":171,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":4},"100561855","effect-of-caries-conceptualizing-and-residential-university-life-100561855","NCT06595589","Effect of Caries Conceptualizing and Residential University Life","The Effect of Dental Caries Conceptualizing and the Residential University Life on the Caries Prevalence and Caries Prevention Practice of Egyptian Dental Students: Observational Cross-Sectional Study.","Inclusion criteria will be:\n\n* Students already taught a dental cariology in 4th year of university.\n* Students registered in the Galala dental program science year one.\n* Medically free students.\n* Students having at least 1year clinical practice.\n\nExclusion criteria will be:\n\n* First, second-, and third-year students.\n* Non dental students.","22 Years",{"count":168,"type":22},303,"The study aims to detect the conceptualization of dental caries among dental student and compare the caries prevalence in residential and non residential dental student",[28],[172,173,174],"caries prevalence","residential students","dental students","2024-09-17",{"date":177,"type":35},"2024-09-19",{"date":179,"type":22},"2024-10-01",{"date":181,"type":22},"2025-08-01",{"name":183,"class":76},"Sara Ibrahim Ahmed Hedia",{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":4,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":191,"enrollmentInfo":192,"targetDuration":4,"studyType":23,"phases":194,"briefSummary":195,"conditions":196,"keywords":197,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":201,"lastUpdatePostDateStruct":202,"startDateStruct":203,"completionDateStruct":204,"leadSponsor":206,"locationsCount":4},"100562346","partial-caries-removal-in-permanent-molars-restored-using-giomer-100562346","NCT06601972","Partial Caries Removal in Permanent Molars Restored Using Giomer","Clinical and Radiographic Evaluation of Partial Caries Removal in Permanent Molars Restored Using Giomer Compared to Resin Composite Restorations After 24 Months (A Randomized Clinical Trial)","Inclusion Criteria:\n\n1. Inclusion criteria of participants:\n\n   * 18 -35 years.\n   * Not received antibiotic therapy since 1 month before sampling.\n   * Males or Females (Both genders).\n   * Co-operative patients approving the trial.\n   * Good to fair oral hygiene\n2. Inclusion criteria of teeth:\n\n   * Class I cavitated lesions in permanent molars (reaching \\>1\u002F2 of the dentin on radiographic examination)\n   * Absence of spontaneous pain; negative sensitivity to percussion; and absence of periapical lesions (radiographic examination).\n\nExclusion Criteria:\n\n1. Exclusion criteria of participants:\n\n   * known allergic reaction to resinous materials.\n   * Systemic disease or severe medical complications.\n   * Periodontal problem.\n   * Bruxism\n   * Poor oral hygiene\n2. Exclusion criteria of teeth:\n\n   * Class II caries lesion\n   * Shallow or enamel caries\n   * Teeth with periapical lesions.\n   * Mobile teeth, arrest caries and non-vital teeth","35 Years",{"count":193,"type":22},122,[25],"Dental manufacturers\\' constant tweaks and improvements to composite compositions have resulted in a wider spectrum of restorative materials with positive long-term clinical performance. For example, the creation of bioactive giomer material with proven continuous multi-ion release has been beneficial in avoiding demineralization and imparting acid resistance to enamel and dentin.",[28],[198,199,200],"partial caries removal","bioactive","giomer","2024-09-16",{"date":177,"type":35},{"date":179,"type":22},{"date":205,"type":22},"2026-12-01",{"name":207,"class":76},"NewGiza University"]