[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"carious-exposure-of-pulp\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:carious-exposure-of-pulp":33},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,59,86],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":36,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":58},"100644947","oxymetazoline-versus-sodium-hypochlorite-as-hemostatic-agents-in-mta-pulpotomy-of-primary-molars-100644947",false,"NCT07675330","Oxymetazoline Versus Sodium Hypochlorite as Hemostatic Agents in MTA Pulpotomy of Primary Molars","Comparative Evaluation of Clinical and Radiographic Success of Oxymetazoline Versus Sodium Hypochlorite as Hemostatic Agents in MTA Pulpotomy of Primary Molars in a Group of Egyptian Children: A Randomized Controlled Trial","OXY - MTA","Inclusion Criteria:\n\n• Patients: Egyptian children with carious mandibular primary molars aged 4-8 years.\n\n• Teeth: Restorable mandibular primary molars with no clinical signs or symptoms of irreversible pulpitis.\n\n• Pre-operative Radiograph: No radiographic signs of internal or external root resorption and no furcation or periapical radiolucencies.\n\n\\-\n\nExclusion Criteria:\n\n* • Patients:\n\n  1. Uncooperative children.\n  2. Medically compromised children.\n  3. Patients whose parents refuse to participate or refuse to sign the informed consent.\n\n     * Teeth:\n\n  \u003C!-- -->\n\n  1. Previously accessed molars.\n  2. Mobile primary molars.\n  3. Presence of sinus tract or pain on percussion.","ALL","4 Years","8 Years",{"count":21,"type":22},50,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study aims to evaluate clinical and radiographic success of oxymetazoline versus sodium hypochlorite as hemostatic agents in MTA pulpotomy of primary molars.",[28,29,30,31,32,33,34,35],"Pulp Disease, Dental","Pulp Therapy in Primary Molars","Pulpitis - Reversible","Pulp Inflammation","Vital Pulp Therapies","Carious Exposure of Pulp","Primary Molar Tooth","Primary Molar Pulpotomy",[37,38,39,40,41,42,43,44,45],"Pulp therapy in primary molars","pulpotomy","MTA pulpotomy for primary molars","Sodium hypochlorite","Oxymetazoline","Hemostatic agents","NaOCl","Oxy","Oxymetazoline nasal spray","NOT_YET_RECRUITING","2026-06-26",{"date":49,"type":50},"2026-06-30","ACTUAL",{"date":52,"type":22},"2026-08",{"date":54,"type":22},"2027-12",{"name":56,"class":57},"Cairo University","OTHER",1,{"id":60,"slug":61,"hasResults":11,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":4,"eligibilityCriteria":65,"healthyVolunteers":11,"sex":17,"minAge":66,"maxAge":4,"enrollmentInfo":67,"targetDuration":4,"studyType":23,"phases":69,"briefSummary":71,"conditions":72,"keywords":73,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":4},"100621696","early-phase-1-comparison-of-postoperative-pain-after-pulpotomy-performed-with-versus-without-dental-operating-microscope-in-carious-mature-permanent-teeth-100621696","NCT07373977","Comparison of Postoperative Pain After Pulpotomy Performed With Versus Without Dental Operating Microscope in Carious Mature Permanent Teeth","Comparison of Postoperative Pain After Pulpotomy Performed With Versus Without Dental Operating Microscope in Carious Mature Permanent Teeth : A Randomized Controlled Trial","Inclusion Criteria:\n\n* Healthy patients aged at least 18 years old with deep or extremely deep carious lesions in mature permanent teeth diagnose with symptomatic irreversible pulpitis. Diagnoses are confirmed using EPT and cold tests. Pulpal and periapical diagnoses are based on terminology from the American Association of Endodontists (AAE, 2013)20.\n* Posterior teeth with moderate or severe pain according to The NRS (Numeric Rating Scale) According to this scale, the level of pain is documented in the range of 0-10 numerically and verbally as no pain (0), mild pain, non-disruptive to routine activities (1-3), moderate pain that interferes with daily life but no need analgesics intake (4-6) and severe pain that significantly disrupts normal acitivities requiring analgesic intervention (7-10).\n* Teeth that response negatively to percussion and palpation tests.\n* Teeth are restorable with direct composite restoration.\n\nExclusion Criteria:\n\n* Teeth with subgingival caries and\u002For clinical attachment loss more than 3 mm and probing depth more than 4 mm.\n* Negative responses to pulp sensibility tests, presence of sinus tracts, swelling, non-restorable crowns, immature roots, or no pulp exposure following complete caries removal in case of pre-operative diagnosis as asymptomatic irreversible pulpitis.\n* Patients with systemic diseases involving bleeding disorders such as hemophilia, Von Willebrand disease, platelet disorders. And patients under taking all kind of anticoagulant and anti-platelet.\n* Patients who had taken analgesics or anti-inflammatory drugs within the previous 24 hours. If necessary, record how many and dose that taken.\n* Patients taking opioids.\n* Known allergies to non-steroidal anti-inflammatory drugs (NSAIDs).\n* Pregnant or lactating patients.\n* Teeth with pulpal obliteration.\n* Necrotic pulp is found after access opening\n* Bleed cannot be stopped within 8 minutes after full pulpotomy","18 Years",{"count":68,"type":22},82,[70],"EARLY_PHASE1","The goal of this \\[randomized clinical trials\\] is to investigate the effect of using dental operating microscope incorperated in full pulpotomy procedure in mature carious posterior teeth.\n\nThe main questions it aims to answer are:\n\ninvestigate postoperative pain levels.\n\ninvestigate the quality of life of patient after treatment.\n\nIf there is a comparison group: Researchers will compare the pulpotomy procedure with and without using dental operating microscope.\n\nParticipants will will be asked to do\n\n* Pain evaluation with numerical rating scale\n* OHIP 14 survey before and after treatment",[33],[74,75,76],"Pulpotomy","Dental operating microscope","post-operative pain","2026-01-28",{"date":79,"type":50},"2026-01-30",{"date":81,"type":22},"2026-02-10",{"date":83,"type":22},"2026-12-31",{"name":85,"class":57},"Chulalongkorn University",{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":94,"sex":17,"minAge":66,"maxAge":4,"enrollmentInfo":95,"targetDuration":4,"studyType":23,"phases":97,"briefSummary":98,"conditions":99,"keywords":4,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":4},"100545201","outcome-of-selective--nonselective-caries-removal-in-permanent-teeth-100545201","NCT06378814","Outcome of Selective & Nonselective Caries Removal in Permanent Teeth","Randomized Clinical Trial of Treatment Outcomes of Selective Versus Nonselective Caries Removal in Deep Carious Lesions in Permanent Teeth.","RCT-SNCR","Inclusion Criteria:\n\n1. Dental patients from routine dental care at ADC (Acute Dental Care) clinics, both undergraduate and postgraduate dental clinics in Guy's Hospital.\n2. Both male and female individuals aged 18 years and older.\n3. Capable of providing informed consent.\n4. Generally, in good overall health from a medical standpoint.\n5. Possess at least one molar or premolar tooth exhibiting a clinically significant deep carious lesion, with or without carious pulp exposure.\n6. Displaying signs and symptoms indicative of a normal pulp or reversible pulpitis.\n7. positive response to the cold test (refrigerated gas).\n8. Absence of spontaneous pain.\n9. Absence of periapical lesions, as determined by routine radiographic examination\n\nExclusion Criteria:\n\n1. Presence of fistulas or swelling.\n2. Involvement of anterior teeth.\n3. Evidence of external or internal root resorption.\n4. Multiple teeth with carious lesions within the same quadrant.\n5. Pregnancy in women.\n6. Patients under the age of 18.\n7. Individuals unable to provide informed consent.\n8. Patients who have received antibiotics in the preceding month.\n9. Immunocompromised patients.\n10. Teeth with tooth surface loss resulting from traumatic parafunctional habits or teeth displaying craze lines.\n11. Caries located beneath the gingival margin .\n12. Teeth affected by periodontal issues, characterized by bone loss or severe gingival recession.\n13. Teeth with pulp exposure where operators cannot achieve hemostasis after applying a cotton pellet soaked with 2.5% sodium hypochlorite (NaOCl) for three cycles, with each cycle consisting of a 2-minute application of NaOCl.\n14. People with difficulty to understand the clinical trial concept, procedure and details including language barrier.\n15. participants who are involved in other research at the same period of our study.",true,{"count":96,"type":22},168,[25],"Patients presenting with deep decay within permanent teeth presents a common clinical challenge to dentists. The aim of this trial is to compare the success rate of the non-selective caries removal (NSCR) and selective caries removal (SCR) in managing deep caries, as both methods are commonly used in clinical practice.\n\nThis study will be a randomized controlled trial, with participants divided into two groups: NSCR group and SCR group. Participants of deep caries lesions (reaching more than two-thirds of dentin on periapical radiographs) Both groups will undergo either NSCR or SCR, followed by Partial Pulpotomy (PP) in cases with pulp exposure. Success rates will be assessed at follow-up visits scheduled 1, 3, and 5 years radiographs will be used to assess for pulp health(vitality).\n\nThe success rate of the two categories will be assessed using a scale that includes factors such as tooth vitality, caries recurrence, and clinical signs of pulpitis. The scale will be applied at follow-up visits. The trial will be conducted in post-graduate dental clinics at Guy's hospital.\n\nDeep caries in permanent teeth is a common clinical problem that can lead to pulp exposure and subsequent restorative challenges. The aim of this study is to provide evidence-based guidance for clinicians in managing deep caries lesions, as both NSCR and SCR are commonly used in clinical practice. The results of this study will help clinicians to make informed decisions when choosing the appropriate treatment approach for their patients.\n\nIn conclusion, this trial aims to compare the success rate of NSCR and SCR in managing deep caries lesions in permanent teeth, as both methods are commonly used in clinical practice. The results of this study will provide valuable insights into the effectiveness of these two treatment approaches and will help clinicians to make informed decisions when choosing the appropriate treatment approaches.",[100,33],"Deep Caries","2024-04-25",{"date":103,"type":50},"2024-04-29",{"date":105,"type":22},"2024-05-01",{"date":107,"type":22},"2030-04-30",{"name":109,"class":57},"King's College London"]