[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"carotid-artery-stenosis-symptomatic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:carotid-artery-stenosis-symptomatic":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,66,98],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":37,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":65},"100635761","clinical-impact-of-using-improve-to-select-patients-for-carotid-revascularisation-100635761",false,"NCT07556887","Clinical Impact of Using IMPROVE to Select Patients for Carotid Revascularisation","Clinical Impact of the Use of IMPROVE for Selection of Patients for Carotid Revascularisation: a Randomized Controlled Multicentre Non-inferiority Trial in Symptomatic Patients With 30-99% Carotid Stenosis","IMPROVE","Inclusion Criteria:\n\n* Mentally competent\n* 18 years or older\n* Recent (\\\u003C30 days) stroke (modified Rankin scale ≤3) or TIA\n* Ipsilateral 30-99% atheromatous stenosis at the carotid bifurcation assessed using non-invasive imaging according to NASCET criteria\n* Life expectancy \\>5 years\n* Patient and stenosis are suitable for carotid revascularisation\n* Patient is agreeable to randomisation and willing to accept either IMPROVE-based or CAU-based selection method for carotid revascularisation\n\nExclusion Criteria:\n\n* Cardiac source of embolism\n* Carotid stenosis caused by non-atherosclerotic disease e.g. dissection, fibromuscular disease or neck radiotherapy.\n* MRI contra-indications\n* Pregnancy","ALL","18 Years",{"count":20,"type":21},613,"ESTIMATED","INTERVENTIONAL",[24],"NA","Narrowing of the carotid artery due to atherosclerosis with an unstable plaque can cause a stroke. Patients with carotid artery disease who have had a TIA or minor stroke and are at high risk of another stroke are often treated with surgery or stenting to remove the plaque. For lower-risk patients, medication alone is the better option, as surgery also carries risks. A new decision method, based on MRI detection of unstable plaques (IMPROVE), can better assess stroke risk and help determine which patients do or do not need surgery. We are investigating whether this method is at least as effective as the standard approach, which mainly considers the degree of narrowing. We expect that this new method will help reduce strokes and lower healthcare costs.\n\nPatients will be followed for several years to compare which method is better for health and costs.",[27,28,29,30,31,32,33,34,35,36],"Carotid Artery Stenosis Symptomatic","Ischemic Cerebral Infarction","Stroke Ischemic","Atheroscleroses","Stroke (CVA) or TIA","Stroke","Intraplaque Hemorrhage","TIA (Transient Ischemic Attack)","Atherosclerosis Cerebral Infarction","Carotid Arteriosclerosis",[38,39,40,41,42,43,44,45,46,47,48,49,50,51,52],"Carotid Artery Stenosis","Transient Ischemic Attack","Ischemic Stroke","Atherosclerosis","Plaque Rupture","Revascularisation","Carotid Endarterectomy","Carotid Artery Stenting","Magnetic Resonance Imaging","Stroke Risk Prediction","Intraplaque hemorrhage","Clinical Decision Support","Randomized Controlled Mulitcentre Trial","Cost-Effectiveness Analysis","Optimal Medical Therapy","RECRUITING","2026-05-12",{"date":56,"type":57},"2026-05-15","ACTUAL",{"date":59,"type":57},"2026-03-31",{"date":61,"type":21},"2031-08-31",{"name":63,"class":64},"Maastricht University Medical Center","OTHER",10,{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":73,"targetDuration":75,"studyType":76,"phases":4,"briefSummary":77,"conditions":78,"keywords":81,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":97},"100604495","correlation-between-carotid-stump-pressure-and-interhemispheric-rso-asymmetry-during-awake-carotid-endarterectomy-100604495","NCT07150260","Correlation Between Carotid Stump Pressure and Interhemispheric rSO₂ Asymmetry During Awake Carotid Endarterectomy","Evaluation of the Correlation Between Carotid Stump Pressure and Interhemispheric rSO₂ Asymmetry in Awake Carotid Endarterectomy: A Prospective Cohort Study","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Scheduled for elective carotid endarterectomy (CEA)\n* Able to tolerate surgery under regional anesthesia (superficial cervical plexus block)\n* Availability of bilateral regional cerebral oxygen saturation (rSO₂) measurements by near-infrared spectroscopy (NIRS)\n* Successful intraoperative carotid stump pressure (SP) measurement after cross-clamping\n* Provided written informed consent\n\nExclusion Criteria:\n\n* Incomplete NIRS or SP recordings\n* Conversion from regional to general anesthesia\n* Intraoperative technical complications preventing monitoring\n* History of prior ipsilateral carotid endarterectomy or carotid artery stenting\n* Recent major stroke with permanent neurological deficit\n* Recent myocardial infarction within the past 3 months\n* History of traumatic brain injury within the past 6 months",{"count":74,"type":21},60,"30 Days","OBSERVATIONAL","This study aims to better understand how well the brain is perfused (supplied with blood and oxygen) during a specific type of surgery called carotid endarterectomy (CEA), which is performed to prevent strokes in people with stenosis of carotid arteries.\n\nDuring this surgery, the surgeon temporarily clamps the carotid artery to remove a blockage, which can reduce blood flow to the brain. Monitoring brain oxygen levels during this time is important to prevent brain injury. Two common monitoring methods are:\n\nStump pressure (SP) - a pressure measurement taken from the carotid artery during surgery.\n\nNear-infrared spectroscopy (NIRS) - a non-invasive technique that tracks brain oxygen levels in real time.\n\nThis study focuses on the relationship between carotid stump pressure and differences in brain oxygenation between the two sides of the brain (interhemispheric asymmetry), as measured by NIRS.\n\nThe study will include patients undergoing awake CEA (under regional anesthesia) at a single center university hospital. Oxygen levels in both hemispheres of the brain will be monitored before and after the carotid artery is clamped after 3 minutes. Stump pressure will also be measured. The researchers will examine whether low stump pressure is linked to greater differences in brain oxygen levels between the two sides.\n\nThe primary goal is to determine whether a large difference in brain oxygenation between the two hemispheres (greater than 10%) is associated with low carotid stump pressure. Secondary goals include identifying a stump pressure threshold that predicts significant asymmetry and analyzing the influence of patient and surgical factors.\n\nThe findings may help improve how surgeons and anesthesiologists monitor and protect the brain during CEA, particularly in patients who are awake and can be observed for neurological changes.",[27,79,80],"Carotid Endarterectomy (CEA) Surgical Patients","Cerebral Hypoperfusion",[82,83,84,85,86,87],"Carotid stump pressure","Near-infrared spectroscopy","rSO₂ asymmetry","Cerebral oxygenation","Awake carotid endarterectomy","Regional anesthesia","2026-01-06",{"date":90,"type":57},"2026-01-07",{"date":92,"type":57},"2025-09-01",{"date":94,"type":21},"2026-10-01",{"name":96,"class":64},"Izmir Katip Celebi University",1,{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":76,"phases":4,"briefSummary":108,"conditions":109,"keywords":4,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":4},"100611587","non-canonical-activation-of-bood-coagulation-100611587","NCT07242521","NON CANONICAL ACTIVATION OF BOOD COAGULATION","NON CANONICAL ACTIVATION OF BOOD COAGULATION (WORK PACKAGE 1) - VIE ALTERNATIVE DI ATTIVAZIONE DELLA CASCATA COAGULATIVA (PROGETTO 1)","NCA-BC","Inclusion Criteria:Patients with carotid artery stenosis (CAS). One hundred patients with atheromatous carotid artery stenosis (CAS), admitted to the Unit of Vascular Surgery (RU-UniCATT) of Fondazione Policlinico Universitario A. Gemelli IRCCS for carotid endoarterectomy or stenting as per standard of care, will be enrolled. These patients will be divided into two cohorts composed of 50 patients each: 1) asymptomatic form of CAS (Cohort A) and 2) symptomatic CAS (Cohort B). In each cohort, T2DM and not diabetic patients will be enrolled with a 1:1 ratio. Patients on low-dose aspirin, statins, ACE inhibitors, metformin, pioglitazone, and sulfonylureas for DM patients.\n\nExclusion Criteria:any hemorrhagic coagulopathy, familial hypercholesterolemia, liver cirrhosis, sepsis, recent (12 months) surgery, trauma, IMA, or ischemic stroke, age \\\u003C18 years old and inability to understand and sign the informed consent form.",{"count":107,"type":21},200,"Cardiovascular diseases (CVD) are the major cause of mortality and morbidity worldwide and most of them are characterized by enhanced generation of active -thrombin (T) from the inactive Prothrombin zymogen (ProT), a reaction catalysed by factor Xa. CVD may be idiopathic, but also appear as the expression of thrombotic complications occurring with variable incidence and severity in different (apparently unrelated) diseases, such as for instance Type-2 Diabetes (T2D) , Chronic Kidney Disease (CKD), Inflammatory Bowel Disease (IBD) , Cancer , rheumatoid (RA) arthritis , autoimmune diseases such as the AntiPhospholipid Syndrome (APS), bacterial and viral infectious diseases, and amyloid-related diseases such as Alzheimer's disease, IgG light-chain amyloidosis and human transthyretin (hTTR) Senile Systemic Amyloidosis.This Project aims at combining different and complementary expertise with the general purpose of identifying new pathogenetic mechanisms for CVD and explored the possibility to devise novel and more effective therapeutic strategies.",[110,111,27,112],"Oxidative Stress","vonWillebrand Disease","Carotid Artery Stenosis Asymptomatic","NOT_YET_RECRUITING","2025-11-17",{"date":116,"type":57},"2025-11-21",{"date":118,"type":21},"2025-11",{"date":120,"type":21},"2026-02-06",{"name":122,"class":64},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS"]